Withdrawal of life sustaining therapies in patients with or without acute brain injury +++

COMMENTS Withdrawal of life sustaining therapies in patients with or without acute brain injury Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00008-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-810NB0yb5F8Y3mQoTvgEnf3PBxQ_x-1_TZ_8qLvO7IHfC9d4cH8fwl837ny6wVo7ZBi_HMBcBsoxGB_MQIwToj-LKXew&_hsmi=352808950&utm_content=352808950&utm_source=hs_email Preoxygenation for tracheal intubation in adults who are critically ill: time to abandon the facemask? Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00056-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-_O2ezWCvjfoZz5Q5ESOfmMX6NmtsAph4KPJkiMLFDXsHHDjpAl6I4HvHH8Ww64Xvi02BFm_leL5eaPP96IfcdY-QCaLA&_hsmi=352808950&utm_content=352808950&utm_source=hs_email Nasal high-flow oxygen for apnoeic oxygenation during emergency endotracheal intubation of children Free with registration until Mar 29, 2025 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00085-2/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz--vIxGOCPiYLzDZXz_tTE-g7z71XuylR7mYeYYxliVH1B5fYWRJq79KXw5gzRg4Z2kKmV_acKuRo7B_XU9omyDPco3h-Q&_hsmi=352808950&utm_content=352808950&utm_source=hs_email

Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies +++

Decisions to withdraw or withhold life-sustaining therapies in patients with and without acute brain injury: a secondary analysis of two prospective cohort studies Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00404-1/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-9yZxutbZcCCq90aHFGFVGigqyWw0ryhTVRtZORXNKm5SfJl2a2q36-jaAm66P9iSc_Ff7A_ocSAOASqzeQZxPim9GNCA&_hsmi=352808950&utm_content=352808950&utm_source=hs_email Preoxygenation strategies for intubation of patients who are critically ill: a systematic review and network meta-analysis of randomised trials Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00029-3/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-8YsCucNxqabXI7lq-b43RHwLyzSAs9pQQTyNsn-LUHgTnhstNAOxLwjykk17dC8vGq4bSbqM1mRCOCdC5KHUt9vuGqwg&_hsmi=352808950&utm_content=352808950&utm_source=hs_email Effectiveness of nasal high-flow oxygen during apnoea on hypoxaemia and intubation success in paediatric emergency and ICU settings: a randomised, controlled, open-label trial Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00074-8/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-8jUBeMLPijDy0bwg1TQH1_RbLw2zWd7vX1hcRb35Aj7gT-MdubfKY9D3CrwuuA-UaW9JbfTZyquqOSQMhV3_YzefrtNQ&_hsmi=352808950&utm_content=352808950&utm_source=hs_email

RESILIENT ROOTS: EMPOWERING LATINO COMMUNITIES TO THRIVE

Resilient Roots: Empowering Latino Communities to Thrive By Ivanhoe Broadcast News on March 31, 2025 https://www.ivanhoe.com/?p=35205&preview=1&_ppp=8ed3416d74

High-Dose Vitamin D Curbs Disease Activity in Early Multiple Sclerosis Megan Brooks March 13, 2025 +++++ +++

