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Clinical Epigenetics

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Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure. FASD has proven difficult to identify in the absence of the overt physical features characteristic of fetal alcohol syndrome. As interventions may have the greatest impact at an early age, accurate biomarkers are needed to identify children at risk for FASD. Building on prior research, this study aims to develop a possible epigenetic predictor of FASD.

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1. Content Type:Research

     |  27 February 2018

   The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest

   Authors:Yan Zhang, Jiangxia Fan, Yichao Fan, Lili Li, Xiaoqian He, Qin Xiang, Junhao Mu, Danfeng Zhou, Xuejuan Sun, Yucheng Yang, Guosheng Ren, Qian Tao and Tingxiu Xiang
2. Content Type:Research

     |  23 February 2018

   Epigenome-wide analysis in newborn blood spots from monozygotic twins discordant for cerebral palsy reveals consistent regional differences in DNA methylation

   Authors:Namitha Mohandas, Sebastian Bass-Stringer, Jovana Maksimovic, Kylie Crompton, Yuk J. Loke, Janet Walstab, Susan M. Reid, David J. Amor, Dinah Reddihough and Jeffrey M. Craig
3. Content Type:Methodology

     |  21 February 2018

   A robust internal control for high-precision DNA methylation analyses by droplet digital PCR

   Authors:Heidi D. Pharo, Kim Andresen, Kaja C. G. Berg, Ragnhild A. Lothe, Marine Jeanmougin and Guro E. Lind
4. Content Type:Hypothesis

     |  21 February 2018

   Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?

   Authors:Angela Sparago, Flavia Cerrato and Andrea Riccio
5. Content Type:Letter To The Editor

     |  14 February 2018

   Letter to the editor: blood processing and sample storage have negligible effects on methylation

   Authors:Kira Groen, Rodney A. Lea, Vicki E. Maltby, Rodney J. Scott and Jeannette Lechner-Scott

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Article collections

2016

Epigenetic drugs
Edited by: Lucia Altucci & Marianne Rots
First published: 23 May 2016

2015

Breakthroughs in clinical epigenetics
Edited by: Marianne Rots
First published: 1 March 2015