sábado, 18 de mayo de 2024
#RAREis Global Advocate Grant
#RAREis Global Advocate Grant
The #RAREis Global Advocate Grant is now accepting applications. This program was established and designed to support the rare disease community by providing financial assistance to global patient advocacy organizations working to advance, educate and address community needs. This year, 75 patient advocacy organizations will be eligible to receive a $5,000 grant to address the needs of the community for support programs and disease education initiatives. Applications close 31 May.
https://www.rareiscommunity.com/rareis-global-advocate-grant/
2ND MULTI-STAKEHOLDER MEETING – ENSURING PATIENT CENTRICITY IN OSTEOGENESIS IMPERFECTA RESEARCH 13 June 2024 @ 8:30 am - 5:40 pm
https://remedi4all.org/event/2nd-multi-stakeholder-meeting-ensuring-patient-centricity-in-osteogenesis-imperfecta-research/
2nd REMEDI4ALL Multi-Stakeholder meeting
REMEDi4ALL invites all stakeholders in the Osteogenesis Imperfecta (OI) research community to join for a day of learning, discussion, and inspiration on 13 June. The meeting will welcome clinicians, academics, patients and patient representatives, pharmaceutical companies, regulators, payers, health economists and all interested in OI and Rare Bone Diseases research. It will discuss and develop patient centric approaches to research and medicines development for OI.
Genetics and genomics
Increase your knowledge and skills in the rare disease space
https://openacademy.eurordis.org/
Enrol in the new EURORDIS Open Academy online course, "Introduction to Genetics and Genomics”. From exploring inheritance patterns to dissecting DNA structures, participants will gain a solid foundation in the fundamental principles of genetics and their crucial role in rare diseases.
Solène Jouan: Enrico Letta’s report and rare diseases in the single market
https://www.eurordis.org/solene-jouan-staff-blog/
Solène Jouan: Enrico Letta’s report and rare diseases in the single market
The former Italian Prime Minister Enrico Letta released a report entitled ‘Much More Than a Market‘, stressing the key actions needed to ensure the modernisation of the European Single Market. Solène Jouan, our EU Public Affairs Manager, discusses what this could mean for people living with rare diseases.
https://www.consilium.europa.eu/media/ny3j24sm/much-more-than-a-market-report-by-enrico-letta.pdf
European Health Data Space clears the last hurdle in Parliament By Catherine Feore | Euractiv
https://www.euractiv.com/section/health-consumers/news/european-health-data-space-clears-the-last-hurdle-in-parliament/
The European Parliament adopted on 24 April the European Health Data Space Regulation, a key step for Europe’s digital healthcare that should facilitate access to cross-border medical data. EURORDIS' Data Director, Jelena Malinina, reacts to the result in this Euractiv article.
Podcast: Rare on Air
https://www.eurordis.org/rare-on-air/
Rare On Air
Tune in to the brand new episode of Rare On Air! In this latest instalment, Julien Poulain speaks with Nicole Faccio, a social media advocate and winner of the EURORDIS Social Media Award at the 2023 Black Pearl Awards. Nicole recounts her experiences with lymphedema, and her interactions with national healthcare systems in Puerto Rico, the UK, and other countries. She shares messages for policymakers, and describes her journey of using social media as a platform for advocacy, and how she harnesses fashion to empower herself and inspire others.
EURORDIS responds to European Parliament adoption of legislation on health data space
https://www.eurordis.org/eurordis-responds-to-legislation-on-health-data-space/
– EURORDIS – Rare Diseases Europe has welcomed the newly adopted position of the European Parliament on the European Health Data Space (EHDS) proposal. A total of 445 Members of the European Parliament voted in favour of the regulatory framework.
EURORDIS responds to European Parliament plenary vote on European Disability Card
https://www.eurordis.org/response-parliament-plenary-vote-on-disability-card/
– EURORDIS – Rare Diseases Europe welcomes the European Parliament’s approval of the provisional agreement on the European Disability Card and the European Parking Card.
For a Strong and Stable EU4Health Programme: The EU4Health Civil Society Alliance’s Statement
https://eu4health.eu/for-a-strong-and-stable-eu4health-programme/
EU4Health statement
EURORDIS stands alongside fellow members of the EU4Health Civil Society Alliance, who have reiterated concerns over the midterm review of the EU Multiannual Financial Framework (MFF) which saw the EU4Health Programme affected by a one billion cut of its total budget.
Patient Partnership in Outreach Webinar: Go East! Project by ERN Lung
https://www.eurordis.org/patient-partnership-in-outreach-webinar/
Patient Partnership in Outreach Webinar: Go East! Project by ERN Lung
➡️ Register now!
🗓️ 28 May 2024
⏰ 17h00 – 17h45 CET
Go East!
Join Gergely Meszaros, European Reference Networks (ERN) Lung project manager and patient advocate, together with Francesco Bonella, clinical expert and investigator in ERN Lung, where they will present the Go East! Project, on 28 May, a patient-led initiative to raise awareness about ERNs among health professionals in Eastern European
#ActRare2024: Life with MCOPS12 and how European action can make a difference May 2024
https://www.eurordis.org/how-european-action-can-make-a-difference/
#ActRare2024
With the EU elections quickly approaching, we spoke to Reinhard Pell, co-founder of patient organisation Cure MCOPS12, where we discussed his family's experiences living with an ultra-rare disease, and what the next EU commission can do to support Europe's rare disease community.
Mental health open webinar: What are the building blocks for Psychosocial Care? May 2024
https://www.eurordis.org/what-are-the-building-blocks-for-psychosocial-care/
Mental wellbeing
Psychosocial care for people living with rare condition requires a flexible and tailored approach that addresses their specific needs. This webinar on 21 May will explore, through an interview format, the core components of care needed to address the psychosocial needs of people living with a rare condition. Register now.
Beacon for rare diseases: ensuring that no one faces their rare journey alone
https://www.rarebeacon.org/
Beacon (formerly known as Findacure) is a UK-based charity that is building a united rare disease community with patient groups at its heart. We envision a world in which no one faces their rare journey alone.
Major survey reveals lengthy diagnostic delays for rare disease patients May 2024
https://www.eurordis.org/survey-reveals-lengthy-diagnostic-delays/
EURORDIS-Rare Diseases Europe has released findings from an extensive Rare Barometer survey highlighting the prolonged and inequitable diagnostic journeys faced by rare disease patients right across Europe.
Conducted between 17 March and 15 June 2022, the landmark Rare Barometer survey encompassed responses from over 10,000 patients from 42 countries, representing 1,675 rare diseases.
In the area of diagnosis, EURORDIS has outlined the a range of policy recommendations for the EU’s incoming policymakers, including promoting equal access to screening and diagnosis services, strengthening collaborative networks, enhancing data systems and recognising undiagnosed patients.
