Shorter-Course Radiotherapy Is Safe Option for High-Risk Breast Cancer Dawn Attride

https://www.medscape.com/viewarticle/shorter-course-radiotherapy-safe-option-high-risk-breast-2026a10010pm?src= Locoregional recurrence remained low over 10 years in patients with high-risk breast cancer who received shorter courses of radiotherapy after mastectomy in a phase 3 trial. Among postmastectomy patients requiring regional nodal irradiation, hypofractionated radiotherapy and conventional fractionated radiotherapy showed comparable cumulative incidence of locoregional recurrence at 5 years (9.6% vs 8.6%), the primary endpoint of the trial. There were no significant differences in survival outcomes or increases in severe late adverse effects. American Society for Radiation Oncology (ASTRO) 2026 Annual Meeting https://www.medscape.com/c25/p14/american-society-radiation-oncology-astro-2026-annual-2026a1000rs5