sábado, 27 de diciembre de 2025
RAS-Targeted Strategies in Pancreatic Cancer Progress and Future Directions CME/CNE/CPE Marriott Marquis San Francisco Friday, January 9, 2026 | 6:30 PM - 8:00 PM PT
https://na.eventscloud.com/website/91375/
This January in San Francisco, join a panel of 3 leading experts for a 90-minute program on the evolving landscape of pancreatic adenocarcinoma (PDAC) treatment. This dynamic discussion will focus on the remarkable evolution of renin-angiotensin system (RAS) inhibitors in PDAC, tracing the journey from when RAS was considered undruggable to the latest data on novel mechanisms and therapies targeting RAS in its active state. Don't miss this opportunity to gain insights into the future of PDAC management and engage with the experts directly during a dedicated question-and-answer session.
Not an official event of the 2026 ASCO® Gastrointestinal Cancers Symposium. Not sponsored, endorsed, or accredited by ASCO®, Association for Clinical Oncology, or Conquer Cancer®, the ASCO Foundation
Nanozyme Hydrogel Directly Targets Cause of Diabetic Osteoarthritis
https://www.azonano.com/news.aspx?newsID=41596&utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
Researchers have developed a nanozyme-integrated hydrogel that directly targets advanced glycation end products (AGEs), a key driver of diabetic osteoarthritis (DOA).
Arthritis and safeguarding joint health
https://www.news-medical.net/whitepaper/20251210/Arthritis-and-safeguarding-joint-health.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
World Arthritis Day, observed each year on October 12, serves as a reminder of the widespread impact of this highly disabling disease. Rheumatoid Arthritis (RA), one of its most severe forms, impacts the health and quality of life of around 23.7 million individuals across the world.
Psoriasis and advancing skin health
https://www.news-medical.net/whitepaper/20251210/Psoriasis-and-advancing-skin-health.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
October 29, World Psoriasis Day, was established to raise global awareness and promote an accurate understanding of psoriasis (PsO). The chronic, recurrent autoimmune disease is commonly associated with comorbidities that impact both the skin and systemic organs.
TikTok videos about gout often contain misleading informationTikTok videos about gout often contain misleading information +++
Wheelchair? Hearing aids? Yes. ‘Disabled?' No way.Wheelchair? Hearing aids? Yes. ‘Disabled?' No way.
https://www.news-medical.net/news/20251211/Wheelchair-Hearing-aids-Yes-e28098Disabled-No-way.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
In her house in Ypsilanti, Michigan, Barbara Meade said, "there are walkers and wheelchairs and oxygen and cannulas all over the place."
EULAR proposes new guidance to assess disease activity in adult-onset Still’s diseaseEULAR proposes new guidance to assess disease activity in adult-onset Still’s disease
https://www.news-medical.net/news/20251212/EULAR-proposes-new-guidance-to-assess-disease-activity-in-adult-onset-Stille28099s-disease.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
EULAR - The European Alliance of Associations for Rheumatology - has identified an unmet clinical need around the assessment of disease activity in people with adult-onset Still's disease.
TikTok videos about gout often contain misleading informationTikTok videos about gout often contain misleading information
https://www.news-medical.net/news/20251211/TikTok-videos-about-gout-often-contain-misleading-information.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
A new paper in Rheumatology Advances in Practice, published by Oxford University Press, indicates that TikTok videos about gout are commonly misleading, inconsistent, or inaccurate.
Why female athletes need injury prevention rules built for women, not men
https://www.news-medical.net/news/20251208/Why-female-athletes-need-injury-prevention-rules-built-for-women-not-men.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=arthritis_newsletter_21_december_2025
A landmark IOC consensus sets out the first comprehensive, female-focused roadmap for preventing sports injuries, calling for changes in training, equipment, rules, and sporting culture to truly protect women and girls in sport.
Do leave-on benzoyl peroxide products present lower benzene risk than wash-off formulations? (Medscape AI)
https://www.medscape.com/ai-search?query=Do%20leave-on%20benzoyl%20peroxide%20products%20present%20lower%20benzene%20risk%20than%20wash-off%20formulations%3F&ecd=mkm_ret_251227_mscpmrk_derm_best-of-the-year_etid7981588&uac=148436CN&impID=7981588
Recent analyses suggest that leave-on benzoyl peroxide formulations tend to have lower benzene content compared with wash-off products. In particular, Valisure’s petition data and subsequent investigations by the FDA and academic groups have shown that leave-on products often contain benzene concentrations below those detected in some wash-off cleansers. One proposed explanation is that leave-on formulations are typically manufactured in smaller batches, allowing faster cooling post-production and thereby limiting the thermal generation of benzene during processing1.
Why Some Livers Can’t Recover After Alcohol Abstinence Eugenia Tsai, MD +++
https://www.medscape.com/viewarticle/why-some-livers-cant-recover-after-alcohol-abstinence-2025a1000wji?ecd=mkm_ret_251227_mscpmrk-OUS_InFocus_etid7965367&uac=148436CN&impID=7965367
Readiness-to-Change Scores Predict Alcohol Treatment Uptake
https://www.medscape.com/viewarticle/higher-readiness-change-scores-emergency-department-patients-2025a1000xa2?ecd=mkm_ret_251227_mscpmrk-OUS_InFocus_etid7965367&uac=148436CN&impID=7965367
Cannabis Users Should Be Wary of Weed’s Effects on the Heart
https://www.medscape.com/viewarticle/warn-your-patients-cannabis-use-can-have-serious-2025a1000waq?ecd=mkm_ret_251227_mscpmrk-OUS_InFocus_etid7965367&uac=148436CN&impID=7965367
The Brain’s ‘Gray Hairs’ a Common Referral Source ++++++ +++
Expert Insights
The Brain’s ‘Gray Hairs’ a Common Referral Source
https://www.medscape.com/viewarticle/brains-gray-hairs-common-referral-source-2025a1000s1h?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
Not What You Can Buy but What You Can Do: Wellness in PD
https://www.medscape.com/viewarticle/not-what-you-can-buy-what-you-can-do-holistic-approach-2025a1000x4v?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
How Does EBV Cause MS -- Hit and Run or Chronic Driver?
https://www.medscape.com/viewarticle/how-does-ebv-cause-multiple-sclerosis-hit-and-run-or-chronic-2025a1000uq8?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
McDonald Criteria Updates Boost MS Diagnostic Specificity
https://www.medscape.com/viewarticle/mcdonald-criteria-updates-boost-ms-diagnostic-specificity-2025a1000skj?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
The Glymphatic System: Not a Typo
https://www.medscape.com/viewarticle/glymphatic-system-not-typo-brains-lymphatic-system-2025a1000nh1?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
Do You Really See What I See?
