Aporte a la rutina de la trinchera asistencial donde los conocimientos se funden con las demandas de los pacientes, sus necesidades y las esperanzas de permanecer en la gracia de la SALUD.
domingo, 30 de junio de 2024
CHILL OUT! MONEY-SAVING TIPS FOR BEATING THE HEAT THIS SUMMER
Chill Out! Money-Saving Tips to Beat the Heat This Summer
By Ivanhoe Broadcast News on June 29, 2024
https://www.ivanhoe.com/smart-living/chill-out-money-saving-tips-to-beat-the-heat-this-summer/
“HEALTHY” KIDS’ FOODS THAT ARE NOT HEALTHY
“Healthy” Kids’ Foods That Are Not Healthy
By Ivanhoe Broadcast News on June 30, 2024
https://www.ivanhoe.com/smart-living/healthy-kids-foods-that-are-not-healthy/
TRAINING BRAIN CELLS TO STOP EPILEPTIC SEIZURES
Training Brain Cells to Stop Epilepsy
By Ivanhoe Broadcast News on June 27, 2024
https://www.ivanhoe.com/medical-breakthroughs/training-brain-cells-to-stop-epilepsy/
RELEARNING THE ART OF SWALLOWING
Relearning the Art of Swallowing
By Ivanhoe Broadcast News on June 28, 2024
https://www.ivanhoe.com/medical-breakthroughs/relearning-the-art-of-swallowing/
BUSTING FOOD MYTHS
Busting Food Myths
By Ivanhoe Broadcast News on July 7, 2024
https://www.ivanhoe.com/?p=33621&preview=1&_ppp=434aa7a261
LOWER BLOOD PRESSURE NATURALLY
Lower Blood Pressure Naturally
By Ivanhoe Broadcast News on July 6, 2024
https://www.ivanhoe.com/?p=33618&preview=1&_ppp=00023e09d9
HOW TO COPE WITH CANCER AS A COUPLE
How to Cope with Cancer as a Couple
By Ivanhoe Broadcast News on July 6, 2024
https://www.ivanhoe.com/?p=33615&preview=1&_ppp=3d05a4d6c9
REVOLUTIONARY CELLULAR THERAPY FOR MELANOMA
Melanoma: Revolutionary Cellular Therapy
By Ivanhoe Broadcast News on July 5, 2024
https://www.ivanhoe.com/?p=33612&preview=1&_ppp=f99e4b02b2
PLASTICS ARE EVERYWHERE AND POSE A REAL THREAT TO OUR HEALTH
Plastics Are Everywhere and Pose a Real Threat to Our Health
By Ivanhoe Broadcast News on July 4, 2024
https://www.ivanhoe.com/?p=33609&preview=1&_ppp=bcc872ab43
SILENCING THE SOUNDS: BREAKTHROUGH TINNITUS TREATMENT
Breakthrough Tinnitus Treatment
By Ivanhoe Broadcast News on July 3, 2024
https://www.ivanhoe.com/?p=33606&preview=1&_ppp=fe99bb8c87
LISTEN UP! RECOGNIZE AND AVOID HEARING HAZARDS
Listen Up! Recognize And Avoid Hearing Hazards
By Ivanhoe Broadcast News on July 2, 2024
https://www.ivanhoe.com/?p=33603&preview=1&_ppp=29cd8035cd
CAN YOU HEAR ME NOW? EARLENS FOR YOUR HEARING
Earlens For Your Hearing
By Ivanhoe Broadcast News on July 1, 2024
https://www.ivanhoe.com/?p=33600&preview=1&_ppp=2e18853441
The Lancet Psychiatry Commission on Transforming Mental Health Implementation Research
Executive Summary
Effective approaches exist to prevent and treat mental illness and to promote mental health but most people who could benefit from evidence-based interventions (policies, programmes, and individual-level practices or services) do not receive them. Too often, research produces interventions and implementation strategies that are difficult to scale owing to misalignment with the political, cultural, policy, system, community, provider, and individual realities of real-world settings. This Commission considers strategies for transforming how research is done to produce more actionable evidence. It examines how to integrate research and real-world implementation; centre equity in mental health intervention and implementation research; apply a complexity science lens to mental health research; expand designs beyond the randomised clinical trial; and value transdisciplinarity across endeavours. Most mental health implementation research has been done in high-income countries but the Commission’s recommendations incorporate research from low-income and middle-income countries and call for strategies to expand mental health implementation research globally.
https://www.thelancet.com/commissions/implementation-mental-health?dgcid=hubspot_email_infocusalerts-psychiatry_feature_lanpsymentalhealthresearch24&utm_campaign=infocusalerts-psychiatry&utm_medium=email&_hsenc=p2ANqtz-9WLFs2dATjYkFL5_u4BUK0GCuF_oHdSoYwTlkf85jE9YIPV0e2GIzAi_Ei0zN2v6f24hOKR-3Z4FjzRBCjXKxNLNZyJQ&_hsmi=313766710&utm_content=312437395&utm_source=hs_email
sábado, 29 de junio de 2024
In the News: Magnesium Supplements for Sleep Disorders
https://www.nccih.nih.gov/health/in-the-news-magnesium-supplements-for-sleep-disorders?nav=govd
There’s been much discussion lately about the possibility that magnesium supplements may improve sleep. However, very little research has been done on the effects of these supplements on insomnia and other sleep disorders. There isn’t enough rigorous scientific evidence to show whether magnesium is effective.
If you take magnesium supplements, avoid taking more than the upper limit. Too much magnesium can cause diarrhea, nausea, and cramping.
Can magnesium be harmful?
https://ods.od.nih.gov/factsheets/Magnesium-Consumer/#h12
Safety and efficacy of stent retrievers plus contact aspiration in patients with acute ischaemic anterior circulation stroke and positive susceptibility vessel sign in France (VECTOR): a randomised, single-blind trial
The Lancet NeurologyVol. 23No. 7p700–711
https://www.thelancet.com/collections/neurology?dgcid=hubspot_email_infocusalerts-neurology_feature&parent=001585&startPage=&ContentItemType=fla&utm_campaign=infocusalerts-neurology&utm_medium=email&_hsenc=p2ANqtz-_AcZTamZrq_87RNDeYElFY9uqbs7S6YycaWoFqdAfN-_8D2Q38AJM3VfbX2_TodH_z9M9yANyBE6x6vRpbr6A5WFJSHQ&_hsmi=313683249&utm_content=312436856&utm_source=hs_email
Published: July, 2024
viernes, 28 de junio de 2024
Neural Mechanism of Encoding Familiar Faces
https://www.tsukuba.ac.jp/en/research-news/20240611140000.html
Researchers at University of Tsukuba demonstrated that faces of familiar individuals with whom one has frequent social interactions with are learned in the basal ganglia region (specifically the tail part of the striatum) through the same neural mechanisms that recognize the value of objects.
The robots making cell therapies | Drug Discovery News
The robots making cell therapies | Drug Discovery News: Scientists and engineers teamed up to use robots to streamline cell therapy manufacturing, aiming to give more patients access to these lifesaving therapies.
Engineering bacteria for drug delivery | Drug Discovery News
Engineering bacteria for drug delivery | Drug Discovery News: Researchers investigated the feasibility of microbiome-based drug delivery as a longer-lasting alternative to current topical formulations.
Breast cancer cells adapt to survive despite starvation | Drug Discovery News
Breast cancer cells adapt to survive despite starvation | Drug Discovery News: The extracellular matrix provides breast cancer cells vital amino acids that allow the cells to grow and thrive when nutrients are scarce.