ECRD 2024 culminates with conclusive calls ahead of EU elections
https://www.eurordis.org/conclusive-call-for-action-ecrd-2024/
The 12th European Conference on Rare Diseases and Orphan Products (ECRD 2024) has now concluded, after two action-packed days of activity, discussions and networking.
Hepatitis Awareness Month
https://www.cdc.gov/hepatitis/awareness/HepatitisAwarenessMonth.htm
National Hepatitis Testing Day is a day dedicated to raising awareness of hepatitis B and hepatitis C as well as encouraging more individuals to learn their status. According to the Centers for Disease Control and Prevention (CDC), an estimated 580,000 to 1.17 million people are living with hepatitis B and 2.4 million are people living with hepatitis C in the United States. However, an estimated two-thirds of persons living with hepatitis B and almost half of persons living with hepatitis C, do not know they have the virus, putting them at risk of severe and fatal complications such as liver disease and liver cancer.
Webinar: NIH’s Definition of a Clinical Trial Date and Time June 20, 2024 9:00–10:00 a.m. ET
https://www.nimh.nih.gov/news/events/announcements/webinar-nihs-definition-of-a-clinical-trial
Webinar: NIH’s Definition of a Clinical Trial
Date/Time: June 20, 2024, 9:00–10:00 a.m. ET
Location: Virtual
Does your research study meet the National Institutes of Health (NIH) definition of a clinical trial? Tune into this webinar to find out!
Experts from the National Institute of Mental Health (NIMH) will provide an overview of NIH clinical trial classifications, with a particular focus on global mental health research. They’ll help you correctly identify whether a study is considered a clinical trial so you can:
Select the right NIH funding opportunity for your research study
Write the research strategy and human subjects sections of your grant application and contract proposal
Comply with appropriate policies and regulations
The webinar is appropriate for researchers and early career investigators.
NIH Study Shows Chronic Wasting Disease Unlikely to Move from Animals to People Study of Cerebral Organoids Reinforces Evidence for Substantial Species Barrier May 17, 2024
https://www.niaid.nih.gov/news-events/nih-study-shows-chronic-wasting-disease-unlikely-move-animals-people?utm_campaign=+60631239&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
A new NIAID study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids—deer, elk and moose—to people. The findings, published in Emerging Infectious Diseases, are consistent with decades of similar NIAID research in animal models. CWD is a type of prion disease found in cervids, which are popular game animals. While CWD has never been found in people, a question about its transmission potential has lingered for decades: Can people who eat meat from CWD-infected cervids develop prion disease? Historically, scientists have used mice, hamsters, squirrel monkeys and cynomolgus macaques to mimic prion diseases in people. In 2019, NIAID scientists developed a human cerebral organoid model of Creutzfeldt-Jakob Disease (CJD) to evaluate treatments and to study human prion diseases. These small spheres of human brain cells grown from human skin cells are the closest available laboratory model to the human brain. In the new CWD study, the researchers directly exposed healthy human cerebral organoids for seven days with high concentrations of CWD prions from white-tailed deer, mule deer, elk, and based on six months of observation, found none infected with CWD.
viernes, 17 de mayo de 2024
FISH OIL SUPPLEMENT: IS MORE ACTUALLY BETTER?
Fish Oil Supplement: Is More Actually Better?
By Ivanhoe Broadcast News on May 26, 2024
https://www.ivanhoe.com/?p=33237&preview=1&_ppp=759a7f2a3a
RED FLAGS FOR YOUNG-ONSET DEMENTIA
Red Flags for Young-Onset Dementia
By Ivanhoe Broadcast News on May 25, 2024
https://www.ivanhoe.com/?p=33234&preview=1&_ppp=884301003e
STEP INTO COMFORT: BREAKTHROUGH BUNION PROCEDURE
Breakthrough Bunion Procedure
By Ivanhoe Broadcast News on May 24, 2024
https://www.ivanhoe.com/?p=33282&preview=1&_ppp=4d487ad853
KIDS’ CONCUSSIONS: WHOSE RESPONSIBILITY IS IT ANYWAY?:
Kids’ Concussions: Whose Responsibility is it Anyway?
By Ivanhoe Broadcast News on May 22, 2024
https://www.ivanhoe.com/?p=33268&preview=1&_ppp=ced6aa6406
MIXING MEDICATIONS CAN PRODUCE A DANGEROUS COCKTAIL
Mixing Medications can Produce a Dangerous Cocktail
By Ivanhoe Broadcast News on May 21, 2024
https://www.ivanhoe.com/?p=33259&preview=1&_ppp=1e6eca5c5f
SCRAMBLER THERAPY: TRICKING THE BRAIN TO FEEL LESS PAIN
Scrambler Therapy: Tricking the Brain to Feel Less Pain
By Ivanhoe Broadcast News on May 20, 2024
https://www.ivanhoe.com/?p=33244&preview=1&_ppp=582bdcdb58
Coenzyme Q10
https://www.nccih.nih.gov/health/coenzyme-q10?nav=govd
Coenzyme Q10 (CoQ10) is a substance that is naturally present in the human body, with the highest levels in the heart, liver, kidneys, and pancreas. It is sold in the United States as a dietary supplement. Because CoQ10 has important functions in the body and because people with some diseases have reduced levels of this substance, researchers have been interested in finding out whether CoQ10 supplements might have health benefits
jueves, 16 de mayo de 2024
Speeding the Diagnosis of Rare Genetic Disorders with the Help of Artificial Intelligence Posted on May 16th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/05/16/speeding-the-diagnosis-of-rare-genetic-disorders-with-the-help-of-artificial-intelligence/
Millions of children around the world are born each year with severe genetic disorders. Many of these are Mendelian disorders, which are rare genetic conditions caused by mutations in a single gene. But pinpointing the specific gene responsible for a disorder to get a clear diagnosis for an individual can be labor-intensive, and reanalysis of undiagnosed cases is also difficult. As a result, only about 30% of people with a rare genetic disorder get a definitive diagnosis, and on average, it takes 6 years from symptom onset to diagnosis.
Progress is needed to get accurate diagnoses to individuals and families more often and faster, and to create more efficient ways to update genetic diagnoses as new discoveries are made. As an important step in this direction, a team funded in part by NIH has developed a new artificial intelligence (AI) system called AI-MARRVEL (AI-Model organism Aggregated Resources for Rare Variant ExpLoration).
Public health researchers develop drought response guide
https://www.unmc.edu/newsroom/2024/05/08/public-health-researchers-develop-drought-response-guide/?utm_medium=email&utm_source=govdelivery
Drought Response Guide for Public Health Professionals and Healthcare Providers
From worsening water quality to respiratory and metal health impacts, drought can have profound and widespread impacts on the health of communities across the nation.
To better prepare health professionals’ response to these impacts, a UNMC College of Public Health research team recently released a guide to assist health care providers and public health officials in communicating about the health risks of drought with their patients and communities.
