Do we need T cells to achieve deep B cell depletion? As deep B cell depletion moves into autoimmune disease, antibody-directed allogeneic NK cell therapy may offer a different path to potency, scalability, and outpatient treatment. Written byFred Aslan

https://www.drugdiscoverynews.com/do-we-need-t-cells-to-achieve-deep-b-cell-depletion-17396 The most important debate in autoimmune cell therapy is no longer whether deep B cell depletion can reset the immune system, as CAR T therapy has helped settle that question. The harder question is how to deliver and achieve this effect safely, reproducibly, and practically at scale.