https://www.medscape.com/viewarticle/do-you-really-see-what-i-see-2025a1000nq8?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
PRACTICE ESSENTIALS
Key Updates in Relapsing-Remitting Multiple Sclerosis
Key Updates in Relapsing-Remitting Multiple Sclerosis From ECTRIMS 2025
Patricia Coyle, MD
https://www.medscape.com/viewarticle/multiple-sclerosis-disease-modifying-therapy-rrms-ectrims-2025a1000112?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
October 17, 2025
Acute Migraine Treatment With Triptans
https://decisionpoint.medscape.com/neurology/viewarticle/920165?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
Anticipating Key Disease-Modifying Therapy Data for RRMS
ECTRIMS 2025: Anticipating Key Disease-Modifying Therapy Data for RRMS
Devon S. Conway, MD, MS
https://www.medscape.com/viewarticle/mdangle-ectrims-2025-dmt-in-rrms-preview-2025a1000hjq?ecd=mkm_ret_251227_mscpmrk_neuro_perspectives_etid7984775&uac=148436CN&impID=7984775
September 17, 2025
viernes, 26 de diciembre de 2025
New CMS models could reshape the landscape for lifestyle medicine practice and reimbursement ++++ ++++
New CMS models could reshape the landscape for lifestyle medicine practice and reimbursement
https://www.news-medical.net/news/20251212/New-CMS-models-could-reshape-the-landscape-for-lifestyle-medicine-practice-and-reimbursement.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
The American College of Lifestyle Medicine (ACLM) applauds two new Centers for Medicare and Medicaid Services (CMS) models that could significantly reshape the landscape for lifestyle medicine practice and reimbursement.
Plant-based diets support healthy growth when properly planned for children
https://www.news-medical.net/news/20251212/Plant-based-diets-support-healthy-growth-when-properly-planned-for-children.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Plant-based diets support healthy growth when properly planned for childrenVegetarian and vegan diets can support healthy growth when carefully planned with appropriate supplementation, finds a major new meta-analysis – the most comprehensive study to-date of plant-based diets in children.
Lowering blood sugar reduces heart risk in prediabetes
https://www.news-medical.net/news/20251212/Lowering-blood-sugar-reduces-heart-risk-in-prediabetes.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Lowering blood sugar levels halves the likelihood of serious heart problems in people with prediabetes.
Frequency and quantity of alcohol consumption influence cancer risk
https://www.news-medical.net/news/20251211/Frequency-and-quantity-of-alcohol-consumption-influence-cancer-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
As Americans gear up for the holiday season, new research offers a timely reminder to reflect on the long-term health effects of raising a celebratory glass – or two.
New research reveals underestimation of food insecurity
https://www.news-medical.net/news/20251213/New-research-reveals-underestimation-of-food-insecurity.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
New research reveals underestimation of food insecurityBefore you can address a problem, you need to understand its scope. That's why the United Nations developed the Integrated Food Security Phase Classification System. Aid organizations rely on analyses from this global partnership, which monitors and classifies the severity of food insecurity to help target assistance where and when it is most needed.
How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOS
https://www.news-medical.net/news/20251216/How-Traditional-Chinese-Medicine-may-reshape-the-gut-microbiome-to-ease-insulin-resistance-in-PCOS.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOSThis review synthesizes evidence that gut microbiota dysbiosis contributes to insulin resistance and symptom severity in polycystic ovary syndrome through impaired barrier function, inflammation, and altered microbial metabolites. It evaluates how Traditional Chinese Medicine may modulate these pathways while highlighting major gaps in clinical validation, safety, and standardization.
Many parents struggle to navigate conversations about nutrition with teens
https://www.news-medical.net/news/20251215/Many-parents-struggle-to-navigate-conversations-about-nutrition-with-teens.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
As teens gain more independence in their food choices, many parents struggle to navigate conversations about nutrition -which could be especially important during the holidays, when celebrations often center around meals.
Indiana University physician joins FDA panel on male hormone therapy
https://www.news-medical.net/news/20251212/Indiana-University-physician-joins-FDA-panel-on-male-hormone-therapy.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Indiana University physician joins FDA panel on male hormone therapyHelen Bernie, DO, MPH, assistant professor of urology at Indiana University School of Medicine, will participate in an expert panel on testosterone replacement therapy and men's health to be held Wednesday, Dec. 10, by the U.S. Food and Drug Administration. Bernie's role on the panel is that of a clinical expert on men's reproductive health, which is the focus of both her practice and academic research.
High fructose intake increases fatty liver risk ++++ +++
High fructose intake increases fatty liver risk
https://www.news-medical.net/news/20251216/High-fructose-intake-increases-fatty-liver-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
High fructose intake increases fatty liver riskExcessive fructose intake from soft drinks is linked to liver damage and NAFLD. Lifestyle modifications are essential for effective prevention and treatment.
Unnecessary gluten-free diets may put children at risk
https://www.news-medical.net/news/20251215/Unnecessary-gluten-free-diets-may-put-children-at-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Unnecessary gluten-free diets may put children at riskUnderstanding gluten-related disorders is crucial for pediatric nutrition, as gluten-free diets can pose health risks without appropriate medical supervision.
A new trial investigates whether the MIND diet can be scaled for obesity management
https://www.news-medical.net/news/20251214/A-new-trial-investigates-whether-the-MIND-diet-can-be-scaled-for-obesity-management.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
A new trial investigates whether the MIND diet can be scaled for obesity managementThis study protocol outlines a 12-week randomized trial testing whether a MIND diet intervention is feasible, acceptable, and sustainable for adults with obesity in Sweden. It will generate preliminary evidence on adherence, mental well-being, and gut microbiota changes to inform larger efficacy trials.
Scientists map how cinnamon’s bioactives interact with cancer signaling
https://www.news-medical.net/news/20251215/Scientists-map-how-cinnamone28099s-bioactives-interact-with-cancer-signaling.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Scientists map how cinnamon’s bioactives interact with cancer signalingThis review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.
Swapping high-carb snacks for tree nuts cuts food cravings in young adults at metabolic risk
https://www.news-medical.net/news/20251214/Swapping-high-carb-snacks-for-tree-nuts-cuts-food-cravings-in-young-adults-at-metabolic-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Swapping high-carb snacks for tree nuts cuts food cravings in young adults at metabolic riskDaily replacement of typical high-carbohydrate snacks with mixed tree nuts for 16 weeks reduced cravings for sweets and fast foods in young adults with early metabolic syndrome risk. This dietary swap improved overall diet quality, measured by the Healthy Eating Index, without increasing body weight or altering short-term glycaemic markers.
How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help
https://www.news-medical.net/news/20251211/How-ultra-processed-foods-shape-Crohne28099s-disease-risk-and-what-dietary-strategies-can-really-help.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really helpThis narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.