“Drought is often overlooked as a human health threat in the United States,” said co-author, Jesse Bell, PhD, Claire M. Hubbard Professor of Water, Climate and Health. “However, we are starting to better identify the health impacts of drought. For example, our team has identified increases in respiratory mortality, heat-related mortality and reported stress associated with drought events.”
The guide is a product of a multi-year effort supported by NOAA’s National Integrated Drought Information System, the NASA Health & Air Quality Program and the Claire M. Hubbard Foundation.
Blood Test Accurately Detects Early-Stage Pancreatic Cancer
https://www.cancer.gov/news-events/cancer-currents-blog/2024/liquid-biopsy-detects-pancreatic-cancer?cid=eb_govdel
ctDNA May Guide Who Needs Chemo After Colorectal Cancer Surgery
https://www.cancer.gov/news-events/cancer-currents-blog/2024/colorectal-cancer-ctdna-may-guide-adjuvant-therapy?cid=eb_govdel
Protecting and Advancing the Health of Women Through Policy, Research, Education and Outreach
https://www.fda.gov/news-events/fda-voices/protecting-and-advancing-health-women-through-policy-research-education-and-outreach?utm_medium=email&utm_source=govdelivery
Thirty years ago, the U.S. Food and Drug Administration’s Office of Women’s Health (OWH) was established to promote the inclusion of women in clinical trials and to provide leadership on topics related to the health of women.
Since its inception in 1994, OWH has been at the forefront of ensuring that the unique health needs of women are prioritized through a multifaceted approach that encompasses policy, research, education, and outreach.
In honor of OWH’s 30th anniversary, FDA Commissioner of Food and Drugs, Robert M. Califf, M.D., and Kaveeta P. Vasisht, M.D., PharmD, Associate Commissioner for Women’s Health and Director of the Office of Women’s Health are spotlighting the office’s history and ongoing efforts to advance women’s health in this special FDA Voices blog post.
EvidenceNOW: Managing Urinary Incontinence
EvidenceNOW: Managing Urinary Incontinence: This project builds on AHRQ’s EvidenceNOW model of external support to implement nonsurgical treatment of UI for women in primary care practice.
Working Together to Tackle Inequities—Centering the Voices of Women
Working Together to Tackle Inequities—Centering the Voices of Women: The theme for this year's National Women's Health Week—Empowering Women, Cultivating Health: Celebrating Voices, Wellness, and Resilience—aligns with AHRQ's ongoing efforts to address the healthcare needs of all women.
Chicago nurse is finally free of COVID-19-related PTSD and depression after electrical brain tapping therapy Woman says deep TMS therapy released her from depression: 'I could hear the birds again' Angelica Stabile By Angelica Stabile Fox News Published May 16, 2024 5:00am EDTChicago nurse is finally free of COVID-19-related PTSD and depression after electrical brain tapping therapy Woman says deep TMS therapy released her from depression: 'I could hear the birds again' Angelica Stabile By Angelica Stabile Fox News Published May 16, 2024 5:00am EDT
Chicago nurse is finally free of COVID-19-related PTSD and depression after electrical brain tapping therapy
Woman says deep TMS therapy released her from depression: 'I could hear the birds again'
Angelica Stabile By Angelica Stabile Fox News
Published May 16, 2024 5:00am EDT
https://www.foxnews.com/health/chicago-nurse-free-covid-19-related-ptsd-depression-electrical-brain-tapping-therapy
miércoles, 15 de mayo de 2024
Diabetes in America
https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/diabetes-in-america?utm_medium=e-mail&utm_source=health+information+news
Read the Latest Diabetes in America Article
NIDDK’s Diabetes in America report is a comprehensive scientific resource that seeks to convey the scope and impact of diabetes and its complications, help guide diabetes health policy and priorities, and identify areas for needed research. Whether you’re a person with diabetes who wants to know more about their condition, a clinician who wants to advise their patients, or a researcher who wants to know about the gaps in diabetes research—this report is for you.
In an effort to remain dynamic as diabetes research continues to advance, new or updated Diabetes in America articles are released on an ongoing basis. The latest new article, entitled Obesity Management for the Treatment of Type 2 Diabetes, is now available.
The full Diabetes in America report is organized into four broad topic areas—spectrum of diabetes, complications of diabetes and related conditions, medical care for diabetes, and prevention of diabetes. Visit the NIDDK website to learn more about this go-to resource on diabetes.
Research in Context: Treating depression
Everyone has a bad day sometimes. People experience various types of stress in the course of everyday life. These stressors can cause sadness, anxiety, hopelessness, frustration, or guilt. You may not enjoy the activities you usually do. These feelings tend to be only temporary. Once circumstances change, and the source of stress goes away, your mood usually improves. But sometimes, these feelings don’t go away. When these feelings stick around for at least two weeks and interfere with your daily activities, it’s called major depression, or clinical depression.
https://www.nih.gov/news-events/nih-research-matters/research-context-treating-depression
Anger may harm heart and blood vessel health
https://www.nih.gov/news-events/nih-research-matters/anger-may-harm-heart-blood-vessel-health
Several studies have found links between negative emotions and cardiovascular problems. The underlying mechanisms have been unclear, but impaired blood vessel function may contribute. The inner lining of blood vessels, called the endothelium, is known to help control blood vessel dilation. Previous research suggests that faulty activity of endothelial cells may be an early step leading to atherosclerosis and other heart-related disorders.
Study defines major genetic form of Alzheimer’s disease
https://www.nih.gov/news-events/nih-research-matters/study-defines-major-genetic-form-alzheimer-s-disease
A small portion of early-onset Alzheimer’s disease (AD) cases are known to be genetically determined. These include early-onset autosomal dominant AD and Down syndrome-associated AD. In these conditions, almost everyone with the associated gene variants will develop the disease. Symptoms typically begin between 40 and 60 years of age. Clinical, pathological, and biomarker changes follow a predictable sequence.
Understanding how exercise affects the body
https://www.nih.gov/news-events/nih-research-matters/understanding-how-exercise-affects-body
Exercise is one of the most beneficial activities that people can engage in. Regular exercise reduces the risk of heart disease, diabetes, cancer, and other health problems. It can even help people with many mental health conditions feel better.Exercise is one of the most beneficial activities that people can engage in. Regular exercise reduces the risk of heart disease, diabetes, cancer, and other health problems. It can even help people with many mental health conditions feel better.
20-I-0160—Dose-Escalation Study of a Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model
https://www.niaid.nih.gov/clinical-trials/20-i-0160-dose-escalation-study-low-pathogenicity-avian-h10n7-influenza-virus?utm_medium=social&utm_source=govdelivery&utm_campaign=clinicaltrail_influenzavirus_9252023
NIAID is enrolling healthy, nonsmoking adults 18-50 years of age for an inpatient flu study. The study is being conducted by NIAID and will take place at the National Institutes of Health Clinical Center in Bethesda, MD. There is no cost to participate and compensation may be provided.
