Current Highlight from February 15, 2013
Cigarette Smoke Condensate Induces Epigenetic Changes In Vitro
NCTR scientists demonstrated that treatment of a lung epithelial cell line with cigarette smoke condensates (CSCs) resulted in changes in gene expression and promoter methylation of a number of critical genes shown to be involved in lung cancer development (i.e., ECAD, MGMT, and RASSF1A). Furthermore, cells treated with CSCs for 28 days showed changes in morphology, invasion capacities, and global methylation status. These results suggest that epigenetic changes could serve as early biomarkers of harm due to cigarette smoke exposure. The results of this study have been published in an article in the International Journal of Toxicology2 3.For additional information, please contact George Hammons, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.