What happens to your body during an ultramarathon? New study reveals key metabolic changes
https://www.news-medical.net/news/20251210/What-happens-to-your-body-during-an-ultramarathon-New-study-reveals-key-metabolic-changes.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
What happens to your body during an ultramarathon? New study reveals key metabolic changesThis study tracked ultramarathon runners across 100 km, 160.9 km, and 230 km events to examine real-world metabolic, hormonal, and muscle stress responses. Severe energy deficits, muscle damage, and heterogeneous hormonal shifts were observed, with the greatest strain seen in the 230 km distance.
What happens to your body when you eat takeaway food too often? +++++
https://www.news-medical.net/news/20251211/What-happens-to-your-body-when-you-eat-takeaway-food-too-often.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
New evidence reveals how frequent takeaway meals elevate dietary inflammation and quietly reshape key metabolic risk factors, underscoring why reducing high-frequency takeaway habits could meaningfully improve long-term heart and metabolic health.
What drinking kefir really does to your gut and oral microbiome
A comprehensive review of human studies reveals that kefir can alter certain gut and oral bacteria. However, inconsistent results and small trials mean its true health impact remains an open scientific question.
https://www.news-medical.net/news/20251215/What-drinking-kefir-really-does-to-your-gut-and-oral-microbiome.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
How much omega-3 do you need daily? New global review reveals DHA and EPA requirements
https://www.news-medical.net/news/20251210/How-much-omega-3-do-you-need-daily-New-global-review-reveals-DHA-and-EPA-requirements.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Global and national guidelines for long-chain omega-3 intake vary widely across life stages, with many countries lacking clear recommendations. Most authorities advise at least 250 mg/day of EPA and DHA, yet population intakes remain far below optimal levels.
How specific foods reshape oxidative stress responses during and after high-intensity trainingHow specific foods reshape oxidative stress responses during and after high-intensity training
https://www.news-medical.net/news/20251211/How-specific-foods-reshape-oxidative-stress-responses-during-and-after-high-intensity-training.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
Carbohydrate-rich foods blunt acute oxidative stress during fasted high-intensity exercise, while polyphenol-rich foods accelerate early recovery by reducing post-exercise ROS. Findings highlight how nutrient timing shapes redox responses in sedentary young women undergoing resistance-circuit HIIT.
White bread vs wholegrain: which one is actually better for your health?White bread vs wholegrain: which one is actually better for your health?
https://www.news-medical.net/news/20251211/White-bread-vs-wholegrain-which-one-is-actually-better-for-your-health.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=nutrition_newsletter_18_december_2025
This review dispels common myths about white and wholegrain bread by examining their composition processing and health effects. It concludes that while wholegrain breads offer added benefits white bread remains a safe affordable and nutritionally meaningful staple when fortified.
Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients. Maram Alshreef, Hanin AbaAlkhayl, Qoot Almdainy, Abdulaziz Alshammari, Shahad Alajmi, Shatha Alruwaite, Ebtisam Alqahtani, Reema Almalke, Tagreed Alonazi International Journal of Clinical Pharmacology and Therapeutics 2025 December 5
https://read.qxmd.com/read/41347381/comparison-of-vasopressin-first-weaning-versus-norepinephrine-first-weaning-in-critically-ill-patients?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients.
Septic shock is a critical condition requiring vasopressor support and mechanical ventilation. The sequence of vasopressor weaning may affect clinical outcomes,..
Dec 5, 2025: International Journal of Clinical Pharmacology and Therapeutics
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia. Yewei Chen, Yating Zhou, Yao Qi, Tingting Miao, Jianan Shi, Daqing Jin, Tao P Zhong Communications Biology 2025 December 10
https://read.qxmd.com/read/41372612/rab23-gtpase-and-ift43-regulate-the-trafficking-of-prostaglandin-e-receptor-4-to-primary-cilia?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Rab23 GTPase and IFT43 regulate the trafficking of prostaglandin E receptor 4 to primary cilia.
Primary cilia are crucial organelles involved in various cellular signaling pathways. Prostaglandin E receptor 4 (EP4), a G protein-coupled receptor (GPCR), loc..
Dec 10, 2025: Communications Biology
What is the impact of nutrition interventions on incidence of anastomotic leak after colorectal surgery? A systematic review of randomized trials. Leslee Hasil, Andrew Milks, Angelea Panagakos, Dominique Engel, Emily Jaeger-McEnroe, Chelsia Gillis European Journal of Surgical Oncology 2025 December 4
https://read.qxmd.com/read/41401601/what-is-the-impact-of-nutrition-interventions-on-incidence-of-anastomotic-leak-after-colorectal-surgery-a-systematic-review-of-randomized-trials?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
What is the impact of nutrition interventions on incidence of anastomotic leak after colorectal surgery? A systematic review of randomized trials.
Nutrition-related factors have been associated with increased incidence of anastomotic leak (AL) following colorectal surgery; however, specific perioperative n..
Dec 4, 2025: European Journal of Surgical Oncology
Early CAR T-cell therapy in relapsed/refractory large B-cell lymphoma is associated with lower hematotoxicity burden. Vanja Zeremski, Enver Aydilek, Akhil Behringer, Franziska Brunner, Tobias Ronny Haage, Mathias Haenel, Igor Age Kos, William Hermann Krueger, Georg Lenz, Vadim Lesan, Jessica Schneider, Christian R Schultze-Florey, Evgenii Shumilov, Thomas Weber, Gerald Georg Wulf, Vladan Vucinic, Dimitrios Mougiakakos Blood Advances 2025 December 18
https://read.qxmd.com/read/41411524/early-car-t-cell-therapy-in-relapsed-refractory-large-b-cell-lymphoma-is-associated-with-lower-hematotoxicity-burden?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Early CAR T-cell therapy in relapsed/refractory large B-cell lymphoma is associated with lower hematotoxicity burden.
Dec 18, 2025: Blood Advances
HER2-Targeted Antibody-Drug Conjugate Toxicities in Breast Cancer. Seohyuk Lee, Adriana M Kahn, Mariya Rozenblit, Mridula A George, Cristina Naranjo Ortiz, Maryam B Lustberg Cancer Medicine 2025 December
https://read.qxmd.com/read/41361931/her2-targeted-antibody-drug-conjugate-toxicities-in-breast-cancer?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
HER2-Targeted Antibody-Drug Conjugate Toxicities in Breast Cancer.
HER2-targeted antibody-drug conjugates (ADCs) have dramatically advanced breast cancer outcomes. Two HER2-targeted ADCs, trastuzumab deruxtecan and trastuzumab ..
Dec 2025: Cancer Medicine
An updated meta-analysis of head-to-head trials comparing the efficacy, safety, and adherence of mirabegron and vibegron in overactive bladder. Wei-Zhen Bai, Shi-Yu Zhou, Yuan-Yuan Mou, Liao Peng, Ling-Li Li Medicine (Baltimore) 2025 December 5
https://read.qxmd.com/read/41366890/an-updated-meta-analysis-of-head-to-head-trials-comparing-the-efficacy-safety-and-adherence-of-mirabegron-and-vibegron-in-overactive-bladder?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
An updated meta-analysis of head-to-head trials comparing the efficacy, safety, and adherence of mirabegron and vibegron in overactive bladder.