The path to treating Parkinson’s disease begins in the gut | Drug Discovery News
The path to treating Parkinson’s disease begins in the gut | Drug Discovery News: New research is unraveling the connection between the gut microbiome and Parkinson’s disease, revealing potential gut-targeted therapeutic strategies.
Musical medicine for Parkinson’s disease | Drug Discovery News
Musical medicine for Parkinson’s disease | Drug Discovery News: By measuring neural oscillations in the brain, Isabelle Buard studies the effect of music therapy on improving fine motor movements in neurological disorders.
An mRNA-degrading strategy attacks the root of Parkinson’s disease | Drug Discovery News
An mRNA-degrading strategy attacks the root of Parkinson’s disease | Drug Discovery News: Targeting α-synuclein mRNA before it had a chance to aggregate reduced its protein levels in cultured dopaminergic neurons and may protect neurons.
Autism and Complementary Health Approaches
https://www.nccih.nih.gov/health/autism?nav=govd
Many individuals with autism and their families use complementary health approaches, often along with conventional medical care, to address concerns and improve their health and well-being.
A variety of complementary approaches—such as animal-assisted therapy, arts-based therapies, yoga, acupuncture, massage therapy, and exercise-based therapies, may be helpful in treating hypersensitivity, reducing anxiety, and improving social skills and mental health in people with autism.
Low doses of melatonin may help with sleep problems in people with autism. Children with autism generally tolerate pediatric-appropriate prolonged-release melatonin well.
There’s no scientific evidence that secretin, hyperbaric oxygen, chelation therapies, or antifungal agents can help people with autism.
6 Tips: Psychological and Physical Practices for Older Adults
https://www.nccih.nih.gov/health/tips/psychological-and-physical-practices-for-older-adults?nav=govd
Psychological and physical practices, including relaxation techniques and meditative exercise forms such as yoga, tai chi, and qigong, are widely used by older Americans. Research shows that these approaches may be helpful for some health conditions common among older people.
Aerobic exercise, strength training, tai chi, and other nondrug approaches may be helpful for osteoarthritis symptoms.
Tai chi and qigong may reduce the risk of falling in older adults.
Meditative exercise programs such as tai chi, qigong, and yoga may modestly enhance cognitive function in older adults without cognitive impairment.
Five virtual resources to explore on PTSD Screening Day Access PTSD virtual support tools
https://news.va.gov/132587/five-virtual-resources-on-ptsd-screening-day/
June 27 is PTSD Screening Day. VA encourages Veterans to get screened for posttraumatic stress disorder (PTSD) any time they experience symptoms that could be related to PTSD and seek treatment if needed.
New Funding Opportunity To Advance the Field of Whole Person Research Director’s Page Helene M. Langevin, M.D.
https://www.nccih.nih.gov/about/offices/od/director/past-messages/new-funding-opportunity-to-advance-the-field-of-whole-person-research?nav=govd
Director's Message from Helene M. Langevin, M.D.
June 20, 2024
I’m proud to share that the National Center for Complementary and Integrative Health (NCCIH) has just announced a new funding opportunity under the National Institutes of Health (NIH) Whole Person Initiative that will transform our ability to conduct whole person research. NCCIH, along with 14 other Institutes, Centers, and Offices at NIH, is seeking applications to establish a Whole Person Research and Coordination Center (Whole Person RCC) that will provide the necessary infrastructure to help researchers explore how our bodies’ different systems interact with one another.
https://www.nccih.nih.gov/grants/whole-person-research-and-coordination-center
Transcranial Focused Ultrasound Improves the Performance of a Noninvasive Brain-Computer Interface
https://www.nccih.nih.gov/research/research-results/transcranial-focused-ultrasound-improves-the-performance-of-a-noninvasive-brain-computer-interface?nav=govd
In a new study from Carnegie Mellon University, volunteers’ ability to type letters with their minds using a noninvasive brain-computer interface increased in response to ultrasound stimulation of a brain area associated with visual motion processing. This research, which was partly funded by the National Center for Complementary and Integrative Health and is part of the National Institutes of Health Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, was published in the journal Nature Communications.
jueves, 27 de junio de 2024
NIH Statement on Preliminary Efficacy Results of Twice-Yearly Lenacapavir for HIV Prevention in Cisgender Women
https://www.niaid.nih.gov/news-events/nih-statement-preliminary-efficacy-results-twice-yearly-lenacapavir-hiv-prevention?utm_campaign=+61149283&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
NIAID applauds the top-line Phase 3 findings of twice-yearly lenacapavir for HIV pre-exposure prophylaxis among cisgender women, a population for whom biomedical HIV prevention evidence has been limited to date. The findings build on decades of discovery and translational research and collaboration between public and private sector to steer promising concepts from the laboratory to the clinic. The Institute looks forward to the release of additional data from this pivotal study, as well as the outcomes of companion studies of lenacapavir in other populations.
Increased Risk of Dengue Virus Infections in the United States
https://emergency.cdc.gov/han/2024/han00511.asp?ACSTrackingID=USCDC_511-DM131024&ACSTrackingLabel=HAN%20511%20-%20General%20Public&deliveryName=USCDC_511-DM131024&utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_5S257_ClSvr0HeuLjEGAPXV450Llr9x90CPCSD8nMMtPX8EjaAIqkRdMI89k4O9ByX8HPKTKXp1pyWRHcR9fOAp5FQg&_hsmi=313187806&utm_content=313187806&utm_source=hs_email
CDC issues warning on higher risk of dengue virus in the U.S.
There’s an increased risk of contracting dengue virus in the U.S. this year, the CDC announced yesterday in a health advisory. Countries in North and South America have reported twice as many cases so far this year as in all of 2023. Puerto Rico has declared a public health emergency, with almost 1,500 cases as of Tuesday’s alert. The agency recommends health care providers look out for dengue among people with a fever who have been in areas with high transmission and promote ways to prevent mosquito bites in those areas.
But dengue infections likely aren’t going to be rampant across the continental U.S., STAT’s Helen Branswell told me, though people who travel to places where dengue circulates could be infected. (So far, there have been 745 cases among U.S. travelers.)
Diseases like dengue that are transmitted to humans through vectors like mosquitoes have historically affected few people in the U.S. But as climate change accelerates, the range of these vectors can shift. West Nile, Lyme, and other diseases are also on the rise. So while continental U.S. dwellers probably don’t need to worry right now about dengue-carrying mosquitoes in their backyards, it’s worth thinking about climate change, infectious disease, and how prepared we are for the changes ahead.
West Nile, Lyme, and other diseases are on the rise with climate change. Experts warn the U.S. is not prepared
By Sara Van No
https://www.statnews.com/2023/03/15/climate-change-diseases-west-nile-dengue-lyme/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-93kLfmRrnNE01l6CnQZphCaICQDmW2j2D_UASewiZxC_rasTuJQm4f6QEQXojKSFL9jkrK5-gPYt7nIFanoQqf3fgf9g&_hsmi=313187806&utm_content=313187806&utm_source=hs_email
Safely Soothing Teething Pain in Infants and Children
https://www.fda.gov/consumers/consumer-updates/safely-soothing-teething-pain-infants-and-children?utm_medium=email&utm_source=govdelivery
Teething is a normal experience for infants and children, but it can be painful. Many well-meaning parents and caregivers who want to ease a child’s pain might turn to products that could be harmful.
Soothing children’s gums with prescription or nonprescription medicines containing benzocaine or lidocaine – or homeopathic tablets and other products – might seem like good options. The FDA warns that these products can be dangerous to children and can lead to serious injury, and even death.
