Study finds no evidence black cohosh damages liver: MedlinePlus

Study finds no evidence black cohosh damages liver

URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_108256.html(*this news item will not be available after 04/28/2011)

Friday, January 28, 2011
Related MedlinePlus Pages

Herbal Medicine
Liver Diseases
Menopause
By Amy Norton

NEW YORK (Reuters Health) - Despite reports of liver damage in some women using black cohosh to ease menopause symptoms, clinical trials testing one major brand of this herb have so far found no evidence that it is to blame, according to a research review.

Extracts of black cohosh, a plant native to North America, are marketed as a "natural" form of hormone replacement therapy (HRT) and are most commonly used to treat hot flashes and other symptoms of menopause.

Studies so far have come to conflicting conclusions about whether black cohosh works.

There have also been concerns raised about its safety. Reports of liver inflammation and liver failure in a small number of black cohosh users prompted some countries, like Australia and the UK, to require warning labels on the products.

But it has never been clear that black cohosh was to blame for those cases of liver damage. In most cases, doctors were unable to account for the patients' drinking habits or use of medications that can harm the liver.

And many postmenopausal women who are plagued by hot flashes and night sweats prefer to try black cohosh instead of taking hormones. Hormone replacement therapy, or HRT, has been controversial since 2002, when the Women's Health Initiative, a massive government-sponsored clinical trial, found that women on HRT had higher rates of heart attack, stroke, breast cancer and blood clots than placebo users.

Experts now advise that while HRT is effective for menopausal symptoms, women should take the lowest possible dose for the shortest time possible.

For the new study, reported in the journal Menopause, researchers combined the results of five previously published clinical trials of the black cohosh product Remifemin. Together, the studies involved more than 1,100 women who used either this black cohosh product or a comparison substance -- either an inactive placebo or a hormonal medication called tibolone -- for three to six months.

Overall, the researchers found, 88 women dropped out of the studies, but none did so because of abnormal liver enzymes, a potential sign of liver damage.

And there was no evidence that black cohosh triggered harmful changes in liver enzymes. In both the black cohosh and comparison groups, about 5 percent of women developed abnormally high levels of a liver enzyme known as AST.

On the other hand, of 37 black cohosh users who had abnormally high AST levels before treatment, 62 percent saw those levels drop back into the normal range during therapy.

The study was led by Dr. Belal Naser of Salzgitter, Germany-based Schaper & Brummer GmbH & Co., which manufactures Remifemin.

But an expert not involved in the study said the findings are consistent with other evidence that black cohosh is safe for the liver.

Dr. Richard B. van Breemen, a professor at the University of Illinois College of Pharmacy in Chicago, was part of a 2009 clinical trial that tested black cohosh against a placebo, standard hormone replacement and red clover -- another alternative therapy for menopause symptoms.

They found that over one year, black cohosh was no better than the placebo for easing hot flashes and night sweats.

But there was also no evidence that the herb harmed women's liver function.

"Although black cohosh did not prevent hot flashes in menopausal women in our study, we found that black cohosh was safe," van Breemen told Reuters Health in an email. "In particular, we tested for liver damage in our study and found that black cohosh was not hepatotoxic (toxic to the liver)."

That trial, which was funded by the U.S. National Institutes of Health, was not included in the current analysis -- which focused only on trials of Remifemin.

That narrow focus, van Breemen noted, is a weakness of the study.

Still, he said, "the conclusion...that black cohosh does not cause liver damage is consistent with the results of our investigation and many other clinical trials."

In general, experts do advise that women stop using black cohosh and tell their doctor if they develop any potential signs of liver toxicity, including abdominal pain, dark urine or jaundice (yellowing of the skin and whites of the eyes).

Three months worth of Remifemin tablets costs about $30 in the U.S. -- roughly the same as Premarin, a widely used hormone replacement drug.

SOURCE: http://bit.ly/gANnQZ Menopause, online January 11, 2011.
Reuters Health
(c) Copyright Thomson Reuters 2011. Check for restrictions at: http://about.reuters.com/fulllegal.asp
Study finds no evidence black cohosh damages liver: MedlinePlus

Starting HRT early raises breast cancer risk: study: MedlinePlus

Starting HRT early raises breast cancer risk: study

URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_108252.html(*this news item will not be available after 04/28/2011)

Friday, January 28, 2011
Related MedlinePlus Pages

Breast Cancer
Hormone Replacement Therapy
By Maggie Fox, Health and Science Editor

WASHINGTON (Reuters) - Women who start hormone replacement therapy (HRT) as they begin to go through menopause have a higher risk of breast cancer than women who start taking the drugs later, researchers reported on Friday.

The findings, published in the Journal of the National Cancer Institute, help answer lingering questions about just who is and who is not at greater risk of side-effects from taking HRT.

The study of more than 1 million British women showed that those who waited five years or more to take HRT had little or no increased risk of breast cancer. But those who started it as they entered menopause had a 43 percent higher risk.

"In this large study, we found greater risks of breast cancer if hormonal therapy use began either before or soon after menopause than after a longer gap," Dr. Valerie Beral of Britain's Oxford University and colleagues wrote.

"And this pattern of risk was seen across different types of hormonal therapy, among women who used hormonal therapy for either short of long durations, and also in lean and in overweight and obese women."

The findings match those of the U.S.-based Women's Health Initiative, which found women who took HRT right at menopause had a 41 percent higher risk of breast cancer than those who waited, said Dr. Rowan Chlebowski of the Los Angeles BioMedical Research Institute and Garnet Anderson of the Fred Hutchinson Cancer Research Center in Seattle.

But, in a commentary on the findings, Chlebowski and Anderson pointed out that the opposite is true of heart disease -- women who start HRT earlier have a lower risk than women who start later.

Before 2002, doctors widely prescribed hormone replacement therapy to lower the risk of heart disease and osteoporosis, both of which go up sharply after menopause, as well as annoying symptoms such as hot flashes.

But the Women's Health Initiative study found HRT raised the risk of heart disease, stroke and breast cancer. Sales of HRT plummeted, especially Wyeth's estrogen-progestin Prempro pills, which have fallen by about 50 percent since 2001 to around $1 billion a year. Wyeth is now owned by Pfizer.

In 2001, more than 16 million U.S. women took some form of HRT pill, but by 2009 only 6 million did.

Doctors noted that the Women's Health Initiative study involved women whose average age was 63, who took relatively high-dose Prempro pills and who were mostly overweight.

No one was sure what would happen for younger, healthier women taking different formulations.

Beral's team confirmed that no matter which formulation, younger women using HRT raised their risk of breast cancer, but this risk disappeared almost as soon as they stopped.

The overall risk of breast cancer remains low in either group -- less than 1 percent a year.

Other studies have also shown that breast cancer rates fell as soon as women stopped using HRT. A study from Canada last September found breast cancer rates among older women fell 10 percent after 2002.

Chelbowski's team reported last October that women who took hormone replacement pills had more advanced breast cancers and were more likely to die from them than women who took a dummy pill.

(Editing by Paul Simao)

Reuters Health
(c) Copyright Thomson Reuters 2011. Check for restrictions at: http://about.reuters.com/fulllegal.asp
Starting HRT early raises breast cancer risk: study: MedlinePlus

Psychopaths' Lack of Empathy Mimics Brain Injury: Research: MedlinePlus

Psychopaths' Lack of Empathy Mimics Brain Injury: Research
Treatment for frontal lobe damage may also help those with personality disorder

URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_108228.html(*this news item will not be available after 04/28/2011)

By Robert Preidt
Friday, January 28, 2011

Related MedlinePlus Page

Personality Disorders


FRIDAY, Jan. 28 (HealthDay News) -- People who have suffered a frontal brain injury have been known to have difficulty showing empathy, and new research shows that people diagnosed as psychopathic also have the same emotional deficiency.

The finding suggests that psychopaths may benefit from therapy similar to that used to treat frontal brain injury patients, said the researchers at the University of Haifa in Israel.

Psychopathy is a personality disorder characterized by extreme anti-social behavior and intention to harm others. Empathy is the ability to identify and understand another person's feelings and thoughts.

The study included 17 people who had been diagnosed as psychotic and did not have any brain damage, along with 25 patients with a frontal lobe brain injury. All of the participants were tested to determine their ability to show empathy and all of them demonstrated a similar difficulty in this area.

"Seeing as psychopathic behavior is similar to that of a person with brain damage, it could be that it could benefit from similar forms of treatment," study author Dr. Simone Shamay-Tsoory said in a university news release.

SOURCE: University of Haifa, news release, Jan. 25, 2011
HealthDay
Copyright (c) 2011 HealthDay. All rights reserved.
Psychopaths' Lack of Empathy Mimics Brain Injury: Research: MedlinePlus

Exercise Helps Ease Irritable Bowel Symptoms: MedlinePlus

Exercise Helps Ease Irritable Bowel Symptoms
Swedish study finds active group had much less pain and discomfort, compared to control group

URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_108237.html(*this news item will not be available after 04/28/2011)

By Alan Mozes
Friday, January 28, 2011

Related MedlinePlus Pages

Exercise and Physical Fitness
Irritable Bowel Syndrome


FRIDAY, Jan. 28 (HealthDay News) -- Increasing one's physical activity routine can help improve symptoms among irritable bowel syndrome (IBS) patients, Swedish researchers report.

