domingo, 9 de noviembre de 2014

JAMA Network | JAMA Neurology | Exploring the Epigenetics of Alzheimer Disease

JAMA Network | JAMA Neurology | Exploring the Epigenetics of Alzheimer Disease

Exploring the Epigenetics of Alzheimer DiseaseONLINE FIRST

Bryan J. Traynor, MD, PhD1,2; Alan E. Renton, PhD1
JAMA Neurol. Published online November 03, 2014. doi:10.1001/jamaneurol.2014.3057
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Genome-wide association studies have been tremendously successful at unraveling the genetic architecture of neurological disorders (see for an updated list). Alzheimer disease is a particularly good example of the power of this technology, with multiple loci already identified.1Although the publication of a susceptibility locus is an important milestone in any disease, it represents only the opening act because the identity of the responsible gene within a locus is not always obvious. Without this knowledge, it becomes difficult (if not impossible) to establish a functional connection between genetic variation and the underlying pathobiology. Not surprisingly, this circumstance is a major challenge now faced by the entire genomics field. To bridge this gap, a multipronged approach has been adopted to delineate the effect of genetic variation on the expression of neighboring genes (known as expression quantitative trait loci mapping2) and to quantify the effects of epigenetic phenomena in regulating gene transcription. The term epigenetics covers a gamut of mechanisms such as DNA methylation, chromatin remodeling, gene expression regulation by microRNA, histone modification, and others.

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