BREAKTHROUGHS & SETBACKS High-Dose Vitamin D Tames Early MS High-Dose Vitamin D Curbs Disease Activity in Early Multiple Sclerosis Megan Brooks March 13, 2025 https://www.medscape.com/viewarticle/high-dose-vitamin-d-curbs-disease-activity-early-multiple-2025a100062t?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 Neurologic Dysfunction & Microplastics Linked Marine Microplastics Linked to Neurologic Dysfunction Megan Brooks March 07, 2025 https://www.medscape.com/viewarticle/marine-microplastics-linked-neurologic-dysfunction-2025a10005na?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 MS Subtyping: Does It Really Matter? Is MS Subtyping Clinically Meaningful? Experts Weigh In Ted Bosworth March 14, 2025 https://www.medscape.com/viewarticle/ms-subtyping-clinically-meaningful-experts-weigh-2025a100066h?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 Stopping DMTs in Older MS Patients: What the Data Show Stopping DMTs in Older MS Patients: What the Data Show Ted Bosworth March 03, 2025 https://www.medscape.com/viewarticle/stopping-dmts-older-ms-patients-what-data-show-2025a100058n?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 Teen's Death Raises Concerns for Gene Therapy Tx Sarepta Says Teen Died After Its Gene Therapy Treatment Sriparna Roy And Bhanvi Satija March 18, 2025 https://www.medscape.com/s/viewarticle/sarepta-reports-teen-death-after-gene-therapy-treatment-2025a10006h3?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 GUIDELINES & CLINICAL INSIGHTS New Guidance on Seizures, Driving, and Medical Reporting New Guidance on Seizures, Driving, and Medical Reporting Patrice Wendling March 12, 2025 https://www.medscape.com/viewarticle/new-guidance-seizures-driving-and-medical-reporting-2025a1000621?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 How to Deliver a Dementia Diagnosis Breaking Bad News: Guidance on Disclosing a Dementia Diagnosis Megan Brooks March 03, 2025 https://www.medscape.com/viewarticle/breaking-bad-news-guidance-disclosing-dementia-diagnosis-2025a100057h?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753 OTC Analgesics Improve Concussion Outcomes Over-the-Counter Analgesics Improve Concussion Outcomes Pauline Anderson March 13, 2025 https://www.medscape.com/viewarticle/over-counter-analgesics-improve-concussion-outcomes-2025a100063h?ecd=mkm_ret_250329_mscpmrk_neuro_topcontent_etid7324753&uac=148436CN&impID=7324753

Treatment & Guidelines: ASCO Updates Treatment Guidance for Newly Diagnosed, Advanced Ovarian Cancer Christos Evangelou, MSc, PhD ++++ ++++

Treatment & Guidelines ASCO Guidelines: Ovarian Cancer Updates ASCO Updates Treatment Guidance for Newly Diagnosed, Advanced Ovarian Cancer Christos Evangelou, MSc, PhD February 24, 2025 https://www.medscape.com/viewarticle/asco-updates-treatment-guidance-newly-diagnosed-advanced-2025a10004ox?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Cervical Cancer: Does Adding Chemo to RT Improve Survival? Does Adding Adjuvant Chemo to Radiation Improve Survival in Early Cervical Cancer? Megan Brooks March 24, 2025 https://www.medscape.com/viewarticle/does-adding-adjuvant-chemo-radiation-improve-survival-early-2025a10006xd?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Pembrolizumab Improves PFS in Cervical Cancer Pembrolizumab Improves 36-Month PFS in Cervical Cancer Jim Kling March 18, 2025 https://www.medscape.com/viewarticle/pembrolizumab-improves-36-month-pfs-cervical-cancer-2025a10006gu?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Is Adjuvant Chemo Necessary for Intermediate-Risk Cervical Cancer? Do Patients With Intermediate-Risk Cervical Cancer Need Adjuvant Chemotherapy? Whitney McKnight March 20, 2025 https://www.medscape.com/viewarticle/do-patients-intermediate-risk-cervical-cancer-need-adjuvant-2025a10006q4?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Detection & Research Tampon Test for Endometrial Cancer Tampon-Based Test Detects Endometrial Cancer Using Vaginal Fluid Biomarkers M. Alexander Otto, PA, MMS March 25, 2025 https://www.medscape.com/viewarticle/tampon-based-test-detects-endometrial-cancer-using-vaginal-2025a1000706?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Risk-Reduction Surgery Benefit in Non-BRCA Ovarian Cancer? TNBC Outcomes Show Progress Medscape Medical News March 28, 2025 https://www.medscape.com/resource/ovarian-cancer?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 Adjuvant Chemo vs Radiotherapy Alone in Cervical Cancer Do Patients With Intermediate-Risk Cervical Cancer Need Adjuvant Chemotherapy? Whitney McKnight March 20, 2025 https://www.medscape.com/viewarticle/do-patients-intermediate-risk-cervical-cancer-need-adjuvant-2025a10006q4?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 What's New in Endometrial Cancer Research? Endometrial Cancer: Molecular Classification, Genetics, When to Rebiopsy, and What's New in the Research Ursula A. Matulonis, MD; Katherine Fuh, MD, PhD https://www.medscape.com/viewarticle/1001980?ecd=mkm_ret_250329_mscpmrk_onc-gyno_etid7324513&uac=148436CN&impID=7324513 March 12, 2025

