Most Read Cancer Science & Oncogenesis +...

https://read.qxmd.com/collection/1133?ecd=wnl_readmost_260529 Triple-negative breast cancer: current understanding and future perspectives. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype defined by the absence of estrogen receptors, progesterone receptors, and human epid.. 2026: Exploration of targeted anti-tumor therapy.

Interprofessional Approach to Adverse Event Care for the Patient With High-Risk Hormone Receptor-Positive/HER2-Negative Early Breast Cancer Authors: Jonathan Malara, PharmD, BCOP; Nelli Zafman, CRNP, MSN, AOCNP

https://www.medscape.org/viewarticle/interprofessional-approach-adverse-event-care-patient-high-2026a1000gez?page=1

Fact vs. Fallacy: Challenging the Norms of Cancer Care Fallacies in Medicine Bishal Gyawali, MD, PhD

https://www.medscape.com/viewarticle/fact-vs-fallacy-challenging-norms-cancer-care-fallacies-2026a1000gei Hello, everyone. This is Dr Bishal Gyawali, from Queens University, Kingston, Canada. Today, I’m back with you to talk about some of the fallacies that I have seen in medicine, oncology, and the drug regulatory space. I wanted to clarify some of these fallacies.

American Society of Clinical Oncology (ASCO) 2026

https://www.medscape.com/c25/p14/american-society-clinical-oncology-asco-2026-2026a1000c7g

Which Patients With Early HCC Should Undergo Resection? Daniela Barros l Medscape Europe May 29, 2026

https://www.medscape.com/viewarticle/which-patients-early-hcc-should-undergo-resection-2026a1000hwk For years, patients with early-stage hepatocellular carcinoma (HCC) who had multiple liver nodules were typically referred for less-invasive locoregional therapies such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE). The logic seemed sound: to avoid surgical trauma in people who often already have cirrhosis or limited liver function. Now, a new national multicenter meta-analysis suggests that, in carefully selected patients, this approach may need to be reconsidered.

CAR-T Therapy Shows Promise in CNS and Extramedullary B-ALL Edited by Gargi Mukherjee May 29, 2026

https://www.medscape.com/viewarticle/car-t-therapy-shows-promise-cns-and-extramedullary-b-all-2026a1000hyx CD19 chimeric antigen receptor (CAR) T-cell therapy achieved high response rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and extramedullary disease or central nervous system (CNS) involvement, according to a retrospective review. More than 80% of patients achieved clearance of their extramedullary or CNS disease; however, patients with concurrent high bone marrow disease burden experienced significantly worse survival than those with low bone marrow burden.

A single viral platform shows promise across infectious disease and cancer ReiThera’s gorilla-derived adenovirus vector is helping advance vaccines and therapies for COVID-19, HIV, Ebola, and even cancer. Written byBree Foster, PhD

A single viral platform shows promise across infectious disease and cancer ReiThera’s gorilla-derived adenovirus vector is helping advance vaccines and therapies for COVID-19, HIV, Ebola, and even cancer. Written byBree Foster, PhD https://www.drugdiscoverynews.com/a-single-viral-platform-shows-promise-across-infectious-disease-and-cancer-17103?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-_Tdx3m2iMvdp1D3k42S5hPo1PrPtt3IjBfdsUwgZ-0LEAiv-XA5590T3h9k7W1V0wPFzJZ4rS9-snPUOaMSLUTIou5bg&_hsmi=421171733&utm_content=421171733&utm_source=hs_email At Advanced Therapies 2026, DDN spoke with Claudio Panzarella, Head of Business Development, and Angelo Raggioli, Head of Technology Development, at ReiThera, about how the company’s early COVID-19 vaccine efforts shaped its current scientific programs, including the gorilla adenovirus (GRAd) platform, ongoing HIV vaccine trials, and the potential for oncology therapeutics.

Ultrasound-triggered nanocatchers turn tumors into personalized vaccines The approach pairs ultrasound-induced tumor cell death with real-time antigen capture to drive both local and systemic immune responses. Written byAndrea Corona

Ultrasound-triggered nanocatchers turn tumors into personalized vaccines The approach pairs ultrasound-induced tumor cell death with real-time antigen capture to drive both local and systemic immune responses. Written byAndrea Corona https://www.drugdiscoverynews.com/ultrasound-triggered-nanocatchers-turn-tumors-into-personalized-vaccines-16921?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-8cYDfDkA7hLpNiUtfdXSdBDOWTg0LnoRAnLedX9FV9zUCHeyTuubBA8-NHcn3eg-gjRUFSkVliklr1_12zV6qe7O48bQ&_hsmi=421171733&utm_content=421171733&utm_source=hs_email A research team in China has developed an ultrasound-responsive nanomaterial that can capture tumor antigens within the tumor microenvironment, addressing one of the central challenges in cancer immunotherapy: how to generate patient-specific immune responses in the face of extreme tumor heterogeneity.

Can one drug repair the brain across multiple CNS diseases? A first-in-class synaptic regenerative approach shows promise across multiple neurodegenerative and neuropsychiatric diseases. Written byBree Foster, PhD

Can one drug repair the brain across multiple CNS diseases? A first-in-class synaptic regenerative approach shows promise across multiple neurodegenerative and neuropsychiatric diseases. Written byBree Foster, PhD https://www.drugdiscoverynews.com/can-one-drug-repair-the-brain-across-multiple-cns-diseases-17191 The human brain contains roughly one hundred billion neurons arranged in extremely intricate networks that generate every thought, memory, emotion, and dream, and coordinate our ability to perceive, respond to, and interact with the world. These remarkable capabilities are only possible if neurons can efficiently coordinate with other cells in the network, using specialized junctions known as synapses.

Weekly Rundown: Oxford scientists develop rapid Ebola vaccine as Congo outbreak grows FDA approvals, pharma deals, and genetic testing advancements led the news this week. Written byDDN editorial team

Weekly Rundown: Oxford scientists develop rapid Ebola vaccine as Congo outbreak grows FDA approvals, pharma deals, and genetic testing advancements led the news this week. Written byDDN editorial team https://www.drugdiscoverynews.com/weekly-rundown-oxford-scientists-develop-rapid-ebola-vaccine-as-congo-outbreak-grows-17195?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9CaSYgo64yBacJHTMjO0uKmroqOegAhmVtlluB9iWyyDXKDHmEvlq9T9XJICNraOUq19CuKzvGGM2JLTybPa_2yKsXAg&_hsmi=421171733&utm_content=421171733&utm_source=hs_email Scientists at the University of Oxford are developing an experimental Ebola vaccine that could be ready for clinical trials within two to three months, as health authorities race to contain an outbreak in the Democratic Republic of Congo that has caused around 750 suspected cases and 177 deaths. The outbreak, driven by the rare Bundibugyo strain of Ebola has been classified by the World Health Organization as a “very high” risk nationally, with a declared public health emergency of international concern. The Oxford team’s candidate uses the ChAdOx1 viral vector platform, previously deployed in the COVID-19 vaccine developed with AstraZeneca, to deliver genetic material from the Bundibugyo virus via a modified chimpanzee cold virus that cannot cause disease but trains the immune system to recognize the pathogen. While animal studies are now under way and production plans are being prepared with the Serum Institute of India, researchers stress that the vaccine’s effectiveness remains unproven and depends on preclinical and early clinical results. – Bree Foster

Hot Topics from Berlin 2025: What Experts Say About the Future of Metastatic Breast Cancer Care Authors: Paolo Tarantino, MD, PhD; Valentina Guarneri, MD, PhD; Rebecca A. Dent, MD

https://www.medscape.org/viewarticle/hot-topics-berlin-2025-what-experts-say-about-future-2025a1000x8r?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260528-OUS-HONC-hot-topics-berlin-2025-what-experts-say-about-future-2025a1000x8r-cta

The Next Frontier in Metastatic CRPC: The EZH2 Pathway and Emerging Therapies Authors: Elena Castro, MD, PhD; Michael Schweizer, MD; Neal D. Shore, MD, FACS

https://www.medscape.org/viewarticle/next-frontier-metastatic-crpc-ezh2-pathway-and-emerging-2026a10009uq?page=1&src=mkmcmr_driv_stan_mscpedu_260528-OUS-HONC-next-frontier-metastatic-crpc-ezh2-pathway-and-emerging-2026a10009uq-cta&uac=148436CN

Optimizing the Transplant Experience: A Patient Journey Through Conditioning and GvHD Management Authors: Daniele Avenoso, MD, PhD; Filippo Milano, MD, PhD; Mareike Verbeek, MD; Robert Zeiser, MD

https://www.medscape.org/viewarticle/optimizing-transplant-experience-patient-journey-through-2026a1000bh8?page=1&src=mkmcmr_driv_stan_mscpedu_260529-OUS-HONC-optimizing-transplant-experience-patient-journey-through-2026a1000bh8-cta&uac=148436CN

New Clinical Trial Testing On-Demand Use of Deucrictibant in Patients With Hereditary Angioedema by Madaline Spencer| Published on: Mar 20, 2026

New Clinical Trial Testing On-Demand Use of Deucrictibant in Patients With Hereditary Angioedema by Madaline Spencer| Published on: Mar 20, 2026 Peng Lu, MD, PhD, Chief Medical Officer at Pharvaris, and Wim Souverijns, PhD, Chief Commercial Officer at Pharvaris, discuss the RAPIDe-3 clinical trial of deucrictibant for patients with hereditary angioedema (HAE). https://checkrare.com/new-clinical-trial-testing-on-demand-use-of-deucrictibant-in-patients-with-hereditary-angioedema/

Upcoming Regulatory Decision for LNTH-2501 in the Imaging of Neuroendocrine Tumors by Madaline Spencer| Published on: May 26, 2026

Upcoming Regulatory Decision for LNTH-2501 in the Imaging of Neuroendocrine Tumors by Madaline Spencer| Published on: May 26, 2026 Mauro Cives, MD, Associate Professor of Medical Oncology at the University of Bari, Italy, discusses the upcoming regulatory decision for LNTH-2501 to improve imaging of neuroendocrine tumors (NETs). https://checkrare.com/upcoming-regulatory-decision-for-lnth-2501-in-the-imaging-of-neuroendocrine-tumors/

DUET Clinical Trial of Xywav in Patients With Narcolepsy by Madaline Spencer| Published on: May 29, 2026