Decompressive craniectomy for deep intracerebral haemorrhage: a SWITCH towards better outcomes? 10th European Stroke Organisation Conference in Basel, Switzerland.
Decompressive craniectomy for deep intracerebral haemorrhage: a SWITCH towards better outcomes?
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00703-7/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_esoc24&_hsenc=p2ANqtz-_TI2xfC1JzTROU8nbEZgTFX2QkRK7-dQ1K3_JGk7S23i4Iy9GFpWuhICJr7xNbjRqlC0cZ3SAYC_CHi8P8jAD1H7G1IA&_hsmi=306941884&utm_content=306941884&utm_source=hs_email
Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00702-5/fulltext?dgcid=hubspot_email_conferencealerts_esoc24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz--k5a_1iwKoj6aZ9p07QWlpBbDMpEDYpTBF66ey_G4WgKkZuuijvbUc73R1CIN89PKpTPKBP8t5Z5AQxiux-UlJf1GtpQ&_hsmi=306941884&utm_content=306941884&utm_source=hs_email
What we know about extreme heat’s health impacts after the hottest summer on record Theresa Gaffney By Theresa Gaffney May 14, 2024
https://www.statnews.com/2024/05/14/hottest-summer-2000-years-nature-study-climate-change-effects-health/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--mlO43Q5moqZObx9gDLmtHrG0lUNczQP59ZkBprHlJcaDt-wZI1X1wVkNIez5mTaU5GcriBgHlWjMAyIe9IIx3qmPxRg&_hsmi=307106714&utm_content=307106714&utm_source=hs_email
https://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1004364&utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-97avUvYAsLvk7y_S1XcUkuCkhPKwsKFnJkgsOlZFIVdfFcDGAQjSseyA-8oewRk9oGYW8KBnqFt79qhz4kIET65NqfSA&_hsmi=307106714&utm_content=307106714&utm_source=hs_email
What we know about the health impacts of extreme heat
Last summer’s heat waves demonstrated all the ways that extreme heat takes a toll on the human body. In Texas, more than 300 people died from heat last year — the highest number since the state started tracking the deaths in 1989. Globally, more than 150,000 deaths are associated with heat waves each year, according to a new study in PLOS Medicine. And authors of another study published in Nature yesterday found that last summer was the hottest in the Northern Hemisphere in 2,000 years.
The stakes are as high as the temps. I spoke with experts about the wide-ranging health consequences of extreme heat, and what policymakers can do to keep people cool and safe. Read more.
THE OBESITY REVOLUTION A new generation of obesity drugs is transforming patients’ lives, dividing medical experts, and spurring the biggest business battle in years. Known as GLP-1-based drugs, this medication class could have the medical and societal impact of blockbuste…
https://www.statnews.com/category/the-obesity-revolution/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9UQ02Vdmn6qc85sOD1OAP7ngwMw3YxDr-pqnDv5P32wSoyWovTdZotFxdAzNc0-cpk1LWexoEbYy6iDWnBs8ycJWJfFg&_hsmi=307106714&utm_content=307106714&utm_source=hs_email
Since GLP-1 drugs began revolutionizing the way we consider addressing obesity last year, academics have wondered if the injectable treatments could affect people’s cravings for substances. But drug companies have yet to get involved — until now. Novo Nordisk, which makes Ozempic and Wegovy, will test whether GLP-1 drugs can help people with alcohol-associated liver disease.
The company will not test the drugs purely in relation to substance misuse. The primary outcome tested in the nine-month study will be changes in liver scarring, and one of the secondary outcomes is changes in alcohol consumption. The trial comes at a time when alcohol-associated liver disease has been surging among younger people and women, making it the leading cause for transplant in the U.S. Read more from my colleagues Isa Cueto and Elaine Chen.
The new weight loss drugs are revolutionizing our understanding of desire. Food cravings could be just the beginning
Megan Molteni
By Megan Molteni
https://www.statnews.com/2023/07/10/new-weight-loss-drugs-wegovy-food-cravings/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8j03E9NQeNhYihTgykm91sB-gNAb1e4iUKlhNBCT-D1I-vjiSCl-88o1hR3PgvF3Jn_2TJMp61w2B4ys4RHU2CT_roRg&_hsmi=307106714&utm_content=307106714&utm_source=hs_email
Novo to test Wegovy and other obesity drugs against alcohol-related liver disease
Isabella Cueto
Elaine Chen
By Isabella Cueto and Elaine Chen May 14, 2024
https://www.statnews.com/2024/05/14/wegovy-alcohol-related-liver-disease-novo-nordisk/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9gpD_qgUAhkXtpSE_NY4PB0PLfWqFK2O7Nh6uHZMRcbdmdXrv59oBOb4MsIPzDU9jfK8hawhxd1SMLDHZ1CBVf9m-Z6A&_hsmi=307106714&utm_content=307106714&utm_source=hs_email
martes, 14 de mayo de 2024
Genetic variant common among West African descendants contributes to large cardiovascular disease burden Deborah Balthazar By Deborah Balthazar May 13, 2024
https://www.statnews.com/2024/05/13/genetic-variant-west-african-descendants-adds-cardiovascular-disease-risk/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--uun1RQm52WRk34ahKo_vEGwiNjEG1GIQ833cjjOOY_j0HynBtvx7g3pGouL3QZHB2Tj41b87_j2d4ev9nd5G_fEksZA&_hsmi=306900761&utm_content=306900761&utm_source=hs_email
A genetic risk factor for heart failure in Black Americans
When a protein called transthyretin folds up the wrong way, it can build up in the heart’s muscle layer and sometimes cause heart failure. The most common gene variant causing that misfolding, V142I, originated in western Africa, and occurs in 3% to 4% of people in the U.S. who self-identify as Black or African-American. In a study published yesterday in JAMA, researchers found that Black individuals carrying the V142I variant were at much higher risk of heart failure and death.
Heart failure affects African Americans at nearly twice the rate that it affects white people in the U.S. And while this genetic variant doesn’t explain away those racial disparities, it could inform the care and genetic screening offered to Black patients at risk of heart disease. Read more from STAT’s Debbie Balthazar on the implications of the findings for genetic counseling and heart disease.
Uncoupling interferons and the interferon signature explains clinical and transcriptional subsets in SLE
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00261-1?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_emSTJq3splzKD4ZJBu88HQ-y1D8PNtkwI5pEcMOgPBgzsySsgXUBVsjd00SuAl1SaEWf6g5nwcC1QOKQWjK1fx0rC6Q&_hsmi=306900761&utm_content=306900761&utm_source=hs_email
New study provides a clue for better potential lupus treatments
STAT’s chronic disease reporter Isa Cueto has described lupus as “a confounding and severe autoimmune disease.” It affects up to 1.5 million people in the U.S., causing problems in organs including the kidneys, spleen, heart, and brain. Some treatments for the disease are designed to suppress immune system proteins called interferons. But they don’t always work.
