CIENCIASMEDICASNEWS: Medical News | Medical Articles: Visual observation of phase transformations in pharmaceutical solids

martes, 2 de julio de 2019

Medical News | Medical Articles: Visual observation of phase transformations in pharmaceutical solids

	July 2, 2019
	Drug Discovery and Production
	The latest drug discovery news from News Medical

Visual observation of phase transformations in pharmaceutical solids

Studying phase transformations in pharmaceutical solids during vapor sorption is important in understanding their physicochemical properties. The new video microscope for the Hiden Isochema IGAsorp DVS analyzer allows high resolution image collection and TGA measurements up to 350 °C. This option facilitates the study of phase changes including crystallization, hydration and deliquescence.

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			Understanding Lead Optimization The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization.

			Transmission Raman Spectroscopy Advantages and Limitations Transmission Raman Spectroscopy is a variation of transmission Raman spectroscopy that is often used to probe the bulk properties of samples that scatter diffusely. It is particularly useful for the analysis of materials that are opaque or turbid.

	Protein Interaction Studies Using Microfluidics Microfluidics is an upcoming technology that has been used in many areas of chemical and biological research. One valuable application of this technique is in studying protein-protein interactions in cell biology. This is essential in allowing insights into cell signaling and gene regulatory pathways for further understanding of biological processes.

	Current and Future Applications of Rabbit Monoclonal Antibodies In most clinical applications, the monoclonal antibodies (mAbs) used are of murine origin; however, the small spleen of the mouse is limited in its ability to generate antibodies. Also, the mice used for laboratory experiments are usually inbred in a controlled environment, further restricting their ability to demonstrate diverse immune responses.

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	Are fruit fly 'avatars' the next step in personalized medicine? Researchers have created fruit fly “avatars” that have helped to guide treatment for a man who had terminal colon cancer. The team genetically engineered flies that had the same mutations as the man’s tumor and then tested different drug combinations to see which ones kept the flies alive. Doctors eventually settled on a drug combination that was the most effective and administered it to the man.

	Short Hairpin RNA (shRNA) Interference: Therapeutic Applications RNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) interference has many therapeutic applications, and research is still ongoing into new areas of focus.

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