DUET Clinical Trial of Xywav in Patients With Narcolepsy by Madaline Spencer| Published on: May 29, 2026 Logan Schneider, MD, Adjunct Clinical Associate Professor of Psychiatry and Behavioral Sciences at Stanford University, discusses the DUET clinical trial of Xywav (low sodium oxybate) in patients with narcolepsy. https://checkrare.com/duet-clinical-trial-of-xywav-in-patients-with-narcolepsy/

Smarter Step: New Tech Helping Amputees By Ivanhoe Broadcast News on June 5, 2026

Smarter Step: New Tech Helping Amputees By Ivanhoe Broadcast News on June 5, 2026 RALEIGH, N.C. (Ivanhoe Newswire) — According to the Amputee Coalition, more than two million people in the United States are living with limb loss. And, that number is expected to double by 2050. Losing a leg doesn’t just change how someone walks — it can change how their entire body moves. For many amputees, years of compensating with other muscles can lead to chronic hips, back, and joint pain. Ivanhoe shows us how technology could change lives https://www.ivanhoe.com/?p=37137&preview=1&_ppp=44d165aa7a

Miles from Maternity Care: AI Helping Expectant Moms By Ivanhoe Broadcast News on June 4, 2026

Miles from Maternity Care: AI Helping Expectant Moms By Ivanhoe Broadcast News on June 4, 2026 RALEIGH, N.C. (Ivanhoe Newswire) — Across the US, more than 35 percent of counties are now considered a maternity care desert — with no birthing hospital, no birth center, and no obstetric clinician. https://www.ivanhoe.com/?p=37134&preview=1&_ppp=dd33a2f874

AI’S Impact on Depression By Ivanhoe Broadcast News on June 3, 2026

AI’S Impact on Depression By Ivanhoe Broadcast News on June 3, 2026 ORLANDO, Fla. (Ivanhoe Newswire) — Artificial Intelligence, or AI for short, has made its way into our everyday lives. Today, more than 65 percent of people use AI on a regular basis. While it can make life easier, some research shows AI may be harmful to your mental health. https://www.ivanhoe.com/?p=37131&preview=1&_ppp=6df9416ddd

Extreme Cells Hold Key to Pregnancy & Cancer By Ivanhoe Broadcast News on June 2, 2026

Extreme Cells Hold Key to Pregnancy & Cancer By Ivanhoe Broadcast News on June 2, 2026 RALEIGH, N.C. (Ivanhoe Newswire) — During pregnancy, a mother and baby are connected by a remarkable organ — the placenta. Researchers now say a single massive cell inside that organ may hold clues to pregnancy complications, certain diseases, and even cancer. These so-called “extreme cells” don’t follow the normal rules of biology, and studying them may help scientists better understand how diseases begin. https://www.ivanhoe.com/?p=37128&preview=1&_ppp=f84fb00356

Arlene’s Fight for 2: Saving Mom & Saving Baby By Ivanhoe Broadcast News on June 1, 2026

Arlene’s Fight for 2: Saving Mom & Saving Baby By Ivanhoe Broadcast News on June 1, 2026 RALEIGH, NC. (Ivanhoe Newswire) — Breast cancer remains the most common cancer among women in the United States with more than 300 thousand new cases expected this year. About 15 % will be triple-negative — a fast-moving form that does not respond to hormone therapies and often requires aggressive treatment. For some women, there’s another layer of complexity — they’re pregnant. Martie salt introduces us to one mom who faced both battles at once. https://www.ivanhoe.com/?p=37125&preview=1&_ppp=4115975174

Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial Liem T. Nguyena,b,e Send email to liem.nt@vinuni.edu.vn ∙ Kien T. Nguyena,e ∙ Lan T.M. Daoa,e ∙ Van T. Hoanga ∙ Trang T.K. Phana ∙ Nhung T.H. Dinha ∙ et al.

Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial Liem T. Nguyena,b,e Send email to liem.nt@vinuni.edu.vn ∙ Kien T. Nguyena,e ∙ Lan T.M. Daoa,e ∙ Van T. Hoanga ∙ Trang T.K. Phana ∙ Nhung T.H. Dinha ∙ et al. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00150-7/fulltext?dgcid=hubspot_update_feature_updatealerts_ebiom&utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz--eN-PeSYMQzVYYXXrkjzFcoIRR6Cnnpqq4cP_TpoEPWSf8RfhuoOX-zmM-fDQKPZE7uQ-UGVcQrinK7qjMklwMRQANyg&_hsmi=420912456&utm_content=420560842&utm_source=hs_email

Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study Chenhao Yanga ∙ Yongxin Xua ∙ Yichao Dua ∙ Xiaonan Shena ∙ Tingting Lia ∙ Nan Chenb ∙ et al.

Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study Chenhao Yanga ∙ Yongxin Xua ∙ Yichao Dua ∙ Xiaonan Shena ∙ Tingting Lia ∙ Nan Chenb ∙ et al. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00127-1/fulltext?dgcid=hubspot_update_feature_updatealerts_ebiom&utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz-90qIaSCtX0-9wJOwZbEDqX_hGQFTuYAsKopdKPQ8fMA6JLUmpCFgpENjQuZWiOShAprfnFOrGbXl-t7PZ8ozZ3lwzyaQ&_hsmi=420912456&utm_content=420560842&utm_source=hs_email

Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies Yue Shia,i ∙ Yongkang Yangb,c,i ∙ Xianghao Guoc ∙ Shuai Shic ∙ Qin Lib,c ∙ Chi Chiu Wanga,d ∙ et al.

Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies Yue Shia,i ∙ Yongkang Yangb,c,i ∙ Xianghao Guoc ∙ Shuai Shic ∙ Qin Lib,c ∙ Chi Chiu Wanga,d ∙ et al. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00135-0/fulltext?dgcid=hubspot_update_feature_updatealerts_ebiom&utm_campaign=update-ebiom&utm_medium=email&_hsenc=p2ANqtz-93LGpatUDNPkdATM4s8RaZjVEFMZ88kEKWDnHfZyvE3h-8QKE1X99QNJEKw_EF7xmblNT4BpsuKVmAHqQuCqnhtojnJA&_hsmi=420912456&utm_content=420560842&utm_source=hs_email

Editorial Towards biology-informed therapies for long COVID eBioMedicine +...

Editorial Towards biology-informed therapies for long COVID eBioMedicine https://www.thelancet.com/journals/ebiom/issue/vol127nonull/PIIS2352-3964(26)X2003-5

Editorial p393 Shared ownership with young people in health research The Lancet Child & Adolescent Health +... +

Editorial p393 Shared ownership with young people in health research The Lancet Child & Adolescent Health https://www.thelancet.com/journals/lanchi/issue/vol10no6/PIIS2352-4642(26)X2004-1 Safety of in vivo gene therapy in children: mechanisms and management of liver injury Rebecca Jeyaraj, MRCPCHa,b,c,e Send email to r.jeyaraj@bham.ac.uk ∙ Li-An K Brown, FRCPathd,e ∙ Barath Jagadisan, MDf ∙ Prof Francesco Muntoni, MDe,g ∙ Julien Baruteau, MD PhDc,e,h ∙ Girish Gupte, MDb ∙ et al. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00380-3/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-9QrxCRagSs_beTr6XJq_XoVjWGW6gSKMSYxR2hLpd1P6j4oUALM441QANXP-ElFBT_hoi88aYoY721gS0UoFamI--fIA&_hsmi=420884426&utm_content=420561182&utm_source=hs_email

Setting priorities for research in addiction Anne Lingford-Hughesa Send email to anne.lingford-hughes@ic.ac.uk ∙ Toto Gronlundb ∙ Eilish Gilvarryc,d on behalf of the James Lind Alliance Priority Setting Partnership for Addiction

Setting priorities for research in addiction Anne Lingford-Hughesa Send email to anne.lingford-hughes@ic.ac.uk ∙ Toto Gronlundb ∙ Eilish Gilvarryc,d on behalf of the James Lind Alliance Priority Setting Partnership for Addiction https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(26)00023-4/abstract?utm_campaign=update-lanpsy&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanpsy&_hsenc=p2ANqtz-8CF8Ml92mDNnLNHY8nuz6FwfLUvUUi24ALE9xMLjq7TaCSjX66o78hTbp8t6-WohKU5h15vvByjU-RJ6hd8bnUyxfYMQ&_hsmi=420895767&utm_content=420561075&utm_source=hs_email

Editorial p445 Maternal depression: improving estimates and care The Lancet Psychiatry +...

Editorial p445 Maternal depression: improving estimates and care The Lancet Psychiatry https://www.thelancet.com/journals/lanpsy/issue/vol13no6/PIIS2215-0366(26)X2004-1

The value of infectious disease conferences The Lancet Infectious Diseases ++... ++

The value of infectious disease conferences The Lancet Infectious Diseases https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00245-8/fulltext?dgcid=raven_jbs_etoc_email Jun 2026 Volume 26Number 6p549-650, e209-e267 https://www.thelancet.com/journals/laninf/issue/vol26no6/PIIS1473-3099(26)X2005-9 Case presentation of patients hospitalised with mpox (subclade Ib/2023sh) including children, adolescents, and adults in South Kivu, Democratic Republic of the Congo: an observational cohort study Luis Flores Girón, MSca,b,c,* ∙ Gustavo Sganzerla Martinez, PhDd,e,h,* ∙ Baganda Ntahuma Daniel, MDb ∙ Alfred Kesheni Bisimwa, MDb ∙ Nkonzi Pacific, MDb ∙ Georges Assumani Martin, BVSca,b,c ∙ et al. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00051-4/fulltext?dgcid=raven_jbs_etoc_feature_laninf Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial Tamiru Shibiru Degaga, MDa,b ∙ Prof Ayodhia Pitaloka Pasaribu, PhDc,d ∙ Rupam Tripura, PhDe,f ∙ Najia Ghanchi, PhDg ∙ Megha Rajasekhar, PhDh ∙ Bipin Adhikari, PhDe,f ∙ et al. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00729-7/fulltext?dgcid=raven_jbs_etoc_feature_laninf

Editorial e349 Climate change and health: closing the gaps The Lancet Public Health + +... +

