Researchers uncover key mechanism driving chronic Sjögren disease

https://www.news-medical.net/news/20260624/Researchers-uncover-key-mechanism-driving-chronic-Sjogren-disease.aspx Sjögren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients’ quality of life. While CD4+ T cells are key drivers of immune-mediated tissue damage and chronic inflammation, the role of pathogenic CD4+ T cell subsets and their non-immune cell partners remains unexplored. Researchers have now identified the preferential CD4+ T cell-fibroblast cellular interaction that amplifies inflammatory proteins and tissue damage, representing a potential target for therapeutic intervention in Sjögren disease.