Regulation of the hematopoietic stem cell pool by C-Kit–associated trogocytosis

https://www.science.org/doi/10.1126/science.adp2065?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9H_NvI0JT5JEQekWF34AWEBJCOnGNIqGpdTKQ01QzZgYb1keuULvm8sq7VmhHevDdQODOqRVstu0o_v6sD1ILDWdnEEQ&_hsmi=319570921&utm_content=319570921&utm_source=hs_email Helping stem cells come out of their bone homes For anyone donating stem cells for a bone marrow transplant (or becoming their own donor, as recipients of the new gene therapies for sickle cell disease and beta thalassemia do), it's necessary to undergo stem cell collection. However, convincing enough stem cells to exit their niches in the bone marrow and enter the bloodstream, where they can be collected, is difficult. New research in Science looking at mouse and human cells explains one way blood cells resist entering the bloodstream. The study found that cells with certain macrophage markers on their surface were better at staying in the bone marrow and that cells could use a process called trogocytosis to attach these sticky markers to themselves. However, drugs used to push stem cells out of the bone marrow help turn off trogocytosis, and this new understanding gives a new target for future drugs that might improve stem cell collection efficiency. https://www.statnews.com/2023/12/13/gene-therapy-zynteglo-bluebird-beta-thalassemia/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--uOJMj8TPGyvC6tqbv0sxOR4QmUGTlRxI3We9TOuGg4gdd2dFSdy1thCng540bSGXNtCWyX7m_k4ruMszpRh1ND4w7TA&_hsmi=319570921&utm_content=319570921&utm_source=hs_email