The 2026 Europe report of the Lancet Countdown on health and climate change: narrowing window for decisive health action Hedi K Kriit, PhDa,b,c Send email to Hedi.kriit@uni-heidelberg.de ∙ José Chen-Xu, PhDd,e ∙ Prof Jan C Semenza, PhDa,c ∙ Hannah Heiliger, PhDf ∙ Prof Anil Markandya, PhDg ∙ Prof Niheer Dasandi, PhDh ∙ et al. https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(26)00025-3/fulltext?dgcid=raven_jbs_etoc_feature_lanpub Editorial e349 Climate change and health: closing the gaps The Lancet Public Health https://www.thelancet.com/journals/lanpub/issue/vol11no6/PIIS2468-2667(26)X2005-9 The effects of the Rx Kids unconditional cash prescription programme during pregnancy and infancy on birth outcomes in the USA: a population-based, quasi-experimental study Sumit Agarwal, MDa Send email to sumitag@med.umich.edu ∙ Prof H Luke Shaefer, PhDb ∙ Yasamean Zamani-Hank, PhDc ∙ Eric Finegood, PhDd ∙ Jenny LaChance, MSe ∙ Prof Mona Hanna, MD https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(26)00055-1/fulltext?dgcid=raven_jbs_etoc_feature_lanpub

Research challenges long standing beliefs about cannabis and male hormones

https://www.news-medical.net/news/20260528/Research-challenges-long-standing-beliefs-about-cannabis-and-male-hormones.aspx The effects of cannabis on the hormonal system and male fertility remain controversial within the scientific community. A study conducted by the University of Geneva (UNIGE), in collaboration with the Swiss Center for Applied Human Toxicology (SCAHT), provides a new answer by showing that cannabis use does not reduce testosterone levels in young men and may even increase its testicular synthesis.

How common spices may improve gut, brain, and metabolic health

https://www.news-medical.net/news/20260528/How-common-spices-may-improve-gut-brain-and-metabolic-health.aspx From cinnamon and turmeric to black pepper and oregano, researchers say common kitchen spices may do far more than add flavor, potentially influencing blood sugar, inflammation, brain function, and even the gut microbiome. Researchers reviewed available literature, particularly studies conducted at the University of California–Los Angeles (UCLA) Center for Human Nutrition, to examine the effects of spices and herbs on human health. This review is available in Nutrition Reviews.

Outcomes of Pegcetacoplan Treatment in Adolescents With C3G and IC-MPGN by Madaline Spencer| Published on: May 22, 2026 +... +...

Outcomes of Pegcetacoplan Treatment in Adolescents With C3G and IC-MPGN by Madaline Spencer| Published on: May 22, 2026 A recent publication in the Clinical Journal of the American Society of Nephrology presented outcomes of pegcetacoplan treatment in adolescents with C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN). https://checkrare.com/outcomes-of-pegcetacoplan-treatment-in-adolescents-with-c3g-and-ic-mpgn/ Results From the ACUITY Clinical Trial in Patients With Acute Optic Neuritis by Madaline Spencer and James Radke, PhD| Published on: May 22, 2026 Pablo Villoslada, MD, PhD, Founder and Medical Director of Accure Therapeutics and Head of Pathogenesis and New Therapies MS at IDIBAPS in Hospital Clínic in Barcelona, discusses results from the ACUITY clinical trial testing privosegtor to treat patients with acute optic neuritis (AON). The data was recently presented at the American Academy of Neurology Annual Meeting (AAN 2026) in Chicago, IL. https://checkrare.com/results-from-the-acuity-clinical-trial-in-patients-with-acute-optic-neuritis/

Overview of Arginine Vasopressin Deficiency by CheckRare Staff| Published on: May 28, 2026

Overview of Arginine Vasopressin Deficiency by CheckRare Staff| Published on: May 28, 2026 The name of the rare disease central diabetes insipidus was changed in 2024 to better reflect its etiology. CheckRare discussed this disorder with Christopher Romero, MD, a pediatric endocrinologist at Mount Sinai Medical Center, New York City, and Associate Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai. https://checkrare.com/overview-of-arginine-vasopressin-deficiency/

Decision-Making for Managing Myelofibrosis-Related Cytopenias: What Is Best Practice? Authors: Paola Guglielmelli, MD, PhD

https://www.medscape.org/viewarticle/decision-making-managing-myelofibrosis-related-cytopenias-2026a1000ar2?page=1&src=mkmcmr_driv_stan_mscpedu_260528-OUS-HONC-decision-making-managing-myelofibrosis-related-cytopenias-2026a1000ar2-cta&uac=148436CN

Beyond diagnosis and treatment: Delivering holistic care for people living with rare diseases May 2026

https://www.eurordis.org/beyond-diagnosis-and-treatment-delivering-holistic-care-for-people-living-with-rare-disease/ Living with a rare disease impacts every aspect of a person’s life, from education and employment to mental health and social participation. Yet, regardless of whether someone receives a diagnosis or access to treatment, health and social care systems often fail to support them.

How Are Oral SERDs Changing the Management of Advanced HR-Positive Breast Cancer? Authors: Erica L. Mayer, MD, MPH; François-Clément Bidard, MD, PhD

https://www.medscape.org/viewarticle/how-are-oral-serds-changing-management-advanced-hr-positive-2025a1000xkg?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260527-OUS-HONC-how-are-oral-serds-changing-management-advanced-hr-positive-2025a1000xkg-cta

Coconut Oil Leslie S. Baumann, MD

https://www.medscape.com/viewarticle/coconut-oil-2026a1000gkx?ecd=wnl_edit_tpal_etid8377805&uac=148436CN&impID=8377805 Coconut oil, derived from the dried Cocos nucifera (coconut) fruit, is made up of 90% saturated triglycerides and is used as a skin- and hair-conditioning agent as well as a fragrance ingredient in hundreds of formulations at concentrations ranging from 0.0001% to 70%. Notably, coconut oil also has a long history of traditional medicine use in China and India and in food preparation. Indeed, coconut oil is a staple ingredient in the Sri Lankan diet as well as others in South Asia, Africa, and South America, where coconut is cultivated.

Do We Need to Rethink MS Classification? Andrew N. Wilner, MD; Jodie M. Burton, MD, MSc

https://www.medscape.com/viewarticle/do-we-need-rethink-ms-classification-2026a1000f5p?ecd=wnl_edit_tpal_etid8377805&uac=148436CN&impID=8377805 Andrew N. Wilner, MD: Welcome to Medscape. I'm your host, Dr Andrew Wilner. Today, I have the pleasure of speaking with Dr Jodie Burton. Dr Burton is a neuroimmunologist and clinical associate professor in the departments of Clinical Neurosciences and Community Health Sciences at the University of Calgary, Canada. We're going to discuss a recent publication in JAMA Neurology by Dr Shirani and colleagues about the classification of multiple sclerosis (MS). Welcome, Dr Burton.

DNA origami vaccine nanoparticles improve humoral and cellular immune responses to infectious diseases Yang C. Zeng, Olivia J. Young, Qiancheng Xiong, Longlong Si, Min Wen Ku, Sylvie G. Bernier, Hawa Dembele, Giorgia Isinelli, Tal Gilboa, Zoe Swank, Su Hyun Seok, Anjali Rajwar, Amanda Jiang, Yunhao Zhai, LaTonya D. Williams, Caleb A. Hellman, Chris M. Wintersinger, Amanda R. Graveline, Andyna Vernet, Melinda Sanchez, Sarai Bardales, Georgia D. Tomaras, Ju Hee Ryu, Ick Chan Kwon, …William M. Shih

https://www.nature.com/articles/s41551-026-01614-w?utm_medium=email&_hsenc=p2ANqtz--IfJSyYHc0U7-oUr667PyekarXQaUk6sxxhiyhUjE5ZRS2-6ts9GfkD-655BWV1_ebhztY_1xUnTAyS9NaMkjFcubrDQ&_hsmi=136907737&utm_content=136917285&utm_source=hs_email Current SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccines have shown robust induction of neutralizing antibodies and CD4+ T cell activation; however, CD8+ responses are variable, and the duration of immunity and protection against variants are limited. Here we repurpose our DNA origami vaccine nanotechnology DoriVac to target infectious viruses, namely, SARS-CoV-2, HIV and Ebola. The DNA origami nanoparticle, conjugated with infectious-disease-specific heptad repeat 2 peptides, which act as highly conserved antigens, and CpG adjuvant at precise nanoscale spacing, induces neutralizing antibodies, Th1 CD4+ T cells and CD8+ T cells in naive mice, with significant improvement over a bolus control. Pre-clinical studies using lymph-node-on-a-chip systems validate that DoriVac, when conjugated with antigenic peptides or proteins, induces promising cellular and humoral immune responses in human cells. Moreover, DoriVac bearing full-length SARS-CoV-2 spike protein achieves immune responses comparable to current mRNA vaccine platforms while potentially reducing storage constraints. These results suggest that DoriVac holds potential as a versatile, modular vaccine platform, capable of inducing both humoral and cellular immunities, underscoring its potential future use.

Hypothalamic Menin regulates systemic aging and cognitive decline Lige Leng ,Ziqi Yuan,Xiao Su,Zhenlei Chen,Shangchen Yang,Meiqin Chen,Kai Zhuang,Hui Lin,Hao Sun,Huifang Li,Maoqiang Xue,Jun Xu,Jingqi Yan, [ ... ],Jie Zhang

https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.3002033&utm_medium=email&_hsenc=p2ANqtz-_usNpy06_r8JkxN02BpayZ0-VnIvPr0cujvK_R21pn9qkYDKjYTaIWRFYyNHwxZ0J8vSbyhWy7aM6Sn1tIQYOdUKimlw&_hsmi=136907737&utm_content=136917285&utm_source=hs_email Aging is a systemic process, which is a risk factor for impaired physiological functions, and finally death. The molecular mechanisms driving aging process and the associated cognitive decline are not fully understood. The hypothalamus acts as the arbiter that orchestrates systemic aging through neuroinflammatory signaling. Our recent findings revealed that Menin plays important roles in neuroinflammation and brain development. Here, we found that the hypothalamic Menin signaling diminished in aged mice, which correlates with systemic aging and cognitive deficits. Restoring Menin expression in ventromedial nucleus of hypothalamus (VMH) of aged mice extended lifespan, improved learning and memory, and ameliorated aging biomarkers, while inhibiting Menin in VMH of middle-aged mice induced premature aging and accelerated cognitive decline. We further found that Menin epigenetically regulates neuroinflammatory and metabolic pathways, including D-serine metabolism. Aging-associated Menin reduction led to impaired D-serine release by VMH-hippocampus neural circuit, while D-serine supplement rescued cognitive decline in aged mice. Collectively, VMH Menin serves as a key regulator of systemic aging and aging-related cognitive decline.

Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV +... ++++++

https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/community-acquired Community-Acquired Bacterial Pneumonia Updated the recommendations for preferred and alternative empiric treatment of community-acquired pneumonia (CAP). Added treatment recommendations for patients with CAP for whom a viral etiology is identified. Updated the recommendations on the use of corticosteroids in the management of CAP in hospitalized patients. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/hepatitis-b-virus Hepatitis B Virus Infection Updated the recommendations for people with isolated anti–hepatitis B core antibody to reflect that tenofovir-sparing regimens can also be considered with monitoring of alanine aminotransferase. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/malaria Malaria Noted the potential for false-negative rapid diagnostic tests for Plasmodium falciparum due to emerging histidine-rich protein 2 gene deletions in some regions. Updated the medication options, dosing recommendations, and glucose-6-phosphate dehydrogenase deficiency screening requirements for anti-relapse therapy for P. vivax and P. ovale species infections. Updated the preferred treatment recommendations for pregnant women. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/disseminated Disseminated Mycobacterium avium Complex Disease Clarified the use of molecular assays to identify Mycobacterium avium Complex (MAC) subspecies and mutations associated with macrolide resistance. Updated the guidance on diagnostic criteria and treatment for localized pulmonary MAC disease in keeping with the American Thoracic Society/European Respiratory Society/European Society of Clinical Microbiology and Infectious Diseases/Infectious Disease Society of America joint guideline on the treatment of nontuberculous mycobacterial pulmonary disease. Clarified the criteria for severe MAC disease that might require a third or fourth antimycobacterial drug for treatment. Disseminated Mycobacterium avium Complex Disease Pneumocystis pneumonia https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/pneumocystis Revised the recommendation statement regarding indications for initiating primary prophylaxis for Pneumocystis pneumonia for clarity and simplicity. Syphilis https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/syphilis Recommended serologic screening for syphilis in pregnant women at the first prenatal visit, at 28 weeks’ gestation, and at delivery. Noted that doxycycline post-exposure prophylaxis is an option for syphilis prevention for some individuals. These guidelines are published in an electronic format and updated as changes occur in prevention and treatment science. All updates are developed by the subject matter groups listed in Appendix B and reviewed by scientific content experts. To view or download the guidelines, go to the Adult and Adolescent Opportunistic Infection Guidelines section of the Clinicalinfo website. The guidelines tables and recommendations also can be downloaded as separate PDF files. https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/panel-roster?view=full

Persistent gaps in skin cancer prevention + + +... +

A multiparameter model (OsteoSC-M3) for early detection and risk stratification of osteoporosis in women: a multicentre cohort study in China Xiaoyan Tenga,d ∙ Ji Qiaob,d ∙ Yang Xuea ∙ Li Weib ∙ Xiaozhong Jic Send email to 1263830302@qq.com ∙ Yuzhen Du https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00150-1/fulltext?dgcid=raven_jbs_etoc_feature_eclinm Oropouche virus: transmission, epidemiology, genetic diversity, and public health implications Lorenzo Subissia Send email to subissil@who.int ∙ James R. Otienoa ∙ Christopher Ruisb,c,d ∙ Ingrid Rabea ∙ Anurag Agrawale ∙ Laith Jamal Abu-Raddadf ∙ et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00118-5/fulltext?dgcid=raven_jbs_etoc_feature_eclinm May 2026 Volume 95 https://www.thelancet.com/journals/eclinm/issue/vol95nonull/PIIS2589-5370(26)X2004-1 Persistent gaps in skin cancer prevention eClinicalMedicine https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00255-5/fulltext?dgcid=raven_jbs_etoc_email

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV

https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/whats-new Update on Statin Therapy as Primary Prevention of Atherosclerotic Cardiovascular Disease in People With HIV https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/statin-therapy-people-hiv?view=full

Early Palliative Integration for Heart Failure Karel De Pourcq, PhD

https://www.medscape.com/viewarticle/early-palliative-integration-heart-failure-2026a1000hh1

Upcoming Regulatory Decision for LNTH-2501 in the Imaging of Neuroendocrine Tumors by Madaline Spencer| Published on: May 26, 2026

Upcoming Regulatory Decision for LNTH-2501 in the Imaging of Neuroendocrine Tumors by Madaline Spencer| Published on: May 26, 2026 Mauro Cives, MD, Associate Professor of Medical Oncology at the University of Bari, Italy, discusses the upcoming regulatory decision for LNTH-2501 to improve imaging of neuroendocrine tumors (NETs). https://checkrare.com/upcoming-regulatory-decision-for-lnth-2501-in-the-imaging-of-neuroendocrine-tumors/

Itvisma Gene Therapy for Patients With Spinal Muscular Atrophy by CheckRare Staff| Published on: May 27, 2026

Itvisma Gene Therapy for Patients With Spinal Muscular Atrophy by CheckRare Staff| Published on: May 27, 2026 John Day, MD, PhD, Director of Neuromuscular Medicine at Stanford University, discusses the development of Itvisma gene therapy for patients with spinal muscular atrophy (SMA). https://checkrare.com/itvisma-gene-therapy-for-patients-with-spinal-muscular-atrophy/

How multi-omics is changing what scientists can see in the human immune system

https://www.news-medical.net/news/20260429/How-multi-omics-is-changing-what-scientists-can-see-in-the-human-immune-system.aspx?utm_source=azonetwork_newsletter&utm_medium=email&utm_campaign=genomics_newsletter_26_may_2026 By combining high-dimensional immune data with advanced computation, researchers are moving closer to predicting vaccine responses, disease risk, and treatment outcomes, but the field still faces major challenges in data quality, validation, and clinical translation.

New colorectal cancer screening guidelines emphasize advanced stool tests

https://www.news-medical.net/news/20260527/New-colorectal-cancer-screening-guidelines-emphasize-advanced-stool-tests.aspx With colorectal cancer a growing concern among younger people, the American Cancer Society has endorsed two new types of stool tests to encourage people to get screened while also recommending a limited role for new blood tests many patients find appealing.

Prenatal forever chemical exposure may affect puberty timing in children

https://www.news-medical.net/news/20260527/Prenatal-forever-chemical-exposure-may-affect-puberty-timing-in-children.aspx An EHU-University of the Basque Country and Biogipuzkoa Health Research Institute study has linked certain chemicals measured during the first trimester of pregnancy to the subsequent onset of puberty in the children. Within the framework of the INMA project, which studies the impact of environmental pollutants on pregnancy and child development, researchers analysed the concentrations of chemicals known as PFAS measured in the mother's blood, and the onset of puberty in girls and boys. The study showed that certain types of PFAS may be slightly associated with the early or late onset of some pubertal characteristics.

Poor lipid metabolism may reduce cognitive performance in teens

Poor lipid metabolism may reduce cognitive performance in teens A new Finnish study shows that blood markers of dysfunctional lipid metabolism are associated with poorer cognitive function in 15-17-year-olds. The findings are significant because brain development during adolescence is rapid, and protecting it from an early age is critical for lifelong brain health. Preventing lipid metabolism dysfunction from childhood may support not only cardiovascular health, but also healthy brain development.

What Does Organic Mean on Food Labels?

https://www.news-medical.net/health/What-Does-Organic-Mean-on-Food-Labels.aspx Organic food labels reflect certified production standards, not guaranteed health superiority. Organic systems can support biodiversity, soil health, and lower residue exposure, but benefits vary by crop, region, and management. The global organic market has grown rapidly over the past two decades due to rising consumer interest in health, environmental sustainability, and food transparency. Despite the growing popularity of organic products, which currently have a market value of over $106 billion USD, the regulations and scientific standards behind organic labeling remain poorly understood by many consumers.

Highlights From San Francisco: The Evolving Role of The Radiation Oncologist in Lower-Grade Glioma Care Authors: Erik P. Sulman, MD, PhD; Mitchel S. Berger, MD; Benjamin M. Ellingson, PhD; Lia M. Halasz, MD; Michael Weller, MD

https://www.medscape.org/viewarticle/1003169?src=mkmcmr_driv_stan_mscpedu_260527-OUS-HONC-1003169-cta&uac=148436CN

Redefining axial spondyloarthritis: more than just back pain The Lancet Rheumatology ++... ++

Redefining axial spondyloarthritis: more than just back pain The Lancet Rheumatology https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(26)00155-4/fulltext?dgcid=raven_jbs_etoc_email Jun 2026 Volume 8Number 6e407-e492 https://www.thelancet.com/journals/lanrhe/issue/vol8no6/PIIS2665-9913(26)X2005-7 Towards global clinical practice guidelines for the management of non-specific low back pain in primary care: a review of current guideline recommendations and how they have changed over the last 30 years Crystian B Oliveira, PhDa,b,c Send email to crystian.oliveira@sydney.edu.au ∙ Prof Bart W Koes, PhDd,e ∙ Rafael Z Pinto, PhDf,g ∙ Adrian C Traeger, PhDa,b ∙ Gustavo C Machado, PhDa,b ∙ Prof Chung-Wei Christine Lin, PhDa,b ∙ et al. https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(26)00077-9/fulltext?dgcid=raven_jbs_etoc_feature_lanrhe Time to pregnancy in women with rheumatoid arthritis who want to conceive treated according to a treat-to-target approach: a comparison of an observational cohort with a historical reference cohort Cornelia H Quaak, MDa,b Send email to c.witte-quaak@erasmusmc.nl ∙ Esther Röder, PhDa ∙ Hetty M Wintjesa ∙ Anneke J van Steensel-Boona ∙ Annemarie G M G J Mulders, MD PhDc ∙ Laura J C Kranenburg-van Koppen, MD PhDa ∙ et al. https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(26)00001-9/abstract?dgcid=raven_jbs_etoc_feature_lanrhe

Editorial p437 Diabetes-related complications: an evolving spectrum The Lancet Diabetes & Endocrinology +... +++