Why is this startup growing synthetic brains from urine? By Zachy Hennessey March 25, Updated March 27

Why is this startup growing synthetic brains from urine? Itay&Beyond grows brain tissue from patient urine stem cells to test neurological drugs, training the chips via video games to detect autism and other brain disorders. https://www.israel21c.org/why-is-this-startup-growing-synthetic-brains-from-urine/

Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D)

https://www.fda.gov/about-fda/accelerating-rare-disease-cures-arc-program/learning-and-education-advance-and-empower-rare-disease-drug-developers-leader-3d?utm_medium=email&utm_source=govdelivery Now Available: Two LEADER 3D Videos on Understanding the Importance of Endpoints and Considerations for Collecting and Using Natural History Data The CDER ARC Program’s Learning and Education to ADvance and Empower Rare Disease Drug Developers (LEADER 3D) initiative published two new videos titled “Understanding the Importance of Endpoints in Rare Disease Drug Development” and “Considerations for Collecting and Using Natural History Study Data that are Fit for Use in the Regulatory Setting” to the educational video series. The videos provide an overview of important considerations for selecting endpoints when designing clinical trials, and concepts to consider when determining how to leverage natural history study data in rare disease drug development programs.

FDA Approves First Treatment for C3 Glomerulopathy

Mar 25, 2025| Autoimmune / Autoinflammatory Disorders, Kidney And Urinary Diseases, Regulations, Treatment FDA Approves First Treatment for C3 Glomerulopathy The U.S. Food and Drug Administration has approved… https://checkrare.com/

Improved Growth in Children Suffering from Fabry Disease Treated With Agalsidase Beta By: Madaline Spencer| Published on: Mar 11, 2025 +++

Improved Growth in Children Suffering from Fabry Disease Treated With Agalsidase Beta By: Madaline Spencer| Published on: Mar 11, 2025 https://checkrare.com/improved-growth-in-children-suffering-from-fabry-disease-treated-with-agalsidase-beta/ Treatment Comparisons for Left Ventricular Mass Index in Fabry Disease By: Madaline Spencer| Published on: Mar 10, 2025 https://checkrare.com/treatment-comparisons-for-left-ventricular-mass-index-in-fabry-disease/ Five-Year Study Results in Patients With Fabry Disease By: Madaline Spencer| Published on: Feb 26, 2025 https://checkrare.com/five-year-study-results-in-patients-with-fabry-disease/

Watch the DAYBUE® (trofinetide) in Practice Video Series to Hear Expert Insights on the First Treatment for This Rare Disease By: CheckRare Staff | Updated on: Jan 28, 2025

https://checkrare.com/watch-the-daybue-trofinetide-in-practice-video-series-to-hear-expert-insights/ Rett syndrome thought leaders discuss how DAYBUE® (trofinetide), the first and only FDA-approved treatment for Rett syndrome in adults and pediatric patients 2 years of age and older, plays a role in their patients’ treatment plans, while shedding light on their personal experiences with DAYBUE in their practices.[1,2] Watch the entire DAYBUE in Practice video series below to learn about the DAYBUE clinical trial results, gastrointestinal (GI) management strategies, and how DAYBUE plays an important role in comprehensive Rett syndrome care.

