GLP-1 drugs fail to help some people lose weight — scientists are on a quest for answers Understanding why some people see no benefits from potent anti-obesity medications could lead to new therapies and personalized weight-loss regimens. By Mariana Lenharo

https://www.nature.com/articles/d41586-026-03020-3?utm_source=Live+Audience&utm_campaign=5858217fe2-nature-briefing-daily-20260925&utm_medium=email&utm_term=0_-33f35e09ea-50432164 Around 10–15% of people taking popular GLP-1 drugs such as Wegovy lose little to no weight — and researchers don’t really know why. Solving this mystery might lead to new medications for people who don’t benefit from currently available drugs, and could make it possible to match individuals to treatments that are most likely to work for them.