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Cancer Cell International

Featured article: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1

miRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC). However, the function and underlying mechanism of miR-422a in the progression of CRC remain largely unknown. In this study, Wei et al. report that miR-422a is down‑regulated in CRC tissues and cell lines and inhibits cell proliferation in CRC by targeting AKT1 and MAPK1.

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1. Content Type:Primary Research

     |  25 January 2018

   C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells

   Authors:Liangqian Jiang, Yujuan Wang, Guoxiang Liu, Huihui Liu, Feng Zhu, Huanhuan Ji and Bing Li
2. Content Type:Primary Research

     |  23 January 2018

   Exosomal lncRNA 91H is associated with poor development in colorectal cancer by modifying HNRNPK expression

   Authors:Tianyi Gao, Xiangxiang Liu, Bangshun He, Zhenlin Nie, Chengbin Zhu, Pei Zhang and Shukui Wang
3. Content Type:Primary Research

     |  17 January 2018

   MicroRNA-10b regulates epithelial–mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma

   Authors:Gulibaha Hujie, Sheng-hua Zhou, Hua Zhang, Jie Qu, Xiao-wei Xiong, Outikuer Hujie, Cheng-gong Liao and Shun-e Yang
4. Content Type:Hypothesis

     |  16 January 2018

   Xenogeneic cell therapy provides a novel potential therapeutic option for cancers by restoring tissue function, repairing cancer wound and reviving anti-tumor immune responses

   Authors:Chi-Ping Huang, Chi-Cheng Chen and Chih-Rong Shyr
5. Content Type:Primary Research

     |  15 January 2018

   A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery

   Authors:Alessio Metere, Francesca Frezzotti, Claire Elizabeth Graves, Massimo Vergine, Alessandro De Luca, Donatella Pietraforte and Laura Giacomelli

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