lunes, 5 de agosto de 2013

Influenza: Role of Host Genomics

Diseases of the Week

Influenza: Role of Host Genomics

image of person with lungs shown and flu virus in the air
CDC seasonal influenza information
Integrative genomic analysis of the human immune response to influenza vaccination Adobe PDF file [PDF 4.03 MB]External Web Site Icon
Luis M Franco et al. elife July 2013
Could changes in gene expression be used to predict which individuals will respond to the influenza vaccine?External Web Site Icon Ferreira P et al. elife, July 2013
The role of host genetics in susceptibility to influenza: A systematic reviewExternal Web Site Icon
Peter Horby et al. PLoS One, 2012
Role of polymorphisms in host immune genes in determining the severity of respiratory illness caused by pandemic H1N1 influenza.External Web Site Icon
Kenyan W, et al.  Public Health Genomics, Mar 2013
CDC paper: A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults.
Ferdinands J et al. Emerging Inf Dis 2011

All 2012-2013 seasonal influenza vaccine has expired. Vaccine for the 2013-2014 season will be available in the fall. Providers and the public should remember that influenza viruses can circulate year-round and that antiviral drugs can treat the flu. In fact, for certain people, treating flu with antiviral drugs can be life-saving Adobe PDF file [702 KB, 2 pages].
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There are many different influenza A viruses; some are found in humans and others in animals such as avian flu in birds and poultry.
A new avian influenza A (H7N9) virus has been detected in China. CDC is following this situation closely and coordinating with domestic and international partners.


Influenza viruses that normally circulate in pigs are called “variant” viruses when they are found in people. Influenza A H3N2 variant viruses (also known as “H3N2v” viruses) with the matrix (M) gene from the 2009 H1N1 pandemic virus were first detected in people in July 2011.


There are many different influenza A Viruses; some are found in humans and others in animals such as swine flu in pigs.


CDC’s pandemic preparedness efforts include ongoing surveillance of human and animal influenza viruses, risk assessments of influenza viruses with pandemic potential, and the development and improvement of preparedness tools that can aid public health practitioners in the event of an influenza pandemic.


Bat influenza refers to influenza A viruses found in bats. Laboratory research at CDC suggests these viruses would need to undergo significant changes to become capable of infecting and spreading easily among humans. Little yellow shouldered bats are not native to the continental United States, but are common in Central and South America.


Dog flu is a contagious respiratory disease in dogs caused by a specific Type A influenza virus referred to as a “canine influenza virus.” This is a disease of dogs, not of humans.


Influenza A viruses are found in humans and many different animals, including ducks, chickens, pigs, whales, horses and seals. Additional information on 2009 H1N1 influenza,, and Nonpharmaceutical Interventions (NPIs).

Flu Activity & Surveillance

Influenza-Like Illness Activity Level Indicator, United States.
Check where flu is active near you.

International Flu

Influenza Division International Program Fiscal Year 2011 Annual Report Cover
2011 International Program Report

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