Vigorous activity can also help keep IBS symptoms from worsening among such patients, the researchers said.

The authors noted that IBS is a disease that affects between 10 percent to 15 percent of people around the world, and is typically characterized by abdominal pain/discomfort, constipation, diarrhea and bloating.

The current observations stem from a small study of 102 IBS patients between the ages of 18 and 65.

Over a three-month period, half of the participants maintained their normal lifestyle, while the other half was randomly assigned to increase their physical activity, with a suggested goal of moderate to vigorous activity three to five times per week for 20 to 30 minutes a session. Both groups received telephone support from a physiotherapist.

At the study onset and at the end of the three-month period, the participants ranked their IBS symptoms, including abdominal pain, stool difficulties and overall quality of life.

While the group that maintained their normal routine experienced an average 5-point drop in symptoms, those who increased their activity experienced much more dramatic symptom relief (an average 51-point decrease), the researchers noted.

What's more, during the study period only 8 percent of the active group went on to develop worsening symptoms, as compared with nearly one-quarter of the maintenance group.

The Swedish team, led by registered physiotherapist Elisabet Johannesson from the University of Gothenburg, reports their findings online and in an upcoming print issue of the American Journal of Gastroenterology.

SOURCE: University of Gothenburg, news release, Jan. 25, 2011
HealthDay
Copyright (c) 2011 HealthDay. All rights reserved.
Exercise Helps Ease Irritable Bowel Symptoms: MedlinePlus

Blood Protein Level May Not Influence Effectiveness of Statins: MedlinePlus

Blood Protein Level May Not Influence Effectiveness of Statins
Study finds benefit not tied to C-reactive protein

URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_108235.html(*this news item will not be available after 04/28/2011)

By Randy Dotinga
Friday, January 28, 2011

Related MedlinePlus Pages

Heart Diseases
Statins


FRIDAY, Jan. 28 (HealthDay News) -- A new study debunks the idea that the cholesterol-fighting drugs known as statins work better in people with high levels of a certain protein and may not work at all in those with low levels.

Researchers found that the drugs work the same -- at least in heart patients, older men with high blood pressure and diabetics -- regardless of the results of a test that looks for concentrations of so-called C-reactive protein.

"The bottom line is, if you have vascular disease or diabetes, you will derive substantial benefit from statin treatment," said Dr. Gregg C. Fonarow, a cardiology professor at the University of California, Los Angeles, who was not involved in the research.

However, Fonarow said, the findings do not say whether levels of the protein will affect the effectiveness of the drugs in healthy people.

According to Fonarow, research suggests that statins reduce the risk for heart disease "events" -- such as a heart attack -- by 24 percent to 52 percent. "The cardiovascular benefits of statins extend to men and women, old and young, and even to patients with baseline LDL-cholesterol levels lower than 100 milligrams per deciliter [mg/dcl]," he said. LDL, or low-density lipoprotein cholesterol, is the type that causes plaque to form, narrowing arteries.

Some research has linked levels of C-reactive protein to better or worse effectiveness. In the new study, researchers in the United Kingdom assigned 20,536 men and women at high risk for heart problems to take either the statin Zocor (simvastatin) or a placebo for an average of five years.

The study, published online Jan. 28 in The Lancet, found no link between levels of the protein and benefits from the drug. Even people with low levels of LDL cholesterol and the protein -- those thought to perhaps be immune to the drug's effects -- showed benefits.

In the big picture, Fonarow said, people shouldn't worry about levels of the protein in their bodies.

"Patients interested in their cardiovascular health should be most focused on achieving healthy LDL-cholesterol, blood pressure and body weight levels along with engaging in daily exercise, eating a healthy diet, not smoking and avoiding secondhand smoke," he said.

The study was partially funded by Merck, which makes Zocor.

SOURCES: Gregg C. Fonarow, M.D., professor, cardiology, University of California, Los Angeles; Jan. 28, 2011, The Lancet, online
HealthDay
Copyright (c) 2011 HealthDay. All rights reserved.
Blood Protein Level May Not Influence Effectiveness of Statins: MedlinePlus

USDA and HHS Announce New Dietary Guidelines to Help Americans Make Healthier Food Choices and Confront Obesity Epidemic

FOR IMMEDIATE RELEASE
Monday, January 31, 2011
Contact: USDA Office of Communications (202) 720-4623
HHS Press Office (202) 690-6343


USDA and HHS Announce New Dietary Guidelines to Help Americans Make Healthier Food Choices and Confront Obesity Epidemic

WASHINGTON, Jan. 31, 2011 — Agriculture Secretary TomVilsack and Secretary of the Department of Health and Human Services (HHS) Kathleen Sebelius today announced the release of the 2010 Dietary Guidelines for Americans, the federal government's evidence-based nutritional guidance to promote health, reduce the risk of chronic diseases, and reduce the prevalence of overweight and obesity through improved nutrition and physical activity.

Because more than one-third of children and more than two-thirds of adults in the United States are overweight or obese, the 7th edition of Dietary Guidelines for Americans places stronger emphasis on reducing calorie consumption and increasing physical activity.

“The 2010 Dietary Guidelines are being released at a time when the majority of adults and one in three children is overweight or obese and this is a crisis that we can no longer ignore,” said Secretary Vilsack. “These new and improved dietary recommendations give individuals the information to make thoughtful choices of healthier foods in the right portions and to complement those choices with physical activity. The bottom line is that most Americans need to trim our waistlines to reduce the risk of developing diet-related chronic disease. Improving our eating habits is not only good for every individual and family, but also for our country.”

The new 2010 Dietary Guidelines for Americans focus on balancing calories with physical activity, and encourage Americans to consume more healthy foods like vegetables, fruits, whole grains, fat-free and low-fat dairy products, and seafood, and to consume less sodium, saturated and trans fats, added sugars, and refined grains.

“Helping Americans incorporate these guidelines into their everyday lives is important to improving the overall health of the American people,” said HHS Secretary Sebelius. “The new Dietary Guidelines provide concrete action steps to help people live healthier, more physically active and longer lives.”

The 2010 Dietary Guidelines for Americans include 23 Key Recommendations for the general population and six additional Key Recommendations for specific population groups, such as women who are pregnant. Key Recommendations are the most important messages within the Guidelines in terms of their implications for improving public health. The recommendations are intended as an integrated set of advice to achieve an overall healthy eating pattern. To get the full benefit, all Americans should carry out the Dietary Guidelines recommendations in their entirety.

More consumer-friendly advice and tools, including a next generation Food Pyramid, will be released by USDA and HHS in the coming months. Below is a preview of some of the tips that will be provided to help consumers translate the Dietary Guidelines into their everyday lives:

•Enjoy your food, but eat less.
•Avoid oversized portions.
•Make half your plate fruits and vegetables.
•Switch to fat-free or low-fat (1%) milk.
•Compare sodium in foods like soup, bread, and frozen meals – and choose the foods with lower numbers.
•Drink water instead of sugary drinks.

This edition of the Dietary Guidelines comes at a critical juncture for America’s health and prosperity. By adopting the recommendations in the Dietary Guidelines, Americans can live healthier lives and contribute to a lowering of health-care costs, helping to strengthen America’s long-term economic competitiveness and overall productivity.

USDA and HHS have conducted this latest review of the scientific literature, and have developed and issued the 7th edition of the Dietary Guidelines for Americans in a joint effort that is mandated by Congress. The Guidelines form the basis of nutrition education programs, Federal nutrition assistance programs such as school meals programs and Meals on Wheels programs for seniors, and dietary advice provided by health professionals.

The Dietary Guidelines, based on the most sound scientific information, provide authoritative advice for people 2 years and older about how proper dietary habits can promote health and reduce risk for major chronic diseases.

The Dietary Guidelines aid policymakers in designing and implementing nutrition-related programs. They also provide education and health professionals, such as nutritionists, dietitians, and health educators with a compilation of the latest science-based recommendations. A table with key consumer behaviors and potential strategies for professionals to use in implementing the Dietary Guidelines is included in the appendix.

The 2010 Dietary Guidelines is available at www.dietaryguidelines.gov.

For more information on dietary guidelines, see www.health.gov/dietaryguidelines and www.healthfinder.gov/prevention

---------------------------------
USDA is an equal opportunity provider, employer and lender. To file a complaint of discrimination, write: USDA, Director, Office of Civil Rights, 1400 Independence Ave., SW, Washington, DC 20250-9410 or call (800) 795-3272 (voice), or (202) 720-6382 (TDD).

USDA and HHS Announce New Dietary Guidelines to Help Americans Make Healthier Food Choices and Confront Obesity Epidemic

WHO | Set of recommendations on the marketing of foods and non-alcoholic beverages to children [ENGLISH-SPANISH]

Set of recommendations on the marketing of foods and non-alcoholic beverages to children

Authors:
World Health Organization

Publication details
Number of pages: 16
Publication date: 2010
Languages: Currently available in Chinese, English, French, Russian and Spanish. It will soon be published in Arabic.

