Perceived sickness activates real immune responses

https://www.news-medical.net/news/20250731/Perceived-sickness-activates-real-immune-responses.aspx In a new experiment, scientists used virtual reality to show that the brain can sense virtual infection to trigger the body’s immune system, before the first microbe ever makes contact.

An overview of FeNO guidelines in clinical practice

https://www.news-medical.net/whitepaper/20250728/An-overview-of-FeNO-guidelines-in-clinical-practice.aspx Fractional exhaled Nitric Oxide (FeNO) is widely used in both primary and secondary care settings across the world. Many regions recommend incorporating FeNO-guided management into their clinical standards, and resulting FeNO-related guidelines can vary across the UK and other countries. The following explores and compares these approaches.

Don’t Forget These Infectious Disease Screenings +++++ ++ +++++

News Don't Forget These Infectious Disease Screenings https://www.medscape.com/viewarticle/dont-forget-these-infectious-risk-based-disease-screenings-2025a1000f2o?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Europe's Hepatitis A Outbreak: What You Need to Know https://www.medscape.com/viewarticle/europes-hepatitis-outbreak-what-you-need-know-2025a1000h53?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Most Kids Never Get the Cure for Hepatitis C https://www.medscape.com/viewarticle/clinicians-can-prescribe-cure-hepatitis-c-most-kids-never-2025a1000a42?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Does Metabolic Dysfunction Affect Liver Fibrosis in Hep B? https://www.medscape.com/viewarticle/does-metabolic-dysfunction-associated-steatotic-liver-2025a1000hwa?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Preventing Hepatitis B Reactivation: Updated Guidance https://www.medscape.com/viewarticle/preventing-hepatitis-b-reactivation-updated-clinical-2025a10005oi?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Vaccines Hepatitis A Vaccine Inactivated https://reference.medscape.com/drug/vaqta-havrix-hepatitis-a-vaccine-inactivated-343150?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Hepatitis A/B Vaccine https://reference.medscape.com/drug/twinrix-hepatitis-a-b-vaccine-343152?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Overview & Treatment Hepatitis A https://emedicine.medscape.com/article/177484-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Hepatitis B https://emedicine.medscape.com/article/177632-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Hepatitis C https://emedicine.medscape.com/article/177792-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Hepatitis D https://emedicine.medscape.com/article/178038-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337 Hepatitis E https://emedicine.medscape.com/article/178140-overview?ecd=mkm_ret_250728_mscpmrk-OUS_InFocus_etid7594337&uac=148436CN&impID=7594337

Editorial p827 A commission on vector-borne infections The Lancet Infectious Diseases +...

https://www.thelancet.com/issue/S1473-3099(25)X0008-6 TheLancet.com will undergo maintenance on Sunday July 27th, from approximately, 5.30am to 1.30pm US EST. During this time, some of the site functionality will be paused, we apologise for the inconvenience.

FDA Investigating Death of 8-Year-Old Boy Who Received Elevidys

https://www.fda.gov/news-events/press-announcements/fda-investigating-death-8-year-old-boy-who-received-elevidys?utm_medium=email&utm_source=govdelivery FDA Investigating Death of 8-Year-Old Boy Who Received Elevidys The U.S. Food and Drug Administration is investigating the death of an 8-year-old boy who received Elevidys, a Sarepta Therapeutics gene therapy for Duchenne muscular dystrophy. The death occurred on June 7, 2025. The FDA has requested and received voluntary suspension of product distribution as it investigates the safety concerns. Elevidys is an adeno-associated virus vector-based gene therapy using Sarepta Therapeutics, Inc.’s AAVrh74 Platform Technology for the treatment of Duchenne muscular dystrophy. The product is administered as a single intravenous dose. Duchenne muscular dystrophy is a rare genetic condition characterized by progressive muscular weakness. The disease occurs due to a defective gene.