This updated meta-analysis aimed to compare the efficacy, safety, and treatment adherence of mirabegron and vibegron in patients with overactive bladder with he..
Dec 5, 2025: Medicine (Baltimore)
Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial. Everett Meyer, Amandeep Salhotra, Arpita Gandhi, Jeremy Pantin, Sagar S Patel, Rasmus T Hoeg, Alexandra Gomez-Arteaga, Rawan G Faramand, Roni Tamari, Edmund K Waller, Satyajit Kosuri, Antonio M Jimenez Jimenez, Jennifer Holter-Chakrabarty, Bhagirathbhai Dholaria, Yi-Bin Chen, Betty K Hamilton, John M Magenau, Alireza Eghtedar, Joshua M Murray, Anna Pavlova, Nathaniel B Fernhoff, James Scott McClellan, Scott Killian, Ai Li, Robert S Negrin, Caspian Oliai
https://read.qxmd.com/read/41385341/orca-t-versus-allogeneic-hematopoietic-stem-cell-transplantation-precision-t-a-multicenter-randomized-phase-3-trial?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial.
To prevent graft-versus-host disease (GVHD) in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation (alloHSCT), a calcineurin in..
Dec 12, 2025: Blood
Immunotherapy beyond progression combined with platinum-based chemotherapy after primary resistance to first-line immunotherapy in patients with advanced NSCLC and PD-L1 ≥50. A De Giglio, L Zullo, A Di Federico, M Cani, M Aldea, D Soldato, F G Dall'Olio, F Mantuano, F Sperandi, V Favorito, A Sadowska, L E L Hendriks, T Gorria, L Mezquita, F Tabbò, S Novello, F Gelsomino, B Besse, A Ardizzoni
https://read.qxmd.com/read/41252810/immunotherapy-beyond-progression-combined-with-platinum-based-chemotherapy-after-primary-resistance-to-first-line-immunotherapy-in-patients-with-advanced-nsclc-and-pd-l1-50?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Immunotherapy beyond progression combined with platinum-based chemotherapy after primary resistance to first-line immunotherapy in patients with advanced NSCLC and PD-L1 ≥50.
Primary resistance to immune checkpoint inhibitors (ICIs) remains a major challenge in patients with advanced non-small-cell lung cancer (NSCLC) and programmed ..
Nov 17, 2025: ESMO Open
Ultrasound indicators of organ venous congestion: a narrative review. Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, Mohamad Bitar
https://read.qxmd.com/read/41251929/ultrasound-indicators-of-organ-venous-congestion-a-narrative-review?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Ultrasound indicators of organ venous congestion: a narrative review.
Acute kidney injury and other organ dysfunction in the setting of heart failure are primarily determined by a low cardiac output status and venous congestion, w..
Nov 18, 2025: Annals of Intensive Care
Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed. Alberto Martínez-Castelao, José Luis Górriz, Beatriz Fernández-Fernández, María José Soler, Juan F Navarro-González
https://read.qxmd.com/read/41375628/diabetes-mellitus-and-chronic-kidney-disease-the-future-is-being-surpassed?uac=148436CN&ecd=wnl_readmost_251226&sso=true&redirected=slug
Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed.
Diabetes mellitus (DM) continues to be a global world health problem. Despite medical advances, both DM and chronic kidney disease (CKD) remain global health is..
Nov 23, 2025: Journal of Clinical Medicine
Communicating to Enhance Care Through Data and Patient Experience: ER-Positive/HER2-Negative Metastatic Breast Cancer Edition Authors: Kelly Shanahan, MD; Sara Tolaney, MD, MPH; Virginia Kaklamani, MD, DSc; Sarah R. Donahue, MPH, NP, AOCNP; Abigail Shockley, PharmD, BCOP
Comunicación para mejorar la atención a través de los datos y la experiencia del paciente: Edición de cáncer de mama metastásico ER positivo/HER2 negativo
Communicating to Enhance Care Through Data and Patient Experience: ER-Positive/HER2-Negative Metastatic Breast Cancer Edition
Authors: Kelly Shanahan, MD; Sara Tolaney, MD, MPH; Virginia Kaklamani, MD, DSc; Sarah R. Donahue, MPH, NP, AOCNP; Abigail Shockley, PharmD, BCOP
https://www.medscape.org/viewarticle/communicating-enhance-care-through-data-and-patient-2025a1000uqi?page=1
jueves, 25 de diciembre de 2025
Routine PSA Screening May Do More Harm Than Good ++++++
News & Perspectives:
Fast Five Quiz: Presentation and Diagnosis of Iron-Deficiency Anemia
Fast Five Quiz: Presentation and Diagnosis of Iron-Deficiency Anemia
Reviewed by Ruben Rhoades, MD, MS
https://reference.medscape.com/viewarticle/anemia-presentation-and-diagnosis-2025a1000u76?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
The Year’s 10 Best Gastroenterology Guidelines
The Year’s 10 Best Gastroenterology Guidelines
David A. Johnson, MD
https://www.medscape.com/viewarticle/years-10-best-gastroenterology-guidelines-2025a1000zqj?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
December 23, 2025
Hope for Huntington’s With Possible Breakthrough Gene Therapy
Hope for Huntington’s With Possible Breakthrough Gene Therapy
Andrew N. Wilner, MD; Victor Sung, MD
https://www.medscape.com/viewarticle/hope-huntingtons-possible-breakthrough-gene-therapy-2025a1000zqb?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
December 23, 2025
Hereditary Angioedema: 5 Things to Know
Hereditary Angioedema: 5 Things to Know
Jonathan A. Bernstein, MD
https://www.medscape.com/viewarticle/hereditary-angioedema-5-things-know-2025a1000t8t?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
December 23, 2025
ESMO: Pembrolizumab Neoadjuvant/Adjuvant Outperforms Adjuvant Alone in Stage III Melanoma
ESMO: Pembrolizumab Neoadjuvant/Adjuvant Outperforms Adjuvant Alone in Stage III Melanoma
Teresa Amaral, MD, PhD
https://www.medscape.com/viewarticle/esmo-pembrolizumab-neoadjuvant-adjuvant-outperforms-adjuvant-2025a1000yk1?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
December 23, 2025
Routine PSA Screening May Do More Harm Than Good
Routine PSA Screening May Do More Harm Than Good
Kenneth W. Lin, MD, MPH
https://www.medscape.com/viewarticle/routine-psa-screening-may-do-more-harm-than-good-2025a1000zqw?ecd=wnl_edit_tpal_etid7984532&uac=148436CN&impID=7984532
December 23, 2025
miércoles, 24 de diciembre de 2025
How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help ++++++
Fear strongly influences pain perception in inflammatory bowel disease patients
https://www.news-medical.net/news/20251212/Fear-strongly-influences-pain-perception-in-inflammatory-bowel-disease-patients.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Fear strongly influences pain perception in inflammatory bowel disease patientsPain perception in affected individuals is more strongly influenced by learned fear than in healthy individuals. Changes along the gut-brain axis related to chronic inflammation may explain this.
Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies
https://www.news-medical.net/news/20251215/Advances-in-delivering-oxygen-sensitive-gut-bacteria-improve-microbial-therapies.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Advances in delivering oxygen-sensitive gut bacteria improve microbial therapiesRecent research has identified practical ways to protect and deliver oxygen-sensitive gut bacteria for a path toward safer, standardized microbial therapies that could reduce reliance on donor-based faecal microbiota transplants.
White bread vs wholegrain: which one is actually better for your health?
https://www.news-medical.net/news/20251215/Advances-in-delivering-oxygen-sensitive-gut-bacteria-improve-microbial-therapies.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
White bread vs wholegrain: which one is actually better for your health?This review dispels common myths about white and wholegrain bread by examining their composition processing and health effects. It concludes that while wholegrain breads offer added benefits white bread remains a safe affordable and nutritionally meaningful staple when fortified.
How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really help
https://www.news-medical.net/news/20251211/How-ultra-processed-foods-shape-Crohne28099s-disease-risk-and-what-dietary-strategies-can-really-help.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
How ultra-processed foods shape Crohn’s disease risk and what dietary strategies can really helpThis narrative review synthesizes evidence showing that higher intake of ultra-processed foods is consistently associated with increased Crohn’s disease risk, with mechanistic pathways implicating emulsifiers, carrageenan, maltodextrin, titanium dioxide, sweeteners and salt. It also highlights that minimally processed dietary strategies, including EEN and CDED, show therapeutic promise, particularly in pediatric Crohn’s disease.
Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment
https://www.news-medical.net/news/20251216/Revolutionary-quantum-sensors-could-enable-earlier-cancer-diagnosis-and-treatment.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
A revolutionary quantum sensing project that could transform cancer treatment by tracking how immune cells interact with tumors has been awarded a prestigious £2 million Future Leaders Fellowship.
New CDC grant supports expansion of colorectal cancer screening across rural Pennsylvania
https://www.news-medical.net/news/20251211/New-CDC-grant-supports-expansion-of-colorectal-cancer-screening-across-rural-Pennsylvania.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Increasing colorectal cancer screening rates among communities with the greatest need is the goal of a five-year, $4.2 million grant from the Centers for Disease Control and Prevention (CDC) to Penn State College of Medicine.
Scientists map how cinnamon’s bioactives interact with cancer signaling +++++
https://www.news-medical.net/news/20251215/Scientists-map-how-cinnamone28099s-bioactives-interact-with-cancer-signaling.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Laboratory studies suggest cinnamon’s bioactive compounds can alter key cancer-related signaling pathways, but researchers caution that human trials are essential before any preventive or therapeutic claims can be made.
New insights explain the Treg paradox in colorectal cancer
https://www.news-medical.net/news/20251215/New-insights-explain-the-Treg-paradox-in-colorectal-cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Blood test identifies colon cancer patients who benefit from anti-inflammatory medicationBlood test identifies colon cancer patients who benefit from anti-inflammatory medication
https://www.news-medical.net/news/20251215/Blood-test-identifies-colon-cancer-patients-who-benefit-from-anti-inflammatory-medication.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
A blood test could help doctors decide which patients with colon cancer should receive anti-inflammatory medication along with chemotherapy after surgery, according to new study in JAMA Oncology.
Frog-derived bacteria offer dual-action anticancer effects and high safetyFrog-derived bacteria offer dual-action anticancer effects and high safety
https://www.news-medical.net/news/20251216/Frog-derived-bacteria-offer-dual-action-anticancer-effects-and-high-safety.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes.
Early scans reveal prostate radiotherapy toxicity riskEarly scans reveal prostate radiotherapy toxicity risk
https://www.news-medical.net/news/20251211/Early-scans-reveal-prostate-radiotherapy-toxicity-risk.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_18_december_2025
Daily scans taken during prostate cancer radiotherapy could be repurposed to guide changes to treatment, reducing the risk of side effects, a study suggests.
High-fat cheese and cream consumption links to lower dementia risk over 25 years
https://www.news-medical.net/news/20251223/High-fat-cheese-and-cream-consumption-links-to-lower-dementia-risk-over-25-years.aspx
A long-running Swedish study suggests that not all dairy is equal for brain health, with high-fat cheese and cream showing unexpected associations with lower dementia risk.
Study Maps Genes Tied to Targets in IBS ++++++ +...
Study Maps Genes Tied to Targets in Irritable Bowel Syndrome
Nathalie Raffier
https://www.medscape.com/viewarticle/study-maps-genes-tied-targets-irritable-bowel-syndrome-2025a1000xzx?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
Medscape Europe
December 04, 2025
Chronic Gut Pain’s Elusive Cause Found — and Possibly Fixed
David Brzostowicki
https://www.medscape.com/viewarticle/chronic-gut-pains-elusive-cause-found-and-possibly-fixed-2025a1000w33?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
November 18, 2025
Should You Prescribe a Low FODMAP Diet for IBS? Check for Eating Disorders First
Nancy A. Melville
https://www.medscape.com/viewarticle/should-you-prescribe-low-fodmap-diet-ibs-check-eating-2025a1000xnt?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
December 02, 2025
Study Sheds More Light on Long-Term Isotretinoin and Inflammatory Bowel Disease Risk
Edited by Deepa Varma
https://www.medscape.com/viewarticle/study-sheds-more-light-long-term-isotretinoin-and-2025a1000y8p?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
December 08, 2025
1 in 3 Worldwide Have Functional Bowel Disorders
Edited by Archita Rai
https://www.medscape.com/viewarticle/one-three-worldwide-have-functional-bowel-disorders-2025a1000sv2?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
October 23, 2025
The Impact of Emulsifiers on GI Health
Batya Swift Yasgur, MA, LSW
https://www.medscape.com/viewarticle/impact-emulsifiers-gi-health-2025a1000yl7?ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
December 10, 2025
Compare the efficacy and safety profiles of linaclotide versus plecanatide for chronic idiopathic constipation
(Medscape AI)
https://www.medscape.com/ai-search?query=Compare%20the%20efficacy%20and%20safety%20profiles%20of%20linaclotide%20versus%20plecanatide%20for%20chronic%20idiopathic%20constipation&&ecd=mkm_ret_251223_mscpmrk-OUS_InFocus_etid7962906&uac=148436CN&impID=7962906
Why should docs avoid ordering broad food allergy panels for triggers (Medscape AI) +... ++++ ++++ ++ ++
https://www.medscape.com/ai-search?query=Why%20should%20docs%20avoid%20ordering%20broad%20food%20allergy%20panels%20for%20triggers&ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Overly broad food‐allergy test panels frequently identify sensitization without proving true clinical allergy and can lead to unnecessary dietary restrictions, patient anxiety, and increased healthcare utilization.