Improving Health Equity in Hereditary Angioedema (HAE): A Panel Discussion Aleena Banerji, MD, Timothy Craig, DO, Marc Riedl, MD

https://checkrare.com/improving-health-equity-in-hereditary-angioedema-hae-a-panel-discussion/ Hereditary angioedema (HAE) is a rare genetic disease that results in immunologic attacks that can be life-threatening. HAE is the result of reduced levels of C1-inhibitor, a protein involved in various physiological processes in plasma, most notably with the complement system. This panel discussion by three clinical research leaders in HAE, Drs. Aleena Banerji, Timothy Craig, and Marc Riedl, provide an overview of the discrepancies in care observed in certain patient populations, as well as a discussion on best practices to reduce those inequalities moving forward.

lunes, 24 de marzo de 2025

Kids with Down syndrome can live 'abundant lives,' dad tells Fox News contributor Fox News contributor Tom Shillue speaks to the dad of a child with Down syndrome on World Down Syndrome Day Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News Published March 21, 2025 2:43pm EDT

Kids with Down syndrome can live 'abundant lives,' dad tells Fox News contributor Fox News contributor Tom Shillue speaks to the dad of a child with Down syndrome on World Down Syndrome Day Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News Published March 21, 2025 2:43pm EDT https://www.foxnews.com/health/kids-down-syndrome-can-live-abundant-lives-dad-tells-fox-news-contributor

Tennessee reports first measles case amid U.S. outbreak According to the Tennessee Department of Health, the Volunteer State has recorded its first case of measles this year amid a nationwide outbreak Peter D'Abrosca By Peter D'Abrosca Fox News Published March 23, 2025 5:29pm EDT

Tennessee reports first measles case amid U.S. outbreak According to the Tennessee Department of Health, the Volunteer State has recorded its first case of measles this year amid a nationwide outbreak Peter D'Abrosca By Peter D'Abrosca Fox News Published March 23, 2025 5:29pm EDT https://www.foxnews.com/health/tennessee-reports-first-measles-case-amid-u-s-outbreak

Diabetes breakthrough: Chinese trial paves way for insulin-free future In a groundbreaking treatment, insulin-producing cells sourced from a young woman's own body were successfully implanted, effectively eliminating the need for daily injections Daniel Khaykelson/Davidson Institute of Science|Yesterday | 18:11

Diabetes breakthrough: Chinese trial paves way for insulin-free future In a groundbreaking treatment, insulin-producing cells sourced from a young woman's own body were successfully implanted, effectively eliminating the need for daily injections Daniel Khaykelson/Davidson Institute of Science|Yesterday | 18:11 https://www.ynetnews.com/health_science/article/bkn8jp62je

‘Out of breaking points comes opportunity’: Israel maps mental health tech boom After October 7, Israel sees a mental health tech boom: 117 startups tackling trauma, resilience with AI, self-care and automation; Collaboration, funding and policy changes are crucial to accelerate healing, say experts Maayan Hoffman/The Media Line|07:27

‘Out of breaking points comes opportunity’: Israel maps mental health tech boom After October 7, Israel sees a mental health tech boom: 117 startups tackling trauma, resilience with AI, self-care and automation; Collaboration, funding and policy changes are crucial to accelerate healing, say experts Maayan Hoffman/The Media Line|07:27 https://www.ynetnews.com/health_science/article/sy00ndian1x

UP IN SMOKE: THE IMPACT OF WILDFIRES ON LITTLE LUNGS

Up In Smoke: The Impact of Wildfires on Little Lungs By Ivanhoe Broadcast News on March 29, 2025 https://www.ivanhoe.com/?p=35200&preview=1&_ppp=8f05e4d928

REFRIGERATOR RULES: WHAT TURNS TOXIC AND WHAT WON’T?