Is There a Role For GLP-1s in Psoriasis? Role of GLP-1 Drugs in Psoriasis Tx ++++++ ++

TRENDING ON PSORIASIS Re-defining Remission in Plaque Psoriasis https://www.medscape.com/viewarticle/experts-reach-consensus-defining-treatment-remission-plaque-2025a1000i0g?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Current and Future Uses for AI in Dermatology https://www.medscape.com/viewarticle/current-and-future-uses-ai-dermatology-experts-view-2025a1000f1k?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Drug Shows Sustained Improvement of GPP Symptoms https://www.medscape.com/viewarticle/spesolimab-provides-sustained-improvement-gpp-symptoms-and-2025a1000e5e?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Biologic Safety in Psoriasis Patients With Cancer https://www.medscape.com/viewarticle/il-23-inhibitors-appear-safe-psoriasis-cancer-2025a1000gho?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Rethinking Topical Therapy for Psoriasis https://www.medscape.com/viewarticle/1002116?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Volume, Not Price, Drives Derm Drug Costs https://www.medscape.com/viewarticle/volume-not-price-fueling-rise-part-d-specialty-derm-drug-2025a1000j39?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 CLINICAL RESOURCES What Do You Know About Generalized Pustular Psoriasis? Test Your Knowledge https://reference.medscape.com/viewarticle/fast-five-quiz-what-do-you-know-about-generalized-pustular-2025a1000bai?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345 Painful, Rupturing Lesions in a 40-Year-Old Man: What is Your Dx? https://reference.medscape.com/viewarticle/painful-rupturing-lesions-40-year-old-man-2025a1000f4s?ecd=WNL_conf_Derm_Psoriasis-GRAPPA-NON-SPON_250725_MSCPEDIT_etid7592345&uac=148436CN&impID=7592345

Low-gluten diets disrupt gut health by depleting key bacteria

https://www.news-medical.net/news/20250724/Low-gluten-diets-disrupt-gut-health-by-depleting-key-bacteria.aspx Scientists uncover how long-term gluten reduction, often seen as a health boost, can actually upset gut balance, strip away key microbes, and trigger ethanol build-up tied to inflammation and metabolic risks.

Study reveals pandemic life made brains age faster, even without catching COVID-19

https://www.news-medical.net/news/20250723/Study-reveals-pandemic-life-made-brains-age-faster-even-without-catching-COVID-19.aspx New research reveals that social isolation and stress during the COVID-19 pandemic accelerated the aging of the brains of older adults, regardless of whether they contracted the virus, highlighting the urgent need for protective strategies beyond infection control.

Rare Disease Focus: Heart Disease +++ +++ +

CLINICAL PERSPECTIVES Marfan Syndrome: Diagnosis and Management https://checkrare.com/marfan-syndrome-diagnosis-and-management/ David Liang, MD, PhD, Cardiologist at Hoag Hospital, discusses the diagnosis and management of Marfan syndrome. Evolving Policy Landscapes for Rare Disease Access https://checkrare.com/evolving-policy-landscapes-for-rare-disease-access/ Deb Jennings, Head of North America Patient Services Operations at Kyowa Kirin, discusses evolving policy landscapes for rare disease access. The Role of Mental Health in Rare Disease Patient Outcomes https://checkrare.com/the-role-of-mental-health-in-rare-disease-patient-outcomes/ Sumira Riaz, PhD, Health Psychologist & Patient Engagement Consultant at Unboxed Psychology, discusses the role of mental health in rare disease patient outcomes. Disease Severity and Progression in Patients With ENPP1 Deficiency https://checkrare.com/disease-severity-and-progression-in-patients-with-enpp1-deficiency/ Matt Winton, PhD, Senior Vice President and Chief Operating Officer of Inozyme Pharma, discusses results from an analysis characterizing disease severity and progression in patients with ENPP1 deficiency. The Undiagnosed Disease Network https://checkrare.com/the-undiagnosed-disease-network/ Kimberly LeBlanc, Genetic Counselor, Director of the Undiagnosed Diseases Network (UDN) Coordinating Center at Harvard Medical School, discusses approaching variants of uncertain significance in rare diseases. Ethical Concerns in Rare Diseases and Expanded Access Programs https://checkrare.com/ethical-concerns-in-rare-diseases-and-expanded-access-programs/ Alison Bateman-House, PhD, Assistant Professor Division of Medical Ethics at NYU Grossman School of Medicine, discusses ethical concerns in rare diseases and expanded access programs. The Diversity of Patient Advocacy Group Initiatives https://checkrare.com/the-diversity-of-patient-advocacy-group-initiatives/ Connie Lee, PsyD, Chief Executive Officer of Alliance to Cure Cavernous Malformations, discusses cerebral cavernous malformation (CMM) and the diversity of patient advocacy group initiatives.