Editorial p437 Diabetes-related complications: an evolving spectrum The Lancet Diabetes & Endocrinology https://www.thelancet.com/journals/landia/issue/vol14no6/PIIS2213-8587(26)X2004-6 Continuous glucose monitoring versus self-monitoring of blood glucose in individuals with type 2 diabetes: a randomised, multicentre, open-label, superiority trial Emma G Wilmot, PhDa,b Send email to emma.wilmot@nottingham.ac.uk ∙ Patrick Moore, MRCGPc ∙ Prof Thozhukat Sathyapalan, PhDd,e ∙ Prof Pratik Choudhary, MDf,g ∙ Jonathan Z M Lim, PhDh ∙ Prof Sankalpa Neupane, PhDi,j ∙ et al. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(26)00076-8/fulltext?dgcid=hubspot_update_feature_updatealerts_landia&utm_campaign=update-landia&utm_medium=email&_hsenc=p2ANqtz-_xluE4-r7gy5mW3cv0mHuxzmTwmvAhnv2EgCbjtIDdhP_Iv4z9R85BAtzEkQwGpAFKHTe349DiOYFUltwzIlMd8rR7ig&_hsmi=420591049&utm_content=420425813&utm_source=hs_email Safety, tolerability, pharmacokinetics, and efficacy of burosumab in infants with X-linked hypophosphataemia: an open-label, multicentre, non-randomised study Prof Agnès Linglart, MD PhDa ∙ Francesco Emma, MDb ∙ Prof Justine Bacchetta, MD PhDc,d ∙ Francisco de la Cerda, MD PhDe ∙ Prof Wesley Hayes, MB BChirf ∙ Moira Cheung, MBBS PhDg ∙ et al. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(26)00013-6/abstract?utm_campaign=update-landia&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_landia&_hsenc=p2ANqtz-8UY7J_onTjWe-OATN2C9a-Vc5hjr8GENsDoyBXKfVwGILmmWiwdbawjUBOPG8uKJIsEuSFAn0Wxggr-uv-19Fh998VLQ&_hsmi=420591049&utm_content=420425813&utm_source=hs_email Natural history of thyroid function in ageing: an individual participant data analysis of 137 488 participants from 31 prospective cohort studies Yanning Xu, MDa,b,c ∙ Ola Hysaj, Mscd,e ∙ Xiaoyi Qi, MDa,b ∙ Martin Feller, MDd ∙ Alessandro Pingitore, MDf ∙ Suzanne J Brown, BScg ∙ et al. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(26)00009-4/abstract?utm_campaign=update-landia&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_landia&_hsenc=p2ANqtz-8KZNT-6onbs6ezSnVZPwUEKLaPpbUSnKuC6et0GvzAf5FXyjqCvewXTPZHkatf-Ege4a43cO3BtU36W75A0FIeHvO3RA&_hsmi=420591049&utm_content=420425813&utm_source=hs_email

Editorial p533 The US Parkinson's disease community demands prevention The Lancet Neurology +... +++

Editorial p533 The US Parkinson's disease community demands prevention The Lancet Neurology https://www.thelancet.com/journals/laneur/issue/vol25no6/PIIS1474-4422(26)X2004-X Safety, tolerability, and efficacy of acetazolamide in idiopathic normal pressure hydrocephalus (DRAIN) in Sweden: a randomised, double-blind, placebo-controlled, phase 2 trial Johan Virhammar, PhDa Send email to johan.virhammar@uu.se ∙ Oskar Fasth, MDa ∙ Maria Ekblom, Msca ∙ Oskar Ekman, MDa ∙ Nils Holmstrandb ∙ David Fällmar, PhDb ∙ et al. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(26)00126-2/abstract?utm_campaign=update-laneur&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_laneur&_hsenc=p2ANqtz-_Mn2o_yBRyEKuL70_TRj7JiTD2mVaSC7v6VU21YwBnXKCW_X_trqivkayL_VTUNgWWpJ6_7-uWO4SRnG6oi8K8DFoEtA&_hsmi=420598221&utm_content=420423128&utm_source=hs_email Safety and efficacy of the anti-α-synuclein monoclonal antibody amlenetug for the treatment of patients with multiple system atrophy (AMULET): a phase 2, randomised, double-blind, multicentre trial Lotte Kjærsgaard, MDa ∙ Jonas Wiedemann, MSca ∙ Prof Wolfgang Singer, MDb ∙ Atsushi Takeda, MDc ∙ Anna-Karin Berger, PhDa ∙ Mimi Folden Flensburg, DVM PhDa ∙ et al. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(26)00100-6/abstract?utm_campaign=update-laneur&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_laneur&_hsenc=p2ANqtz-9KF3XIEfkWNGopKUFNNumxv3pXcoe2EPIMPZ52qa5d3QyrhNF5qYJZpkGsZdVk70Kp0pJh7_xpmGv-fF-OcJWH1yWmsA&_hsmi=420598221&utm_content=420423128&utm_source=hs_email New evidence on the clinical, genetic, and biochemical bases of GBA1-Parkinson's disease: prospects for treatment Elisa Menozzi, MD PhDa,b ∙ Marco Toffoli, MD PhDa,b ∙ Prof Michela Deleidi, MD PhDb,c ∙ Prof Donato A Di Monte, MDb,d ∙ Prof Fabio Blandini, MD PhDb,e,f ∙ Prof Dimitri Krainc, MD PhDg ∙ et al. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(26)00090-6/abstract?utm_campaign=update-laneur&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_laneur&_hsenc=p2ANqtz-9C-m4aOGYD5aKPQ9zi6QCjyqSEXSbbIGyTSDFFFpWhQEccFB5Ho4pPcRHelIHz012fBfzF1_RepTkEY_dMKV_B_XuhCg&_hsmi=420598221&utm_content=420423128&utm_source=hs_email

Combination therapy doubles one-year survival in pancreatic cancer trial Findings from the randomized trial suggest that modulating the tumour microenvironment alongside chemotherapy may offer a new strategy for improving outcomes in pancreatic cancer Written byBree Foster, PhD

https://www.drugdiscoverynews.com/combination-therapy-doubles-one-year-survival-in-pancreatic-cancer-trial-17121?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-9RjxJ5AZAB6xc-u4klI7ipE7m3TNkJzTFeqS9BgF8sKXBfnuZM3YdZDzZ6GCtBHTzDoDxq03B5R8KLzXFyk1NPbXpDhQ&_hsmi=420563864&utm_content=420563864&utm_source=hs_email A drug developed at Northwestern University has shown a promising survival advantage in patients with metastatic pancreatic cancer, a disease that remains among the deadliest solid tumours and is projected to become the second leading cause of cancer-related deaths in the US within the next decade.

How an enzyme helps lung cancer survive radiation, and how to stop it Researchers identified a mitochondrial enzyme that shields lung cancer cells from a radiation-induced cell death process — and then found that an existing arthritis drug can disable that shield. Written byAndrea Corona

https://www.drugdiscoverynews.com/how-an-enzyme-helps-lung-cancer-survive-radiation-and-how-to-stop-it-17144?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz-91vqyJZuy4gJIWMn0Hb45mQSZ5-nnAUxF-j1kIISeo5MLmxGgGYh6cQL2c8yT6OcMBf_h9DQkWTRfB7rYgM1FzHoht3A&_hsmi=420563864&utm_content=420563864&utm_source=hs_email Radiation therapy is among the most widely used treatments for lung cancer, but its effectiveness is frequently undermined by a familiar problem: Tumors that initially respond to treatment develop resistance and begin growing again. How exactly that resistance forms has remained incompletely understood, and the mechanisms that allow cancer cells to survive radiation-induced damage continue to be an active area of investigation.

Designing microbiome therapies at scale starts with manufacturing As the field moves from fecal transplants toward defined bacterial consortia, the technical gaps in design, analytics, and co-cultivation are coming into sharper focus. Written byAndrea Corona

https://www.drugdiscoverynews.com/designing-microbiome-therapies-at-scale-starts-with-manufacturing-17183 Microbiome-based therapeutics have accumulated a compelling body of clinical evidence over the past decade. What they have lacked is the manufacturing and design infrastructure to turn that rationale into reproducible, scalable drugs. Munich-based mbiomics is attempting to build that infrastructure.

Novel genetic target for fragile X syndrome could improve brain function Using an unbiased molecular screen, researchers found a new gene that could be targeted to treat fragile X syndrome. Written byAllison Whitten, PhD

https://www.drugdiscoverynews.com/novel-genetic-target-for-fragile-x-syndrome-could-improve-brain-function-17189 Fragile X syndrome (FXS) — the most commonly inherited cause of both intellectual disability and autism spectrum disorder — results from a mutation in the FMR1 gene (Fragile X messenger ribonucleoprotein 1). Though it’s just a single gene and should theoretically be a great candidate for gene therapy, preclinical and translational work targeting the FMR1 gene has so far not led to a successful treatment of the disorder.

Expert-Driven, Patient-Focused: Mastering Personalized Care for HER2-Low Metastatic Breast Cancer Authors: Kevin Kalinsky, MD, MS, FASCO

https://www.medscape.org/viewarticle/1002880?uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260526-OUS-HONC-1002880-cta

Patients Progressing on an AI ± CDK4/6 Inhibitors: From Biomarkers to Treatment Strategies Authors: Manali Bhave, MD; Nadia Harbeck, MD, PhD

https://www.medscape.org/viewarticle/patients-progressing-ai-cdk4-6-inhibitors-biomarkers-2025a1000wtp?page=1&src=mkmcmr_driv_stan_mscpedu_260526-OUS-HONC-patients-progressing-ai-cdk4-6-inhibitors-biomarkers-2025a1000wtp-cta&uac=148436CN

More Patient Stories: Palliative Care Helps with Stress, Support, and More

https://getpalliativecare.org/more-patient-stories-palliative-care-helps-with-stress-support-and-more/?utm_source=Get+Palliative+Care&utm_campaign=56f18bddf1-GPC+-+Larry+Patient+Story+%2F+05.27.26&utm_medium=email&utm_term=0_4ef32a103e-56f18bddf1-378264050 You don’t always understand the impact of palliative care until you hear someone’s story. Larry loves spending time outdoors, being with family and friends, traveling, and reading. Throughout his life, a bad cold would often trigger his asthma. During one episode, he went to urgent care for treatment, but before leaving, an X-ray revealed a spot on his upper right lung. He was later diagnosed with stage IV lung cancer. Living with cancer brought unexpected stress. Palliative care has helped Larry manage that stress, while also guiding him through treatment options and conversations about his goals of care. It also improved his quality of life.

