lunes, 20 de mayo de 2013

Genetics of bipolar disorder : The Lancet

Genetics of bipolar disorder : The Lancet

The Lancet, Volume 381, Issue 9878, Pages 1654 - 1662, 11 May 2013

doi:10.1016/S0140-6736(13)60855-7Cite or Link Using DOI

This article can be found in the following collections: Genetics & Genomics; Psychiatry (Psychiatry-other)

Genetics of bipolar disorder

Prof Nick Craddock FRCPsych a Corresponding AuthorEmail Address, Prof Pamela Sklar MD b


Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong evidence exists for a polygenic contribution to risk (ie, many risk alleles of small effect). A notable finding is the overlap of susceptibility between bipolar disorder and schizophrenia for several individual risk alleles and for the polygenic risk. By contrast, genomic structural variation seems to play a smaller part in bipolar disorder than it does in schizophrenia. Together, these genetic findings suggest directions for future studies to delineate the aetiology and pathogenesis of bipolar disorder, indicate the need to re-evaluate our diagnostic classifications, and might eventually pave the way for major improvements in clinical management.

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