A human autoimmune organoid model reveals IL-7 function in coeliac disease

https://www.nature.com/articles/s41586-024-07716-2?utm_campaign=+61507613&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term= NIAID-supported researchers have created an organoid model of celiac disease that enabled them to identify a potential treatment target: an immune-system protein called interleukin 7 (IL-7). The model is unique because it has the tissue structure and immune features of the human intestine, and it mimics celiac disease when exposed to gluten. Scientists hope the model will advance their understanding of how celiac disease develops, which could lead to new treatments. The findings were published today in the journal Nature.