HER2 Evolution in Gastroesophageal Cancer: New Therapies and Optimized Outcomes Authors: Samuel J. Klempner, MD, FASCO

https://www.medscape.org/viewarticle/her2-evolution-gastroesophageal-cancer-new-therapies-and-2025a1000x2t?page=1&src=mkmcmr_driv_stan_mscpedu_260526-OUS-HONC-her2-evolution-gastroesophageal-cancer-new-therapies-and-2025a1000x2t-cta&uac=148436CN

Editorial Multiple sclerosis diagnosis in south Asia: fundamentals first The Lancet Regional Health – Southeast Asia +... + + +

Editorial Multiple sclerosis diagnosis in south Asia: fundamentals first The Lancet Regional Health – Southeast Asia https://www.thelancet.com/journals/lansea/issue/vol48nonull/PIIS2772-3682(26)X2003-0 Accuracy of a smartphone-based 3D imaging tool for height measurement and stunting detection among children 24–59 months of age in Nepal: a validation study Ritika Mukherjeea ∙ Shivangi Kaushikb Send email to shivangi.kaushik@welthungerhilfe.de ∙ Hamza Salaha ∙ Ankit Kumar Guptac ∙ Divita Sharmaa ∙ Miriam Kahramand ∙ et al. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(26)00059-4/fulltext?dgcid=hubspot_update_feature_updatealerts_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz--CmQqJOpt8ZJlyMhorL0J8JYJgX_InfMNWEWXjVQzlkxmYsOAEdtmfokYbDgcsHbo8K1uDKCPhBurVz5-Poyjf2In_YQ&_hsmi=420337931&utm_content=420077340&utm_source=hs_email Burden and risk factors of influenza-associated acute respiratory infections among older adults in India: a multicentric community-based surveillance (2018–2023) Prabu Rajkumara ∙ Girish Kumar Chethrapilly Purushothamana ∙ Ritvik Amarchandb ∙ Aslesh Ottapura Prabhakaranc ∙ Rakesh Kumarb ∙ Suman Kanungod ∙ et al. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(26)00052-1/fulltext?dgcid=hubspot_update_feature_updatealerts_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-_RXVDEpTdHewa9Ttivx77NOt4A7eDWOddzDy8Nni8xFb4Zf3uz5GJzeM8t9JBFCCjZQ9cNxXyVzgyGj4z7335T_JdJFw&_hsmi=420337931&utm_content=420077340&utm_source=hs_email National, state and district-level estimates of stillbirth in India at 20 weeks’ gestation or longer using national family health survey data (2005–21) Anuj Kumar Pandeya ∙ Dyah Anantalia Widyastaria Send email to dyah.ana@mahidol.edu ∙ Bhubate Samutachaka ∙ Sureeporn Punpuinga ∙ Sutapa Bandyopadhyay Neogi https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(26)00042-9/fulltext?dgcid=hubspot_update_feature_updatealerts_lansea&utm_campaign=update-lansea&utm_medium=email&_hsenc=p2ANqtz-9guQRk-jDLMYT8HDUbFuSjBkqgYss5PEnSEGVRpjQY1VK8WUMvwC4HOOxF8C559I3Cn484q_b6B6Yj68TIQ1AYWUOfyQ&_hsmi=420337931&utm_content=420077340&utm_source=hs_email

Editorial Measles, mistrust, and missed protection in the Americas The Lancet Regional Health – Americas +++ +...

Burden of disease and life expectancy decomposition in Brazil and its federated units, 1990–2023: an analysis based on the global burden of disease study 2023 GBD 2023 Brazil Collaborators https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(26)00071-2/fulltext?dgcid=hubspot_update_feature_updatealerts_lanam&utm_campaign=update-lanam&utm_medium=email&_hsenc=p2ANqtz-_3LqcIvmXhbN4vGVdl5H4N7KU3W5bNwvl1FKSDXiLt2adn9p-yiKipGa7y3E-9j8sY6_hHfrWXecZlSlAJoLEana8Ong&_hsmi=420335829&utm_content=420077349&utm_source=hs_email Rapid hepatitis C test and treat with peer support at opioid treatment programs (RAPID HCV): a hybrid effectiveness-implementation type 1 randomized control trial Oluwaseun Falade-Nwuliaa Send email to ofalade1@jhmi.edu ∙ Jennifer C. Priceb ∙ Jordan J. Feldc ∙ Ellen Eatond ∙ Ricardo A. Francod ∙ Brittany Barnabaa ∙ et al https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(26)00069-4/fulltext?dgcid=hubspot_update_feature_updatealerts_lanam&utm_campaign=update-lanam&utm_medium=email&_hsenc=p2ANqtz--IqbRKMgDk3yzA_N9G3EOryH9wutp8tILl0zDBhfs6c0ZC10CkDzalcM3ABsjj1Be0wCXXD9OtsN0HSn1N8ELMFN0QdQ&_hsmi=420335829&utm_content=420077349&utm_source=hs_email The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative Rafeka Hossaina Send email to rhossain@tulane.edu ∙ Deepika Laddub ∙ Carolyn J. Crandallc ∙ Kristine E. Ensrudd ∙ Jane A. Cauleye ∙ Kelley Pettee Gabrielf ∙ et al. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(26)00070-0/fulltext?dgcid=hubspot_update_feature_updatealerts_lanam&utm_campaign=update-lanam&utm_medium=email&_hsenc=p2ANqtz-9-_znUCLRw8MhTs5dvWtRVpkhvvaQmhLl_KAJk3xziu5vg-oCg6GnVeSvQPFJPixmBXR3NFvDxSV-kYgvjblOum6TYHA&_hsmi=420335829&utm_content=420077349&utm_source=hs_email Editorial Measles, mistrust, and missed protection in the Americas The Lancet Regional Health – Americas https://www.thelancet.com/journals/lanam/issue/vol57nonull/PIIS2667-193X(26)X2002-6

Editorial Is WASH a pipe dream for Africa? The Lancet Regional Health – Africa +++ +...

Application and implications of new global definitions of obesity: a cross-sectional study of South African women Jasantha Odayara ∙ Mustafa Shuaiba ∙ Jennifer Jaob ∙ Annibale Coisc ∙ Julia H Goedecked,e,f ∙ Jami L Josefsong ∙ et al. https://www.thelancet.com/journals/lanafr/article/PIIS3050-5011(26)00022-2/fulltext?dgcid=hubspot_update_feature_updatealerts_lanafr&utm_campaign=42584649-update-lanafr&utm_medium=email&_hsenc=p2ANqtz--d0Tj_M6VoT_haVLcH6yA9oB8efoI8Sau9C5tl6p-MTmWjEoOiXwzTxHKknR_w1KrOqI0SMzyWDi53M7ck3lnNjeDBvA&_hsmi=420455767&utm_content=420397131&utm_source=hs_email Aetiology, outcomes, and in-hospital mortality predictors of suspected paediatric central nervous system infections in southwestern Uganda: a prospective cohort study Phuthumani Mlotshwaa,g ∙ Elias Kumbakumbab,g ∙ Dan Nyehanganec ∙ Reza Rastia ∙ Richard Migishad ∙ Milly Nassejjeb ∙ et al. https://www.thelancet.com/journals/lanafr/article/PIIS3050-5011(26)00031-3/fulltext?dgcid=hubspot_update_feature_updatealerts_lanafr&utm_campaign=42584649-update-lanafr&utm_medium=email&_hsenc=p2ANqtz-_iWYeF0Kw1mVEtjXBJVrsK7VnGahZA2wNamp8WHhiHMuviSGG2dyYi-xF1kLOTMJFZ3mDpAKwSzfnUE-QqfAaYRVOVXQ&_hsmi=420455767&utm_content=420397131&utm_source=hs_email Long-term impact of 10-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in Kenya, 2011–2022 E Wangeci Kaguciaa Send email to ekagucia@kemri-wellcome.org ∙ Brian M Nyamwayaa ∙ Gerald Ongayoa ∙ M Wanjiru Kaniua ∙ Samuel Sanga ∙ Ruth Lucindea ∙ et al. https://www.thelancet.com/journals/lanafr/article/PIIS3050-5011(26)00011-8/fulltext?dgcid=hubspot_update_feature_updatealerts_lanafr&utm_campaign=42584649-update-lanafr&utm_medium=email&_hsenc=p2ANqtz-8rRnsojd6Ls0Aragfv2bNv8olRR1O1Qj1gUognWZ_NgmEibRc42PXKhBURCahnLm-xvQgTIaZ5qn6hGzBYx5v59RSyxw&_hsmi=420455767&utm_content=420397131&utm_source=hs_email Editorial Is WASH a pipe dream for Africa? The Lancet Regional Health – Africa https://www.thelancet.com/journals/lanafr/issue/vol3nonull/PIIS3050-5011(26)X2003-X

Microbiology has always been at the root of One Health The Lancet Microbe + + +...

Effect of 13-valent pneumococcal conjugate vaccine on experimental carriage at 1-year post-vaccination on rechallenge with Streptococcus pneumoniae serotype 6B in Blantyre, Malawi: a controlled human infection study and longitudinal follow-up of a randomised controlled trial Anthony E Chirwa, MBBSa Send email to achirwa@mlw.mw ∙ Evaristar Kudowa, MSca ∙ Godwin Tembo, BSca ∙ Ben Morton, MDa,b ∙ Dingase Dula, MMeda ∙ Simon Sichone, MSca ∙ et al. https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00251-4/fulltext?dgcid=raven_jbs_etoc_feature_lanmic Microbiology has always been at the root of One Health The Lancet Microbe https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(26)00089-3/fulltext?dgcid=raven_jbs_etoc_email May 2026 Volume 7Number 5 https://www.thelancet.com/journals/lanmic/issue/vol7no5/PIIS2666-5247(26)X2004-3

Schistosomiasis in women and adolescent girls +...

https://www.thelancet.com/series-do/schistosomiasis-in-women-and-adolescent-girls?dgcid=raven_jbs_etoc_feature_schistosomiasis26 Female genital schistosomiasis (FGS) is a chronic genital disease caused by the deposition of Schistosoma haematobium eggs, affecting at least 40 million women and girls worldwide, primarily in sub-Saharan Africa. Women and girls living with FGS face numerous intersecting challenges and health complications, ultimately contributing to urogenital dysfunction and adverse sexual and reproductive health outcomes. In this four-paper Series, we examine sex-specific aspects of Schistosoma infections in women and girls, diagnostic techniques and treatment strategies, barriers to diagnosis and treatment, management during pregnancy and implications for offspring, and the interactions with other genital infections and their clinical implications.

