Cancer therapy resistance: chasing epigenetics
- Nature Medicine
- 20,
- 340–341
- doi:10.1038/nm.3528
- Published online
Dr. Gopal Murti / Science Source
Resistance to targeted cancer therapies is a challenge to their successful application. T cell acute lymphoblastic leukemia (T-ALL) has been found to be associated with activation of the signaling protein NOTCH1; however, clinical success of NOTCH1-targeted therapies has been transient, probably owing to the development of drug resistance. Knoechel et al.1…
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