Atherosclerosis. 2012 Oct 12. pii: S0021-9150(12)00716-2. doi: 10.1016/j.atherosclerosis.2012.10.032. [Epub ahead of print]
Statin treatment of children with familial hypercholesterolemia - Trying to balance incomplete evidence of long-term safety and clinical accountability: Are we approaching a consensus?
SourceHealth Center Mehiläinen, Vantaa, Finland; Finnish Institute of Occupational Health (FIOH), Lappeenranta, Finland.
AbstractIn the heterozygous form of familial hypercholesterolemia (FH), blood concentrations of low-density lipoprotein cholesterol (LDL-C) are elevated two to three times above the normal range since birth, and cause strongly elevated risk of premature coronary artery disease (CAD). There is no evidence that statin therapy is unsafe in FH children, and it has not been associated with clinically significant changes in measures of growth or maturation, liver enzymes, serum creatine kinase, or incidence of myopathy. However, the opinions among clinicians, and between countries, about the age at which statin therapy should be initiated in FH children vary. This review attempts to critically examine the available data, so that clinically the most appropriate age of initiating statin treatment in FH children as a preventive measure for future CAD could be established.
Copyright © 2012. Published by Elsevier Ireland Ltd.
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