The global landscape and development pipeline for childhood cancer medicines: a comprehensive analysis with dashboard generation +...

https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00142-7/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-__QKaBPTCgE5OrCNkibfyad1p9G1PjyPQ3xANjT0q_G9ndQi_P983dKRTwwC7AVlBtODsIDeaiCq8bRjIjvdbUaG9vgw&_hsmi=372642248&utm_content=372379837&utm_source=hs_email Editorial p519 Research-driven neonatology for equitable neonatal health The Lancet Child & Adolescent Health https://www.thelancet.com/journals/lanchi/issue/vol9no8/PIIS2352-4642(25)X0008-0 The Lancet Child & Adolescent Health Commission on the future of neonatology https://www.thelancet.com/commissions-do/future-neonatology?dgcid=hubspot_update_feature_lanchineonatalrd25&utm_campaign=update-lanchi&utm_medium=email&_hsenc=p2ANqtz-8n6JVObgK59dJ1sqVxJJjBpoWuGpXqt1xrgy8aNSazIUzPMD2aei0GHlxoLu8hGZ63pdJWw3Ecw5z58HM8iGIprPztWg&_hsmi=372642248&utm_content=372379837&utm_source=hs_email Trends and predictions to 2030 in demographic structures and metabolic health for children and adolescents in China: analysis of national school health surveys from 2000 to 2019 https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(25)00140-3/abstract?utm_campaign=update-lanchi&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_lanchi&_hsenc=p2ANqtz-_oV3jp8EXDg9zsj_IndINFHE4gjBmWJ1Y-3gT6Y3p7Ayvp7e7eiuHWEf0plC_9NK8Efds5-5b4dpfZZrzNVEIGVFQeGA&_hsmi=372642248&utm_content=372379837&utm_source=hs_email

A commission on vector-borne infections The Lancet Infectious Diseases +...

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00430-X/fulltext?dgcid=raven_jbs_etoc_email Issue cover for Volume 25, Issue 8 Aug 2025 Volume 25Number 8p827-946, e439-e490 https://www.thelancet.com/journals/laninf/issue/vol25no8/PIIS1473-3099(25)X0008-6 Immunogenicity and safety of an Escherichia coli-produced bivalent human papillomavirus vaccine (Cecolin) in girls aged 9–14 years in Ghana and Bangladesh: a randomised, controlled, open-label, non-inferiority, phase 3 trial https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00031-3/fulltext?dcig=raven_jbs_etoc_feature_laninf

miércoles, 23 de julio de 2025

'Western diet' blamed for growing risk of GI cancers among young adults By Ashley J. DiMella Fox News Published July 16, 2025 8:36am EDT

'Western diet' blamed for growing risk of GI cancers among young adults Processed meats, sugary drinks and refined grains identified as potential risk factors Ashley J. DiMella By Ashley J. DiMella Fox News Published July 16, 2025 8:36am EDT https://www.foxnews.com/health/western-diet-blamed-growing-risk-gi-cancers-among-young-adults

Texas psychiatrist reveals mental health challenges facing flood disaster survivors By Rachel Wolf Fox News Published July 16, 2025 12:19pm EDT

