NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

Current Highlight from February 15, 2013

---

Cigarette Smoke Condensate Induces Epigenetic Changes In Vitro

NCTR scientists demonstrated that treatment of a lung epithelial cell line with cigarette smoke condensates (CSCs) resulted in changes in gene expression and promoter methylation of a number of critical genes shown to be involved in lung cancer development (i.e., ECAD, MGMT, and RASSF1A).  Furthermore, cells treated with CSCs for 28 days showed changes in morphology, invasion capacities, and global methylation status.  These results suggest that epigenetic changes could serve as early biomarkers of harm due to cigarette smoke exposure.  The results of this study have been published in an article in the International Journal of Toxicology^{2 3}.

For additional information, please contact George Hammons, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.

-

NCTR Research Highlights Archives

• 2013-NCTR Research Highlights⁴
  
• 2012-NCTR Research Highlights⁵
  
• 2011-NCTR Research Highlights⁶
  
• 2010-NCTR Research Highlights⁷
  
• 2009-NCTR Research Highlights⁸
  
• 2008-NCTR Research Highlights⁹
  
• 2007-NCTR Research Highlights¹⁰
  
• 2006-NCTR Research Highlights¹¹