Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies

Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies1,2,3
Jia-Yi Dong, Ka He, Peiyu Wang, and Li-Qiang Qin

+ Author Affiliations

1From the Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou, China (J-YD and L-QQ); the Departments of Nutrition and Epidemiology, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (KH); and the Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, China (PW).

+ Author Notes

↵2 There was no funding for this study.

↵3 Address correspondence and reprint requests to Li-Qiang Qin, Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, 199 Renai Road, Dushu Lake Higher Education Town, Suzhou, 215123 China. E-mail: dongjy@mail3.sysu.edu.cn.

Abstract
Background: Observational and preclinical studies suggest that dietary fiber intake may reduce the risk of breast cancer, but the results are inconclusive.

Objective: We aimed to examine the association between dietary fiber intake and risk of breast cancer by conducting a meta-analysis of prospective cohort studies.

Design: Relevant studies were identified by a PubMed database search through January 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported RRs with 95% CIs for the association between dietary fiber intake and breast cancer risk. Both fixed- and random-effects models were used to calculate the summary risk estimates.

Results: We identified 10 prospective cohort studies of dietary fiber intake and risk of breast cancer involving 16,848 cases and 712,195 participants. The combined RR of breast cancer for the highest compared with the lowest dietary fiber intake was 0.89 (95% CI: 0.83, 0.96), and little evidence of heterogeneity was observed. The association between dietary fiber intake and risk of breast cancer did not significantly differ by geographic region, length of follow-up, or menopausal status of the participants. Omission of any single study little changed the combined risk estimate. Dose-response analysis showed that every 10-g/d increment in dietary fiber intake was associated with a significant 7% reduction in breast cancer risk. Little evidence of publication bias was found.

Conclusion: This meta-analysis provides evidence of a significant inverse dose-response association between dietary fiber intake and breast cancer risk.

Received March 12, 2011.
Accepted June 15, 2011.
Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies






GINECOLOGÍA
Las mujeres que consumen mucha fibra presentan menos riesgos de tumor mamario
JANO.es · 03 Agosto 2011 00:03

Un estudio llevado a cabo por investigadores chinos demuestra que las personas con una dieta rica en fibra tienen niveles más bajos de estrógeno, factor de riesgo del cáncer de mama.


Un estudio llevado a cabo por investigadores chinos acaba de demostrar que las mujeres que consumen más fibra son menos propensas a desarrollar cáncer mamario. Concretamente, los expertos determinaron que las que consumían gran cantidad de sustancias vegetales saludables eran un 11% menos propensas a desarrollar la enfermedad que las que ingerían menor cantidad. Sin embargo, esto no prueba que la fibra disminuya el riesgo de tener cáncer, según publica American Journal of Clinical Nutrition.

De acuerdo con los autores, las personas con una dieta rica en fibra tienen niveles más bajos de estrógeno, factor de riesgo del cáncer mamario. El equipo revisó los resultados de 10 estudios publicados sobre la dieta de un grupo de mujeres, a las que siguieron durante 7-18 años para determinar quiénes desarrollaban cáncer.

De las 710.000 mujeres que tomaron parte en el estudio, el 2,4% desarrollaron cáncer mamario. Y las que consumían más fibra fueron un 11% menos propensas a tener la enfermedad que las que menos fibra ingerían, aun tras considerar las diferencias en los factores de riesgo como consumo de alcohol, peso, uso de terapia de reemplazo hormonal y antecedentes familiares de la enfermedad.

Con todo, es imposible determinar si las grandes consumidoras de fibra tenían hábitos más saludables que podrían haberl reducido el riesgo de desarrollar un tumor, indica el equipo de Jia-Yi Dong, de la Soochow University, Suzhou (China).



American Journal of Clinical Nutrition 2011;doi: 10.3945/?ajcn.111.015578
Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies

Soochow University
Soochow University.

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