Downloads
Chinese [pdf 688 Kb]
http://whqlibdoc.who.int/publications/2010/9789245500216_chi.pdf

English [pdf 477 Kb]
http://whqlibdoc.who.int/publications/2010/9789241500210_eng.pdf

French [pdf 544 Kb]
http://whqlibdoc.who.int/publications/2010/9789242500219_fre.pdf

Russian [429 Kb]
http://whqlibdoc.who.int/publications/2010/9789244500217_rus.pdf

Spanish [pdf 597 Kb]
http://whqlibdoc.who.int/publications/2010/9789243500218_spa.pdf


Overview

This report contains the set of recommendations on the marketing of foods and non-alcoholic beverages to children, as presented to the Sixty-third World Health Assembly in May 2010, and the resolution which endorsed them (WHA63.14). The document calls for national and international action to reduce the impact on children of marketing of foods high in saturated fats, trans-fatty acids, free sugars, or salt.

The first part of the document, the set of recommendations, includes a description of the background and process for the development of the recommendations, an evidence section and 12 recommendations structured under five sub-headings: rationale; policy development; policy implementation; policy monitoring and evaluation; and research. The resolution which follows (WHA63.14) contains a preamble and proposed actions for Member States and WHO.
WHO | Set of recommendations on the marketing of foods and non-alcoholic beverages to children





Recomendaciones sobre la promoción de alimentos y bebidas no alcohólicas dirigida a los niños

Autores:
Organización Mundial de la Salud


Detalles de la publicación
Número de páginas: 16
Fecha de publicación: 2010
Idiomas: Chino, español, francés,inglés, ruso

Descargar
Español [pdf 597 Kb]
http://whqlibdoc.who.int/publications/2010/9789243500218_spa.pdf

Chino [pdf 688 Kb]
http://whqlibdoc.who.int/publications/2010/9789245500216_chi.pdf

Francés [pdf 544 Kb]
http://whqlibdoc.who.int/publications/2010/9789242500219_fre.pdf

Inglés [pdf 477 Kb]
http://whqlibdoc.who.int/publications/2010/9789241500210_eng.pdf

Ruso[429 Kb]
http://whqlibdoc.who.int/publications/2010/9789244500217_rus.pdf

Presentación

El documento refleja el creciente reconocimiento, a lo largo de la última década, de la necesidad de combatir las enfermedades no trasmisibles, que tuvo su máxima expresión en el plan de acción de la estrategia mundial para la prevención y el control de las enfermedades no transmisibles (2008-2013), aprobado por la Asamblea Mundial de la Salud en mayo de 2008 (resolución WHA61.14).
Este documento incluye una descripción de los antecedentes y el proceso de elaboración de las recomendaciones, una sección sobre la evidencia disponible y 12 recomendaciones agrupadas en cinco subtítulos: fundamento, formulación de las políticas, aplicación de las políticas, vigilancia y evaluación de las políticas, e investigaciones.

OMS:
OMS | Recomendaciones sobre la promoción de alimentos y bebidas no alcohólicas dirigida a los niños

SpringerLink - Breast Cancer Research and Treatment, Volume 126, Number 1

Epidemiology

Effect of aspirin and other NSAIDs on postmenopausal breast cancer incidence by hormone receptor status: results from a prospective cohort study

Aditya Bardia, Janet E. Olson, Celine M. Vachon, DeAnn Lazovich, Robert A. Vierkant, Alice H. Wang, Paul J. Limburg, Kristin E. Anderson and James R. Cerhan

Download PDF (196.0 KB)View HTML


Abstract

Aspirin and other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can inhibit aromatase activity and thus could selectively lower incidence of hormone receptor positive tumors. We assessed whether the association of aspirin and other NSAIDs with postmenopausal breast cancer risk differs by estrogen and progesterone receptor (ER and PR) status of the tumor. A population-based cohort of 26,580 postmenopausal women was linked to a SEER Cancer Registry to identify incident breast cancers. Regular use of aspirin and other NSAIDs was reported on a self-administered questionnaire mailed in 1992. Cox proportional hazards models were used to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs) of breast cancer incidence overall and by ER and PR status, adjusting for multiple breast cancer risk factors. Through 2005, 1,581 incident breast cancer cases were observed. Compared to aspirin never users, women who regularly consumed aspirin had a lower risk of breast cancer (RR = 0.80; 95% CI: 0.71–0.90), and there was evidence for lower risk with increasing frequency of use (RR = 0.71 for aspirin use 6 or more times/week vs. never use; P trend = 0.00001). Inverse associations for regular aspirin use were observed for ER+ (RR = 0.77; 95% CI 0.67–0.89), ER− (RR = 0.78; 95% CI 0.56–1.08), PR+ (RR = 0.79; 95% CI 0.68–0.92), and PR− (RR = 0.73; 95% CI 0.56–0.95) breast cancers. In contrast, use of other NSAIDs was not associated with breast cancer incidence overall (RR = 0.95, 95% CI: 0.85–1.07), or by ER or PR status. Aspirin, but not other NSAID use, was associated with about 20% lower risk of postmenopausal breast cancer and did not vary by ER or PR status of the tumor, suggesting that the hypothesized protective effects of aspirin may either be through cellular pathways independent of estrogen or
progesterone signaling, or on tumor microenvironment.

Keywords Breast cancer – Aspirin – NSAIDs – Hormone receptors – Prevention

Fulltext Preview
SpringerLink - Breast Cancer Research and Treatment, Volume 126, Number 1



GINECOLOGÍA
Actualidad Ultimas noticias - JANOes
El acido acetilsalicílico podría reducir un 20% el cáncer de mama en mujeres posmenopáusicas
JANO.es · 31 Enero 2011 00:04

Un estudio analizó la influencia de distintos AINEs sobre el riesgo de desarrollar este tipo de cáncer.


El consumo regular de ácido acetilsalicílico en mujeres posmenopáusicas se asocia con una disminución del 20% en el riesgo de desarrollar un cáncer de mama, según los resultados obtenidos en un estudio realizado por un equipo de científicos del Sidney Kimmel Comprehensive Cancer Center, de Baltimore, Estados Unidos, publicado en la revista Breast Cancer Research and Treatment.

El estudio se realizó entre 1992 y 2005 en un total de 26.580 mujeres posmenopáusicas de edades comprendidas entre los 59 y 77 años y analizó la influencia del consumo del ácido acetilsalicílico y también de otros antiinflamatorios no esteroideos (AINEs) sobre el riesgo de este cáncer.

Los resultados indican que las mujeres que tomaban este fármaco regularmente, es decir, entre menos de una vez por semana y más de seis veces a la semana, reducían el riesgo de cáncer de mama en un 20%. Además, los datos apuntan a una relación inversamente proporcional entre la frecuencia de uso del fármaco y el riesgo de tumor.

De hecho, en el grupo que tomaba ácido acetilsalicílico más de seis veces por semana el riesgo resultó ser hasta un 29% inferior comparado con las mujeres que nunca consumían este medicamento. En cuanto a la combinación con otros AINEs, los investigadores observaron una reducción del riesgo si se tomaba ácido acetilsalicílico sólo o en combinación con estos fármacos, pero nunca en mujeres que consumían otros AINEs.

En cuanto al tipo de cáncer, el ácido acetilsalicílico reduce el riesgo en un 23% en los tumores receptores de estrógenos positivos, en un 22% en los receptores de estrógenos negativos, en un 21% en los receptores de progesterona positivos, y en un 27% en los receptores de progesterona negativos.

Según los autores esta investigación sugiere que el uso del ácido acetilsalicílico podría ejercer un efecto "quimiopreventivo" frente al cáncer de mama en mujeres posmenopáusicas, aunque advierten de que "no significa que pueda extrapolarse su consumo diario con este fin".



Breast Cancer Research and Treatment 2011; 126:149-155
SpringerLink - Breast Cancer Research and Treatment, Volume 126, Number 1

Sidney Kimmel Comprehensive Cancer Center
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins: Baltimore, MD

Actualidad Ultimas noticias - JANOes - El acido acetilsalicilico podria reducir un 20 el cancer de mama en mujeres posmenopausicas - JANO.es - ELSEVIER

HuGENavigator|HuGE Literature Finder|Search (version 2.0) January 2011 [5]

HuGE Navigator (version 2.0)
An integrated, searchable knowledge base of genetic associations and human genome epidemiology.

HuGE Navigator > HuGE Literature Finder Last data upload: 26 Jan 2011.
(Total 57630 articles)

open here to see the articles:
HuGENavigator|HuGE Literature Finder|Search

Recent human evolution has shaped geographical dif... [BMC Genomics. 2011] - PubMed result

BMC Genomics. 2011 Jan 24;12(1):55. [Epub ahead of print]

Recent human evolution has shaped geographical differences in susceptibility to disease.
Marigorta UM, Lao O, Casals F, Calafell F, Morcillo-Suarez C, Faria R, Bosch E, Serra F, Bertranpetit J, Dopazo H, Navarro A.

Abstract

ABSTRACT:

BACKGROUND: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies.

RESULTS: We report three main findings. First, contrary to previous results, genes associated to complex diseases present lower degrees of genetic differentiation among human populations than average genome-wide levels. Second, also contrary to previous results, the differences in replicability of disease associated-loci between Europeans and East Asians are highly correlated with genetic differentiation between these populations. Finally, highly replicated genes present increased levels of high-frequency derived alleles in European and Asian populations when compared to African populations.

CONCLUSIONS: Our findings highlight the heterogeneous nature of the genetic etiology of complex disease, confirm the importance of the recent evolutionary history of our species in current patterns of disease susceptibility and could cast doubts on the status as false positives of some associations that have failed to replicate across populations.

