Xylitol may affect cardiovascular health - National Institutes of Health,

https://www.nih.gov/news-events/nih-research-matters/xylitol-may-affect-cardiovascular-health At a Glance Higher blood levels of the artificial sweetener xylitol were associated with increased risk of heart attack and stroke in people. Xylitol enhanced blood clotting in mice and isolated human blood. The results highlight the need for further study of long-term cardiovascular health risks from sugar alcohols, artificial sweeteners that were thought to be safe.