Refrigerator Rules: What Turns Toxic And What Won’t? By Ivanhoe Broadcast News on March 28, 2025 https://www.ivanhoe.com/?p=35220&preview=1&_ppp=4ec4ab5ded

FIVE STARS OR FAKE: SPOTTING DECEPTIVE ONLINE REVIEWS

Five Stars Or Fake: Spotting Deceptive Online Reviews By Ivanhoe Broadcast News on March 25, 2025 https://www.ivanhoe.com/?p=35211&preview=1&_ppp=a17eeba00c

IT’S A SPRING THING: CLEAN UP YOUR LIFE TO LIVE LONGER

It’s A Spring Thing: Clean Up Your Life To Live Longer By Ivanhoe Broadcast News on March 24, 2025 https://www.ivanhoe.com/?p=35208&preview=1&_ppp=c464d723da

Rare Diseases: Betting on the pharma package for timely and equitable access, still awaiting an EU Action Plan

https://www.euractiv.com/section/health-consumers/news/rare-diseases-betting-on-the-pharma-package-for-timely-and-equitable-access-still-awaiting-an-eu-action-plan/ In this recent Euractiv article, Valentina Bottarelli, our Head of Policy and Public Affairs, called for a European Action Plan for Rare Diseases to unify existing efforts and create a coherent strategy that ensures health equity, faster diagnoses, and better access to treatments. She also elaborated on the ongoing reforms to the EU's pharmaceutical legislation and their centrality to strengthening patient engagement, securing medicine supply, and fostering innovation.

Podcast: Rare on Air

https://www.eurordis.org/rare-on-air/ Rare on Air Stories Don't forget to listen to our bonus podcast series marking Rare Disease Day! Hosted by Julien Poulain, the Rare on Air Stories series presents the striking personal stories of individuals living with a rare disease across the globe. From Australia to Mexico, Nepal to Nigeria and the U.S. to the U.K., each episode shares deeply moving personal experiences. Listen now to our latest episode, where we follow the journey of Noah from the United States! Listen to the podcast by subscribing to Spotify, Apple Podcasts, Amazon Music, or YouTube.

39th Workshop of the EURORDIS Round Table of Companies (ERTC): Addressing systemic inequalities through patient-driven innovation & research

https://www.eurordis.org/39th-ertc/ ERTC Workshop Last month, our 39th EURORDIS Round Table of Companies (ERTC) Workshop in Brussels focused on patient-driven innovation to address systemic health inequalities. The workshop focused on integrating patients' priorities into future EU research policies and funding. The discussions explored the need to enhance clinical trials, leveraging public-private investments, corroborating healthcare systems, and promoting fairness in newborn screening.

EURORDIS Membership Meeting (EMM) 2025 March 2025

https://www.eurordis.org/eurordis-membership-meeting-emm-2025/ This year’s EURORDIS Membership Meeting will be held in Riga, Latvia, on 22-24 May. This event represents an invaluable opportunity for the members of the rare disease community to meet while sharing knowledge and building partnerships. Participants will explore topics such as advocacy at national and EU levels, volunteer involvement in healthcare, and leveraging Rare Barometer findings for advocacy. https://www.eurordis.org/rare-barometer/english/

SANT launches public consultation on rare diseases

https://www.europarl.europa.eu/news/en/press-room/20250227IPR27074/sant-launches-public-consultation-on-rare-diseases The European Parliament Committee on Public Health (SANT) has opened a public Consultation on Rare Diseases to identify the challenges faced by those living with a rare disease and the potential EU actions to address them. With SANT now a fully-fledged parliamentary committee, the consultation presents a key moment to advocate for better funding, cooperation, and recognition of our community's unmet needs. EURORDIS' response highlights policy priorities, and you can submit your own response by 31 March! For questions or feedback, contact valentina.bottarelli@eurordis.org. Have your say: Help shape the future of rare disease policy in Europe The European Parliament’s Committee on Public Health (SANT), newly established as a fully-fledged committee, is responsible for shaping EU policies on healthcare, pharmaceutical legislation, and public health. It has now launched a Consultation on Rare Diseases, seeking input from patients, caregivers, researchers, healthcare professionals, and organisations working in the field. https://www.eurordis.org/publications/eurordis-submission-sant-consultation/

