lunes, 15 de abril de 2013

Transforming Epidemiology for 21st Century Medicine and Public Health

Transforming Epidemiology for 21st Century Medicine and Public Health

Transforming Epidemiology for 21st Century Medicine and Public Health

  1. Sheri D. Schully1

+ Author Affiliations

  1. Authors' Affiliations: 1Division of Cancer Control and Population Sciences, 2Division of Cancer Epidemiology and Genetics, and 3Division of Cancer Prevention, National Cancer Institute, and 4Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland; 5Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; 6Stanford Prevention Research Center, Department of Medicine, Department of Health Research and Policy, Stanford University School of Medicine, and Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, California; 7Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas; 8Division of Medicine, Brigham and Women's Hospital; 9Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 10Department of Epidemiology and Nutrition, Harvard School of Public Health; 11Slone Epidemiology Center, Boston University, Boston, Massachusetts; 12Center for Health Research, Kaiser Permanente, Portland, Oregon; 13Center for Genomic Medicine, Institute for Genome Sciences and Policy, Duke University School of Medicine, Durham, North Carolina; 14International Agency for Research on Cancer, Lyon, France; 15Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California; 16Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, Illinois; 17Office of the Director, Moffit Cancer Center, Tampa, Florida; 18Departments of Epidemiology and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; 19Department of Biostatistics and Epidemiology and Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; 20Computational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee; and 21Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York

  1. Corresponding Author:
    Muin J. Khoury, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333. Phone: 404-498-0001; Fax: 404-498-0140; E-mail: muk1@CDC.GOV


In 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating “big data” science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy, and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits. Cancer Epidemiol Biomarkers Prev; 22(4); 508–16. ©2013 AACR.


  • Note from the Editor-in-Chief: This is one in a series of commentaries that have arisen from an initiative of the National Cancer Institute to advance epidemiological science in the 21st century.

  • Received February 7, 2013.

  • Accepted February 17, 2013.

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