Kenneth Olden, Yu-Sheng Lin, David Gruber, and Babasaheb Sonawane. Epigenome: Biosensor of Cumulative Exposure to Chemical and Nonchemical Stressors Related to Environmental Justice. American Journal of Public Health: October 2014, Vol. 104, No. 10, pp. 1816-1821.
doi: 10.2105/AJPH.2014.302130
Accepted on: Jun 13, 2014
Epigenome: Biosensor of Cumulative Exposure to Chemical and Nonchemical Stressors Related to Environmental Justice
Kenneth Olden, PhD, ScD, Yu-Sheng Lin, ScD, David Gruber, PhD, and Babasaheb Sonawane, PhD
Kenneth Olden, Yu-Sheng Lin, and Babasaheb Sonawane are with National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC. David Gruber is with Department of Natural Sciences, Baruch College, City University of New York, New York, NY.
ABSTRACT |
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Understanding differential disease susceptibility requires new tools to quantify the cumulative effects of environmental stress. Evidence suggests that social, physical, and chemical stressors can influence disease through the accumulation of epigenetic modifications.
Geographically stable epigenetic alterations could identify plausible mechanisms for health disparities among the disadvantaged and poor. Relations between neighborhood-specific epigenetic markers and disease would identify the most appropriate targets for medical and environmental intervention. Complex interactions among genes, the environment, and disease require the examination of how epigenetic changes regulate susceptibility to environmental stressors. Progress in understanding disparities in disease susceptibility may depend on assessing the cumulative effect of environmental stressors on genetic substrates.
We highlight key concepts regarding the interface between environmental stress, epigenetics, and chronic disease.
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