LATEST NEWS
COVID May Trigger New Allergies in Children
https://www.medscape.com/viewarticle/sars-cov-2-infection-may-be-linked-new-allergies-children-2025a1000wwk?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Virtual Reality Makes Allergy Testing Less Scary for Kids
https://www.medscape.com/viewarticle/virtual-reality-makes-allergy-testing-less-scary-kids-2025a1000val?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Low Prenatal Vit D Tied to Early Cavities in Children
https://www.medscape.com/viewarticle/low-prenatal-vitamin-d-linked-early-cavities-children-2025a1000yu8?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Food Allergies’ Psychosocial Toll on Families Often Missed
https://www.medscape.com/viewarticle/food-allergies-psychosocial-toll-families-often-missed-2025a1000zk3?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Rural Community Helps Uncover Allergy Defenses
https://www.medscape.com/viewarticle/how-rural-community-helped-uncover-allergy-defenses-2025a1000zeo?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Synbiotic Formula May Benefit Infants With Milk Allergy
https://www.medscape.com/viewarticle/synbiotic-formula-may-benefit-infants-milk-allergy-2025a1000yv6?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Food Allergy Prevention Is No Longer About Avoidance
https://www.medscape.com/viewarticle/food-allergy-prevention-no-longer-about-avoidance-2025a1000yk2?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Lactulose Test May Unveil Hypersensitivity in IBS
https://www.medscape.com/viewarticle/lactulose-nutrient-challenge-test-may-unveil-2025a1000xsf?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
WHAT’S YOUR DX?
A Child With Severe Diaper Rash Unresponsive to Treatment
https://www.medscape.com/viewarticle/23-month-old-persistent-severe-diaper-rash-unresponsive-2025a1000x4q?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
A 36-Year-Old Woman With Epigastric Pain and New Skin Changes
https://reference.medscape.com/viewarticle/36-year-old-woman-epigastric-pain-dysphagia-vomiting-and-new-2025a1000xx5?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
DRUG SPOTLIGHT
Omalizumab
https://reference.medscape.com/drug/xolair-omlyclo-omalizumab-343444?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Belimumab
https://reference.medscape.com/drug/benlysta-belimumab-999632?ecd=mkm_ret_251223_mscpmrk_ped-allergy_etid7978357&uac=148436CN&impID=7978357
Getting a Grip on Gastroparesis Understanding Slowed Digestion +++++
https://newsinhealth.nih.gov/2025/12/getting-grip-gastroparesis
Probiotics
https://ods.od.nih.gov/factsheets/Probiotics-Consumer/
Urinary Tract Health
https://www.nichd.nih.gov/health/topics/urinary
Health coaching before surgery may improve outcomes
https://www.nih.gov/news-events/nih-research-matters/health-coaching-before-surgery-may-improve-outcomes
The Truth About Holiday Spirits
https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/truth-about-holiday-spirits
FDA Approves Drug to Improve Functional Capacity and Symptoms in Adults with Rare Inherited Heart Condition
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/219083s000lbl.pdf?utm_medium=email&utm_source=govdelivery
FDA Approves Drug to Improve Functional Capacity and Symptoms in Adults with Rare Inherited Heart Condition
Action
The U.S. Food and Drug Administration (FDA) approved Myqorzo (aficamten) tablets to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms.
Disease or Condition
Symptomatic oHCM is an inherited condition where patients have thickened heart muscle and reduced blood flow from the left side of the heart to the rest of the body, causing symptoms such as shortness of breath, fatigue, and potentially life-threatening cardiac events.
Myqorzo Effectiveness
The effectiveness and safety of Myqorzo were studied in 282 adults with symptomatic oHCM randomly assigned to receive Myqorzo or placebo for 24 weeks. At the end of the study, participants receiving Myqorzo had an increase in exercise capacity measured by peak oxygen uptake compared to no change in exercise capacity among those receiving placebo. Also, 59 percent of participants receiving Myqorzo experienced an improvement in physical activity limitations (measured using the New York Heart Association Classification system) compared to 24 percent of individuals receiving placebo.
Safety Information
Myqorzo reduces contraction of the heart muscle, which can cause heart failure. Because of the risk for heart failure, patients treated with Myqorzo must be monitored with echocardiograms, an imaging test that shows how well the heart is working. Because of the heart failure risk and need for monitoring, Myqorzo is only available through a restricted program called the Myqorzo Risk Evaluation and Mitigation Strategy (REMS).
Patients must also avoid certain prescription medicines that interfere with the metabolism (breakdown) of Myqorzo.
See the prescribing information for additional information on risks associated with Myqorzo.
Designations
Myqorzo received Orphan Drug Designation and Breakthrough Therapy Designation for this indication.
FDA Approves First Prescription Oral Medicine for Iron Deficiency in Pediatric Patients Ages 10 and Older
FDA Approves First Prescription Oral Medicine for Iron Deficiency in Pediatric Patients Ages 10 and Older
Action
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/212320s019lbl.pdf?utm_medium=email&utm_source=govdelivery
The U.S. Food and Drug Administration (FDA) approved Accrufer (ferric maltol) capsules to treat pediatric patients ages 10 and older with iron deficiency. Accrufer was initially approved in 2019 for adults with iron deficiency.
Disease or Condition
Iron deficiency is the most common cause of anemia and occurs if there is not enough iron in the blood. Without enough iron, the body cannot make sufficient hemoglobin, a protein inside red blood cells that carries oxygen throughout the body. Iron deficiency anemia can result in symptoms such as fatigue, pale skin, and dizziness. Causes can include blood loss from gastrointestinal conditions, menstruation, food malabsorption, and insufficient iron in the diet.
Data Supporting Accrufer
The efficacy of Accrufer to treat iron deficiency in pediatric patients ages 10-17 was assessed in the FORTIS trial (NCT05126901). The trial treated 24 patients with age-based dosing of Accrufer twice daily, and showed a clinically meaningful average increase in hemoglobin of 1.1 g/dL at Week 12. This, on average, would be the expected increase in hemoglobin with one blood transfusion.
