jueves, 8 de agosto de 2013

Rotavirus G9P[4] in 3 Countries in Latin America, 2009–2010 - Vol. 19 No. 8 - August 2013 - Emerging Infectious Disease journal - CDC

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Rotavirus G9P[4] in 3 Countries in Latin America, 2009–2010 - Vol. 19 No. 8 - August 2013 - Emerging Infectious Disease journal - CDC

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Table of Contents
Volume 19, Number 8–August 2013

Volume 19, Number 8—August 2013

Letter

Rotavirus G9P[4] in 3 Countries in Latin America, 2009–2010

Suggested citation for this article
To the Editor: Group A rotaviruses are the most common viral cause of acute gastroenteritis in young children. The most frequently detected group A rotavirus genotype combinations include G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]. The G9 genotype has been associated with multiple P types, including P[8], P[6], and P[4], although genotype G9P[8] is predominant (1).
In Latin America, a large number of unusual G-P combinations have been reported, and among these is the rare G9P[4] genotype, which was identified in Brazil in the 1990s (2), and later reported infrequently elsewhere in Latin America (3). In 2010, cases of group A rotavirus gastroenteritis associated with genotype G9P[4] were reported in Mexico (4). Increases in the incidence of group A rotavirus gastroenteritis were reported in 2010 in Mexico and Guatemala and in 2009 in Honduras (http://new.paho.org/hq/dmdocuments/2010/Epi_Alerts_2010_mar_5_rotavirus.pdf Adobe PDF fileExternal Web Site Icon).
In response to these reports of increased group A rotavirus disease, fecal samples collected in Chiapas State, Mexico (in 2010, 30% of the cases in Mexico were from Chiapas), Guatemala, and Honduras in 2009–2010 that were positive by enzyme immunoassay were sent to the US Centers for Disease Control and Prevention (Atlanta, GA, USA) for characterization. Viral protein 4 (VP4) (P) and VP7 (G) genotyping, nucleotide sequencing, and genotype identification were performed by using consensus and genotype-specific oligonucleotide primers (5), and sequences were subjected to phylogenetic analyses. VP6 and nonstructural protein 4 (NSP4) genes of selected samples were also sequenced.

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