HIV/AIDS Genomics: Advances in Therapy & Tests

Genomics|Update|Current

HIV/AIDS Genomics: Advances in Therapy & Tests

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Hu W, et al.  PNAS, Jul 21, 2014.

Genome editing cuts out HIV
Grens K. The Scientist, Jul 21, 2014.

Gene researchers work to engineer HIV-resistant cells 
Hampton T. JAMA, Jul 9, 2014.

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.

Promising results from HIV gene editing therapy, PHG Foundation, Mar 10

Check out guidelines on genomic tests associated with HIV/AIDS treatment, from the CDC evidence-based table

HLA-B*5701/abacavir	DHHS Advisory Committee  [PDF 1.46 MB] (2013)  CPIC (2014) FDA-PGx Drug Information (2013)
CCR5-tropic HIV-1 /maraviroc	FDA-PGx Drug Information (2013) HHS Panel  [PDF 1.46 MB] (2013)

Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.

Did you know? 1799 genes have been reported in relation to HIV risk & outcomes including 33 genomewide association studies. To find out more, visit the HuGE Navigator