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Original Investigation | December 31, 2013  FREE

Vitamin E and Memantine for Alzheimer Disease

This randomized trial reports that alphatocopherol slows functional decline more than placebo among patients with mild to moderate Alzheimer disease.

Original Investigation | December 24, 2013  FREE

CBT Plus Amitriptyline for Youth With Migraine

This randomized trial reports that cognitive behavioral therapy is more effective than headache education for managing migraine in children 10 years and older.

Original Investigation | December 24, 2013

Therapy for Sexual Abuse–Related PTSD in Adolescent Girls

This randomized trial reports that prolonged exposure therapy is more effective than supportive counseling for treatment of sexual-abuse related post-traumatic stress disorder in adolescent girls.

December 18, 2013  FREE  ONLINE FIRST

2014 Hypertension Guideline

Guideline for Management of High Blood Pressure in Adults, by Panel Members Appointed to the Eighth Joint National Committee (JNC)

Members of the panel appointed to the Eighth Joint National Committee ask 3 key clinical questions and make 9 recommendations for the management of adult patients with high blood pressure.

JAMA High Blood Pressure Guideline Website

Interview with Dr. Paul James, Co-Chair of the Panel Appointed to the Eighth Joint National Committee:

00:00|00:00

Related Editorials

Trustworthiness of High Blood 

Pressure Guidelines

By agreeing to share records of its review process, panel members appointed to the Eighth Joint National Committee have allayed many concerns about the guideline’s trustworthiness.

The Right Goals and Purposes 

for Treating Hypertension

Distilling the complexity of clinical trial data from selected participants into simple recommendations when the evidence is nuanced and rapidly evolving is a challenge.

Updated Guidelines: 

Recommendations, Review, and Responsibility

Whatever the controversies, biomedical journals have a responsibility to disseminate guidelines in a transparent and objective manner.

Review | December 31, 2013

Long-Term Drug Treatment for Obesity

This narrative review of obesity drugs concludes that while none reduce CV morbidity or mortality, some may be useful adjuncts to lifestyle modification for carefully selected patients.

Explore more articles:  Current Issue | Online First