PMID: 21261943 [PubMed - as supplied by publisher]Free Article
Recent human evolution has shaped geographical dif... [BMC Genomics. 2011] - PubMed result

Abstract | Recent human evolution has shaped geographical differences in susceptibility to disease
Abstract | Recent human evolution has shaped geographical differences in susceptibility to disease

Correlated genotypes in friendship networks. [Proc Natl Acad Sci U S A. 2011] - PubMed result

Proc Natl Acad Sci U S A. 2011 Jan 18. [Epub ahead of print]

Correlated genotypes in friendship networks.
Fowler JH, Settle JE, Christakis NA.

Division of Medical Genetics, Department of Political Science, University of California at San Diego, La Jolla, CA 92093.

Abstract

It is well known that humans tend to associate with other humans who have similar characteristics, but it is unclear whether this tendency has consequences for the distribution of genotypes in a population. Although geneticists have shown that populations tend to stratify genetically, this process results from geographic sorting or assortative mating, and it is unknown whether genotypes may be correlated as a consequence of nonreproductive associations or other processes. Here, we study six available genotypes from the National Longitudinal Study of Adolescent Health to test for genetic similarity between friends. Maps of the friendship networks show clustering of genotypes and, after we apply strict controls for population stratification, the results show that one genotype is positively correlated (homophily) and one genotype is negatively correlated (heterophily). A replication study in an independent sample from the Framingham Heart Study verifies that DRD2 exhibits significant homophily and that CYP2A6 exhibits significant heterophily. These unique results show that homophily and heterophily obtain on a genetic (indeed, an allelic) level, which has implications for the study of population genetics and social behavior. In particular, the results suggest that association tests should include friends' genes and that theories of evolution should take into account the fact that humans might, in some sense, be metagenomic with respect to the humans around them.

PMID: 21245293 [PubMed - as supplied by publisher]
Free Article
Correlated genotypes in friendship networks. [Proc Natl Acad Sci U S A. 2011] - PubMed result

EL BIRUNI: DIRECTORIO DE DOCUMENTOS EDITADOS EN ENERO 2011 [*]

CIENCIAS MÉDICAS NEWS
CIENCIAS MÉDICAS APLICADAS
RESEARCH & CLINICAL DEVELOPMENT

lunes 31 de enero de 2011
EL BIRUNI: DIRECTORIO DE DOCUMENTOS EDITADOS EN ENERO 2011 [*]
DIRECTORIO DE DOCUMENTOS EDITADOS EN ENERO 2011 [*]


GRUPO DE BLOGS SALUD EQUITATIVA

► Iniciado en enero de 2009:
http://elbiruniblogspotcom.blogspot.com
▲ CIENCIAS MÉDICAS NEWS


► Iniciado en abril de 2008:
http://saludequitativa.blogspot.com
▲ GESTIÓN EN SALUD PÚBLICA


► Iniciado en enero de 2009:
http://herenciageneticayenfermedad.blogspot.com
▲ CIENCIAS DE LA HERENCIA


Consultas acumuladas desde enero 2009 a la fecha: 295.740
Consultas totales conjuntas (todos los blogs): 1.277.990
Páginas consultadas desde el inicio de los blogs [3]: > 4 millones

Discriminadas como sigue:
1. ARGENTINA: 43.549 [14,7%]
2. ESPAÑA: 41.818 [14,1%]
3. U.S.A.: 39.571 [13,4%]
4. MÉXICO: 38.718 [13,1%]
5. COLOMBIA: 16.720 [ 5,7%]
6. PERÚ: 15.811 [ 5,3%]
7. VENEZUELA: 14.599 [ 4,9%]
8. CHILE: 10.124 [ 3,4%]
9. ECUADOR: 6.852 [ 2,3%]
10. BOLIVIA: 4.828 [ 1,6%]
11. LOS DEMÁS: 63.150 [21,4%]
Total de consultas: 295.740

Documentos del mes de ENERO 2011: 637
Documentos acumulados en 2010: 6.309
Documentos editados desde el inicio del blog: 11.452

MUESTRA ESTADÍSTICA (de un día): (al 30 enero 2011)
Páginas vistas por países (según estadísticas blogger):
Estados Unidos 3.443
Alemania 1.341
España 402
México 330
Francia 282
Reino Unido 196
Argentina 182
Países Bajos 151
Corea del Sur 147
Perú 119


