Multi-ancestry polygenic mechanisms of type 2 diabetes K Smith et al, Nature Medicine, March 6, 2024 (Posted Mar 06, 2024 9AM)

https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=diabetes&query=home From the abstract: "Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic clusters by analyzing genetic data from diverse populations in 37 published T2D genome-wide association studies representing more than 1.4 million individuals. We implemented soft clustering with 650 T2D-associated genetic variants and 110 T2D-related traits, capturing known and novel T2D clusters with distinct cardiometabolic trait associations across two independent biobanks. "