Safety Information
Patients should not take Accrufer if they are allergic to Accrufer or any of its excipients, have hemochromatosis and other iron overload syndromes, or receive repeated blood transfusions. In addition, patients should avoid Accrufer if they are experiencing an inflammatory bowel disease flare and should be aware of the risks of iron overload. The most common side effects of Accrufer are flatulence, diarrhea, constipation, discolored feces, abdominal pain, nausea, vomiting, and abdominal discomfort/distension.
martes, 23 de diciembre de 2025
What impact does melatonin have on sleep cycle? (Medscape AI)
Melatonin is an endogenous hormone that plays a central role in the timing and quality of sleep by acting on the body’s circadian system and facilitating sleep onset and maintenance.
https://www.medscape.com/ai-search?query=What%20impact%20does%20melatonin%20have%20on%20sleep%20cycle%3F&ecd=wnl_tp10_daily_251217_MSCPEDIT_etid7962970&uac=148436CN&impID=7962970
Holiday Heart Syndrome: Which seasonal habits most often trigger atrial fibrillation (Medscape AI)
https://www.medscape.com/ai-search?query=Holiday%20Heart%20Syndrome:%20Which%20seasonal%20habits%20most%20often%20trigger%20atrial%20fibrillation&ecd=wnl_tp10_daily_251220_MSCPEDIT_etid7972120&uac=148436CN&impID=7972120
Holiday Heart Syndrome (HHS) is most commonly precipitated by behavioral changes during holiday periods that promote atrial fibrillation (AF). Key seasonal habits include:
Colorectal cancer: experts discuss the clinical guidelines +... +... +... +...
Neoadjuvant Chemotherapy in Colon Cancer: Who Is the Ideal Candidate?
https://decisionpoint.medscape.com/oncology/viewarticle/944624?src=0_nl_sm_0&uac=148436CN
Chiara Cremolini, MD, PhD, University of Pisa
Appendiceal Cancers: How Are They Different From Colon Cancer?
https://decisionpoint.medscape.com/oncology/viewarticle/921574?src=0_nl_sm_0&uac=148436CN
Katrina S. Pedersen, MS, MD, Washington University
Molecular Profiling for Early-onset Colorectal Cancer (CRC)
https://decisionpoint.medscape.com/oncology/viewarticle/930635?src=0_nl_sm_0&uac=148436CN
John L. Marshall, MD, Georgetown University
Treatment Options for Patients With MSI-H Locally Advanced Rectal Cancer
https://decisionpoint.medscape.com/oncology/viewarticle/990258?src=0_nl_sm_0&uac=148436CN
Katrina S. Pedersen, MS, MD, Washington University
Why are noncardiovascular deaths rising among patients with heart failure (Medscape AI) +...
https://www.medscape.com/ai-search?query=Why%20are%20noncardiovascular%20deaths%20rising%20among%20patients%20with%20heart%20failure&ecd=wnl_tp10_daily_251221_MSCPEDIT_etid7968996&uac=148436CN&impID=7968996
Patients with heart failure are living longer after acute ischemic events, but now face a growing burden of systemic comorbidities that drive non-cardiovascular mortality.
What are the patterns of drug-induced liver injury with GLP-1 agonists? (Medscape AI) +... +++++ ++ +
https://www.medscape.com/ai-search?query=What%20are%20the%20patterns%20of%20drug-induced%20liver%20injury%20with%20GLP-1%20agonists%3F&ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
GLP-1 receptor agonists (GLP-1 RAs) have been associated with idiosyncratic patterns of liver injury that encompass hepatocellular, cholestatic, and mixed presentations.
Just In
Can 6 Depressive Symptoms Predict Dementia?
https://www.medscape.com/viewarticle/can-6-depressive-symptoms-predict-dementia-2025a1000zzc?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Microplastics Raise New Questions for Toxicology
https://www.medscape.com/viewarticle/microplastics-raise-new-questions-toxicology-2025a1000zys?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Cold-Weather Cardio Tips for Patients
https://www.medscape.com/viewarticle/its-cold-outside-cold-weather-cardio-tips-patients-2025a1000zxs?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Frailty Plus Depression Equal Greater Dementia Risk
https://www.medscape.com/viewarticle/frailty-plus-depression-equal-greater-dementia-risk-2025a1000zxl?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Low Vitamin D Levels Signal Increased Heart Risk
https://www.medscape.com/viewarticle/lowvitamin-d-levels-signal-increased-heart-risk-seniors-2025a1000zk1?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Most Popular
Is Sexual Health Overlooked in Axial Spondyloarthritis?
https://www.medscape.com/viewarticle/sexual-health-overlooked-axial-spondyloarthritis-2025a1000zs6?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Is Your Patient a Good Candidate for Bariatric Surgery?
https://www.medscape.com/viewarticle/your-patient-good-candidate-bariatric-surgery-2025a1000zt9?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Case Challenge
Severe Abdominal Pain Following a Hug in a Dog Owner
https://reference.medscape.com/viewarticle/severe-abdominal-pain-following-hug-teenaged-dog-owner-2025a1000ys7?ecd=wnl_tp10_daily_251222_MSCPEDIT_etid7976351&uac=148436CN&impID=7976351
Position-wise mutation analysis and temporal changes in SARS CoV-2 Envelope (E) protein variants Anwesa Saha [1,†] , Diganta Mukherjee [1,†] , Aparna Mukhopadhyay* [1]
https://www.academia.edu/3064-9765/2/4/10.20935/AcadMolBioGen8011
SARS CoV-2 is a positive-sense, single-stranded RNA virus. The genome of the virus undergoes numerous mutations, making the development of universally effective drugs challenging. Among its structural proteins, the Envelope (E) protein acts as an ion transporter and virulence factor, making it a potential therapeutic target. Based on the literature available to date, we have identified several functionally important sites in the E protein. These include residues involved in lysosomal deacidification; those of the FYXY motif, involved in amyloid formation in the host; and the PDZ-binding DLLV motif. We focus our analysis on the significance of these residues while also searching for other interesting mutational patterns. In this study, we conducted a comprehensive mutational analysis of the SARS CoV-2 E protein utilizing bioinformatics, statistics, and structural modeling tools. Over 1.4 million sequences were retrieved from the NCBI virus database, filtered, clustered, and aligned chronologically. By employing a combination of web-based tools and in-house Python scripts, we analyzed per-residue Shannon entropy, mutation types, evolutionary pressure, and predicted structural impact (via ∆∆G). We observed a significant number of residues under diversifying selection. This suggests that new amino acids are being sampled at various positions in the protein, providing functional or structural benefits to the virus. A cyclical pattern of mutation and reversion was observed at position 9, stabilizing at a particular mutation. Similar trends appeared at position 11. These mutations may be functionally relevant, which need to be explored in future. However, the key regions have remained conserved over time.
