Recommendations for the nutrition management of phenylalanine hydroxylase deficiency : Genetics in Medicine : Nature Publishing Group

Recommendations for the nutrition management of phenylalanine hydroxylase deficiency : Genetics in Medicine : Nature Publishing Group

Recommendations for the nutrition management of phenylalanine hydroxylase deficiency

• Rani H. Singh PhD, RD,
• Fran Rohr MS, RD,
• Dianne Frazier PhD, MPH,
• Amy Cunningham MS, RD,
• Shideh Mofidi MS, RD,
• Beth Ogata MS, RD,
• Patricia L. Splett PhD, MPH,
• Kathryn Moseley MS, RD,
• Kathleen Huntington MS, RD,
• Phyllis B. Acosta DrPH, RD,
• Jerry VockleyMD, PhD
• & Sandra C. Van Calcar PhD, RD

• Affiliations
• Corresponding author

Genetics in Medicine

 

(2014)

 

doi:10.1038/gim.2013.179

Received

 

06 September 2013 

Accepted

 

16 October 2013 

Published online 

02 January 2014

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Abstract

• Abstract• 
• References• 
• Author information

The effectiveness of a phenylalanine-restricted diet to improve the outcome of individuals with phenylalanine hydroxylase deficiency (OMIM no. 261600) has been recognized since the first patients were treated 60 years ago. However, the treatment regime is complex, costly, and often difficult to maintain for the long term. Improvements and refinements in the diet for phenylalanine hydroxylase deficiency have been made over the years, and adjunctive therapies have proven to be successful for certain patients. Yet evidence-based guidelines for managing phenylalanine hydroxylase deficiency, optimizing outcomes, and addressing all available therapies are lacking. Thus, recommendations for nutrition management were developed using evidence from peer-reviewed publications, gray literature, and consensus surveys. The areas investigated included choice of appropriate medical foods, integration of adjunctive therapies, treatment during pregnancy, monitoring of nutritional and clinical markers, prevention of nutrient deficiencies, providing of access to care, and compliance strategies. This process has not only provided assessment and refinement of current nutrition management and monitoring recommendations but also charted a direction for future studies. This document serves as a companion to the concurrently published American College of Medical Genetics and Genomics guideline for the medical treatment of phenylalanine hydroxylase deficiency.

Genet Med advance online publication 2 January 2014

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Keywords:

 

medical food; nutrition management of PAH deficiency; nutrition recommendations; phenylalanine hydroxylase deficiency; phenylketonuria

References

• Abstract• 
• References• 
• Author information

1. Agency for Healthcare Research and Quality. Comparative Effectiveness of Treatment for Phenylketonuria (PKU). Comparative Effectiveness Review No. 56. (Prepared by the Vanderbilt Evidence-Based Practice Center under Contract No. 290-2007-10065-I.) AHRQ Publication No. 12-EHC035-EF. 2011;http://www.effectivehealthcare.ahrq.gov/reports/final.cfm.
2. National Institutes of Health. National Institutes of Health Consensus Development Conference Statement: phenylketonuria: screening and management, October 16-18, 2000.Pediatrics 2001;108:972–982.