Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota
- Summary
- Introduction
- Results
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- Exp. Proc.
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- Related Info.
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Cell, Volume 149, Issue 7, 1578-1593, 22 June 2012
Copyright © 2012 Elsevier Inc. All rights reserved.
10.1016/j.cell.2012.04.037
Copyright © 2012 Elsevier Inc. All rights reserved.
10.1016/j.cell.2012.04.037
Referred to by: Host and Microbes Date Exclusively
Authors
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA Departments of Microbiology and Immunology and of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650 begin_of_the_skype_highlighting 186-8650 end_of_the_skype_highlighting, Japan Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA Division of Infectious Diseases, Children's Hospital Boston, Boston, MA 02115, USA Corresponding author Present address: Tempero Pharmaceuticals, Cambridge, MA 02139, USA
- Highlights ► Mouse and human microbiota differ in bacterial species, primarily within Firmicutes ► Human microbiota (HMb) colonized mice have a global immunodeficiency like GF mice ► HMb induced less T cell proliferation and activation than mouse microbiota (MMb) ► HMb mice are more susceptible to enteric and disseminated infection than MMb mice
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