Genome-wide association study on pharmacological outcomes of musculoskeletal pain in UK Biobank. Song Li et al. Pharmacogenomics J 2023 8

https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=pgx&query=home To investigate the genetic component of treatment outcome differences, we performed a genome-wide association study (GWAS) in ~23,000 participants with musculoskeletal pain from the UK Biobank. NSAID vs. opioid users were compared as a reflection of the treatment outcome of NSAIDs. We identified one genome-wide significant hit in chromosome 4 (rs549224715, P?=?3.88?×?10-8). Suggestive significant (P?