Decreasing the invasiveness of deep brain stimulation

Decreasing the invasiveness of deep brain stimulation: Researchers are developing a preclinical method to stimulate the brain without drilling into the skull by guiding a catheter through the cerebrospinal fluid. Deep brain stimulation—the application of electricity to specific deep brain regions to modulate their function—has been used clinically for over 25 years. This technique is used to monitor and treat neurological conditions, especially movement disorders, such as Parkinson’s disease and epilepsy. Yet many of these interfaces are highly invasive, as they require removing part of the skull to implant electrodes in the brain. Finding a way to monitor and stimulate the central nervous system in a less intrusive way has been a holy grail for those in the neuromodulation field. Now, a collaborative team of NIH-funded researchers at Rice University and The University of Texas are developing a method to access and stimulate deep brain regions without drilling into the skull. They engineered a tiny pulse generator that can be implanted in the spine following a lumbar puncture. This pulse generator is connected to a stimulating catheter, which can be guided through the cerebrospinal fluid to the surface of the brain. After preliminary experiments in human cadavers, the team successfully used the device to record and stimulate brain activity in sheep with the aid of a wireless interface. Their work was recently published in Nature Biomedical Engineering.

Seasonal Allergies at a Glance

https://www.nccih.nih.gov/health/seasonal-allergies-at-a-glance?nav=govd As spring approaches, seasonal allergic rhinitis—also called hay fever—becomes a problem for some people. Symptoms may include sneezing, coughing, a runny or stuffy nose, and itching in the eyes, nose, mouth, and throat. Many complementary health approaches have been studied for allergic rhinitis, and there’s evidence that a few may help. Rinsing the sinuses with a neti pot (a device that comes from the Ayurvedic tradition) or other devices may be a useful addition to conventional treatment for seasonal allergies. Make sure to use only distilled, sterile, or boiled and cooled water; tap water may not be safe for use as a nasal rinse. There’s evidence that acupuncture may be helpful for seasonal allergy symptoms. Some studies of probiotics for allergies have had promising results, but others have not. It’s possible that only some types of probiotics are helpful.

Withdrawal of life sustaining therapies in patients with or without acute brain injury +++

COMMENTS Withdrawal of life sustaining therapies in patients with or without acute brain injury Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00008-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz--rQN6km016zetaUjkoDznhldhX3grKw1VNNzDreQ25CnzsSWHhX25e-wN4Twkwf9ejc7mPjv2aGMqaNhhRh3GplxcJMQ&_hsmi=352808851&utm_content=352808851&utm_source=hs_email Preoxygenation for tracheal intubation in adults who are critically ill: time to abandon the facemask? Free with registration https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00056-6/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-9FptrEp4QRM1yekX7fB2o1JwzC59KdPyEtMt0qhIDwd-xO3Rb6OKrWDWAkiWNXISUvnyQUyCg7YvGs_NrOzHPb5PDb6Q&_hsmi=352808851&utm_content=352808851&utm_source=hs_email Nasal high-flow oxygen for apnoeic oxygenation during emergency endotracheal intubation of children Free with registration until Mar 29, 2025 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00085-2/abstract?utm_campaign=conferencealerts&utm_medium=email&dgcid=hubspot_email_conferencealerts_isicem25&_hsenc=p2ANqtz-8ysi4xFSEa7P680VqjRTHyMLr8p9fBZqqTjhXgC9ZiPAH_53o6OX9XPklbv0LTgdritcdmAixx-rG-DpySoqeTCVXycA&_hsmi=352808851&utm_content=352808851&utm_source=hs_email