The evolution of cognitive abilities in marine animals: a hypothesis based on insights about cognition gene polymorphisms in Coelocanths and lungfish
Zhizhou Zhang* [1],
Shuaiyu Zhang [2],
Yongdong Xu* [2]
https://www.academia.edu/3064-9765/2/4/10.20935/AcadMolBioGen8001
Both coelacanths and lungfish have fossil evidence dating back 400 million years, placing them at a critical evolutionary juncture when marine animals transitioned to terrestrial environments. An intriguing question lies in the extent to which their cognitive abilities had evolved before they crawled onto land. While no fossil DNA exist for extinct coelacanths or lungfish, studies on their extant species offer clues. Notably, the biological traits of coelacanths and lungfish have been remarkably stable over the past 70 million years, suggesting that some genomic regions in their genomic sequences possess exceptional stability. This raises the possibility of inferring their cognition gene polymorphism patterns (CGPPs) and evolutionary positioning through genomic analyses of modern samples. By employing 471 whole-genome sequence samples, including archaic humans (Neanderthals, Denisovans and more), modern humans, other vertebrates (fish, amphibians, reptiles, birds, rodents, mammals) plus four coelacanth and three lungfish samples, together with 18 human cognition-related genes and their total of 223 SNVs (Single-Nucleotide Variations),comparative analyses revealed that the CGPPs of both coelacanths and lungfish are evolutionarily closer to those of archaic humans than those of most other animal groups. The CGPP appears to occupy an evolutionary inflection point, bridging diverse animal lineages to archaic hominoids. Our observational results suggest a hypothesis (to be validated in the future) that the genetic architecture underlying human cognitionseemsto have beenestablished during the evolutionary stage of fish, predating the emergence of tetrapods.
FDA Approves Drug to Improve Functional Capacity and Symptoms in Adults with Rare Inherited Heart Condition
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/219083s000lbl.pdf?utm_medium=email&utm_source=govdelivery
FDA Approves Drug to Improve Functional Capacity and Symptoms in Adults with Rare Inherited Heart Condition
Action
The U.S. Food and Drug Administration (FDA) approved Myqorzo (aficamten) tablets to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms.
Disease or Condition
Symptomatic oHCM is an inherited condition where patients have thickened heart muscle and reduced blood flow from the left side of the heart to the rest of the body, causing symptoms such as shortness of breath, fatigue, and potentially life-threatening cardiac events.
Myqorzo Effectiveness
The effectiveness and safety of Myqorzo were studied in 282 adults with symptomatic oHCM randomly assigned to receive Myqorzo or placebo for 24 weeks. At the end of the study, participants receiving Myqorzo had an increase in exercise capacity measured by peak oxygen uptake compared to no change in exercise capacity among those receiving placebo. Also, 59 percent of participants receiving Myqorzo experienced an improvement in physical activity limitations (measured using the New York Heart Association Classification system) compared to 24 percent of individuals receiving placebo.
Safety Information
Myqorzo reduces contraction of the heart muscle which can cause heart failure. Because of the risk for heart failure, patients treated with Myqorzo must be monitored with echocardiograms, an imaging test that shows how well the heart is working. Because of the heart failure risk and need for monitoring, Myqorzo is only available through a restricted program called the Myqorzo Risk Evaluation and Mitigation Strategy (REMS).
Patients must also avoid certain prescription medicines that interfere with the metabolism (breakdown) of Myqorzo.
See the prescribing information for additional information on risks associated with Myqorzo.
Designations
Myqorzo received Orphan Drug Designation and Breakthrough Therapy Designation for this indication.
Update to the Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV
https://clinicalinfo.hiv.gov/en/news/update-guidelines-prevention-and-treatment-opportunistic-infections-children-and-exposed-hiv-2
Guidelines for the Prevention and Treatment of Opportunistic Infections in Children With and Exposed to HIV
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-pediatric-opportunistic-infections/whats-new
FDA Approves First Prescription Oral Medicine for Iron Deficiency in Pediatric Patients Ages 10 and Older
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/212320s019lbl.pdf?utm_medium=email&utm_source=govdelivery
FDA Approves First Prescription Oral Medicine for Iron Deficiency in Pediatric Patients Ages 10 and Older
Action
The U.S. Food and Drug Administration (FDA) approved Accrufer (ferric maltol) capsules to treat pediatric patients ages 10 and older with iron deficiency. Accrufer was initially approved in 2019 for adults with iron deficiency.
Disease or Condition
Iron deficiency is the most common cause of anemia and occurs if there is not enough iron in the blood. Without enough iron, the body cannot make sufficient hemoglobin, a protein inside red blood cells that carries oxygen throughout the body. Iron deficiency anemia can result in symptoms such as fatigue, pale skin, and dizziness. Causes can include blood loss from gastrointestinal conditions, menstruation, food malabsorption, and insufficient iron in the diet.
Data Supporting Accrufer
The efficacy of Accrufer to treat iron deficiency in pediatric patients ages 10-17 was assessed in the FORTIS trial (NCT05126901). The trial treated 24 patients with age-based dosing of Accrufer twice daily, and showed a clinically meaningful average increase in hemoglobin of 1.1 g/dL at Week 12. This, on average, would be the expected increase in hemoglobin with one blood transfusion.
Safety Information
Patients should not take Accrufer if they are allergic to Accrufer or any of its excipients, have hemochromatosis and other iron overload syndromes, or receive repeated blood transfusions. In addition, patients should avoid Accrufer if they are experiencing an inflammatory bowel disease flare and should be aware of the risks of iron overload. The most common side effects of Accrufer are flatulence, diarrhea, constipation, discolored feces, abdominal pain, nausea, vomiting, and abdominal discomfort/distension.
lunes, 22 de diciembre de 2025
E-cigarette use is linked to higher heart attack risk, especially in former smokers
https://www.news-medical.net/news/20251214/E-cigarette-use-is-linked-to-higher-heart-attack-risk-especially-in-former-smokers.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=cardiology_newsletter_17_december_2025
A large meta-analysis suggests that vaping is not cardiovascularly neutral, with elevated heart attack risk concentrated among people who previously smoked, raising questions about e-cigarettes as harm-reduction tools.
Simple fruit granola intervention shows promising cardio-renal signals in CKD patients
https://www.news-medical.net/news/20251221/Simple-fruit-granola-intervention-shows-promising-cardio-renal-signals-in-CKD-patients.aspx
A small Japanese study suggests that a low-salt, oat-based granola breakfast may improve blood pressure, lipid risk markers, and gut health indicators in people with moderate chronic kidney disease, while highlighting the need for larger controlled trials.
Cytokinetics heart drug wins FDA approval, the biotech’s first The clearance of Myqorzo ends one of the longest industry’s R&D droughts in the industry
https://www.statnews.com/2025/12/19/cytokinetics-heart-drug-myqorzo-fda-approval/
By Adam FeuersteinDec. 19, 2025
Adam Feuerstein, a senior writer and biotech columnist, is the author of Adam’s Biotech Scorecard, a subscriber-only newsletter about the crossroads of drug development, business, Wall Street, and biotechnology.
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