To learn more about why that might be, researchers looked at hundreds of samples from just under 200 patients to analyze the activity level of three interferon types — I, II, and III. In a study published Monday in Cell Reports Medicine, they report that some symptoms are correlated with overactivity in specific types. Skin-related symptoms were correlated with overactivity of interferon I, while kidney inflammation were related to elevated activity in all three types. Other symptoms couldn’t be pinned down: Blood clots and low platelet counts didn’t have any particular association.
Isa told me that this research seemed promising because experts would love to get clearer categories of systemic lupus in order to treat it in a more targeted way. Read more of her reporting on lupus and other chronic diseases.
https://www.statnews.com/staff/isabella-cueto/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--J8KrQDpTabR0Hnc96k7wxy1FxgXOVnY5k3GQvT1AySAQQtRuspTgzOYmfAtkobG6LJqZyuWN0yUcUneSvLNptKfBo2A&_hsmi=306900761&utm_content=306900761&utm_source=hs_email
After years of just ‘running, running,’ a crisis led to a lupus diagnosis. Now she connects others
Isabella Cueto
By Isabella Cueto April 9, 2024
https://www.statnews.com/2024/04/09/lupus-autoimmune-diagnosis-treatment-lupuschat/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_dUh1nZy3ozKv_e3lVieFH15cKlbqwkXdeg7eUJkRrYZA33EikE42HO83Dymuvip-YN_PldIs-7T3volTy60C-I_rDjA&_hsmi=306900761&utm_content=306900761&utm_source=hs_email
Girl’s case of lupus leads to new understanding of a perplexing disease
Isabella Cueto
By Isabella Cueto
https://www.statnews.com/2022/06/16/girls-case-of-lupus-leads-to-new-understanding-of-a-perplexing-disease/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9H16-yh7hyJQeMoOQVMdYidXNEVrlz9MckmzrSqxuwodJzfYA5Wxs8PhWXpvW8O0nky_2Rg7Gc1Xp0OtOkeWsLopXghw&_hsmi=306900761&utm_content=306900761&utm_source=hs_email
Food insecurity and quality of life in patients with sickle cell disease +++
https://pubmed.ncbi.nlm.nih.gov/38687256/
Food insecurity and quality of life in patients with sickle cell disease
This study was designed to estimate, among pediatric and young adult (PYA) sickle cell disease (SCD) patients, household food insecurity rates, and the relationship between food insecurity and quality of life. The researchers hypothesized that PYAs with SCD living in food insecure households would have lower quality of life than peers.
Author: Wendy S. Darlington, Sharjeel Syed, Kristen Wroblewski, Gabrielle Lapping-Carr, Stacy Tessler Lindau, Radhika Peddinti
Journal: Pediatric Blood & Cancer, April 30
Differential effects of obesity on perioperative outcomes in renal cell carcinoma patients based on race and ethnicity and neighborhood-level socioeconomic status
https://pubmed.ncbi.nlm.nih.gov/38721286/
Differential effects of obesity on perioperative outcomes in renal cell carcinoma patients based on race and ethnicity and neighborhood-level socioeconomic status
Obesity is a well-established risk factor of renal cell carcinoma (RCC), however the impact of obesity on surgical outcomes for racial and ethnic minority patients with RCC is unclear. This study investigated whether a higher body mass index (BMI) or obesity (BMI ≥30 kg/m2) was associated with worse perioperative outcomes and if there were heterogeneous effects based on race, ethnicity, and neighborhood-level socioeconomic factor.
Author: Waheed Asif, Irasema C. Paster, Kathryn R. Pulling, Kyle Garcia, Patrick Wightman, Alejandro Cruz, Christopher Combates, Eric C. Kauffman, Francine C. Gachupin, Benjamin R. Lee, Juan Chipollini, Ken Batai
Journal: Translational Andrology and Urology, April 12
Comparing Sensitivity, Specificity, and Accuracy of Fall Risk Assessments in Community-Dwelling Older Adults
https://pubmed.ncbi.nlm.nih.gov/38562971/
Comparing sensitivity, specificity, and accuracy of fall risk assessments in community-dwelling older adults
The US Centers for Disease Control and Prevention has implemented the Stopping Elderly Accidents, Deaths, and Injuries (STEADI) initiative. This initiative provides an algorithm for fall risk screening. However, the algorithm has the potential to overcategorize individuals as high risk for falling upon initial screening, which may burden clinicians with the task of recategorizing individuals after follow-up testing. This study aimed to compare the accuracy, sensitivity, and specificity of fall risk appraisal between the STEADI, Short Fall-Efficacy Scale International (FES-I), and portable balance system (BTrackS) assessments in community-dwelling older adults.
Author: Kworweinski Lafontant, Amber Blount, Jethro Raphael M. Suarez, David H. Fukuda, Jeffrey R. Stout, Evette M. Trahan, Nichole R. Lighthall, Joon-Hyuk Park, Rui Xie, Ladda Thiamwong
Journal: Clinical Interventions in Aging, March 27
Racial/ethnic differences in the associations between trust in the U.S. healthcare system and willingness to test for and vaccinate against COVID-19
https://pubmed.ncbi.nlm.nih.gov/38641573/
Trust in the healthcare system may impact adherence to recommended healthcare practices, including willingness to test for and vaccinate against COVID-19. This study examined racial/ethnic differences in the associations between trust in the U.S. healthcare system and willingness to test for and vaccinate against COVID-19 during the first year of the pandemic.
Author: Judy Nanaw*, Juliana S. Sherchan*, Jessica R. Fernandez*, Paula D. Strassle*, Wizdom Powell, Allana T. Forde*
Journal: BMC Public Health, April 19
Discrimination is associated with depression, anxiety, and loneliness symptoms among Asian and Pacific Islander adults during COVID-19 Pandemic
https://pubmed.ncbi.nlm.nih.gov/38658790/
In the United States, Asian and Pacific Islander (A/PI) communities have faced significant discrimination and stigma during the COVID-19 pandemic. Researchers assessed the association between discrimination and depression, anxiety, and loneliness symptoms among Asian or Pacific Islander adults using data from a 116-item nationally distributed online survey of adults (≥ 18 years old) in the United States conducted between 5/2021-1/2022.
Author: Cameron K. Ormiston*, Paula D. Strassle*, Eric Boyd, Faustine Williams*
Journal: Scientific Reports, April 24
Collaborative Modeling to Compare Different Breast Cancer Screening Strategies: A Decision Analysis for the US Preventive Services Task Force
https://pubmed.ncbi.nlm.nih.gov/38687505/
The effects of breast cancer incidence changes and advances in screening and treatment on outcomes of different screening strategies are not well known. This modeling study estimated outcomes of various mammography screening strategies.