Precision T-Cell Therapy Improves Blood Cancer Outcomes Edited by Susan Ruel, PhD March 21, 2025 +++++

Precision T-Cell Therapy Improves Blood Cancer Outcomes Edited by Susan Ruel, PhD March 21, 2025 https://www.medscape.com/viewarticle/precision-t-cell-therapy-improves-blood-cancer-outcomes-2025a10006rv 3D Total Body Photography Shown to Decrease Biopsies, Improve Dx of Nonmelanoma Skin Cancers Richard Mark Kirkner March 21, 2025 https://www.medscape.com/viewarticle/3d-total-body-photography-shown-decrease-biopsies-improve-dx-2025a10006r7 CA-125 Shows Less Accuracy in Black and American Indian Patients with Ovarian Cancer Edited by Katie Lennon March 21, 2025 https://www.medscape.com/viewarticle/ca-125-shows-less-accuracy-black-and-american-indian-2025a10006rk Do Patients With Intermediate-Risk Cervical Cancer Need Adjuvant Chemotherapy? Whitney McKnight March 20, 2025 https://www.medscape.com/viewarticle/do-patients-intermediate-risk-cervical-cancer-need-adjuvant-2025a10006q4 Can Adjuvant Immunotherapy Boost Survival Outcomes in Advanced Nasopharyngeal Cancer? Edited by Gargi Mukherjee March 20, 2025 https://www.medscape.com/viewarticle/can-adjuvant-immunotherapy-boost-survival-outcomes-advanced-2025a10006o6

Encapsulation of a Single-Stranded Form of DNA Impurities into the Capsid of a Recombinant Adeno-Associated Virus

https://www.liebertpub.com/doi/10.1089/hum.2024.264?utm_campaign=MAL_HUM&utm_medium=email&_hsenc=p2ANqtz-8iXI7dSloS6J_pZvH0Om8Np3gdmU7z_JfPtlgF9Df1-IsCiO8RmrWHSt89dd8QhGuOUGtewNJF1u_wWkpOb2ZtWaNEWA&_hsmi=352880154&utm_content=352880154&utm_source=hs_email Evaluating DNA Impurities in Recombinant Adeno-Associated Virus New Rochelle, NY, March 20, 2025—A new study in the peer-reviewed journal Human Gene Therapy indicates that DNA impurities derived from plasmid and host cell DNA are encapsulated into recombinant adeno-associated virus (rAAV) capsids as single-stranded DNA. Click here to read the article now. rAAVs are widely used viral vectors in human gene therapy, but contamination from DNA impurities, such as plasmid and host cell DNA, remains a significant quality control concern for their manufacture. In this study, Kazuhisa Uchida, from Kobe University, and coauthors examined several purifies rAAV samples and found that they contained DNA derived from three plasmids. They determined that the impurities were encapsulated into the rAAV capsids as single-stranded DNA. The investigators suggest that when rAAVs are used in gene therapy, the adverse effects of the single-stranded form of DNA impurities may differ from those of double-stranded DNA. “It may be necessary to reconsider or evaluate the effects of single-strand form of DNA impurities independently,” stated the investigators. “Studies like this are incredibly important to better understand how DNA impurities are generated and what sources they come from during the production process in order to improve the efficiency of manufacturing and purity of the final rAAV product, which will help make the therapy more effective and reduce adverse events for patients,” says Managing Editor of Human Gene Therapy Thomas Gallagher, PhD, from the University of Massachusetts Chan Medical School.

