MutationsI117Vand I117M andOseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

DOI: http://dx.doi.org/10.3201/eid1712.111079
 Suggested citation for this article
Hurt AC, Leang SK, Speers DJ, Barr IG, Maurer-Stroh S. Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses. Emerg Infect Dis [serial on the Internet]. 2011 Dec [date cited]. http://dx.doi.org/10.3201/eid1712.111079
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MutationsI117Vand I117M andOseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

full-text: 
http://wwwnc.cdc.gov/eid/pdfs/11-1079-ahead_of_print.pdf?source=govdelivery

Aeron C. Hurt, Sook Kwan Leang, David J. Speers, Ian G. Barr, and Sebastian Maurer-Stroh

Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt, S.K. Leang, I.G. Barr); PathWest Laboratory Medicine, Nedlands, Western Australia, Australia (D.J. Speers); Agency for Science, Technology and Research, Singapore (S. Maurer-Stroh); Ministry of Health, Singapore (S. Maurer-Stroh); and Nanyang Technological University, Singapore (S. Maurer-Stroh)


Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.

The neuraminidase inhibitors (NAIs) oseltamivir and zanamivir have been widely used in many countries to treat infection with influenza A pandemic (H1N1) 2009 virus. Since the start of the pandemic, >27,000 strains have been tested for oseltamivir resistance, of which 383 (1.4%) have contained the H275Y neuraminidase (NA) mutation, the same mutation that was found in oseltamivir-resistant prepandemic seasonal subtype H1N1 viruses that emerged in 2007–08. Apart from the H275Y mutation, a small number of other NAI resistance mutations have been detected in the NA of pandemic (H1N1) 2009 viruses, such as S247N (
Another NA mutation, I117M, has also recently been associated with oseltamivir resistance in pandemic (H1N1) 2009 viruses (4,5). The I117M NA mutation was detected in a virus from South Korea that was isolated from a patient before oseltamivir treatment and then ...


1), I223V (2), and I223R (3).