Author: Amy Trentham-Dietz, Christina Hunter Chapman, Jinani Jayasekera*, et al
Journal: JAMA, April 30
Food security status and cardiometabolic health by sex/gender and race/ethnicity among adults in the United States
https://pubmed.ncbi.nlm.nih.gov/38698385/
Minoritized racial/ethnic groups and women in the United States are disproportionately burdened by food insecurity, which likely contributes to disparities in cardiovascular health (CVH). Disparities are projected to widen due to the worsening climate crisis that is straining the agricultural system including food supplies. This study investigated the relationship between food security status and 'ideal' CVH in a large, nationally representative and racially/ethnically diverse U.S. sample.
Author: Jamie A. Murkey, Symielle A. Gaston, Dana M. Alhasan, Christopher W. Payne, W. Braxton Jackson 2nd, Chandra L. Jackson*
Journal: BMC Public Health, May 3
STANDARDS FOR REGENERATIVE MEDICINE AND ADVANCED THERAPIES (RMAT)
https://www.nist.gov/mml/bbd/standards-bioeconomy/standards-needs
A new report, co-written and edited by NIST scientists, calls for developing key standards and metrics for the global bioeconomy.
The global bioeconomy is estimated at $4 trillion, though, as the report points out, there is no agreed-upon definition of what the bioeconomy entails. There is also a lack of consensus around lexicon and terminology; metrology and metrics to quantify biological processes; and metrics and standardization for sustainability assessments, according to the report.
“This gap in specific standardization and metrics applicable to fast-paced, advancing biotechnologies based on engineering biology [also known as synthetic biology] is likely to cause significant challenges going forward,” states the report, entitled “Engineering Biology Metrics and Technical Standards for the Global Bioeconomy.”
The report’s recommendations include “establishing best practices and developing technical standards and metrics specific to engineering biology” and continued collaboration among stakeholders in academia, government and regulatory agencies, nonprofits and research institutes.
NIST scientists Elizabeth A. Strychalski, Sheng Lin-Gibson and Eugenia Romantseva contributed to the report. Other participating organizations include Imperial College London, the Engineering Biology Research Consortium (EBRC), the National University of Singapore (NUS) and Schmidt Sciences.
Alabama pastor shares journey of depression, urges others to seek help: ‘Don’t hesitate’ After leading churches for 30 years, one man now helps struggling pastors ‘stay well and finish well’ Melissa Rudy By Melissa Rudy Fox News Published May 14, 2024 4:00am EDT
Alabama pastor shares journey of depression, urges others to seek help: ‘Don’t hesitate’
After leading churches for 30 years, one man now helps struggling pastors ‘stay well and finish well’
Melissa Rudy By Melissa Rudy Fox News
Published May 14, 2024 4:00am EDT
https://www.foxnews.com/health/alabama-pastor-shares-journey-depression-urges-others-seek-help-dont-hesitate
8 of the most important health stories this week, in case you missed them Get up to speed on nursing burnout, sleep solutions, coping with grief and more Melissa Rudy By Melissa Rudy Fox News Published May 12, 2024 3:22pm EDT
8 of the most important health stories this week, in case you missed them
Get up to speed on nursing burnout, sleep solutions, coping with grief and more
Melissa Rudy By Melissa Rudy Fox News
Published May 12, 2024 3:22pm EDT
https://www.foxnews.com/health/8-most-important-health-stories-week-case-missed-them
lunes, 13 de mayo de 2024
NIMH Genomics Team 75th Anniversary Webinar: Celebrating Advancements in Psychiatric Genomics June 10, 2024 11:00 a.m.–1:00 p.m. ET
https://www.nimh.nih.gov/news/events/announcements/nimh-genomics-team-75th-anniversary-webinar-celebrating-advancements-in-psychiatric-genomics
75th Anniversary Webinar: Celebrating Advancements in Psychiatric Genomics
Date/Time: June 10, 2024, 11:00 a.m.–1:00 p.m. ET
Location: Virtual
As part of ongoing 75th Anniversary celebrations, the National Institute of Mental Health (NIMH) is hosting a webinar to explore key advances in genetics and genomics research.
This webinar brings together four distinguished researchers to shed light on the genetic basis of mental illness, the impact of genetic variation and developmental trajectories in neurodevelopmental and psychiatric disorders, and the future of translating genetic findings to patient care.
Exploring a Meningitis Vaccine for Gonorrhea Prevention
https://www.niaid.nih.gov/news-events/meningitis-vaccine-gonorrhea-prevention?utm_campaign=+60567131&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
A preventive vaccine for gonorrhea would be a major advance in public health, according to an editorial co-authored by NIAID Director Jeanne Marrazzo and Myron Cohen of the University of North Carolina at Chapel Hill. The genetic sequences of the bacteria that cause gonorrhea and meningitis B are closely related. This has led researchers to explore whether the 4CMenB vaccine, approved by the Food and Drug Administration for meningitis B, might also prevent gonorrhea. NIAID is sponsoring an efficacy study of the 4CMenB vaccine for gonorrhea prevention in Malawi, Thailand, and the United States
domingo, 12 de mayo de 2024
Sleep experts sound alarm on late night screen time: How your phone could be sabotaging your rest More than half of Americans use their phones within an hour before bedtime, according to the National Sleep Foundation Associated Press Published May 8, 2024 1:58pm EDT
Sleep experts sound alarm on late night screen time: How your phone could be sabotaging your rest
More than half of Americans use their phones within an hour before bedtime, according to the National Sleep Foundation
Associated Press
Published May 8, 2024 1:58pm EDT
https://www.foxnews.com/health/sleep-experts-sound-alarm-late-night-screen-time-phone-sabotaging-sleep
Handling grief on Mother's Day, plus disease-fighting foods and heart health risks And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published May 8, 2024 4:51pm EDT
Handling grief on Mother's Day, plus disease-fighting foods and heart health risks
And more of the top Fox News Health stories and videos from the past week
By Fox News Staff Fox News
Published May 8, 2024 4:51pm EDT
https://www.foxnews.com/health/handling-grief-mothers-day-disease-fighting-foods-heart-health-risks
As Ozzy Osbourne announces stem cell therapy, experts urge caution, highlight risks Rocker, who has Parkinson’s disease, has battled a spinal tumor and other health issues By Shiv Sudhakar Fox News Published May 9, 2024 5:00am EDT
As Ozzy Osbourne announces stem cell therapy, experts urge caution, highlight risks
Rocker, who has Parkinson’s disease, has battled a spinal tumor and other health issues
By Shiv Sudhakar Fox News
Published May 9, 2024 5:00am EDT
https://www.foxnews.com/health/ozzy-osbourne-announces-stem-cell-therapy-experts-urge-caution-highlight-risks
Common cooking ingredient could reduce dementia mortality risk, study suggests Nutritionists echo benefits, but some experts say the study ‘can’t prove cause and effect’ Melissa Rudy By Melissa Rudy Fox News Published May 11, 2024 5:30pm EDT
Common cooking ingredient could reduce dementia mortality risk, study suggests
Nutritionists echo benefits, but some experts say the study ‘can’t prove cause and effect’
Melissa Rudy By Melissa Rudy Fox News
Published May 11, 2024 5:30pm EDT
https://www.foxnews.com/health/common-cooking-ingredient-could-reduce-dementia-mortality-risk-study
STOPPING MIGRAINES BEFORE THEY START
Migraines: Stop Them Before They Start
By Ivanhoe Broadcast News on May 19, 2024
https://www.ivanhoe.com/?p=33174&preview=1&_ppp=42f2510b80
BEATING BABY BLUES: WORLD’S FIRST POSTPARTUM PILL
Baby Blues: World’s First Postpartum Pill
By Ivanhoe Broadcast News on May 18, 2024
https://www.ivanhoe.com/?p=33171&preview=1&_ppp=3518a45b98
PARENTING WITH PURPOSE: TALKING TO YOUR KIDS ABOUT SEX
Parenting with Purpose: Talking to Your Kids About Sex
By Ivanhoe Broadcast News on May 18, 2024
https://www.ivanhoe.com/?p=33153&preview=1&_ppp=30ecf3a0cc
DOULAS OF COLOR: SAVING BLACK BABIES & THEIR MOMS
Doulas of Color: Saving Black Babies & Their Moms
By Ivanhoe Broadcast News on May 17, 2024
https://www.ivanhoe.com/?p=33168&preview=1&_ppp=8eeb9901e6
MALE INFERTILITY TIME BOMBS: MAKING SAUL A DAD AGAIN!