FDA approves first treatment for adults with complement 3 glomerulopathy, a rare kidney disease, to reduce proteinuria

https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-first-treatment-adults-complement-3-glomerulopathy-rare-kidney-disease-reduce?utm_medium=email&utm_source=govdelivery FDA Approves First Treatment for Adults with Complement 3 Glomerulopathy, a Rare Kidney Disease, to Reduce Proteinuria FDA approved Fabhalta (iptacopan) for the treatment of adults with complement 3 glomerulopathy (C3G) to reduce proteinuria. Fabhalta is an oral capsule, taken twice daily. Recommended dosing is available in the prescribing information. C3G is a rare disease that causes inflammation and damage to the kidney glomeruli, which are responsible for filtering blood and producing urine. In C3G, the complement system (proteins in the blood that play a critical role in the immune system) becomes abnormally activated. Complement products can become lodged in the glomeruli causing them to become leaky and harming their ability to filter blood. Waste products and toxins then build up in the blood, which decreases the kidneys’ ability to balance salts and minerals, decreases urine production, and causes continued kidney damage. Fabhalta increases the risk of serious and life-threatening infections caused by encapsulated bacteria, including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b. Patients should complete or update vaccination for encapsulated bacteria at least 2 weeks before the first dose of Fabhalta, unless the risks of delaying treatment outweigh the risks of developing a serious infection. Health care providers should monitor patients for early signs and symptoms of serious infections and evaluate immediately if infection is suspected. Fabhalta may increase total cholesterol, LDL-cholesterol, and serum triglycerides. Health care providers should monitor patients’ serum lipid parameters periodically during treatment with Fabhalta and initiate cholesterol-lowering medication, if indicated. Fabhalta is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS). The most common adverse reactions (reported in at least 10% of patients) to Fabhalta were nasopharyngitis (common cold) and viral infections.

Study Illuminates the Structural Features of Memory Formation at the Cellular and Subcellular Levels NIH-funded study uses cutting-edge imaging techniques to reconstruct features underlying learning and memory in the mouse brain March 20, 2025 • Media Advisory

https://www.nimh.nih.gov/news/science-updates/2025/study-illuminates-the-structural-features-of-memory-formation-at-the-cellular-and-subcellular-levels In a recent study funded by the National Institutes of Health (NIH), researchers shed new light on memory encoding. The researchers exposed mice to a conditioning task and examined their hippocampus about one week later using cutting-edge technology such as 3-D electron microscopy and artificial intelligence. Researchers discovered that neurons involved in memory formation were not preferentially connected. They also found that these neurons reorganized their connections through an atypical connection called a multi-synaptic bouton. This study sheds new light on the fundamentally flexible nature of memory encoding and raises new questions and ideas for future exploration. Read More Study Findings

Mother with rare ALS touts 'miracle drug' that has stopped her disease Since starting a clinical trial more than 7 years ago, Raziel Green says her symptoms have not gotten any worse Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 5:00am EDT

Mother with rare ALS touts 'miracle drug' that has stopped her disease Since starting a clinical trial more than 7 years ago, Raziel Green says her symptoms have not gotten any worse Melissa Rudy By Melissa Rudy Fox News Published March 18, 2025 5:00am EDT https://www.foxnews.com/health/mother-rare-als-touts-miracle-drug-has-stopped-her-disease

A new vaccine is here to protect you and your loved ones from RSV this winter FDA approved a new vaccine for older adults and expanded approval for others

https://magazine.medlineplus.gov/article/a-new-vaccine-is-here-to-protect-you-and-your-loved-ones-from-rsv-this-winter December and January are peak months for respiratory syncytial virus (RSV) infections. While anyone can get RSV, severe infections are more common in young children and older adults. Fortunately, new vaccine approvals by the U.S. Food and Drug Administration (FDA) mean there are more options to avoid getting sick this winter.

Parkinson’s disease explained What you need to know about this movement disorder

https://magazine.medlineplus.gov/article/parkinsons-disease-explained/ Parkinson's disease (PD) is a progressive movement disorder of the nervous system. PD is one of the most common nervous system disorders, especially among older adults. It’s estimated to affect between 500,000 and 1 million Americans.