Functional Food

This hub provides a comprehensive overview and the latest news on functional foods, superfoods, and dietary components that contribute to health and disease prevention. The collection highlights bioactive compounds in foods such as lychee, chia seeds, dates, baobab fruit, and black sesame, alongside evidence-based discussions on fermented foods, postbiotics, and algae-based supplements. Readers will also find insights into the health benefits of traditional and modern diets, including the Atlantic and Washoku patterns, as well as functional beverages and plant-derived oils. By combining nutritional science, clinical research, and updates on emerging food innovations, this hub equips healthcare professionals, researchers, and health-conscious individuals with reliable knowledge to evaluate functional foods and their role in supporting long-term wellness. https://www.news-medical.net/condition/Functional-Food

How a tiny H5N1 dose triggers massive virus shedding in cow milk

https://www.news-medical.net/news/20260525/How-a-tiny-H5N1-dose-triggers-massive-virus-shedding-in-cow-milk.aspx New cow infection experiments reveal a striking paradox: H5N1 needs only a tiny dose to overwhelm mammary tissue and flood milk with virus, yet it failed to spread through contaminated milking equipment in the lab.

Why Kenya, Ethiopia, Japan, and the US stand out in global distance running

https://www.news-medical.net/news/20260526/Why-Kenya-Ethiopia-Japan-and-the-US-stand-out-in-global-distance-running.aspx A worldwide race-record analysis reveals how sex, age, nationality, and distance combine to shape endurance running, from 5 km speed to marathon dominance.

Study explains how environmental acidity destabilizes internal cellular traffic

https://www.news-medical.net/news/20260526/Study-explains-how-environmental-acidity-destabilizes-internal-cellular-traffic.aspx A new scientific study led by the Universidad Carlos III de Madrid (UC3M) describes the mechano-chemical mechanism by which the acidity of the cellular environment destabilizes microtubules, the "avenues" that organize internal cellular traffic. This finding is key to understanding pathologies such as cancer, diabetes, or certain infectious processes, where extracellular acidosis is a distinctive feature in tissues.

Estrogen decline alters brain cell matrix in older females

https://www.news-medical.net/news/20260526/Estrogen-decline-alters-brain-cell-matrix-in-older-females.aspx A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study.

How heat-smart cities can protect outdoor recreation in a warming world

https://www.news-medical.net/news/20260526/How-heat-smart-cities-can-protect-outdoor-recreation-in-a-warming-world.aspx As tropical cities warm, this review reveals why parks, shade, heat advisories, and smarter public messaging must work together to protect the benefits of outdoor recreation without exposing vulnerable communities to unsafe humid heat.

How to Boost CRC Screening Uptake in the Community Edited by Manasi Talwadekar May 26, 2026

https://www.medscape.com/viewarticle/how-boost-crc-screening-uptake-community-2026a1000h3u

Imaging and Staging Essentials in Uveal Melanoma Teresa Amaral, MD, PhD May 26, 2026

https://www.medscape.com/viewarticle/imaging-and-staging-essentials-uveal-melanoma-2026a1000f5z

Endometriosis Linked to Raised Breast & Ovarian Cancer Risks Edited by Vinod Rane, BS Pharm Medscape UK May 26, 2026

https://www.medscape.com/viewarticle/endometriosis-linked-raised-breast-ovarian-cancer-risks-2026a1000gmz

Increased Mortality After Radiotherapy for Pituitary Adenoma Edited by Vinod Rane, BS Pharm Medscape UK May 26, 2026

https://www.medscape.com/viewarticle/increased-mortality-after-radiotherapy-pituitary-adenoma-2026a1000gmy

NF1-Associated Plexiform Neurofibromas in Adults: Which Patients Could Benefit From Emerging Systemic Therapies? Authors: Andrea Gross, MD; João Passos, MD

https://www.medscape.org/viewarticle/1003044?src=mkmcmr_driv_stan_mscpedu_260525-OUS-HONC-1003044-cta&uac=148436CN

Treating Metastatic Colorectal Cancer in the Second Line and Beyond: Oral Therapy Edition Authors: Rahul Gosain, MD, MBA; Rohit Gosain, MD; John Strickler, MD; Chiara Cremolini, MD, PhD

https://www.medscape.org/viewarticle/1003002?src=mkmcmr_driv_stan_mscpedu_260525-OUS-HONC-1003002-cta&uac=148436CN

Communicating to Enhance Care Through Data and Patient Experience: ER-Positive/HER2-Negative Metastatic Breast Cancer Edition Authors: Kelly Shanahan, MD; Sara Tolaney, MD, MPH; Virginia Kaklamani, MD, DSc; Sarah R. Donahue, MPH, NP, AOCNP; Abigail Shockley, PharmD, BCOP

https://www.medscape.org/viewarticle/communicating-enhance-care-through-data-and-patient-2025a1000uqi?page=1&src=mkmcmr_driv_stan_mscpedu_260526-OUS-HONC-communicating-enhance-care-through-data-and-patient-2025a1000uqi-cta&uac=148436CN

How the perimenopause movement is hurting women Two experts say it portrays women as slaves to their hormones — while selling them products they don’t need

https://www.statnews.com/2026/05/23/perimenopause-misinformation-influencers-supplements-hormones/ By Torie BoschMay 23, 2026 Editor, First Opinion Below is a lightly edited, AI-generated transcript of the “First Opinion Podcast” interview with Patricia Bencivenga and Adriane Fugh-Berman. Be sure to sign up for the weekly “First Opinion Podcast” on Apple Podcasts, Spotify, or wherever you get your podcasts. Get alerts about each new episode by signing up for the “First Opinion Podcast” newsletter. And don’t forget to sign up for the First Opinion newsletter, delivered every Sunday.

The Ebola outbreak will lead to devastating violence against women and girls Not building violence prevention into the Ebola response is negligence

https://www.statnews.com/2026/05/26/ebola-outbreak-congo-violence-women-girls/ By Lindsay Stark and Ilana SeffMay 26, 2026 Stark is a professor of public health at Washington University in St. Louis. She co-directs the Center on Violence and Health. Seff is a research associate professor of public health at Washington University in St. Louis.

EURORDIS Paper: Importance of Psychological Support for Living Well with a Rare Condition April 2026

https://www.eurordis.org/publications/eurordis-report-importance-of-psychological-support-for-living-well-with-a-rare-condition/ This latest literature review published by EURORDIS explores the importance of psychosocial support for people living with a rare disease, calling for more holistic, multidisciplinary care models with mental health support embedded throughout care pathways. A companion literature review examines the specific psychological needs of people living with a rare condition.

Claudia Fuchs: Multi-omics and the future of rare disease research and healthcare May 2026

https://www.eurordis.org/claudia-fuchs-on-multi-omics/ You may already have heard about multi-omics and how it is transforming research across many different fields. But what does it mean for rare diseases – and why does it matter for people living with them? Multi-omics is opening up exciting new possibilities for understanding, diagnosing, and treating rare diseases. By bringing together different layers of biological and environmental information, it could help researchers and clinicians see a fuller picture of health and disease – and, ultimately, change the way rare disease care is delivered.

Translating multi-omics into healthcare: requisites for scalable and equitable implementation May 2026

https://www.eurordis.org/publications/translating-multi-omics-into-healthcare-requisites-for-scalable-and-equitable-implementation/ A new paper published in Human Genomics explores the requirements needed to ensure multi-omics can be implemented in healthcare systems in a scalable and equitable way. It further examines how it can improve diagnosis, personalised care and research, while addressing challenges related to governance, data sharing and equitable access to support its integration into healthcare systems across Europe. This paper was co-authored by our Drug Repurposing Projects Senior Manager Claudia Fuchs, who has also this week written a EURORDIS Staff Blog on the subject. "Multi-omics is opening up exciting new possibilities for understanding, diagnosing, and treating rare diseases," writes Claudia.

Europe can already lead in rare diseases – it just needs a plan

https://www.theparliamentmagazine.eu/partner/article/europe-can-already-lead-in-rare-diseases-it-just-needs-a-plan The Parliament magazine, an official Media Partner of ECRD 2026, has published an article by our Head of Policy & Public Affairs Valentina Bottarelli, arguing for a dedicated EU Action Plan for Rare Diseases. Valentina highlights how Europe already has the expertise, innovation capacity and collaborative networks to become a global leader in rare disease healthcare, but adds that stronger coordination and political commitment are essential to turn progress into meaningful change for patients.

How Are Oral SERDs Changing the Management of Advanced HR-Positive Breast Cancer? Authors: Erica L. Mayer, MD, MPH; François-Clément Bidard, MD, PhD

https://www.medscape.org/viewarticle/how-are-oral-serds-changing-management-advanced-hr-positive-2025a1000xkg?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260520-OUS-HONC-how-are-oral-serds-changing-management-advanced-hr-positive-2025a1000xkg-cta

Recognizing a Rare Mitochondrial Myopathy: Implications for Management Authors: Cristina Domínguez-González, MD

https://www.medscape.org/viewarticle/recognizing-rare-mitochondrial-myopathy-implications-2026a10008zj?page=1&uac=148436CN&src=mkmcmr_driv_il_mscpedu_260520-12203518_ES_NEUR#transcript-download-es

Wearable robot boosts strength of children with spinal muscular atrophy The device helps muscle recovery in those receiving gene therapy for the rare neuromuscular condition. By Liam Drew

https://www.nature.com/articles/d41586-026-01573-x?utm_source=Live+Audience&utm_campaign=5aa384d92f-nature-briefing-daily-20260521&utm_medium=email&utm_term=0_-33f35e09ea-50432164 A wearable robot weighing just under one kilogram improves knee function in children living with spinal muscular atrophy (SMA), according to research published in Nature today1.