Texas psychiatrist reveals mental health challenges facing flood disaster survivors 'The reality for these families is that once the camera crews are gone and once the aid organizations are packing up, they’re still going to be living with the repercussions of this,' Dr. Browne said Rachel Wolf By Rachel Wolf Fox News Published July 16, 2025 12:19pm EDT https://www.foxnews.com/health/texas-psychiatrist-reveals-mental-health-challenges-facing-flood-disaster-survivors

Here's what marijuana really does to the developing brain, according to a psychiatrist By Angelica Stabile Fox News Published July 18, 2025 2:58pm EDT

Here's what marijuana really does to the developing brain, according to a psychiatrist Cognitive specialist Dr. Amen warns that cannabis can age the brain and cause mental health issues Angelica Stabile By Angelica Stabile Fox News Published July 18, 2025 2:58pm EDT https://www.foxnews.com/health/heres-what-marijuana-really-does-developing-brain-according-psychiatrist

Alzheimer's risk could rise with specific sleep pattern, experts warn By Angelica Stabile Fox News Published July 21, 2025 5:00am EDT

Alzheimer's risk could rise with specific sleep pattern, experts warn Delayed REM sleep may indicate cognitive decline, study suggests Angelica Stabile By Angelica Stabile Fox News Published July 21, 2025 5:00am EDT https://www.foxnews.com/health/alzheimers-risk-could-rise-specific-sleep-pattern-experts-warn

Higher cancer rates linked to WWII radioactive waste in Midwestern creek By Angelica Stabile Fox News Published July 22, 2025 5:07pm EDT

Higher cancer rates linked to WWII radioactive waste in Midwestern creek Missouri's Coldwater Creek leaves lasting health legacy for those who grew up there Angelica Stabile By Angelica Stabile Fox News Published July 22, 2025 5:07pm EDT https://www.foxnews.com/health/higher-cancer-rates-linked-wwii-radioactive-waste-midwestern-creek

Children's National Hospital in DC to end gender transition medical interventions By Danielle Wallace Fox News Published July 21, 2025 8:57am EDT

Children's National Hospital in DC to end gender transition medical interventions Children's National cites 'escalating legal and regulatory risks' as Justice Department investigates pediatric transgender procedures Danielle Wallace By Danielle Wallace Fox News Published July 21, 2025 8:57am EDT https://www.foxnews.com/health/childrens-national-hospital-dc-end-gender-transition-medical-interventions

Experts reveal 5-step approach to a healthier gut and stronger immunity By Amy McGorry Fox News Published July 17, 2025 5:00am EDT

Experts reveal 5-step approach to a healthier gut and stronger immunity Medical experts reveal how the '5R' plan can boost immunity and reduce inflammation By Amy McGorry Fox News Published July 17, 2025 5:00am EDT https://www.foxnews.com/health/experts-reveal-5-step-approach-healthier-gut-stronger-immunity

Eating foods in this order could help with weight loss and blood sugar, experts say By Amy McGorry Fox News Published July 20, 2025 4:23pm EDT

Eating foods in this order could help with weight loss and blood sugar, experts say ‘Meal sequencing’ technique has been shown to benefit those with diabetes By Amy McGorry Fox News Published July 20, 2025 4:23pm EDT https://www.foxnews.com/health/eating-foods-order-could-help-weight-loss-blood-sugar-experts-say

The impact of living with a rare disease: barriers and enablers of independent living and social participation +++

https://www.eurordis.org/publications/rb-dailylife-report/ EURORDIS responds to European Commission’s proposed 2028-34 budget July 2025 17 July 2025, Brussels – The European Commission has unveiled its long-term budget proposal for the 2028–2034 Multiannual Financial Framework (MFF). The proposal sets out the Union’s roughly €1.8 trillion budget and spending priorities for the seven-year period, including investments in competitiveness, social cohesion, public health, and research. https://www.eurordis.org/eurordis-responds-to-eu-commissions-proposed-2028-34-budget/ Recognising the disabilities of those living with rare diseases July 2025 Between July and September 2024, EURORDIS–Rare Diseases Europe’s Rare Barometer programme carried out one of the widest-reaching surveys to date on the intersection between rare diseases and disability. https://www.eurordis.org/recognising-rare-disease-disabilities/