Archivo del blog

▼  2011 (637)
▼  enero (637)
1. Using information prescriptions to refer patients ...
2. Genome-Wide Association Studies of Alcohol Depende...
3. The Emerging Role of Electronic Medical Records in...
4. Hepatitis C pharmacogenetics: State of the art in ...
5. Genetic Transmission of Cytochrome P450 2D6 (CYP2D...
6. Genetic contribution to common epilepsies. [Curr O...
7. Modeling the Cumulative Genetic Risk for Multiple ...
8. Tryptophan hydroxylase-2 (TPH2) in disorders of co...
9. Genetic Predisposition for Development of Complica...
10. Guidances (Drugs) > Individual Product Bioequivale...
11. Call for Public Review: The Impact of Pre-Transpla...
12. The role of colonoscopy and radiological procedure...
13. Revealing the genetic basis of multiple sclerosis:...
14. Personalizing dermatology: The future of genomic e...
15. Genetic determinants of hepatic steatosis in man. ...
16. PLoS Genetics: A Meta-Analysis of Genome-Wide Asso...
17. The clinical utility of testicular cancer risk loc...
18. Novel Breast Cancer Susceptibility Locus at 9q31.2...
19. Genome-wide association studies for detecting canc...
20. Clinical outcome of triple negative breast cancer ...
21. A clinical perspective on genetic counseling and t...
22. An overview of international literature from cysti...
23. Multi-Disciplinary Faculty Group Examined Ways To ...
24. Genetic sequencing alone doesn't offer a true pict...
25. Study Confirms Parental History as Heart Attack Ri...
26. Gene mutation play a major role in 1 cause of kidn...
27. Blocking rogue gene could stop the spread of most ...
28. Gene test shows which bladder cancer patients may ...
29. Johns Hopkins Scientists Crack Genetic Code For Fo...
30. Uncovering The Genetics Of Prostate Cancer
31. Determining Which Bladder Cancer Patients May Have...
32. Molecular Network That Influences Development Of C...
33. News & Events (Biologics) > OCTGT Learn
34. New videos show NIH studies of communication betwe...
35. Women at High Risk for Diabetes: Access and Qualit...
36. Food Poisoning | FoodSafety.gov
37. News & Events > Important Notice to IRBs Reviewing...
38. Pluripotent Stem Cells in Translation: Early Decis...
39. Research Activities, February 2011: Announcements:...
40. Research Activities, February 2011: Announcements:...
41. Research Activities, February 2011: Announcements:...
42. Research Activities, February 2011: Outcomes/Effec...
43. Research Activities, February 2011: Outcomes/Effec...
44. Research Activities, February 2011: Outcomes/Effec...
45. Research Activities, February 2011: Outcomes/Effec...
46. Research Activities, February 2011: Outcomes/Effec...
47. Research Activities, February 2011: Feature Story:...
48. Ancient body clock keeps all life on time: studies...
49. Revista Española de Cardiología: Texto completo
50. HIV+ Liver Cancer Patients Less Likely to Get Tran...
51. Celiac and Crohn's Disease May Share Genetic Risk ...
52. Discovery May Explain Why Brain Cancer Is So Hard ...
53. Gene protects U.S. blacks from heart disease: stud...
54. CDC Issues Guidance on Daily Pill to Prevent Infec...
55. Study Ties Hot Flashes to Lower Breast Cancer Risk...
56. Shockable cardiac arrests are more common in publi...
57. AHRQ News and Numbers: Approximately 5 Percent of ...
58. Effectiveness of Noninvasive Diagnostic Tests for ...
59. Cancer Screening and Treatment in Women: Program B...
60. Cancer Screening and Treatment in Women: Program B...
61. Cancer Screening and Treatment in Women: Recent Fi...
62. Recalls, Market Withdrawals, & Safety Alerts > Imp...
63. Fourth FDA orphan drug designation workshop schedu...
64. Orangutan Genomes Reveal Some Surprises: MedlinePl...
65. Spotting Gene Variants May Boost Hepatitis C Treat...
66. Cancer Doctors Urge Earlier End-of-Life Care Talks...
67. Notes from the Field: Respiratory Diphtheria-Like ...
68. Updated Recommendations for Use of Meningococcal C...
69. Lead Poisoning of a Child Associated with Use of a...
70. Interim Guidance: Preexposure Prophylaxis for the ...
71. General Recommendations on Immunization
72. National Guideline Clearinghouse | Sexual and repr...
73. National Guideline Clearinghouse | Management of u...
74. National Guideline Clearinghouse | Diagnosis, prev...
75. National Guideline Clearinghouse | Clinical practi...
76. National Guideline Clearinghouse | European Federa...
77. National Guideline Clearinghouse | EFNS guidelines...
78. National Guideline Clearinghouse | Evidence review...
79. National Guideline Clearinghouse | Evidence review...
80. National Guideline Clearinghouse | ASD and PTSD. I...
81. NIH-funded scientists publish orangutan genome seq...
82. Little-known growth factor enhances memory, preven...
83. Shockable cardiac arrests are more common in publi...
84. Breast Cancer Drug May Also Help Lung Cancer Patie...
85. Effect of Occult Metastases on Survival in Node-Ne...
86. CDC - Diabetes Public Health Resources - Publicati...
87. Warm Homes in Winter May Contribute to Obesity Epi...
88. Safety Alerts for Human Medical Products > Breast ...
89. FDA review indicates possible association between ...
90. Loud Road Noise Linked to Stroke in Older Adults: ...
91. Untimely jolts not uncommon with heart device: Med...
92. Some Older Drivers' Vision Problems Different Than...
93. Lowering blood pressure in middle-aged women reduc...
94. Changing Parental Behavior May Help Obese Kids Los...
95. Elderly With Dementia, Delirium Confused by ER Vis...
96. Breast-Feeding May Counter Some Effects of Childho...
97. Chopin's Hallucinations Likely Caused by Epilepsy:...
98. Rise in Some Head and Neck Cancers Tied to Oral Se...
99. FDA's Sentinel Initiative
100. A Study of Severe Viral Infections in Non-immunoco...
101. FDA Updates Safety Review of Diabetes Drug for Pos...
102. Dose-Adjusted Chemotherapy for Untreated c-MYC-Pos...
103. Seeking Better Treatments for Brain Tumors in Chil...
104. Can Aspirin Reduce Cancer Risk and Mortality? - NC...
105. Rising Costs of Cancer Care - NCI Cancer Bulletin ...
106. NCI Cancer Bulletin for January 25, 2011 - Nationa...
107. Genetic Study Reveals Clues to Pancreatic Neuroend...
108. Predictive factors of ESBL versus non-ESBL Escheri...
109. Secondary prevention in osteoporotic fractures. Th...
110. Association of hyperhomocysteinemia with liver ste...
111. Reduction of Coxiella burnetii Prevalence by Vacci...
112. Flat feet tied to knee pain in older adults: Medli...
113. Breast Cancer Drug May Also Help Lung Cancer Patie...
114. Increasingly, Other Ailments Prove Fatal for Peopl...
115. Lowering BP Can Help Cut Women's Heart Disease Ris...
116. Heavy Smoking Linked to Small Increase in Breast C...
117. Brief Behavioral Counseling May Help Seniors Sleep...
118. World's top blood pressure drug gets failing mark:...
119. Cdc42 Protein Is a Potential Drug Target for Osteo...
120. Parents' Divorce May Contribute to Suicidal Though...
121. Stress-Reduction Therapy May Help Heart Disease Pa...
122. Pen Mightier Than Keyboard for Making Imprint on B...
123. CDC - Fast Facts and Statistics on GBS - Group B S...
124. National Guideline Clearinghouse | ACR Appropriate...
125. National Guideline Clearinghouse | ACR Appropriate...
126. National Guideline Clearinghouse | ACR Appropriate...
127. National Guideline Clearinghouse | ACR Appropriate...
128. National Guideline Clearinghouse | ACR Appropriate...
129. National Guideline Clearinghouse | Guideline Synth...
130. National Guideline Clearinghouse | Guideline Synth...
131. Endocrine and nutritional management of the post-b...
132. AIDSinfo - HIV Guidelines - Adult and Adolescent
133. Clinical Practice Guideline : Tonsillectomy in Chi...
134. Long-Term Cardiovascular Mortality After Radiother...
135. Journal of Clinical Investigation -- Maternal T ce...
136. Access : Selective targeting of activating and inh...
137. Tinnitus Cure May Lie in the Brain
138. Chemotherapy Using Nanoparticles
139. Technology Gives Scientists Peek Deep Into Brain
140. Rep. Giffords Set to Begin Rehab in Houston: Medli...
141. Living Near a Major Roadway Linked with Atheroscle...
142. Brain Aneurysm Statistics and Facts | The Brain An...
143. Severe Mental Health Disorders Untreated in Many U...
144. Key to Hormone-Resistant Prostate Tumors Discovere...
145. Mother's Exposure to Urban Air Pollutants Affects ...
146. Link Discovered Between Particulate Matter Air Pol...
147. Some child hearing loss tied to virus in pregnancy...
148. Alzheimer's Scan Might Help Spot Disease: MedlineP...
149. Bladder control problems more common in ADHD: Medl...
150. Endocrine Disruptor Knowledge Base (EDKB) > EDKB R...
151. vilazodone hydrochloride: FDA approves Viibryd (vi...
152. Are antibiotics necessary after 48 hours of improv...
153. HuGENavigator|HuGE Literature Finder|Search (versi...
154. GAPPKB|Home (beta version) January 2011 - 3 -
155. Genetic testing and cancer risk management recomme...
156. Systematic Review of Thiopurine Methyltransferase ...
157. Gene-environment interactions: early life stress a...
158. Personalized medicine and oncology practice guidel...
159. Current Progress in Pharmacogenetics. [Br J Clin P...
160. Pharmacoeconomic evaluation of warfarin pharmacoge...
161. Pharmacogenetics of endocrine therapy for breast c...
162. Effect of model choice in genetic association stud...
163. Moving Closer to a Public Health Model of Language...
164. Genome-wide association studies: results from the ...
165. Genetic Risk Score and Risk of Myocardial Infarcti...
166. What's new in non-small cell lung cancer for patho...
167. Impact of computer-assisted data collection, evalu...
168. Evaluation of the association studies of single nu...
169. Rare Disease Day 2011 - Participating National All...
170. Changes in glitazone use among office-based physic...
171. New Method Will Triple Amount Of Genetic Informati...
172. UBC-VCH Researchers Find Critical Link Between Dow...
173. New England Journal Of Medicine Publishes Initial ...
174. "A Stark Warning:" Smoking Causes Genetic Damage W...
175. Certain Genetic Profiles Increase Risk Of CAD, Oth...
176. First View Of DNA Damage Within Entire Human Genom...
177. 'Patchwork' Of Gene Faults Could Help Predict Cerv...
178. PLoS Biology Announces Genome Wide Association Stu...
179. 23andMe Presents Top 10 Most Interesting Genetic F...
180. Scientists view genome as it turns on and off insi...
181. Kidney Cancer: Same Gene Mutation In One Third Of ...
182. Science Report - www.cedepap.tv - Edición Enero 20...
183. Cancer Scientists Discover Genetic Diversity In Le...
184. Environmental Health Perspectives: Environmental C...
185. Adolescent alcohol use linked with genetic variati...
186. Kidney gene implicated in increased heart failure ...
187. 2009 Progress Report on Alzheimer's Disease
188. H1N1 Flu Is Raging in Britain; Could U.S. Be Next?...
189. Study Finds Lack of Sleep Leads to Lost Calories: ...
190. Fewer Cancer Patients May Be Depressed Than Though...
191. Studies show swift impact of rotavirus vaccines: M...
192. Bladder control problems more common in ADHD: Medl...
193. Good Bond Between Therapist, Depressed Patient Aid...
194. Genes map study finds clues to pancreatic cancer: ...
195. Sleep Study May Be Advisable Before Removing Tonsi...
196. Breast Cancer Patients With Diabetes May Fare Wors...
197. Emotions May Sidetrack Use of Safety Devices: Medl...
198. California woman regains voice in rare transplant:...
199. Back surgery does not end careers for NFL linemen:...
200. School Closures and Student Contact Patterns | CDC...
201. NDM-1 in Traveler, Canada | CDC EID - Volume 17, N...
202. Gene variants predict treatment success for alcoho...
203. Approved Products > January 13, 2011 Approval Lett...
204. Vaccine Safety & Availability > Fluzone Vaccine Sa...
205. The National Vaccine Advisory Committee (NVAC)
206. CDC - Blogs - Safe Healthcare – Preventing Uninten...
207. Vaccines and Related Biological Products Advisory ...
208. CDC - DHDSP - Heart Disease - February is American...
209. Recalls, Market Withdrawals, & Safety Alerts > Imp...
210. CDC Grand Rounds: Childhood Obesity in the United ...
211. STD 2010 Treatment Guidelines Webinar Available
212. QuickStats: Age-Adjusted Daily Kilocalorie Intake ...
213. Self-Reported Influenza-Like Illness During the 20...
