Polymorphisms of Tumor Necrosis Factor-Alpha and H... [Dig Dis Sci. 2011] - PubMed result

Dig Dis Sci. 2011 Feb 19. [Epub ahead of print]

Polymorphisms of Tumor Necrosis Factor-Alpha and Hepatocellular Carcinoma Risk: A HuGE Systematic Review and Meta-Analysis.
Wei Y, Liu F, Li B, Chen X, Ma Y, Yan L, Wen T, Xu M, Wang W, Yang J.

Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, 610041, Chengdu, Sichuan Province, China.


Abstract

BACKGROUND: Studies investigating the associations between tumor necrosis factor-alpha (TNFA) polymorphisms and hepatocellular carcinoma (HCC) risk report conflicting results. We conducted a meta-analysis to assess the association between TNFA gene TNFA-308(G/A), TNFA-238(G/A), TNFA-863(C/A), TNFA-857(C/T), TNFA-1031 (T/C) polymorphisms and HCC susceptibility.

METHODS: Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for TNFA polymorphisms and HCC were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate.

RESULTS: This meta-analysis included 17 case-control studies, which included 2,357 HCC cases and 3,161 controls. Overall, the variant genotypes AA/AG of -308G/A were associated with a significantly increased HCC risk, when compared with GG genotype (AA vs. GG, OR = 1.97, 95%CI = 1.01-3.83; AG vs. GG, OR = 1.88, 95%CI = 1.23-2.88; AA/AG vs. GG, OR = 1.80, 95%CI = 1.19-2.72). When stratifying for ethnicity, significantly elevated HCC risk was found among Asians. Moreover, similar results were observed between TNFA-238G/A, TNFA-863C/A polymorphisms and HCC risk among Asians (for -238G/A, AG vs. GG OR = 1.63, 95%CI = 1.17-2.26, AA/AG vs. GG OR = 1.61, 95%CI = 1.16-2.24; for -863 C/A, AC vs. CC OR = 1.72, 95%CI = 1.03-2.88, AA/AC vs. CC OR = 1.71, 95%CI = 1.02-2.86), while no associations were observed between TNFA-857C/T, TNFA-1031T/C polymorphisms and HCC susceptibility.

CONCLUSIONS: This meta-analysis shows that TNFA-308G/A, TNFA-238G/A and TNFA-863C/A polymorphisms may be associated with HCC among Asians. TNFA-857C/T and TNFA-1031T/C polymorphisms were not detected to be related to the risk for HCC.

PMID: 21336601 [PubMed - as supplied by publisher]

Polymorphisms of Tumor Necrosis Factor-Alpha and H... [Dig Dis Sci. 2011] - PubMed result