Male Infertility Time Bombs: Making Saul a Dad Again!
By Ivanhoe Broadcast News on May 16, 2024
https://www.ivanhoe.com/?p=33167&preview=1&_ppp=9acd48dc96
REVERSE SHOULDER SURGERY: RETHINKING IMPLANTS
Reverse Shoulder Surgery: Rethinking Implants
By Ivanhoe Broadcast News on May 15, 2024
https://www.ivanhoe.com/?p=33210&preview=1&_ppp=b35e7060b8
RELIEVING BACK PAIN: FIXING FAILED SPINE SURGERIES
Failed Back Surgery Syndrome: Relieving Back Pain
By Ivanhoe Broadcast News on May 14, 2024
https://www.ivanhoe.com/?p=33203&preview=1&_ppp=b3b69a3573
BACK IN THE GAME! NEW HOPE FOR COMPLEX KNEE SURGERIES
Knee Surgeries: New Hope
By Ivanhoe Broadcast News on May 13, 2024
https://www.ivanhoe.com/?p=33196&preview=1&_ppp=0ce9d42a1f
Nurses call for change as many reveal they're ‘extremely likely’ to leave profession: ‘Emotional, stressful' More than half of nurses are likely to switch jobs this year, a new survey found Melissa Rudy By Melissa Rudy Fox News Published May 10, 2024 4:30am EDT
Nurses call for change as many reveal they're ‘extremely likely’ to leave profession: ‘Emotional, stressful'
More than half of nurses are likely to switch jobs this year, a new survey found
Melissa Rudy By Melissa Rudy Fox News
Published May 10, 2024 4:30am EDT
https://www.foxnews.com/health/nurses-call-change-many-extremely-likely-leave-profession-emotional-stressful
Artificial intelligence not always helpful for reducing doctor burnout, studies suggest Some chatbots could actually increase workload, researchers say Angelica Stabile By Angelica Stabile Fox News Published May 11, 2024 5:58pm EDT
Artificial intelligence not always helpful for reducing doctor burnout, studies suggest
Some chatbots could actually increase workload, researchers say
Angelica Stabile By Angelica Stabile Fox News
Published May 11, 2024 5:58pm EDT
https://www.foxnews.com/health/artificial-intelligence-not-always-helpful-reducing-doctor-burnout-studies-suggest
Experimental cancer treatment gives New Jersey mom a chance for a second baby: ‘I decided to go for it’ Kelly Spill was just 28 when she received her stage 3 diagnosis: ‘I knew deep down it was cancer’ Melissa Rudy By Melissa Rudy Fox News Published May 12, 2024 4:00am EDT
Experimental cancer treatment gives New Jersey mom a chance for a second baby: ‘I decided to go for it’
Kelly Spill was just 28 when she received her stage 3 diagnosis: ‘I knew deep down it was cancer’
Melissa Rudy By Melissa Rudy Fox News
Published May 12, 2024 4:00am EDT
https://www.foxnews.com/health/experimental-cancer-treatment-gives-new-jersey-mom-chance-second-baby-go-for-it
sábado, 11 de mayo de 2024
viernes, 10 de mayo de 2024
Cubic millimetre of brain mapped in spectacular detail Google scientists have modelled a fragment of the human brain at nanoscale resolution, revealing cells with previously undiscovered features.Cubic millimetre of brain mapped in spectacular detail Google scientists have modelled a fragment of the human brain at nanoscale resolution, revealing cells with previously undiscovered features.
https://www.nature.com/articles/d41586-024-01387-9?utm_source=Live+Audience&utm_campaign=8aabb11098-nature-briefing-daily-20240510&utm_medium=email&utm_term=0_b27a691814-8aabb11098-50432164
A millimetre of brain in spectacular detail
Researchers have created an exquisitely detailed atlas of a tiny piece of one woman’s brain, which had been removed during surgery to treat her epilepsy. The sample was cut into thousands of nanometre-thick slices and each was imaged with electron microscopes. AI tools then classified different structures and cells, and created a 3D reconstruction of the sample. “I remember this moment, going into the map and looking at one individual synapse from this woman’s brain, and then zooming out into these other millions of pixels,” says neuroscientist and study co-author Viren Jain. “It felt sort of spiritual.”
CRISPR Gene Editing Leads to Improvements in Vision for People With Inherited Blindness, Clinical Trial Shows
https://www.masseyeandear.org/news/press-releases/2024/05/crispr-gene-editing-improves-vision-for-people-with-inherited-blindness
Participants of pioneering CRISPR gene editing trial see vision improve
Results indicate that first-of-its-kind experimental treatment for Leber Congenital Amaurosis was safe and efficacious
May 6, 2024
https://www.nei.nih.gov/about/news-and-events/news/participants-pioneering-crispr-gene-editing-trial-see-vision-improve
Participants of pioneering CRISPR gene editing trial see vision improve
OHSU scientist: Results show CRISPR can treat inherited retinal disease, support further research
https://news.ohsu.edu/2024/05/06/participants-of-pioneering-crispr-gene-editing-trial-see-vision-improve
AI Tool Using Single-Cell Data Has Promise for Optimally Matching Cancer Drugs to Patients Posted on May 9th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/05/09/ai-tool-using-single-cell-data-has-promise-for-optimally-matching-cancer-drugs-to-patients/
Precision oncology, in which doctors choose cancer treatment options based on the underlying molecular or genetic signature of individual tumors, has come a long way. The Food and Drug Administration has approved a growing number of tests that look for specific genetic changes that drive cancer growth to match patients to targeted treatments. The NCI-MATCH trial, supported by the National Cancer Institute, in which participants with advanced or rare cancer had their tumors sequenced in search of genetic changes that matched them to a treatment, has also suggested benefits for guiding treatment through genetic sequencing. But there remains a need to better predict treatment responses for people with cancer.