214. Antiviral Agents for the Treatment and Chemoprophy...
215. CDC Data & Statistics | Feature: Birth Defects: Le...
216. 1 in 5 Cancer Survivors Suffers Chronic Pain, Stud...
217. New Clue to How Chinese Remedy Curbs Drinking: Med...
218. Organs From High-Risk Donors Often Shunned, Study ...
219. Scientists Map Key Structure HIV Uses to Infect Ce...
220. People with HIV have high stroke risk: study: Medl...
221. Small Spreads of Breast Cancer May Not Affect Surv...
222. Second Heart Attack Not Always Tied to Original Bl...
223. Bedbugs Reveal Their Genetic Secrets in Lab Study:...
224. Hoarseness rare in kids with cleft palate: study: ...
225. Study Questions Safety of Pneumonia Treatment Guid...
226. Evaluation of Consistency in Dosing Directions and...
227. Winter 2011 Issue: Volume 5 Number 4 | NIH Medline...
228. Confusing Children's Medication Information
229. Call for Public Review: The Impact of Pre-Transpla...
230. Water Consumption and Use, Trihalomethane Exposure...
231. SAVE THE DATE: NIAID to Host March 7 Meeting on Fu...
232. Weight-Loss Surgery May Ease Incontinence in Women...
233. Congenital diaphragmatic hernia - Genetics Home Re...
234. MOPDII - Microcephalic osteodysplastic primordial ...
235. Warfarin Use May Raise Risk of Death From Traumati...
236. January 19, 2011 -- NIAID Funding Newsletter -- NI...
237. PRECLINICAL SERVICES FOR THE DEVELOPMENT OF BIOPHA...
238. Immune Epitope Database and Analysis Resource Prog...
239. January 19, 2011 -- NIAID Funding Newsletter -- NI...
240. January 19, 2011 -- NIAID Funding Newsletter -- NI...
241. January 19, 2011 -- NIAID Funding Newsletter -- NI...
242. CDC | National Public Health Radio Network (NPHRN)...
243. Gene variants predict treatment success for alcoho...
244. NIH study in mice uncovers pathway critical for UV...
245. FDA to improve most common review path for medical...
246. Antibiotics, blood pressure drugs can be risky mix...
247. Genetics Could Play Role in Teen Drinking: Medline...
248. Population-wide reduction in salt consumption reco...
249. More Evidence That TV, Computer Time Could Harm He...
250. Many Surgeons Have Contemplated Suicide, Study Fin...
251. Progress Reported in Predicting Alzheimer's: Medli...
252. Antidepressant Might Help Ease Hot Flashes: Medlin...
253. Damage of 'False-Positive' Mammograms Overlooked: ...
254. Gene Test Might Predict Colon Cancer's Return: Med...
255. Best Practices for Parenteral and Ophthalmic Drug ...
256. New (FREE) CME Course -- Antimicrobial Resistance ...
257. Non-invasive prenatal assessment of trisomy 21 by ...
258. Quality of Life and Safety of Tai Chi and Green Te...
259. Cancer Facts & Figures for African Americans, 2009...
260. 100 Great Hacks for the Green-Minded Mom | Nursing...
261. 2011 National HIV Prevention Conference
262. NIAID Grantees Find Implications for Immunity in E...
263. FDA Approves Head Lice Treatment for Children and ...
264. Federal government obtains permanent injunction ag...
265. Bright Lights at Night May Raise Diabetes Risk: Me...
266. NIH-funded study uses new technology to peek deep ...
267. Drug-resistant malaria could spread fast, expert w...
268. Most Guidelines for Infectious Diseases Don't Come...
269. Study Shows Cranberry Juice Cocktail Is No Better ...
270. Identification of ADAMTS7 as a novel locus for cor...
271. Semen allergy suspected in rare post-orgasm illnes...
272. Antibiotics, blood pressure drugs can be risky mix...
273. Worsening Depression Adds to Heart Failure Risks: ...
274. Warfarin Use May Raise Risk of Death From Traumati...
275. Thorough Exams a Must for Those at High Risk of Sk...
276. Some Severe MS Flares Helped by Blood Filtering Tr...
277. Heavy Drinking May Boost Risk for Atrial Fibrillat...
278. New Osteoporosis Screening Recommendations Issued:...
279. Breast Cancer Radiation Before 1984 Tied to Heart ...
280. Rad52 inactivation is synthetically lethal with BR...
281. Cataract-associated mutant E107A of human γD-cryst...
282. Pravastatin induces placental growth factor (PGF) ...
283. Modelling the long QT syndrome with induced plurip...
284. Routine Osteoporosis Screening Recommended for All...
285. National Guideline Clearinghouse | Clinical practi...
286. National Guideline Clearinghouse | Urological canc...
287. National Guideline Clearinghouse | Skin cancer. In...
288. National Guideline Clearinghouse | Psychosocial su...
289. National Guideline Clearinghouse | Lung cancer. In...
290. National Guideline Clearinghouse | Head and neck c...
291. National Guideline Clearinghouse | Haematological ...
292. National Guideline Clearinghouse | Gynaecological ...
293. National Guideline Clearinghouse | General princip...
294. National Guideline Clearinghouse | Gastrointestina...
295. National Guideline Clearinghouse | Disparity and a...
296. National Guideline Clearinghouse | Cancer in child...
297. National Guideline Clearinghouse | Breast cancer. ...
298. National Guideline Clearinghouse | Brain and centr...
299. National Guideline Clearinghouse | Bone cancer and...
300. ACOG Education Pamphlet AP100 -- Repeated Miscarri...
301. AHRQ Nursing Home Survey on Patient Safety Culture...
302. Epilepsy Drugs May Raise Fracture Risk in Older Ad...
303. Immediate Consequences of Cigarette Smoking: Rapid...
304. GAPPKB|Home (beta version) January 2011 - 2 -
305. HuGENavigator|HuGE Literature Finder|Search (versi...
306. Effect of Direct-to-Consumer Genomewide Profiling ...
307. Parental Understanding of Newborn Screening for Cy...
308. The Promise of a Personalized Genomic Approach to ...
309. Blinders, phenotype, and fashionable genetic analy...
310. Cardiac ion channel mutations in the sudden infant...
311. Comparison of the prognostic and predictive utilit...
312. Familial aggregation of dementia with lewy bodies....
313. Colorectal Cancer Epigenetics: Complex Simplicity....
314. Dorothy Hodgkin Lecture 2010^. From hype to hope? ...
315. Genome-wide association studies of adolescent idio...
316. Development Resources > Medical, Statistical, and ...
317. Information by Drug Class > Acetaminophen Informat...
318. Safety Information > December 2010
319. Call for Public Review: The Impact of Pre-Transpla...
320. PHG Foundation | Progress in non-invasive testing ...
321. Most consumers want predictive tests to learn if a...
322. Researchers create 'scoring system' for PTEN mutat...
323. PLoS ONE: Detection of Heteroplasmic Mitochondrial...
324. Extracting cellular 'engines' may aid in understan...
325. New User-friendly Resource Connects Human Genes To...
326. New Hope In Fight Against Huntington's Disease
327. First Genetic Test For Predicting IVF Success
328. Brain-Tumor Development Promoted By Loss Of Gene, ...
329. MicroRNA-TP53 Circuit Connected To Chronic Lymphoc...
330. Progress in Immunization Information Systems --- U...
331. Updated Recommendations for Use of Tetanus Toxoid,...
332. X-Ray Repair Cross-Complementing Group 1 (XRCC1) G...
333. A Primer on a Hepatocellular Carcinoma Bioresource...
334. Nanodisk gene therapy
335. Punctuated evolution in cancer genomes
336. Genomics|Genetic Testing|EGAPP Recommendations|FVL...
337. Recommendations from the EGAPP Working Group: Rout...
338. EGAPP|Evaluation of Genomic Applications in Practi...
339. EGAPP|Recommendations|Breast Cancer
340. CDC Health Disparities and Inequalities Report Uni...
341. Multidisciplinary Versus One-on-One Setting: A Qua...
342. Palliative Care Consultations in Patients With Can...
343. Prospective Study of Combined Colon and Endometria...
344. Ingredients for Success: A Familial Cancer Clinic ...
345. Cancer Portal Project: A Multidisciplinary Approac...
346. Factors Influencing Treatment Recommendations in N...
347. Multidisciplinary Health Care Professionals' Perce...
348. Commentary: Chemotherapy Dosing in Obese Patients ...
349. Evaluation of Chemotherapy-Induced Severe Myelosup...
350. Safe Handling of Oral Chemotherapeutic Agents in C...
351. Medication Safety of Five Oral Chemotherapies: A P...
352. A comparison of active management and expectant ma...
353. Effect of 7,8-Dihydroxyflavone, a Small-Molecule T...
354. 9-oxo-10(E),12(E)-octadecadienoic acid derived fro...
355. JAD - Volume 23, Number 2
356. Aberrant Overexpression of Satellite Repeats in Pa...
357. Drug Safety and Availability > FDA Drug Safety Com...
358. Scientists make chickens that don't spread bird fl...
359. Talk therapy may help tough-to-treat depression: M...
360. Sesame and nut allergies may often strike together...
361. Dialysis Options Remain After Kidney Transplant Fa...
362. Common sleep drug can leave people groggy, clumsy:...
363. FDA limits acetaminophen in prescription combinati...
364. Heart Rhythm Disorder May Double Death Risk for Di...
365. CDC Report Finds 8% of Americans Have Asthma: Medl...
366. Pill-Splitting Potentially Perilous, Study Suggest...
367. Electronic Source Documentation in Clinical Invest...
368. Notices to Readers: Changes to the National Notifi...
369. Notes from the Field: Congenital Lymphocytic Chori...
370. Updated Recommendations for Use of Tetanus Toxoid,...
371. TRIALs: Open Studies | "Riboflavin" - List Results...
372. TRIALs: Open Studies | "Vitamin B Complex" - List ...
373. TRIALs: Open Studies | "Thiamine" - List Results -...
374. TRIALs: Open Studies | "Niacin" - List Results - C...
375. TRIALs: Open Studies | "Biotin" - List Results - C...
376. CDC Report Finds 8% of Americans Have Asthma: Medl...
377. Drug-resistant malaria could spread fast, expert w...
378. High Level of 'Good' Cholesterol Alone May Not Pro...
379. Antibiotics Can Ease Kids' Ear Infections, Studies...
380. FDA limits acetaminophen in prescription combinati...
381. Preserving Fertility While Battling Cancer
382. Comparing First-Line Therapies for Mucinous Ovaria...
383. Best Pharmaceuticals for Children: Development Res...
384. Drug Safety and Availability FDA Drug Safety Comm...
385. Herpes Zoster Vaccine in Older Adults and the Risk...
386. Actualidad Ultimas noticias - JANOes y agencias - ...
387. The heads of the measles virus attachment protein ...
388. Erratum to 2010 STD Treatment Guidelines
389. Vaccines: Ed/CIINC/NetConf: main page
390. Research Activities, January 2011: Chronic Disease...
391. Research Activities, January 2011: Chronic Disease...
392. Research Activities, January 2011: Chronic Disease...
393. Research Activities, January 2011: Announcements: ...
394. Research Activities, January 2011: Health Informat...
395. Rebooting the brain helps stop the ring of tinnitu...
396. La terapia antimicrobiana de la otitis, mejor que ...
397. Funding Opportunities About the Office on Women's...
398. Research Available for Comment | AHRQ Effective He...
399. Chemical tied to hormonal syndrome: MedlinePlus
400. Epilepsy Drugs May Raise Fracture Risk in Older Ad...
401. Most Guidelines for Infectious Diseases Don't Come...
402. Therapy May Help Cut Incontinence After Prostate S...
403. Not All Heart Failure Drugs Boost Survival Equally...
404. Arm Artery No Better Than Leg Vein for Heart Bypas...
405. Certain Painkillers Appear to Boost Odds for Heart...
406. Smoking around your kindergartner could raise thei...
407. Thiopurine Methyltransferase Activity: Structured ...
408. Vaccines: Recs/Schedules/Child Schedule main page
409. CDC - Mercury and Thimerosal - Vaccine Safety
410. Early thimerosal exposure and neuropsychological o...
411. Third- and fourth-degree perineal tears: prevalenc...
412. Using mechanobiological mimicry of red blood cells...
413. Regeneration of the articular surface of the rabbi...
414. Hysterectomy and risk of cardiovascular disease: a...
415. Proteomic Signature of Apolipoprotein J in the Ear...
416. PLoS Medicine: Estimates of Pandemic Influenza Vac...
417. CANCER RESEARCH HIGHLIGHTS - NCI
418. Continued Shortage of Chemotherapy Drugs Causing C...
419. Safety Alerts for Human Medical Products Morphine...
420. Sibling spacing may be tied to autism risk: study:...
421. While Doctors Are Optimistic, Prognosis for Wounde...
422. Likely no tie between male birth defect, chemical:...
423. People Who Recovered From H1N1 Offer Clues to Bett...
424. Statins May Be Harmful After Stroke: MedlinePlus
425. Secondhand Smoke Tied to High Blood Pressure in Ki...
