Inflammasome activation in patients with Kaposi sarcoma herpesvirus (KSHV)-associated disorders

https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2024024144/516801/Inflammasome-activation-in-patients-with-Kaposi?redirectedFrom=fulltext Kaposi sarcoma herpesvirus (KSHV) associated disorders (KAD) are linked to activation of innate immune processes that cause detrimental inflammation in people with KAD and HIV, a NIAID study found. KAD include Kaposi sarcoma, primary effusion lymphoma, KSHV-associated multicentric Castleman disease, and KSHV-inflammatory cytokine syndrome. KAD tend to affect people whose immune systems are suppressed. The findings, published in the journal Blood, may inform novel treatments for this complex group of disorders.