Volume 17, Number 6–June 2011
Dispatch
Immunologic Changes during Pandemic (H1N1) 2009, China
Hong-Hui Shen,1 Jun Hou,1 Wei-Wei Chen, Bing-Ke Bai, Hai-Bin Wang, Tong-Sheng Guo, Ai-Xia Liu, Yong-Li Li, Min Zhao, Pan-Yong Mao, Jin Li, Bo-An Li, and Yuan-Li Mao1
Author affiliation: Beijing 302 Hospital, Beijing, People's Republic of China
Suggested citation for this article
Abstract
We analyzed changes in immunologic values over time for 28 hospitalized patients with pandemic (H1N1) 2009. Levels of interleukin-6, interferon-γ, and interleukin-10 increased 1 day after illness onset and then decreased to baseline levels. Levels of virus-specific antibody were undetectable 1 day after illness onset and peaked 36 days later.
Pandemic (H1N1) 2009 virus emerged in March 2009 and spread worldwide (1,2). Most patient laboratory data result from samples or information obtained on the day of hospitalization or when the patient was experiencing the acute phase of infection. Changes in laboratory data throughout the disease course have rarely been reported. We retrospectively analyzed immunologic changes for hospitalized patients through the entire course of pandemic (H1N1) 2009. These data may provide a better understanding of disease pathogenesis.
full-text:
Immunologic Changes during Pandemic (H1N1) 2009 | CDC EID
Suggested Citation for this Article
Shen H-H, Hou J, Chen W-W, Bai B-K, Wang H-B, Guo T-S, et al. Immunologic changes during pandemic (H1N1) 2009, China. Emerg Infect Dis [serial on the Internet]. 2011 Jun [date cited]. http://www.cdc.gov/EID/content/17/6/1053.htm
DOI: 10.3201/eid1706.100643
1These authors contributed equally to this article.
Comments to the Authors
Please use the form below to submit correspondence to the authors or contact them at the following address:
Bo-An Li, Center of Laboratory Medicine, Beijing 302 Hospital, 100 W 4th Ring Middle Rd, Beijing 100039, People's Republic of China; email: lba@263.net
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