CAR-T Therapy Shows Promise in CNS and Extramedullary B-ALL Edited by Gargi Mukherjee May 29, 2026

https://www.medscape.com/viewarticle/car-t-therapy-shows-promise-cns-and-extramedullary-b-all-2026a1000hyx CD19 chimeric antigen receptor (CAR) T-cell therapy achieved high response rates in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and extramedullary disease or central nervous system (CNS) involvement, according to a retrospective review. More than 80% of patients achieved clearance of their extramedullary or CNS disease; however, patients with concurrent high bone marrow disease burden experienced significantly worse survival than those with low bone marrow burden.