Neurologic Disorders and Hepatitis E | CDC EID > Volume 17, Number 8–August 2011

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Volume 17, Number 8–August 2011
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Neurologic Disorders and Hepatitis E, France, 2010

Laura-Anne Despierres, Elsa Kaphan, Shahram Attarian, Stephan Cohen-Bacrie, Jean Pelletier, Jean Pouget, Anne Motte, Rémi Charrel, René Gerolami, and Philippe Colson Comments to Author
Author affiliations: Centre Hospitalo-Universitaire Timone, Marseille, France (L.-A. Despierres, E. Kaphan, S. Attarian, S. Cohen-Bacrie, J. Pelletier, J. Pouget , A. Motte, R. Charrel, P. Colson); Université de la Méditerranée, Marseille (S. Cohen-Bacrie, R. Charrel, P. Colson); and Centre Hospitalo-Universitaire Conception, Marseille (R. Gerolami)

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Abstract
We report meningitis with diffuse neuralgic pain or polyradiculoneuropathy associated with PCR-documented acute hepatitis E in 2 adults. These observations suggest that diagnostic testing for hepatitis E virus should be conducted for patients who have neurologic symptoms and liver cytolysis.

Hepatitis E virus (HEV), a major cause of acute hepatitis in tropical and subtropical countries, is emerging in industrialized countries, where an increasing number of autochthonous hepatitis E cases have been reported (1–5). Nonetheless, the clinical spectrum of HEV infection still might be incompletely characterized. During the past decade, 12 cases of hepatitis E with neurologic signs and symptoms have been reported (1–4,6–13). We report 2 cases of meningitis or polyradiculoneuropathy in association with PCR-documented acute hepatitis E in France during 2010.

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Suggested Citation for this Article

Despierres L-A, Kaphan E, Attarian S, Cohen-Bacrie S, Pelletier J, Pouget J, et al. Neurologic disorders and hepatitis E, France, 2010. Emerg Infect Dis [serial on the Internet]. 2011 Aug [date cited]. http://www.cdc.gov/EID/content/17/8/102028.htm

DOI: 10.3201/eid1708.102028

Comments to the Authors

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Philippe Colson, Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, Centre Hospitalo-Universitaire Timone, 264 Rue Saint-Pierre 13385, Marseille CEDEX 05, France; email: philippe.colson@ap-hm.fr