Your smile (and mouth) can tell you more than you might think Oral health is important for your overall health and well-being
https://magazine.medlineplus.gov/article/your-smile-and-mouth-can-tell-you-more-than-you-might-think?utm_medium=email&utm_source=govdelivery
While you might not realize it, your mouth plays an important role in your health and well-being. Good oral health is about more than just avoiding cavities. It's about being able to speak, chew, taste, swallow, and express yourself. And having a pain-free mouth allows us to sleep better at night and makes it easier to focus on our everyday routines. A two-way street: Mouth to body and body
More than two decades of NIH research gives answers on a rare disease affecting bones, skin, and the endocrine system Fibrous dysplasia/McCune-Albright Syndrome is genetic with no cureMore than two decades of NIH research gives answers on a rare disease affecting bones, skin, and the endocrine system Fibrous dysplasia/McCune-Albright Syndrome is genetic with no cure
https://magazine.medlineplus.gov/article/more-than-two-decades-of-nih-research-gives-answers-on-a-rare-disease-affecting-bones-skin-and-the-endocrine-system?utm_medium=email&utm_source=govdelivery
Why do patients with fibrous dysplasia/McCune-Albright Syndrome break their bones so easily? Or hit puberty as early as infancy? Or sometimes lose their vision and hearing? Doctors have tried to answer these questions for decades. Twenty-six years ago, researchers at NIH began piecing it together. Today, clinicians have more effective treatments for this rare disease. And patients have more tools to get the help they need. What is fibrous
NIAID Discovery Leads to Novel Probiotic for Eczema Scientists Identified Beneficial Bacteria that Relieve Eczema Symptoms in Adults and Children
https://www.niaid.nih.gov/news-events/niaid-discovery-leads-novel-probiotic-eczema?utm_campaign=+61154383&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
NIAID scientists discovered that bacteria present on healthy skin called Roseomonas mucosa can safely relieve eczema symptoms in adults and children. That research has led to the availability of a novel over-the-counter topical eczema probiotic. Eczema—also known as atopic dermatitis—is a chronic inflammatory skin condition that affects approximately 20% of children and 10% of adults worldwide.
Exploring the Potential of Pharmacies to Increase Access to HIV Testing
https://www.niaid.nih.gov/news-events/exploring-potential-pharmacies-increase-access?utm_campaign=+61162827&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
Today, NIAID joins our community and federal partners to observe the 29th National HIV Testing Day themed “Level up your self-love: check your status.” This day is intended to empower people to access testing, learn their status, and get linked to HIV prevention or treatment services from which they could benefit, depending on their results. Research highlights the critical role pharmacists can play in HIV testing and related services. NIH-funded projects are identifying innovative models to leverage pharmacies for HIV testing, prevention, and care through partnerships between academic institutions and state and local leaders. The outcomes from current and future NIH-funded EHE pharmacy projects are being released through scientific channels to inform policy and practice
Molecular Portrait of Key Driver of Pancreatic Cancer Offers Hope for Continued Treatment Advances Posted on June 27th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/author/dr-monica-m-bertagnolli/
Cancer arises when changes in genes that normally control cell division lead to unchecked growth at the expense of healthy tissues. One of the most common genetic alterations across human cancers—occurring in 95% of pancreatic cancers but also many non-small cell lung cancers, colorectal cancers, and others—is in a gene known as KRAS. While promising new treatments targeting KRAS to shrink cancerous tumors have recently gained approval, less than 40% of pancreatic cancers respond to treatment with KRAS inhibitors for reasons that aren’t well understood.
There’s much more to learn about how KRAS spurs cancer growth—and how KRAS-mutant cancers resist treatment with existing KRAS inhibitors. To address this need, researchers behind two studies in Science have established the most comprehensive molecular portrait yet of the workings of KRAS and how its many downstream impacts may influence outcomes for people with pancreatic cancer. The findings could lead to new treatment approaches, including ways to potentially guide treatment for individuals with pancreatic cancer, the third leading cause of cancer-related death in the U.S.
Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts JAMA Netw Open. 2024;7(6):e2418729. doi:10.1001/jamanetworkopen.2024.18729
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820369?utm_term=062624&utm_campaign=ftm_links&utm_medium=referral&_hsenc=p2ANqtz-9RS1V36tvcjyXfuBjgrVBMF8-bap0I3NK0xCbAv5UhbkRXKoHmobepz-JvP5RDd-j-qClZEAjKGTMkxyDy_invY5ECbw&_hsmi=313371527&utm_source=For_The_Media
Multivitamins don’t lower risk of dying, study says
One in three adults in the U.S. take multivitamins to prevent disease, despite limited evidence on the practice. Adding to the case against daily pills: A study published yesterday in JAMA Network Open showed that multivitamins don’t lower your risk of dying. The study analyzed data from three cohort studies that tracked almost 400,000 participants for nearly 30 years starting in the late 90s.
But hold on — in a supplementary commentary on the studies, three researchers who were not involved note that mortality assessments like this miss some non-life-or-death benefits. Especially for older adults, multivitamins can help delay age-related vision loss and improve memory and cognitive decline. But hold on again — these studies also miss important risks that come with overloading certain micronutrients. All in all, the evidence points to the importance of getting vitamins from real food rather than supplements whenever possible, the commentary authors write. (And if you’re still not convinced, just FYI that the FDA doesn’t even really know what’s in those vitamins on the shelf, anyway.)
June 26, 2024
The Limited Value of Multivitamin Supplements
Neal D. Barnard, MD1,2; Hana Kahleova, MD, PhD2,3; Roxanne Becker, MBChB2
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820375?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8qTa4g8GfOhWN0XCyz_homXgPVTqr176Y45gp_16l_NsKG-_xlFLXI1iBzmZUNZd3k5GsIPDhNjl1rZ1ZQstUQFdb8DQ&_hsmi=313371527&utm_content=313371527&utm_source=hs_email
Daily multivitamins improved the brain function of seniors in a trial — but plenty of questions remain
Jonathan Wosen
By Jonathan Wosen
https://www.statnews.com/2022/09/14/daily-multivitamins-improved-the-brain-function-of-seniors-in-a-trial-but-plenty-of-questions-remain/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_FBNHRElK9gWXrSwi3fWypg08E-9tImGssoJzYfvRmosQaG8dG3WoKiZdWPRBKxwHiYcsWGC0N79NmS6zJLIHqfz3InA&_hsmi=313371527&utm_content=313371527&utm_source=hs_email
The FDA says it’s in the dark about thousands of dietary supplement ingredients
Nicholas Florko
By Nicholas Florko
https://www.statnews.com/2022/05/24/fda-in-the-dark-supplement-ingredients/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8xCl-5DGOUwKZQYi_dEGdx14vee8_s2zg1wFygTIoe1GnhU26uP0nYSuiyMQ80ZjzTIifp87GeFSY3O3Vk0jJ5cu_2pQ&_hsmi=313371527&utm_content=313371527&utm_source=hs_email
WHO warns global health toll of alcohol remains ‘unacceptably high’ Lev Facher By Lev FacherJune 25, 2024
https://www.statnews.com/2024/06/25/alcohol-related-deaths-global-who/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_yaykjkwhX6nAYsA4zZ7Zh2EV1hPuUnBXMA8y3xoaikhu-Y5r6YlLaF899LS6lXiPuGexcTrvsejsh57NqfEmTcAqOMg&_hsmi=313371527&utm_content=313371527&utm_source=hs_email
Think of the last time you had alcohol. How much did you have? Did you have drinks throughout the week, or stacked over the weekend? The pandemic fundamentally changed many people’s relationship to alcohol — between 2019 and 2020, the U.S. saw a 25.5% spike in alcohol-related deaths. Earlier this week, the WHO said that the global health toll of alcohol remains “unacceptably high.”