Beyond Baby KJ: Next Steps in Manufacturing Genome Editing Cures Wednesday, July 30, 2025 9:00 am PT, 12:00 pm ET, 18:00 CEST

https://www.genengnews.com/multimedia/beyond-baby-kj-next-steps-in-manufacturing-genome-editing-cures/?utm_campaign=15735301-GEN_GEN_Live_20250730&utm_medium=email&_hsenc=p2ANqtz-_xvOAUKG2p4KdRdbi2NsfE8bof_3qboBP99tJfi8mWve8-JVTuRpbYdxUpvspPy11laT-IBX4khaJicE_RjumSQeD6IQ&_hsmi=372453060&utm_content=372400580&utm_source=hs_email Last month, for the first time, a baby with a rare genetic disorder known as “Baby KJ” was treated with a gene-editing therapy tailored to his rare mutation. The milestone made headlines—and marked a win for the genome editing field, offering new promise for the future of genomic medicine. But there is another layer to the story: how the treatment was manufactured. Developing a single, personalized therapy required a coordinated sprint from teams at IDT, Aldevron, and Danaher, working under intense pressure to produce the gene-editing payload and its delivery system. Now, the real challenge lies ahead—delivering treatments like this to more patients. On this GEN Live, we take a close look at the work behind this successful treatment and perhaps more importantly, we explore how this can be done on a larger scale in the future. We will discuss the challenges that lie ahead, including scale and cost, and how some companies are thinking about solving those.

Blocking GAPDH aggregation protects brain cells and opens new path for stroke therapy

https://www.news-medical.net/news/20250720/Blocking-GAPDH-aggregation-protects-brain-cells-and-opens-new-path-for-stroke-therapy.aspx A novel study reveals that targeting a single protein’s aggregation can dramatically reduce brain injury after stroke, potentially transforming how acute ischemic strokes are treated.

Can probiotics help you sleep better?

Could the key to better sleep and brighter mood lie in your gut? New research suggests probiotic supplements may safely ease insomnia and depressive symptoms, but more studies are needed to pinpoint who benefits most. https://www.news-medical.net/news/20250720/Can-probiotics-help-you-sleep-better.aspx

Erythritol alters brain vessel function and may raise stroke risk

Scientists show how a common zero-calorie sweetener found in many diet drinks may harm the brain's vascular system by increasing oxidative stress and impairing vital blood vessel functions. https://www.news-medical.net/news/20250721/Erythritol-alters-brain-vessel-function-and-may-raise-stroke-risk.aspx

Meat hummus lowers microbes and raises nutrition

https://www.news-medical.net/news/20250721/Meat-hummus-lowers-microbes-and-raises-nutrition.aspx Scientists show that lamb-infused hummus packs more protein, iron, and flavor while staying fresher, offering flexitarians and athletes a nutrient-rich twist on the classic dip.

Fast Facts: Inflammatory Bowel DiseaseFree By David S. Rampton; Fergus Shanahan

https://karger.com/books/book/6019/Fast-Facts-Inflammatory-Bowel-Disease?utm_source=email&utm_medium=external&utm_campaign=azo_newsletter_gastro The seventh edition of Fast Facts: Inflammatory Bowel Disease offers an updated overview of Crohn’s disease and ulcerative colitis, highlighting microbiome research and evolving treatment strategies. It covers the use of immunomodulators, biologics, and emerging therapies. Designed for non-specialist doctors, nurses, dietitians, and other healthcare professionals, this concise guide supports those involved in the care of patients with IBD.