426. Age-Related Eye Disease Declining in U.S.: Medline...
427. For the Very Obese, H1N1 Was More Apt to Be Fatal:...
428. Working With Plasticizers, Pesticides May Reduce F...
429. Request for Information on 2,3-Pentanedione and Ot...
430. CDC - NIOSH Docket: 156 - Current Intelligence Bul...
431. CDC NIOSH Science Blog: Helical CT Scans and Lung ...
432. The January 2011 FDA Patient Safety News - Show #1...
433. Treating Latent TB After 65 Raises Serious Side-Ef...
434. Sugary Drinks, Foods Might Put Teens at Risk for H...
435. Postmarket Drug Safety Information for Patients an...
436. Quality-of-Life Measurement in Randomized Clinical...
437. National Guideline Clearinghouse | Ductal carcinom...
438. National Guideline Clearinghouse | Follow-up. In: ...
439. National Guideline Clearinghouse | General princip...
440. National Guideline Clearinghouse | Radiotherapy. I...
441. National Guideline Clearinghouse | Special issues....
442. National Guideline Clearinghouse | Staging. In: Ma...
443. National Guideline Clearinghouse | Surgery for ear...
444. National Guideline Clearinghouse | Systemic therap...
445. National Guideline Clearinghouse | Systemic therap...
446. National Guideline Clearinghouse | Basic guideline...
447. National Guideline Clearinghouse | Preconception c...
448. National Guideline Clearinghouse | HIV prophylaxis...
449. National Guideline Clearinghouse | HIV prophylaxis...
450. National Guideline Clearinghouse | HIV post-exposu...
451. HIV/AIDS Update - Revised Adult HIV Treatment Guid...
452. Newer antipsychotics overused, U.S. study suggests...
453. Quality of Life Key Measure in Breast Cancer Clini...
454. U.S. lowers limits for fluoride in water: MedlineP...
455. Study Refutes Myth That Eating Disorders Affect Wh...
456. Prozac May Speed Physical Rehabilitation After Str...
457. Immune Disorders May Raise Blood Clot Risk in Hosp...
458. Nose May Be Best Place to Screen for MRSA Infectio...
459. Cell - Identification of Candidate IgG Biomarkers ...
460. Journal of Clinical Investigation -- Bald scalp in...
461. Wakefield’s article linking MMR vaccine and autism...
462. Table of Contents — December 20, 2010, 207 (13) — ...
463. FDA approves opioid analgesic to help cancer patie...
464. SÍFILIS, AUMENTO MARCADO DE CASOS - CANADÁ
465. BAYLISASCARIS PROCYONIS, MAPACHES, RIESGO DE INFEC...
466. CLOSTRIDIUM DIFFICILE, FRECUENCIA CRECIENTE EN NIÑ...
467. IntraMed - Artículos - Jornadas IntraMed Rosario /...
468. IntraMed - Artículos - Shunt portosistémcio transy...
469. CDC Features - United States Cancer Statistics (US...
470. FDA approves opioid analgesic to help cancer patie...
471. Surveys on Patient Safety Culture: Nursing Home Su...
472. Task Force Seeks Public Comments on Screening, Beh...
473. Primary medication non-adherence: analysis of 195,...
474. The relationship between religious involvement and...
475. Adverse events after stopping clopidogrel in post-...
476. Risk adjustment for comparing hospital quality wit...
477. Variations in prevalent cardiovascular disease and...
478. GAPPKB|Home (beta version) NEW January 2011 - 1 -
479. HuGENavigator|HuGE Literature Finder|Search (versi...
480. Reporters and Editors are Invited to Apply for 201...
481. Clostridium sphenoides Bloodstream Infection in Ma...
482. Primary Infections with PARV4, Finland | CDC EID
483. Alert System to Detect Possible School-based Outbr...
484. HIV/AIDS Update - Tentative approval of lamivudine...
485. Cholera: The Biography | CDC EID
486. Influenza in Early Pregnancy and Fetal Demise | CD...
487. Dengue Virus Type 2, Puerto Rico | CDC EID
488. HEV in Solid-Organ Transplant Recipients | CDC EID...
489. How Safe Is Our Food? | CDC EID [3/3]
490. Foodborne Illness, USA—Unspecified Agents | CDC EI...
491. Foodborne Illness, USA—Major Pathogens | CDC EID [...
492. Biological Approvals by Year > 2010 Biological Dev...
493. Biological Approvals by Year > 2010 Biological Lic...
494. Novel HIV-1 Recombinant Forms in Antenatal Cohort,...
495. Cysticercosis Acquired in the United States | CDC ...
496. Giving IV Fluids on Scene Might Raise Death Risk f...
497. Guidelines Issued for Drug-Resistant Staph Infecti...
498. No Surgery for Moderate Tonsillitis, New Guideline...
499. Resurrecting The So-Called "Depression Gene"
500. A Clinical Scoring System for Selection of Patient...
501. Genome-wide epigenetic modifications in cancer. [P...
502. Genetics of type 2 diabetes: pathophysiologic and ...
503. Large-Scale Study Identifies New Genetic Variants ...
504. Scientists Closer To Finding Treatment For Life-th...
505. USP–NF: U.S. Pharmocopeia (USP) Seeks Comments on ...
506. Pharmacogenetics of Drug Metabolizing Enzymes and ...
507. Meta-analysis of Dense Genecentric Association Stu...
508. Systematic Review: Anti-Epidermal Growth Factor Re...
509. Psychological Impact of Genetic Counseling for Her...
510. Influence of polymorphisms on EGFR targeted therap...
511. Researchers Find Gene That Protects Against Dement...
512. Large-scale screening of the Gaucher's disease-rel...
513. Women With MS More Likely To Have MS-Related Gene ...
514. Singapore And US Scientists First To Develop A Pub...
515. Family history not the sole risk for breast cancer...
516. Ovarian Cancer Progresses When Genes are Silenced ...
517. Gene Alteration Identified That Predisposes To Syn...
518. Missing Gene: A Cause for Common Brain Cancer? | M...
519. Trace amounts of germ-killing molecules predict di...
520. Global HIV/AIDS Epidemic and International Health:...
521. TRIALs: Open Studies | "Anti-HIV Agents" - List Re...
522. TRIALs: Open Studies | "Antiretroviral Therapy, Hi...
523. TRIALs: Open Studies | "AIDS-Related Opportunistic...
524. Notice to Readers: Extension of Continuing Educati...
525. Announcements: National Birth Defects Prevention M...
526. Announcements: Clinical Vaccinology Course --- Mar...
527. Public Health Response to a Rabid Dog in an Animal...
528. Post-Earthquake Injuries Treated at a Field Hospit...
529. Patients underestimate CT scan radiation, risks: M...
530. Study Sheds Light on Genetic Risk of MS: MedlinePl...
531. Fish Oil May Help Some Heart Failure Patients: Med...
532. Diabetes Soaring Among American Adults: Report: Me...
533. Arsenic-laced water ups TB risk: report: MedlinePl...
534. Experimental Drug Helps Fight Aggressive Breast Ca...
535. Antibiotic May Help Ease Irritable Bowel: MedlineP...
536. Bread at top of UK sodium-rich food purchases: Med...
537. FDA to require substantial equivalence reviews for...
538. CDRH Transparency
539. CDRH Transparency > Premarket Approval (PMA) Summa...
540. Drug Approvals and Databases > Drugs@FDA Data File...
541. Postmarket Drug Safety Information for Patients an...
542. Development Resources > List of Determinations Inc...
543. IntraMed - Noticias médicas - Investigación en cél...
544. Factor de riesgo -IntraMed - Artículos - Repercusi...
545. Flu activity increasing around the country | Flu.g...
546. GSK and Italian Telethon enter historic partnershi...
547. NIAID Grantees Trace Evolution of the Plague
548. RABIA HUMANA, DEFUNCIONES - CHINA (GUANGDONG)
549. TUBERCULOSIS, RIESGO AUMENTADO DE CANCER PULMONAR...
550. DENGUE 2, GENOTIPO III ASIÁTICO/AMERICANO, SEVERID...
551. ESCHERICHIA COLI, MULTIRESISTENTE, TRANSMISIÓN PO...
552. NCCN Patient Safety Summit Webinars
553. NCCN Guidelines Update Webinar Series: Kidney Canc...
554. NCCN Educational Opportunities: Best Practices in ...
555. NCCN Educational Opportunities: Role of the Advanc...
556. NCCN Annual Conference: Clinical Practice Guidelin...
557. CDC - Blogs - Safe Healthcare – Delivering the 201...
558. Smog Contributes to Dangerous Heart Rhythm Disorde...
559. Hysterectomy linked to cardiovascular disease: Med...
560. Stem Cell Defect Might Help Spur Common Baldness: ...
561. More Evidence Links Avastin to Heart Failure in Br...
562. Study Gauges Best Treatments for Chronic Pelvic Pa...
563. Warfarin may be underused to prevent strokes: Medl...
564. Effectiveness of Oral Contraceptive Pills in a Lar...
565. Vitamin D deficiency and reduced lung function in ...
566. Arch Gen Psychiatry -- Abstract: The Emerging Link...
567. CDK1-dependent phosphorylation of EZH2 suppresses ...
568. Estrogen and Cytochrome P450 1B1 Contribute to Bot...
569. Vaccines: Stats-Surv/NHIS/2009 adult vaccination c...
570. TRIALs: Open Studies | "Memory" - List Results - C...
571. CDC - NIOSH Publications and Products - Slip, Trip...
572. CDC - NIOSH Docket: 215 - NIOSH Guideline: Applica...
573. Colonoscopies May Not Have 'Blind Spot' After All:...
574. Soldiers' PTSD Tied to Lasting Psychosocial Effect...
575. In Women, Diabetes Plus Depression a Deadly Combo:...
576. Studies Decipher How Anti-Smoking Drugs Work: Medl...
577. PLoS ONE: Placebos without Deception: A Randomized...
578. National Conversation on Public Health and Chemica...
579. PS1-14: Utilization and Effectiveness of KRAS Test...
580. PS1-09: Public Opinion of Family History and Genet...
581. Immunity & Ageing | Full text | The Conselice Stud...
582. Preferred Practice Patterns : American Academy of ...
583. Guideline on the Treatment of Symptomatic Osteopor...
584. National Guideline Clearinghouse | Guidelines for ...
585. National Guideline Clearinghouse | VA/DoD clinical...
586. National Guideline Clearinghouse | VA/DoD clinical...
587. National Guideline Clearinghouse | VA/DoD clinical...
588. National Guideline Clearinghouse | The optimal eva...
589. National Guideline Clearinghouse | The management ...
590. National Guideline Clearinghouse | The evaluation ...
591. National Guideline Clearinghouse | Consensus state...
592. National Guideline Clearinghouse | Occupational th...
593. National Guideline Clearinghouse | Management of h...
594. National Guideline Clearinghouse | Diagnosis and m...
595. National Guideline Clearinghouse | Work-related ne...
596. Vaccines: Events/Calendar of Upcoming Meetings-Con...
597. Vaccines: VFC/Operations Guide
598. Researchers Find Links Between Sleep, Anesthesia a...
599. A new year in medicine : The Lancet
600. Decrease in Depression Symptoms Is Associated With...
601. PLoS Computational Biology: A New Integrated Varia...
602. Pharmacogenomics of Human ABC Transporter ABCC11 (...
603. Pharmacogenomic biomarkers: new tools in current a...
604. How pharmacogenomics of biological response modifi...
605. Clinical Drugs Undergoing Polymorphic Metabolism b...
606. Complex genetic mechanisms in glaucoma: an overvie...
607. Plasmodium falciparum malaria and the immunogeneti...
608. Knowledge gaining by human genetic studies on tube...
609. IntraMed - Noticias médicas - "Terapéutica clínica...
610. PS1-12: Use of Tumor Registry to Obtain Family His...
611. Estimated risk of invasive breast cancer in postme...
612. Abstract | Epigenetics and obesity: the devil is i...
613. Family coronary heart disease: a call to action. [...
614. Tamoxifen, cytochrome P450 genes and breast cancer...
615. PS1-08: Genetic Service Providers Identify Barrier...
616. Polymorphisms in Inflammatory Response Genes and T...
617. Familial gastric cancer: update for practice manag...
618. Modifier genes in Mendelian disorders: the example...
619. SpringerLink - Journal of Clinical Immunology, Onl...
620. Journal of Clinical Investigation -- Gene defects ...
621. VKORC1 Common Variation and Bone Mineral Density i...
622. Review: Age-related macular degeneration: genetic ...
623. Safety Alerts for Human Medical Products > Acetado...
624. New annotated database sifts through mountains of ...
625. Mechanism Behind Rare Muscle Disorders Explained B...
626. NIH scientists identify possible gene target for t...
627. Genetic Defect at Work in Deadly Brain Tumors
628. Higher Cancer Risk For Those With Cowden Syndrome ...
629. Genome Code Cracked For Most Common Form Of Pediat...
630. National Guideline Clearinghouse | Primary prevent...
631. National Guideline Clearinghouse | Preoperative ev...
632. National Guideline Clearinghouse | Major depressio...
633. National Guideline Clearinghouse | Supracervical h...
634. National Guideline Clearinghouse | Ovulation induc...
635. National Guideline Clearinghouse | Obesity in preg...
636. National Guideline Clearinghouse | Elective single...
637. National Guideline Clearinghouse | Cytomegalovirus...