Guarding biotech from China and big bets in longevity By Allison DeAngelis, Elaine Chen, and Adam FeuersteinMay 21, 2026

https://www.statnews.com/2026/05/21/guarding-biotech-from-china-and-big-bets-in-longevity/

Merck-Kelun lung cancer drug cut risk of tumor progression by 65%, ASCO abstract shows Developed in China, the combination therapy has potential to become a new, global standard of care

https://www.statnews.com/2026/05/21/merck-kelun-sac-tmt-lung-cancer-drug-trial-results/ By Adam FeuersteinMay 21, 2026 Senior Writer, Biotech

The seed oil panic is hurting my cardiac patients As a clinical dietitian who works with cardiac patients, here’s what I want people to know

https://www.statnews.com/2026/05/22/seed-oils-healthy-fats-tallow-fact-check-cardiac-health/ By Cole HansonMay 22, 2026 Hanson is a registered dietitian and clinical inpatient dietitian in Minneapolis.

How the perimenopause movement is hurting women Two experts say it portrays women as slaves to their hormones — while selling them products they don’t need

https://www.statnews.com/2026/05/23/perimenopause-misinformation-influencers-supplements-hormones/ By Torie BoschMay 23, 2026 Editor, First Opinion

1 in 8 women drink during pregnancy. Experts dread the consequences Largely considered a problem of the past, prenatal alcohol exposure is still a leading driver of disability in the U.S. By Isabella CuetoMay 19, 2026

https://www.statnews.com/2026/05/19/drinking-while-pregnant-fetal-alcohol-exposure-explored-part-5-deadliest-drug-series/

A Violaceous Retiform Rash With Progressive Lower Extremity Ischemia in a 66-Year-Old Man Margaret Mercante; Rishab Revankar, MD; Shira Lanyi, MD; Gabrielle Schwartzman, MD; Danielle Nelson, MD; Scott Berg, MD; Barrett Zlotoff, MD

https://reference.medscape.com/viewarticle/violaceous-retiform-rash-progressive-lower-extremity-2026a1000d6p?ecd=WNL_casechlg_260524_MSCPREF_etid8365124&uac=148436CN&impID=8365124 A 66-year-old man with a history of JAK2-positive essential thrombocytosis, polysubstance use disorder, and prior right lower extremity osteomyelitis status post-toe amputation presents with worsening right foot pain, ulceration, and a violaceous rash extending proximally up the lower extremity. What's the diagnosis?

Hot Topics from Berlin 2025: What Experts Say About the Future of Metastatic Breast Cancer Care Authors: Paolo Tarantino, MD, PhD; Valentina Guarneri, MD, PhD; Rebecca A. Dent, MD

https://www.medscape.org/viewarticle/hot-topics-berlin-2025-what-experts-say-about-future-2025a1000x8r?page=1&src=mkmcmr_driv_stan_mscpedu_260524-OUS-HONC-hot-topics-berlin-2025-what-experts-say-about-future-2025a1000x8r-cta&uac=148436CN

Individualized treatment for non-metastatic nasopharyngeal cancer: current practice and future perspectives Qin Liu [1,2] , Wei Dai [2] , Matthew Shing-Cheung Yik [2,3,4] , Ka-Man Cheung [5] , Anne W. M. Lee* [3]

https://www.academia.edu/2998-7741/3/1/10.20935/AcadOnco8183 The management of non-metastatic nasopharyngeal carcinoma (NPC) is undergoing a profound paradigm shift from a uniform, stage-based approach to a personalized, risk-adapted strategy. This review synthesizes the current landscape and future directions of individualized treatment. Contemporary management is increasingly guided by refined risk stratification that incorporates biomarkers such as plasma EBV DNA into the fundamental tumor-node-metastasis (TNM) staging, enabling tailored treatment strategies—de-escalation for low-risk and escalation for high-risk patients. Advances in precision radiotherapy, including response-adapted target volumes and genomically guided dosing, further enhance the potential of personalized radiotherapy. Future research will focus on dismantling the immunosuppressive tumor microenvironment and targeting unique oncogenic drivers to overcome therapeutic resistance, as well as treating cancer from an evolutionary ecological standpoint. Targeting not only tumor cells but the adaptive dynamics of the pathological ecosystem, represent a promising frontier in the post-genomic era. All these concerted efforts aim to establish a precision oncology framework for NPC, fundamentally guided by individualized biomarkers to design treatment strategies that maximize tumor control while minimizing treatment-related morbidity. https://www.academia.edu/journals/academia-oncology/articles?source=journal-top-nav Case report: safe reintroduction of pembrolizumab after anti-LGI1 encephalitis Maud Rijnders, Anna E. M. Bastiaansen, Marjolein Geurts, Ece Erdag, Rob Verdijk, Ronald de Wit, Maarten J. Titulaer, Astrid A. M. van der Veldt Volume 3, Issue 2

Latest Advances in mHSPC: An Update From Berlin 2025 Authors: Karim Fizazi, MD, PhD

https://www.medscape.org/viewarticle/latest-advances-mhspc-update-berlin-2025-2025a1000vlk?page=1&uac=148436CN&src=mkmcmr_driv_stan_mscpedu_260524-OUS-HONC-latest-advances-mhspc-update-berlin-2025-2025a1000vlk-cta

How Are ADCs Shaping the Future of Early Breast Cancer Care? Latest Insights and Emerging Strategies Authors: Nadia Harbeck, MD, PhD; Giuseppe Curigliano, MD, PhD

https://www.medscape.org/viewarticle/how-are-adcs-shaping-future-early-breast-cancer-care-latest-2025a1000yca?page=1&src=mkmcmr_driv_stan_mscpedu_260524-OUS-HONC-how-are-adcs-shaping-future-early-breast-cancer-care-latest-2025a1000yca-cta&uac=148436CN

HER2-Positive Gastroesophageal Adenocarcinoma and Biliary Tract Cancer: Updates and Insights Authors: Haley Ellis, MD; Steven Maron, MD, MSc

https://www.medscape.org/viewarticle/her2-positive-gastroesophageal-adenocarcinoma-and-biliary-2025a1000sr3?page=1&src=mkmcmr_driv_stan_mscpedu_260525-OUS-HONC-her2-positive-gastroesophageal-adenocarcinoma-and-biliary-2025a1000sr3-cta&uac=148436CN

RARE Revolution RARE Bite +...

https://editions.rarerevolutionmagazine.com/html5/reader/production/default.aspx?pubname=&edid=cfec555e-0bf6-4813-9494-6b9538dbfd94&pnum=64 The topic of disease classification may sound dry and technical—an issue for coders, not for families. But for Dan Lewi of the CATS Foundation and Toni Mathieson, NPUK, it’s anything but abstract. It’s about who gets diagnosed, who gets a care plan, who gets access to trials and treatments—and conversely who gets left behind.

Tattooing Linked to Lymphoma and Skin Cancer Risk | Rise in Global Skin Cancer Burden Projected to Continue +++++ +++

Tattooing Linked to Lymphoma and Skin Cancer Risk Mónica M. Bernardo https://www.medscape.com/viewarticle/tattooing-linked-lymphoma-and-skin-cancer-risk-2026a1000e42?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 May 04, 2026 A woman in her early thirties presented with persistent cervical swelling. The swelling was painless, showed no clear progression, and occurred without other symptoms; however, it did not resolve. The patient was otherwise healthy with no relevant medical history. The only detail noted during history taking was the presence of several recent tattoos, including medium-sized tattoos on her back. Initially, no clear association was observed. Subsequent diagnostic tests confirmed the diagnosis of lymphoma. This raises a clinical question: coincidence or a signal that is not yet fully understood? Global Skin Cancer Burden Projected to Surge Through 2050 in Low- and Middle-Income Regions Edited by Gargi Mukherjee https://www.medscape.com/viewarticle/global-skin-cancer-burden-projected-surge-through-2050-low-2026a1000fed?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 May 13, 2026 The prevalence of three types of skin cancer has increased since 1990 and is projected to rise further through 2050, a global analysis has found. Squamous Cell Cancer Location May Be an Independent Predictor of Poor Outcomes Tara Haelle https://www.medscape.com/viewarticle/squamous-cell-cancer-location-may-be-independent-predictor-2026a1000f02?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 May 11, 2026 AUSTIN, Texas — The anatomic location of a cutaneous squamous cell carcinoma (cSCC) tumor can be a clue to the risk for a poor outcome, such as metastasis or local recurrence, according to research presented at the American College of Mohs Surgery (ACMS) Annual Meeting 2026. Indoor Tanning Linked to Melanoma Diagnosis at Younger Age Fran Lowry https://www.medscape.com/viewarticle/indoor-tanning-linked-melanoma-diagnosis-younger-age-2026a1000a1v?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 Medscape Canada April 02, 2026 Among patients who used indoor tanning, melanoma was diagnosed nearly 10 years earlier than among those who had never used indoor tanning, according to a Canadian study that surveyed more than 800 patients with melanoma. Chronic Lymphocytic Leukemia Tied to Increased Skin Cancer Risk Over 10 Years Edited by Deepa Varma https://www.medscape.com/viewarticle/chronic-lymphocytic-leukemia-tied-increased-skin-cancer-risk-2026a10009v2?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 April 01, 2026 In a Danish study, patients with chronic lymphocytic leukemia (CLL) showed a higher risk for skin cancer, metastasis, and death than matched individuals at 10 years. Management of Actinic Keratosis Source: American Academy of Dermatology https://reference.medscape.com/cc2/p10/management-actinic-keratosis-guideline-2026a10008wa?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 March 26, 2026 This concise Medscape summary covers AAD recommendations on managing AK, which is one of the most common conditions diagnosed and treated by dermatologists in the US. This guideline addresses the management of AK from the perspective of US dermatologists, other practitioners who treat AK, and patients. Premalignant neoplasia on nonkeratinizing epithelium, such as actinic cheilitis, is not addressed. Malignant Melanoma Updated: Oct 14, 2024 Author: Winston W Tan, MD, FACP; Chief Editor: Dirk M Elston, MD https://emedicine.medscape.com/article/280245-overview?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412 Malignant melanoma (see the image below) is a neoplasm of melanocytes or of the cells that develop from melanocytes. Although it was once considered uncommon, the annual incidence has increased dramatically over the past few decades. Surgery is the definitive treatment for early-stage melanoma, with medical management generally reserved for adjuvant treatment of high-risk locally advanced melanoma and metastatic disease. Deadly Skin Cancers Brian P Hibler, MD; Anthony M Rossi, MD, FAAD | July 9, 2025 | https://reference.medscape.com/slideshow/deadly-skin-cancers-6009474?ecd=mkm_ret_260525_mscpmrk-OUS_InFocus_etid8364412&uac=148436CN&impID=8364412