Influenza B viruses with mutation in the neuraminidase active site, north Carolina, USA, 2010-11.

Sleeman K, Sheu TG, Moore Z, Kilpatrick S, Garg S, Fry AM, Gubareva LV.

Source

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

Oseltamivir is 1 of 2 antiviral medications available for the treatment of influenza B virus infections. We describe and characterize a cluster of influenza B viruses circulating in North Carolina with a mutation in the neuraminidase active site that may reduce susceptibility to oseltamivir and the investigational drug peramivir but not to zanamivir.