martes, 7 de octubre de 2014

NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

National Center for Toxicological Researh log with FDA on left side

Current Highlight from October 5, 2014

International Conference on Neuroprotective Agents
NCTR scientists presented their preclinical research results at the 12th International Conference on Neuroprotective Agents held September 28-October 1, 2014, in Charlottesville, VA.  The topics of presentations involved issues ranging from penetration of the blood-brain barrier by therapeutics to the reversible/irreversible effects of anesthetics on neural cells.  The specific topics for the presentations were:
  • Mediation of tight junctions in the blood-brain barrier by A25-35-RAGE
  • Neuroprotective role of the TRPC6 receptor in a mouse model of Parkinson’s disease
  • Protective effects of N-acetylcysteine against nanoparticle-induced cytotoxicity in an in vitro blood-brain barrier model
  • Mobilization of neural stem cells after developmental estrogen treatment
  • Potential use of leukemia drugs for neuroprotection in Parkinson’s disease
  • Effects of silver nanoparticles on human and rat embryonic neural stem cells
  • Long-lasting cognitive deficits in nonhuman primates after general anesthesia administered during the first week post-partum
  • Neuroprotective effects of acetyl-L-carnitine in a mouse model of Parkinson’s disease
  • Use of small-animal PET to monitor sevoflurane-induced neuronal injury in neonatal nonhuman primates
  • Effects of propofol on neural stem cells in culture.
For additional information, please contact Merle Paule, Ph.D., Director of Neurotoxicology, FDA/NCTR.

Contact FDA

National Center for Toxicological Research
Food and Drug Administration
3900 NCTR Road
Jefferson, AR 72079

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