A promising approach is to analyze a tumor’s RNA in addition to its DNA. The idea is to not only better understand underlying genetic changes, but also learn how those changes impact gene activity as measured by RNA sequencing data. A recent study introduces an artificial intelligence (AI)-driven tool, dubbed PERCEPTION (PERsonalized single-Cell Expression-based Planning for Treatments In ONcology), developed by an NIH-led team to do just this. This proof-of-concept study, published in Nature Cancer, shows that it’s possible to fine-tune predictions of a patient’s treatment responses from bulk RNA data by zeroing in on what’s happening inside single cells.
Drug Trials Snapshots: FRUZAQLA (fruquintinib)
FRUZAQLA is a drug used for the treatment of adults with colorectal cancer that cannot be removed by surgery or has spread to other parts of the body (metastatic).
It should be used in patients who have been previously treated with chemotherapy and other anticancer agents.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-fruzaqla
Drug Trials Snapshots: RYSTIGGO (rozanolixizumab-noli)
RYSTIGGO is a drug for the treatment of generalized myasthenia gravis (gMG) in adult patients. It is used by patients whose blood has antibodies against the acetylcholine receptor (AChR) or muscle-specific kinase (MuSK).
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-rystiggo
Analysis identifies 50 new genomic regions associated with kidney cancer risk
https://www.cancer.gov/news-events/press-releases/2024/genomic-analysis-kidney-cancer-risk
In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genomeExit Disclaimer that are associated with the risk of developing kidney cancer. These insights could one day be used to advance our understanding of the molecular basis of kidney cancer, inform screening efforts for those at highest risk, and identify new drug targets. The study was led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).
Promoting Mental Health for Sexual and Gender Minority Youth: Evidence-Based Developmental Perspectives Monday June 10th and Tuesday June 11
https://www.eventbrite.com/e/promoting-mental-health-for-sexual-and-gender-minority-youth-tickets-899381994757
NIH Workshop: Promoting Mental Health for Sexual and Gender Minority Youth: Evidence-Based Developmental Perspectives
Date/Time: June 10-11, 2024, 11:00 a.m.–5:00 p.m. ET
Location: Virtual
This two-day virtual workshop will convene researchers, youth advocates, and federal officials to review the state of the science on developmental trajectories of gender identity and sexuality with a focus on research aimed at the promotion of mental health for sexual and gender minority youth. Session themes include epidemiological and population health studies of developmental trends, social determinants of health that drive mental health outcomes at multiple levels (i.e., national, community, interpersonal, and individual), and preventive and treatment interventions to ensure healthy futures for all youth.
The workshop is free and open to the scientific community and the public.
jueves, 9 de mayo de 2024
Glaucoma: What you need to know
https://magazine.medlineplus.gov/article/glaucoma-what-you-need-to-know
Glaucoma is the name for a group of diseases that can damage the optic nerve in the eye. Glaucoma usually happens when the fluid pressure inside the eyes slowly rises and increases pressure inside the eye. About 3 million Americans have glaucoma, and it’s the second-leading cause of blindness worldwide.
H20 for healthy aging Could staying hydrated help you live a longer, healthier life?
https://magazine.medlineplus.gov/article/h20-for-healthy-aging?utm_medium=email&utm_source=govdelivery
Water is essential for just about every function in our bodies, from keeping our organs working properly to regulating our body temperature. Losing more water than we take in can lead to dehydration, which happens when your body doesn’t have enough fluid to function properly. Our bodies are constantly losing fluids. Sweating during exercise or in hot weather, dealing with an illness such as diarrhea or vomiting, and even
Hacking the immune system could slow ageing — here’s how Our immune system falters over time, which could explain the negative effects of ageing.
Hacking the immune system could slow ageing — here’s how
Our immune system falters over time, which could explain the negative effects of ageing.
https://www.nature.com/articles/d41586-024-01274-3?utm_source=Live+Audience&utm_campaign=a5697c9afa-nature-briefing-daily-20240508&utm_medium=email&utm_term=0_b27a691814-a5697c9afa-50432164
Drug Trials Snapshots: ZELSUVMI (berdazimer)
ZELSUVMI is a nitric oxide releasing agent that is indicated for the topical treatment of molluscum contagiosum (MC) in adults and pediatric patients 1 year of age and older.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-zelsuvmi
Drug Trials Snapshots: TEVIMBRA (tislelizumab-jsgr)
TEVIMBRA is a programmed death receptor-1 (PD-1) blocking antibody for the treatment of adults with a type of esophageal cancer called esophageal squamous cell carcinoma (ESCC) that has spread to other parts of the body (metastatic) or cannot be completely removed by surgery (unresectable). It is approved to treat patients who have undergone prior treatment with chemotherapy for their ESCC that did not include a PD-1 blocking antibody.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-tevimbra
miércoles, 8 de mayo de 2024
Drug Trials Snapshots: ZURZUVAE (zuranolone)
Drug Trials Snapshots: ZURZUVAE (zuranolone)
ZURZUVAE is a neuroactive steroid drug used for the treatment of postpartum depression in adults.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-zurzuvae
Drug Trials Snapshots: JOENJA (leniolisib)
Drug Trials Snapshots: JOENJA (leniolisib)
JOENJA is a kinase inhibitor that is used to treat activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) in adult and pediatric patients 12 years of age and older who weigh at least 45 kg.
APDS is an inherited disease that impacts the immune system. APDS often causes a decrease in T and B cells that fight infection as well as an increase in lymph node size.
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-joenja
Facebook Live: Brain Stimulation Therapies
In recognition of National Mental Health Awareness Month, the National Institute of Mental Health (NIMH) hosted a Facebook Live event on brain stimulation therapies on May 1. The event featured NIMH expert Sarah H. Lisanby, M.D., Director of the Noninvasive Neuromodulation Unit in the Experimental Therapeutics and Pathophysiology Branch and Director of the NIMH Division of Translational Research.
Brain stimulation therapies can help people with certain mental disorders who have not responded to other treatments. During the event, Dr. Lisanby describes common types of brain stimulation therapies and why they are used, dispels misconceptions, and highlights NIMH-supported research.v
Facebook Live: Brain Stimulation Therapies
https://www.nimh.nih.gov/news/media/2024/facebook-live-brain-stimulation-therapies?utm_campaign=MHM24&utm_medium=email&utm_source=govd
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