Chemo- or Surgery-First in Advanced Gastric Cancer?

https://www.medscape.com/viewarticle/chemo-or-surgery-first-advanced-gastric-cancer-2026a10011tu?src= Patients with gastric cancer and positive peritoneal lavage cytology (CY1) and/or localized peritoneal metastasis (P1a) who received upfront chemotherapy followed by gastrectomy had a higher 5-year overall survival rate than those who underwent upfront gastrectomy followed by postoperative chemotherapy. Survival was highest among patients who achieved conversion to no peritoneal metastasis and negative cytology (P0CY0) before gastrectomy, with a 5-year overall survival rate of about 50%.