Three out of six adults in the U.S. don’t drink, but another two are drinking excessively. (Only the last drinks in moderation.) And experts are increasingly worried about these trends, STAT’s Isa Cueto reports. In a new comprehensive report, rich with graphics by our colleague Emory Parker, Isa lays out the patterns of American drinking today alongside the alarming health effects.
By the numbers: America’s alcohol-related health problems are rising fast
Isabella Cueto
J. Emory Parker
By Isabella Cueto and J. Emory Parker June 27, 2024
https://www.statnews.com/2024/06/27/alcohol-related-health-problems-rise/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9IBRcV0RWvCALPV-yb4h4M-ucnDsksM9g2TVTXma4HwYymvJs9lsaNzp6or5_DmC6v-6U77aodaHwihXi1kyoAvz2k0g&_hsmi=313371527&utm_content=313371527&utm_source=hs_email
Driving Innovation in Mental Health Technology Through Small Business Programs NIMH Small Business Innovation Research Team June 20, 2024 •
https://www.nimh.nih.gov/about/director/messages/2024/driving-innovation-in-mental-health-technology-through-small-business-programs?utm_campaign=75&utm_medium=email&utm_source=govd
Did you know that small businesses are often at the forefront of innovative science? These businesses are developing new technologies that push mental health research into the future.
To learn how NIMH supports research led by small businesses, read our latest Director’s Message, guest-written by NIMH’s Small Business Innovation Research Program and Small Business Technology Transfer Program.
Updates on Highly Pathogenic Avian Influenza (HPAI)
https://www.fda.gov/food/alerts-advisories-safety-information/updates-highly-pathogenic-avian-influenza-hpai?utm_medium=email&utm_source=govdelivery
Highly Pathogenic Avian Influenza (HPAI) is a disease that is highly contagious and often deadly in poultry, caused by highly pathogenic avian influenza A (H5) and A (H7) viruses; it is also known as bird or avian flu. HPAI viruses can be transmitted by wild birds to domestic poultry and other bird and animal species. Although bird flu viruses do not normally infect humans, sporadic human infections have occurred. It is important to note that “highly pathogenic” refers to severe impact in birds, not necessarily in humans.
How Breast Cancer Risk Assessment Tools Work
In March 2024, the actress Olivia Munn announced that she had been diagnosed with breast cancer. Ms. Munn also highlighted the role a cancer risk assessment tool played in the process that led to her diagnosis. In this Q&A, Ruth Pfeiffer, Ph.D., and Peter Kraft, Ph.D., of NCI’s Division of Cancer Epidemiology and Genetics discuss how these tools are created and how people can use them to understand and manage their risk.
https://www.cancer.gov/news-events/cancer-currents-blog/2024/understanding-breast-cancer-risk-assessment-tools?cid=eb_govdel
miércoles, 26 de junio de 2024
NIAID Scientists Use Special Antibodies to Discover a Potent Antibody That Neutralizes Influenza A Viruses
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1399960/full?utm_campaign=%2061148053&utm_content&utm_medium=email&utm_source=govdelivery&utm_term
NIAID scientists discovered a new, potent antibody that can neutralize a broad range of influenza type A viruses. The antibody, L5A7, was isolated using a special type of antibody called “anti-idiotypic,” which recognizes desired features on other antibodies. The researchers say the newly discovered antibody could be used to develop improved diagnostics and therapeutics for a broad range of flu viruses. The findings were published in Frontiers in Immunology.
Ask a doctor: ‘Is it ever OK to take someone else’s prescription medication?’ It may be tempting to share meds, but read this carefully first By Erica Lamberg Fox News Published June 24, 2024 7:18pm EDT
Ask a doctor: ‘Is it ever OK to take someone else’s prescription medication?’
It may be tempting to share meds, but read this carefully first
By Erica Lamberg Fox News
Published June 24, 2024 7:18pm EDT
https://www.foxnews.com/health/ask-doctor-ok-take-someone-elses-prescription-medication
Surgeon general declares firearm violence in America a public health crisis Murthy's public health advisory is the first document of its kind produced by the Surgeon General's Office By Timothy H.J. Nerozzi Fox News Published June 25, 2024 8:25am EDT
Surgeon general declares firearm violence in America a public health crisis
Murthy's public health advisory is the first document of its kind produced by the Surgeon General's Office
By Timothy H.J. Nerozzi Fox News
Published June 25, 2024 8:25am EDT
https://www.foxnews.com/health/surgeon-general-declares-firearm-violence-america-public-health-crisis
For diabetes patients, inhaled insulin is shown just as effective as injections and pumps In a study, inhalers achieved target glucose levels with ‘no major concerns,’ doctor says Melissa Rudy By Melissa Rudy Fox News Published June 25, 2024 5:30am EDT
For diabetes patients, inhaled insulin is shown just as effective as injections and pumps
In a study, inhalers achieved target glucose levels with ‘no major concerns,’ doctor says
Melissa Rudy By Melissa Rudy Fox News
Published June 25, 2024 5:30am EDT
https://www.foxnews.com/health/diabetes-patients-inhaled-insulin-shown-just-effective-injections-pumps
New Parkinson's drug could slow or reverse progression of disease, researchers say: 'Big step forward' While results were 'promising,' another doctor cautioned there's still a 'long way to go' Angelica Stabile By Angelica Stabile Fox News Published June 25, 2024 5:04pm EDT
New Parkinson's drug could slow or reverse progression of disease, researchers say: 'Big step forward'
While results were 'promising,' another doctor cautioned there's still a 'long way to go'
Angelica Stabile By Angelica Stabile Fox News
Published June 25, 2024 5:04pm EDT
https://www.foxnews.com/health/new-parkinsons-drug-could-slow-reverse-progression-disease-researchers-step-forward
CDC warns of mosquito-driven virus as cases spike Dengue infections in the Americas this year have more than doubled 2023 totals, the CDC says Greg Norman By Greg Norman Fox News Published June 26, 2024 9:06am EDT
CDC warns of mosquito-driven virus as cases spike
Dengue infections in the Americas this year have more than doubled 2023 totals, the CDC says
Greg Norman By Greg Norman Fox News
Published June 26, 2024 9:06am EDT
https://www.foxnews.com/health/cdc-warns-mosquito-driven-virus-cases-spike
Experts weigh in on the benefits, risks of using castor oil for weight loss 'The first thing that comes to mind is diarrhea,' said one obesity doctor about certain uses of castor oil Angelica Stabile By Angelica Stabile Fox News Published June 22, 2024 8:17am EDT
Experts weigh in on the benefits, risks of using castor oil for weight loss
'The first thing that comes to mind is diarrhea,' said one obesity doctor about certain uses of castor oil
Angelica Stabile By Angelica Stabile Fox News
Published June 22, 2024 8:17am EDT
https://www.foxnews.com/health/experts-weigh-benefits-risks-castor-oil-weight-loss
Ohio woman with epilepsy finds safety with her service dog: ‘Our bond is set in stone’ Service dogs reduced seizures by 31% in people with epilepsy, a study found, as woman shares her happy tale Melissa Rudy By Melissa Rudy Fox News Published June 24, 2024 4:00am EDT
Ohio woman with epilepsy finds safety with her service dog: ‘Our bond is set in stone’
Service dogs reduced seizures by 31% in people with epilepsy, a study found, as woman shares her happy tale
Melissa Rudy By Melissa Rudy Fox News
Published June 24, 2024 4:00am EDT
https://www.foxnews.com/health/woman-epilepsy-finds-safety-service-dog-bond-set-stone
California doctor reveals the 10 big ‘lies’ the medical community is telling patients Physician and professor says he got a ‘wake-up call’ when diagnosed with 4 chronic diseases Melissa Rudy By Melissa Rudy Fox News Published June 26, 2024 4:00am EDT
California doctor reveals the 10 big ‘lies’ the medical community is telling patients
Physician and professor says he got a ‘wake-up call’ when diagnosed with 4 chronic diseases
Melissa Rudy By Melissa Rudy Fox News
Published June 26, 2024 4:00am EDT
https://www.foxnews.com/health/california-doctor-reveals-10-big-lies-medical-community-telling-patients
martes, 25 de junio de 2024
Unseen details of human brain structure revealed
https://www.nih.gov/news-events/nih-research-matters/study-reveals-unseen-details-human-brain-structure
At a Glance
Researchers generated a high-resolution map of all the cells and connections in a single cubic millimeter of the human brain.
The results reveal previously unseen details of brain structure and provide a resource for further studies.
Quick test could help reduce dementia care disparities - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/quick-test-could-help-reduce-dementia-care-disparities
At a Glance
A five-minute, culturally neutral test for cognitive problems improved dementia detection and management in older adults.
The simple tool could help increase access to dementia care for people living throughout the U.S, including in disadvantaged areas.
AI tool predicts response to cancer therapy - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/ai-tool-predicts-response-cancer-therapy
At a Glance
Scientists developed an AI tool that uses routine clinical data to identify cancer patients most likely to respond to immunotherapy drugs called checkpoint inhibitors.
The approach could help guide personalized cancer treatments for patients.
Xylitol may affect cardiovascular health - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/xylitol-may-affect-cardiovascular-health
At a Glance
Higher blood levels of the artificial sweetener xylitol were associated with increased risk of heart attack and stroke in people.
Xylitol enhanced blood clotting in mice and isolated human blood.
The results highlight the need for further study of long-term cardiovascular health risks from sugar alcohols, artificial sweeteners that were thought to be safe.
An alternative to brain surgery for patients with epilepsy | Drug Discovery News
An alternative to brain surgery for patients with epilepsy | Drug Discovery News: A gene therapy targeting excitatory neurons significantly reduced seizures in a mouse model of the most common cause of child epilepsy.
A sex-specific protein panel detects early-stage cancers | Drug Discovery News
A sex-specific protein panel detects early-stage cancers | Drug Discovery News: A limited set of plasma proteins identified 18 solid tumors in all major human organs.
Robotic pills deliver gastrointestinal injections | Drug Discovery News
Robotic pills deliver gastrointestinal injections | Drug Discovery News: Researchers developed ingestible capsules that inject drugs into the stomach and small intestine, providing a novel oral delivery method for biologics.
Meet the microrobots primed to take down cancer | Drug Discovery News
Meet the microrobots primed to take down cancer | Drug Discovery News: Sperm, bacteria, bubbles, and shuttles are just some of the latest cancer-treating microrobots in development for human use in the next few years.
The robots making cell therapies | Drug Discovery News
The robots making cell therapies | Drug Discovery News: Scientists and engineers teamed up to use robots to streamline cell therapy manufacturing, aiming to give more patients access to these lifesaving therapies.
The Lancet Series on Gestational Diabetes
https://www.thelancet.com/infographics-do/gestational-diabetes?dgcid=hubspot_email_conferencealerts_lancetgestdiab24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz--xJPvGfbjY4I30StH7fd4rULJHbOawTs4JFwKmwwhlWvnDeFHV4_kv5upuvte6iL7zayleWkim7xMhoCYlbx-K9tZqkw&_hsmi=312875476&utm_content=312875476&utm_source=hs_email
Gestational Diabetes Mellitus (GDM) is the most common medical pregnancy complication worldwide. Early diagnosis and treatment of GDM is greatly needed to improve the health of both woman and child.
The Lancet Series on gestational diabetes Published: June 20, 2024
https://www.thelancet.com/series/gestational-diabetes?dgcid=hubspot_email_conferencealerts_lancetgestdiab24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_3nGsFCgQ1G0UmRJNSMy3U3i6iBOsKYgNSu09UoJo2thsM5zl4RgL5k_j_ZsQ227Y_sr0Bra4VEX7r_i1oGPW9HGe4wg&_hsmi=312875476&utm_content=312875476&utm_source=hs_email
Gestational diabetes is the most common medical pregnancy complication worldwide, affecting one in seven pregnancies. GDM cases are increasing globally alongside a parallel rise in obesity and diabetes in women of childbearing age. Without treatment, gestational diabetes can lead to high blood pressure, increased risk of Caesarean sections, mental health conditions, and complications for the baby at delivery, alongside health complications later in life for both mother and child, such as type 2 diabetes and cardiovascular disease. A new Series on gestational diabetes published in The Lancet calls for a greater focus on early gestational diabetes and a shift to a holistic life-course approach in how we manage the disease. The Series offers a comprehensive and inclusive analysis of the most current evidence on pathophysiology, screening, management, prevention, and long-term complications for mothers and their babies.
lunes, 24 de junio de 2024
Mimicking insect traits kills fungus | Drug Discovery News
Mimicking insect traits kills fungus | Drug Discovery News: Insect wings contain micropillars that kill harmful microbes. Researchers designed a similar titanium surface to prevent fungal infections on medical devices.
An evolving answer to excess sweating | Drug Discovery News
An evolving answer to excess sweating | Drug Discovery News: The cause of hyperhidrosis, an excessive sweating condition, is enigmatic, but treatment options are plentiful and growing.
A missing Y chromosome gene links to heart failure | Drug Discovery News
A missing Y chromosome gene links to heart failure | Drug Discovery News: Researchers revealed a connection between age-related Y chromosome gene loss and increased heart scarring in men.
Spiny mice hold the key to regenerative wound healing | Drug Discovery News
Spiny mice hold the key to regenerative wound healing | Drug Discovery News: Researchers developed a novel approach for activating neutrophils and boosting anti-tumor immunity.
Why Lykos Therapeutics’ MDMA data had a bad trip | Drug Discovery News
Why Lykos Therapeutics’ MDMA data had a bad trip | Drug Discovery News: An FDA advisory panel voted against recommending the psychedelic MDMA for PTSD, puncturing excitement around the drug’s potential.
Neutrophil backpacks for cancer immunotherapy | Drug Discovery News
Neutrophil backpacks for cancer immunotherapy | Drug Discovery News: Researchers developed a novel approach for activating neutrophils and boosting anti-tumor immunity.
The bacteria-fighting skills of non-antibiotic drugs | Drug Discovery News
The bacteria-fighting skills of non-antibiotic drugs | Drug Discovery News: Researchers identified existing medications that target novel pathways in E. coli, offering a potential solution to the growing antibiotic resistance threat.
Stem cell therapy for macular degeneration | Drug Discovery News
Stem cell therapy for macular degeneration | Drug Discovery News: Age-related macular degeneration is the most common cause of vision loss in adults over age 50, but there are few treatments available. Researchers are now developing promising stem cell therapies to treat the disease.
CAR T cells attack fungal infections | Drug Discovery News
CAR T cells attack fungal infections | Drug Discovery News: Mycologists programmed immune cells to attack Aspergillus fumigatus, a common infectious species rapidly growing resistant to antifungals.
Kyverna Therapeutics tests CAR T cells for autoimmune disease | Drug Discovery News
Kyverna Therapeutics tests CAR T cells for autoimmune disease | Drug Discovery News: Rheumatologist James Chung leads efforts to expand CAR T cell therapy beyond the oncology field.
H5N1 BIRD FLU H5N1 bird flu update: Stories include the risk of avian flu transmission to humans, what would be needed for wide availability of a H5N1 vaccine, the perils of bird flu virus in raw milk, and scientific concerns about a potential pandemic.
https://www.statnews.com/topic/h5n1-bird-flu/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8HZUcU6pulWDUknFobp_9hPprk6MgfV91GLsJ1xx1lyKE2qm6BVrJd5BE0OiWD2YK4n9F6B729Yy9q1gwmtNstFehxUg&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Bird flu snapshot: three months later
As the H5N1 outbreak in dairy herds approaches the three-month mark, America’s top animal health official is calling on farmers to step up the use of personal protective equipment, limit traffic onto their farms, and increase cleaning and disinfection practices in their barns and milking parlors.
“The more we learn about H5N1, the more we understand that good biosecurity is a critically important path to containing the virus,” U.S. Department of Agriculture Secretary Tom Vilsack wrote in an Agri-Pulse op-ed on Friday. Vilsack’s plea comes at a time when it’s becoming clear that in addition to slow-walking the testing of animals and farmworkers and resisting the use of PPE, the dairy industry is also struggling to effectively separate sick cows and limit their movement. In a recent USDA survey of affected farms, 60% of respondents acknowledged moving animals off the farm after some of their cows started showing bird flu symptoms.
Bird flu snapshot: USDA secretary urges farmers to take protective measures
Megan Molteni
By Megan Molteni June 24, 2024
https://www.statnews.com/2024/06/24/bird-flu-snapshot-usda-secretary/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-87-txzNM6_W-kvIIo5y2AeQz0wyroVCA4QyPF2sIJGGw8824InyswmfJkTB4W_e-19ON8MtKaa7_8Bp7jwqhUjfRr0qg&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
In dribs and drabs, USDA reports suggest containing bird flu outbreak in dairy cows will be challenging
Helen Branswell
By Helen Branswell June 13, 2024
https://www.statnews.com/2024/06/13/h5n1-bird-flu-usda-reports/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-86yblfbBldeV7dpOSgBjxKhk_j3j6fGduQuaEWJ_YEljGjumm4k9vFlKm91RXN6tIQ_3tcv4S_R9cRlxoF48M5jDAwng&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Loneliness, Lack of Social and Emotional Support, and Mental Health Issues — United States, 2022 Katherine V. Bruss, PsyD1; Puja Seth, PhD1; Guixiang Zhao, MD, PhD1
https://www.cdc.gov/mmwr/volumes/73/wr/pdfs/mm7324-H.pdf?ACSTrackingID=USCDC_921-DM130544&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20June%2020%2C%202024&deliveryName=USCDC_921-DM130544&utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_K43CgihC8VH_UX7HVI4i0wBIDpjTjiveQD0NGYiDthQIdRJr9RnVP9VIp01dPDA1TxL0awhDQItlvLyL6VjYf3IwaiQ&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Who is the most lonely, according to the CDC
The CDC recently released a report on loneliness, lack of social and emotional support, and mental health issues. Here are some of the takeaways that struck me most:
It may sound intuitive, but the data show that people who reported loneliness and a lack of social or emotional support were significantly more likely to experience mental health problems, including stress, frequent distress, and depression.
One in three U.S. adults feel lonely, but bisexual and trans adults in particular are nearly twice as likely as their straight and cis peers to report loneliness. These groups also reported the most stress, frequent mental distress, and depression.
People are more likely to be lonely if they’re ages 18 to 34, have less than a high school education, never married, or have a household income below $25,000.
Women are lonelier than men, but it’s more common among men to lack social and emotional support. (Riddle me that, folks.)
‘We’re failing right now’ in type 2 diabetes, FDA chief says Elizabeth Cooney By Elizabeth Cooney June 21, 2024
https://www.statnews.com/2024/06/21/robert-califf-diabetes-type-2-chronic-disease/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--Clmx5K8Xc7JxuvVCaZAh9CeU2s89QYAqH5MVEaPCPZWm83zb00hat6v1FZztJ7TQ8VmmYGt0tf_TLAxEslHRizLzAtA&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
ONE NOTABLE QUOTE
'We’re failing right now.'
That’s FDA Commissioner Robert Califf, speaking about a lack of progress on type 2 diabetes on Friday at the American Diabetes Association conference. He believes that providers are underutilizing options like bariatric surgery and the new obesity drugs for treating an “epidemic” of type 2 diabetes. Califf expressed more hope for the research happening in type 1 diabetes. Read more on Califf’s comments from STAT’s Liz Cooney.
Here are the dozens of weight loss drugs in development to catch a booming market
Elaine Chen
Allison DeAngelis
J. Emory Parker
By Elaine Chen , Allison DeAngelis , and J. Emory Parker
https://www.statnews.com/2023/09/12/new-weight-loss-drug-tracker-novo-nordisk-eli-lilly/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8UKrY8vTzLwdqejKjOmNRcEVV8HI26znkm4qq43-jxvqcCZ8SoqEz_CC-hB2MeaMAunJonuUS47PD4mXQHMm4MUhZ5BQ&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Sept. 12, 2023
What do new weight loss drugs mean for the future of bariatric surgery?
By Simar BajajAug. 28, 2023
https://www.statnews.com/2023/08/28/obesity-bariatric-surgery-new-weight-loss-drugs/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--mMt9BaJ2wdm7yGsY5DDpsXbPbDoBJnptcZkfQOhkAFcbzECEH5vg9Guf0SIcHMOc2NeVtZtrxQuhqWDx43peWSGiuNw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
THE OBESITY REVOLUTION A new generation of obesity drugs is transforming patients’ lives, dividing medical experts, and spurring the biggest business battle in years. Known as GLP-1-based drugs, this medication class could have the medical and societal impact of blockbuste…
https://www.statnews.com/category/the-obesity-revolution/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8GIuqTfDCs8IhICvVtUJjh6GbLp7fYjOkKm8z8qXE_rD7L-3wbJfvcsBIrMwwhS0klvZDeMumN5QczIUUVlyJSlg01yw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
The Aspen Ideas: Health conference took place this weekend, bringing together leaders from around the world. STAT’s Usha Lee McFarling was there and brings us these tidbits:
Of course, no health conference these days is complete without talking about weight loss drugs. Rep. Larry Bucshon (R-Ind.), also a cardiothoracic surgeon, asked if there was data showing long-term health benefits that could curb health care costs and thus convince Congress to push for the expensive drugs to be paid for by CMS, which private insurers would likely follow. “I think these are the most important studies for us to do right now,” said panelist and cardiologist Harlan Krumholz.
New studies suggest GLP-1 health care costs have only begun to climb
Elaine Chen
By Elaine Chen April 24, 2024
https://www.statnews.com/2024/04/24/weight-loss-drugs-to-drive-health-care-spending-reports-show/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--QjEy7vBm6OuIarTmYDKJpHhzoHVchvcEzb-C-TDOiO8rT3H2jhGPXy0T3ZSnkcjtjVJxcRjrA_B_oqi7g5EvvC8LQVw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
What’s the evidence for the surgeon general’s proposed social media warning? Annalisa Merelli By Annalisa Merelli June 17, 2024
https://www.statnews.com/2024/06/17/surgeon-general-social-media-warning-praise-pushback/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8kRcdWIlPN_UMRD0hjU-gQX0nhVO-WT-iZCMvpalM1vkHUBwJ7wZ-HN8TQ9lvrvfT-kBJdA16U7kA2Ux6V8ss0NN-pcA&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
The Aspen Ideas: Health conference took place this weekend, bringing together leaders from around the world. STAT’s Usha Lee McFarling was there and brings us these tidbits:
Sen. John Fetterman (D-Pa.), pictured above on stage in shorts, sneakers, and black Carhartt hoodie, spoke about his mental health struggles, saying that he hears from people daily that his story affected them. “I just want to be the voice I would have wanted to hear,” he said. Fetterman believes that the warning label for social media proposed by Surgeon General Vivek Murthy is a great idea. “If you’re not willing to make it safer … Congress has to force you to do that,” he said.
Director’s Innovation Speaker Series: Beyond the Lab: Navigating Ethical Challenges of Emerging Neurotechnology Date and Time June 25, 2024 2:00–3:00 p.m. ET
https://www.nimh.nih.gov/news/events/announcements/directors-innovation-speaker-series-beyond-the-lab-navigating-ethical-challenges-of-emerging-neurotechnology
NIMH Directors Innovations Series Presents: Beyond the Lab: Navigating Ethical Challenges of Emerging Neurotechnology
Date and Time: June 25, 2024, from 2:00–3:00 p.m. ET
Location: Hybrid
Join us on June 25, 2024, from 2:00–3:00 p.m. ET as Anna Wexler, Ph.D., explores ethical challenges and considerations with expanding neurotechnology from controlled laboratory environments to consumer use.
Dr. Wexler will draw on her research surrounding do-it-yourself, direct-to-consumer, and alternative neurotherapies to highlight the importance of addressing unintended uses of neurotechnology. She will also share insights from her current research efforts about how to guide the ethical development of neurotechnology.
domingo, 23 de junio de 2024
Developing new engineering tools to improve vision loss diagnosis and management, and restore sight
https://engineeringvision.northwestern.edu/
The personal impact of vision loss is immense. The Northwestern University Center for Engineering in Vision and Ophthalmology (CEVO) connects engineering innovations with clinical needs by developing, translating, and disseminating new tools to improve the diagnosis and management of vision loss, and to ultimately restore sight.
sábado, 22 de junio de 2024
Global health for rare diseases through primary care (Posted Jun 21, 2024 8AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=rare&query=home
From the article: " Genetic testing shows promise in diagnosing people with rare diseases, as over 72% of rare diseases have a genetic basis. Next-generation sequencing and other technologies have facilitated the time-effective and cost-effective diagnosis of most genetic diseases, but substantial challenges hinder widespread adoption. The lack of genetic workforce capacity is a global concern, even in high-income countries, with many regions and countries lacking sufficient genetic expertise. The low reimbursement by governments and private insurers for genetic services also poses an additional barrier. The combination of these factors prevent primary care providers from referring people with suspected rare disease to specialists, which delays diagnosis and treatment. "
Genetic Testing for Global Developmental Delay in Early Childhood (Posted Jun 06, 2024 2PM)
From the article: "What are the implications of genetic testing for global developmental delay (GDD) in early childhood? Findings: In this cohort study of 434 children with GDD, a diagnostic positivity rate of 61% was identified when using trio whole exome sequencing combined with copy number variation sequencing. A thorough analysis expanded the scope of indications for genetic testing, and the pathogenesis of GDD was further elucidated using a bioinformatics approach. Meaning: These findings suggest that early use of combined genetic testing for GDD may diminish the misdiagnosis rate, elucidate the etiologic diagnosis, and lay the groundwork for identifying novel early diagnostic biomarkers and intervention targets. "
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=rch&query=home
Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution? (Posted Jun 18, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=HLBS&query=home
From the abstract: "Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed to assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) and the recommended screening criteria in the United Kingdom in identifying individuals with FH-causing variants, presenting a scalable screening criteria for general populations. "
Implications of Provider Specialty, Test Type, and Demographic Factors on Genetic Testing Outcomes for Patients with Autism Spectrum Disorder (Posted Jun 18, 2024 4PM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=nd&query=home
From the abstract: "A minority of patients with autism spectrum disorder (ASD) are offered genetic testing by their providers or referred for genetics evaluation despite published guidelines and consensus statements supporting genetics-informed care for this population. This study aimed to investigate the ordering habits of providers of different specialties and to additionally assess the diagnostic utility of genetic testing by test type, patient sex, and race and ethnicity.
Research biobank participants attitudes towards genetic exceptionalism and health record confidentiality. Victoria Dortenzio et al. J Community Genet 2024 3 (Posted Apr 08, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=fhh&query=home
From the abstract: "The goals of this study were to determine biobank participants’ attitudes towards genetic exceptionalism and confidentiality and whether those attitudes are related to their preference for return of genetic results. An online questionnaire was distributed to patients with an EHR and email address who had previously enrolled in the BioMe Biobank program. Most participants responded with similar levels of concern in scenarios involving the use of genetic information and other types of health information, suggesting that participants want similar protections for genetic data as other types of sensitive health information, particularly mental health and family history records. "
Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores (Posted May 26, 2024 11AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=diabetes&query=home
From the abstract: "Identifying biomarkers of functional ß-cell loss is an important step in the risk stratification of type 1 diabetes. Genetic risk scores (GRS), generated by profiling an array of single nucleotide polymorphisms, are a widely used type 1 diabetes risk-prediction tool. Type 1 diabetes screening studies have relied on a combination of biochemical (autoantibody) and GRS screening methodologies for identifying individuals at high-risk of type 1 diabetes. "
Family communication of cancer genetic test results in an ethnically diverse population: a qualitative exploration of more than 200 patients (Posted Jun 06, 2024 2PM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=cancer&query=home
From the abstract: " Previous research on family communication of cancer genetic test results has primarily focused on non-Hispanic White patients with high-risk pathogenic variants (PV). There are limited data on patient communication of moderate-risk PVs, variants of uncertain significance (VUS), and negative results. This qualitative study examined communication of positive, negative, and VUS hereditary cancer multi-gene panel (MGP) results in an ethnically and socioeconomically diverse population. "
Our Words Have Power—NIAID Embraces Respectful, Inclusive, and Person-First Language
https://www.niaid.nih.gov/news-events/our-words-have-power?utm_campaign=+61086892&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
Our Words Have Power—NIAID Embraces Respectful, Inclusive, and Person-First Language
By Jeanne Marrazzo, M.D., M.P.H., NIAID Director
The power of word choice is obvious every day in my life as a researcher, clinician, colleague, patient, spouse, and friend. Language can inform, delight and inspire, but it can mislead and wound if words are not chosen carefully. At worst, language can invoke stigma, shame, and even violence, all of which undermine NIAID’s mission as part of a health agency. Our institute is responsible not only for advancing scientific knowledge, but for doing so in a way that honors the dignity, individuality, and autonomy of the people affected by the health issues we address. For this reason, I am very proud to share the updated NIAID HIV Language Guide, a thoroughly vetted resource to inform our written and verbal communications. This guide originated as a resource for the HIV field, but respectful, inclusive, and person-first language is essential in all scientific communication. I am committed to following the guide in my communications, and strongly encourage all NIAID staff, funded research networks, sites, centers, investigators, and partners to do the same.
Berberine and Weight Loss: What You Need To Know
https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know?nav=govd
Berberine is a substance found in a variety of plants, including goldenseal, barberry, Oregon grape, and others. Plants containing berberine have a long history of use in both Ayurvedic and Chinese medicine. In modern times, plants containing berberine have been used for infections, skin diseases, digestive disorders, and other conditions. Berberine is currently being studied for its effects on diabetes and risk factors for heart disease. Recently, it has become popular as a potential weight loss aid.
The Lancet Breast Cancer Commission - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
https://www.thelancet.com/infographics-do/breast-cancer-commission-2024?dgcid=hubspot_email_infocusalerts-obgyn_feature_lancetbreastcancer24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-_CVvvXDvPs7h_2m2ZEzg2rBxXEarCgpvqq1iAu97zSAJZ2ymPr4zTjdMyxb8eNRcJ1GujlS_lbhoRny634P4bgkne47A&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
Urgent breast cancer challenges can—and should—be tackled. The Lancet Breast Cancer Commission report shows glaring inequities, with many groups with breast cancer being systematically left behind and forgotten. This is a global blunder.
Obstetrics & Gynaecology - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
Stay up to date in your field with our Obstetrics & Gynaecology Collection. Explore all related content published across The Lancet Group.
https://www.thelancet.com/collections/obstetrics-gynaecology?dgcid=hubspot_email_infocusalerts-obgyn_feature%20&parent=001603&startPage=&ContentItemType=fla&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-92NQMSyPXpaFbipAWDwoWNha196wah6kzECnHXvk53D__u7i6wLkbP4girXKd04npRzmI6maRvnAXg_dYLL-leKoUkKQ&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
Menopause 2024 - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
Menopause is an inevitable life stage for half the world’s population, but experiences vary hugely. Some women have few or no symptoms over the menopause transition while others have severe symptoms that impair their quality of life and may be persistent. Many women feel unsupported as they transition menopause. To better prepare and support women, the Lancet Series on menopause argues for an approach that goes beyond specific treatments to empower women with high-quality information, tools to support decision making, empathic clinical care, and workplace adjustments as needed. Targeted support is needed for groups who experience early menopause or treatment-induced menopause, and for those at increased risk of mental health problems. The authors recognise how gendered ageism may contribute to negative experiences of menopause and call for reduced stigma and greater recognition of the value and contribution of older women.
https://www.thelancet.com/series/menopause-2024?dgcid=hubspot_email_infocusalerts-obgyn_feature_lancetmenopause24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-86TZPWo7pc6pyQ7FmFFRlJQFvNq1LFq0DPDp9S26Nge1ymsN3lh45BtAED6Amo7UpHDzQ2qcoGvegnlfmiCA28TlTpKw&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
FIGO | World Congress of Gynecology and Obstetrics - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
The following content was published by The Lancet Group and presented at the most recent World Congress of Gynecology and Obstetrics.
https://www.thelancet.com/events/conferences/world-congress-gynecology-obstetrics?dgcid=hubspot_email_infocusalerts-obgyn_feature&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz--goGiSXZX0OUcYQr4hwQVRLoyG_fKxV0WUX6iUUGMHEqcm4aSYr9NN7mVG8MlsV-Sjx-i1DPH5n6LhQogrzv_8bxLusg&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
viernes, 21 de junio de 2024
CHASING HAPPINESS: WORLD HAPPINESS REPORT REVEALED
Chasing Happiness: World Happiness Report Revealed
By Ivanhoe Broadcast News on June 30, 2024
https://www.ivanhoe.com/?p=33527&preview=1&_ppp=541cc42d99
“HEALTHY” KIDS’ FOODS THAT ARE NOT HEALTHY
“Healthy” Kids’ Foods That Are Not Healthy
By Ivanhoe Broadcast News on June 30, 2024
https://www.ivanhoe.com/?p=33524&preview=1&_ppp=fbdcea7315
CHILL OUT! MONEY-SAVING TIPS FOR BEATING THE HEAT THIS SUMMER
Chill Out! Money-Saving Tips to Beat the Heat This Summer
By Ivanhoe Broadcast News on June 29, 2024
https://www.ivanhoe.com/?p=33522&preview=1&_ppp=85396001e9
RE-ENERGIZE YOUR CAREER: TIPS TO BEAT BOREDOM
Career: Re-Energize with Tips to Beat Boredom
By Ivanhoe Broadcast News on June 29, 2024
https://www.ivanhoe.com/?p=33519&preview=1&_ppp=cf8bff4891
RELEARNING THE ART OF SWALLOWING
Relearning the Art of Swallowing
By Ivanhoe Broadcast News on June 28, 2024
https://www.ivanhoe.com/?p=33573&preview=1&_ppp=b2c714f402
TRAINING BRAIN CELLS TO STOP EPILEPTIC SEIZURES
Training Brain Cells to Stop Epilepsy
By Ivanhoe Broadcast News on June 27, 2024
https://www.ivanhoe.com/?p=33564&preview=1&_ppp=72eeae7171
A BRIGHTER OUTLOOK FOR GLAUCOMA PATIENTS
A Brighter Outlook for Glaucoma Patients
By Ivanhoe Broadcast News on June 26, 2024
https://www.ivanhoe.com/?p=33557&preview=1&_ppp=d3079e91a0
GET A KNEE REPLACED TODAY; DRIVE NEXT WEEK
Get a Knee Replacement Today: Drive Next Week
By Ivanhoe Broadcast News on June 25, 2024
https://www.ivanhoe.com/?p=33550&preview=1&_ppp=9b42b232b8
LAST CHANCE: HOW CAR T-CELL THERAPY SAVED JOHN
How CAR T-Cell Therapy Saved John
By Ivanhoe Broadcast News on June 24, 2024
https://www.ivanhoe.com/?p=33542&preview=1&_ppp=17af0795fa
FDA Approves First Gene Therapy for Treatment of Certain Patients with Duchenne Muscular Dystrophy
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy?utm_medium=email&utm_source=govdelivery
LEVIDYS is an adeno-associated virus vector-based gene therapy indicated in individuals at least 4 years of age:
For the treatment of Duchenne muscular dystrophy (DMD) in patients who are ambulatory and have a confirmed mutation in the DMD gene.
For the treatment of DMD in patients who are non-ambulatory and have a confirmed mutation in the DMD gene (1, 12.2) The DMD indication in non-ambulatory patients is approved under accelerated approval based on expression of ELEVIDYS micro-dystrophin (noted hereafter as “micro-dystrophin”). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
https://www.fda.gov/vaccines-blood-biologics/tissue-tissue-products/elevidys?utm_medium=email&utm_source=govdelivery
Antibiotic Compound Kills Hard-to-Treat, Infectious Bacteria While Sparing Healthy Bacteria in the Gut Posted on June 20th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/06/20/antibiotic-compound-kills-hard-to-treat-infectious-bacteria-while-sparing-healthy-bacteria-in-the-gut/
Drug-resistant bacteria are responsible for a rise in serious, hospital-acquired infections, including pneumonia and sepsis. Many of these bacteria are classified as “gram-negative,” and are harder to kill than “gram-positive” bacteria. Unfortunately, the limited number of antibiotics that can help combat these dangerous infections can also damage healthy microbes in the gut, leaving people at risk for other, potentially life-threatening infections. Such antibiotic-induced disruption has also been linked in studies to irritable bowel syndrome, colon cancer, and many other health conditions.
Updated lung function evaluation equation predicted to reclassify lung disease status for millions
https://www.nhlbi.nih.gov/news/2024/updated-lung-function-evaluation-equation-predicted-reclassify-lung-disease-status?utm_source=govdelivery&utm_medium=email&utm_campaign=nhlbi-update-june
Lung function tests are used to detect obstructed airways and these scores are then compared to normal lung function ranges to help diagnose and detect the severity of lung conditions, such as chronic obstructive pulmonary disease (COPD). Researchers have been studying how to update reference ranges for normal lung function with race-neutral criteria and evaluated a recent model, the 2022 Global Lung Function Initiative — which is recommended by the American Thoracic Society and the European Respiratory Society.