CIENCIASMEDICASNEWS: Small Molecules, Big Challenges: Adopting New Methods for Stability Testing

jueves, 14 de marzo de 2019

Small Molecules, Big Challenges: Adopting New Methods for Stability Testing

	March 14, 2019
	Life Science Microscopy
	The latest life science microscopy news from AZoNetwork

Small Molecules, Big Challenges: Adopting New Methods for Stability Testing
A technique that enables determination of active ingredient content of tablets during continuous manufacturing processes is Raman spectroscopy. In addition, this has been combined with optical imaging to form the methodology known as Raman microscopy. This is a powerful tool for providing detailed chemical information in both the spatial and spectral dimensions. As such, it has become the standard way for the pharmaceutical industry to achieve polymorphic characterization of active pharmaceutical ingredients.

Do You Have Your IHC Controls Under Control?

This article outlines three types of control to provide support that the readout of the IHC staining is reliable, in terms of indicating that what you see in the microscope is the true presence of the antigen.

For updates on relevant antibody news for your life sciences research, subscribe to the Atlas Antibodies blog.

Avoiding Cell Death in Fluorescence Microscopy

Fluorescence microscopy is a common laboratory tool used to investigate the physiology of different cells. Specific wavelengths of light are shone onto cells in a sample, where the light is absorbed by molecules called fluorophores.

	Two-Photon Microscopy Applications Two-photon microscopy is a method that enables the imaging of live cell and tissue samples with high resolution. It is a form of fluorescence microscopy and provides visualization of fluorescent signals via an excitation wavelength being absorbed by a fluorophore and an emission wavelength released.

	Types of Scanning Probe Microscopy There are several different types of scanning probe microscopes, the most prominent of which are atomic force microscopy (AFM) and scanning tunneling microscopy (STM). There are also many other types, which are listed at the end of this article.

	Microscopy and British History This British Science Week, we are celebrating the scientific pioneers of the past, present and future. Perhaps one of the greatest British pioneers in microscopy was Robert Hooke, who was the first person to observe insect and plant cells using various magnifying lense.