►  2010 (6309)
►  diciembre (640)
►  noviembre (596)
►  octubre (608)
►  septiembre (561)
►  agosto (468)
►  julio (489)
►  junio (463)
►  mayo (615)
►  abril (504)
►  marzo (510)
►  febrero (345)
►  enero (510)

►  2009 (4504)
►  diciembre (578)
►  noviembre (558)
►  octubre (566)
►  septiembre (505)
►  agosto (472)
►  julio (388)
►  junio (374)
►  mayo (326)
►  abril (272)
►  marzo (214)
►  febrero (182)
►  enero (69)

Using information prescriptions to refer patients ... [J Med Libr Assoc. 2011] - PubMed result

J Med Libr Assoc. 2011 Jan;99(1):70-6.

Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference website.
Beaudoin DE, Longo N, Logan RA, Jones JP, Mitchell JA.

denise.beaudoin@hsc.utah.edu Instructor, 26 South 2000 East, Health Sciences Education Building, Suite 5700, Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112.

Abstract

OBJECTIVES: The objectives of this study were to assess the reactions of adult patients and parents of children with metabolic conditions to receipt of an "information prescription" (IP) to visit Genetics Home Reference (GHR), a National Institutes of Health/National Library of Medicine online resource, and evaluate the perceived utility of information found on the site.

METHODS: Patients seen at the University of Utah Metabolic Service Clinic were invited to participate in the study and asked to complete an initial survey to gather demographic data and an online survey six weeks later to obtain information about user experience.

RESULTS: Fifty-three of 82 individuals completed both surveys, for an overall response rate of 64.6%. Most respondents (88.7%) agreed that receiving the IP was a "good idea," and nearly all used the IP to visit GHR. More than three-quarters (79.6%) agreed that information on GHR supplemented a physician's advice; 60.4% reported an improved understanding of a health condition; and 41.5% either looked for or would consider looking for additional information. Eighty-six percent of respondents were satisfied with the information found on GHR, and 80% would recommend the site.

CONCLUSIONS: Use of an IP to direct patients to GHR was well received, and retrieved information was perceived as useful in key areas. The high level of satisfaction with GHR argues for expanded use of the IP approach in this patient population.

PMID: 21243058 [PubMed - in process]PMCID: PMC3016649
Free PMC Article
Using information prescriptions to refer patients ... [J Med Libr Assoc. 2011] - PubMed result

Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference website: (full-text)
Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference website