Translational Application of Epigenetic Alteration... [FEBS Lett. 2011] - PubMed result

FEBS Lett. 2011 Mar 11. [Epub ahead of print]

Translational Application of Epigenetic Alterations: Ovarian Cancer as a Model.
Maradeo ME, Cairns P.

SPORE in Ovarian Cancer Program Fox Chase Cancer Center Philadelphia, USA.


Abstract
Cancer is a disease initiated and driven by the accumulation and interplay of genetic and epigenetic mutations of genes involved in the regulation of cell growth and signaling. Dysregulation of these genes and pathways in a cell leads to a growth advantage and clonal expansion. The epigenetic alterations involved in the initiation and progression of cancer are DNA methylation and histone modifications which interact to remodel chromatin, as well as RNA interference. These alterations can be used as candidate targets in molecular tests for risk, early detection, prognosis, prediction of response to therapy, and monitoring, as well as new therapeutic targets in cancer. In this review, we discuss the rationale, studies to date, and issues in the translational application of epigenetics using epithelial ovarian cancer as a specific example of all types of cancer.

Copyright © 2011. Published by Elsevier B.V.
PMID: 21402071 [PubMed - as supplied by publisher]

Translational Application of Epigenetic Alteration... [FEBS Lett. 2011] - PubMed result