Aporte a la rutina de la trinchera asistencial donde los conocimientos se funden con las demandas de los pacientes, sus necesidades y las esperanzas de permanecer en la gracia de la SALUD.
domingo, 1 de marzo de 2026
US measles and pertussis outbreaks expose policy failures, not just vaccine hesitancy
https://www.news-medical.net/news/20260224/US-measles-and-pertussis-outbreaks-expose-policy-failures-not-just-vaccine-hesitancy.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=pharmacy_and_pharmacology_newsletter_27_february_2026
As measles and pertussis cases surge across multiple states, researchers argue that the real vulnerability lies not only in individual choice but in the policies that allow immunity gaps to widen and outbreaks to take hold.
Gut microbiome may shape response to GLP-1 drugs, new review suggests
https://www.news-medical.net/news/20260219/Gut-microbiome-may-shape-response-to-GLP-1-drugs-new-review-suggests.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=pharmacy_and_pharmacology_newsletter_27_february_2026
Emerging evidence suggests that microbial metabolites not only regulate endogenous GLP-1 secretion but may also influence therapeutic response to GLP-1 receptor agonists, raising the prospect of microbiome-guided treatment strategies in obesity and type 2 diabetes.
Short-duration psychedelic therapy shows promise for major depression treatment
https://www.news-medical.net/news/20260217/Short-duration-psychedelic-therapy-shows-promise-for-major-depression-treatment.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=pharmacy_and_pharmacology_newsletter_27_february_2026
In a recent study published in the journal Nature Medicine, researchers evaluated the safety and efficacy of a short-acting psychedelic, dimethyltryptamine (DMT), in adults with major depressive disorder (MDD).
Event guide: 4th Nasal Formulation & Delivery Summit
https://www.news-medical.net/industry-focus/Event-guide-4th-Nasal-Formulation-Delivery-Summit?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=pharmacy_and_pharmacology_newsletter_27_february_2026
The 4th Nasal Formulation & Delivery Summit is a specialist meeting focused on the formulation, delivery, and regulatory challenges of intranasal therapeutics.
Acoziborole receives positive opinion for single-dose sleeping sickness treatment
https://www.news-medical.net/news/20260227/Acoziborole-receives-positive-opinion-for-single-dose-sleeping-sickness-treatment.aspx
The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has granted a positive opinion to Acoziborole Winthrop (acoziborole) as a single-dose oral treatment for both early- and advanced-stage gambiense sleeping sickness in adults as well as in adolescents 12 years and older weighing at least 40 kilograms.
Colorful japonica rice varieties show unique health-promoting lipids
https://www.news-medical.net/news/20260227/Colorful-japonica-rice-varieties-show-unique-health-promoting-lipids.aspx
Rice feeds more than half of the world's population, yet we still only partly understand the nutrients it contains. More than 85% of the rice we eat is composed of starch, though it also contains some protein (around 10%), small amounts of fat (roughly 2%), a few vitamins, and trace elements. Because fats, or lipids, make up such a small fraction of rice, they have received relatively little scientific attention despite playing an important role in nutrition, flavor, and grain quality.
Study aims to understand molecular origins of CTNNB1 neurodevelopmental syndrome
https://www.news-medical.net/news/20260227/Study-aims-to-understand-molecular-origins-of-CTNNB1-neurodevelopmental-syndrome.aspx
On the occasion of Rare Disease Day, the Biofisika Institute (CSIC, EHU) presents the progress of a project aimed at understanding the molecular origin of CTNNB1 neurodevelopmental syndrome, a rare disease caused by mutations in the beta-catenin protein. Although fewer than 50 cases of this pathology have been diagnosed in Spain, rare diseases affect a total of nearly three million people.
What is Mycelium? Health Benefits, Nutrition Facts, and Sustainability Explained
https://www.news-medical.net/health/What-is-Mycelium-Health-Benefits-Nutrition-Facts-and-Sustainability-Explained.aspx
Whole-food mycelium, which originates from filamentous fungi such as Fusarium venenatum and Pleurotus species, is currently being evaluated for its potential as an alternative protein source to conventional meat- or plant-based foods. Unlike soy or pea protein, which undergo extensive fractionation and isolation of specific bioactive components, mycelium maintains a complex whole-food matrix that mimics the fibrous structure of animal tissue while delivering a bioavailable amino acid profile.1,4
Why Mankai (Wolffia globosa) Is Emerging as a Functional Food for Metabolic Health
https://www.news-medical.net/health/Why-Mankai-(Wolffia-globosa)-Is-Emerging-as-a-Functional-Food-for-Metabolic-Health.aspx
Mankai (Wolffia globosa) is a fast-growing aquatic plant of the duckweed family that contains high-quality plant protein, including all the essential amino acids, as well as dietary fiber and a broad spectrum of micronutrients like iron, folate, and authentic (bioactive) vitamin B12 forms identified by LC-MS/MS (including OH-B12, Ado-B12, Me-B12, and CN-B12). In analyses comparing Mankai extracts with spirulina, no pseudo-vitamin B12 (pseudo-CN-B12) was detected in Mankai. In controlled dietary interventions, Mankai has commonly been provided as ~100 g frozen biomass/day blended into a “green shake”. Due to its mild flavor and smooth texture, Mankai is an emerging ingredient in dried powders, frozen shakes and smoothies, and other functional food items.1
Are Precision-Fermented Fats Healthier Than Traditional Dairy Fat?
https://www.news-medical.net/health/Are-Precision-Fermented-Fats-Healthier-Than-Traditional-Dairy-Fat.aspx
Precision-fermented, dairy-identical fats are lipids produced using advanced microbial fermentation processes, rather than traditional animal agriculture. During precision fermentation, selected microorganisms, such as yeasts or fungi, are engineered and cultivated to synthesize fats that structurally and functionally resemble those in conventional dairy products.
Can peanut butter improve mobility after 65?
https://www.news-medical.net/news/20260227/Can-peanut-butter-improve-mobility-after-65.aspx
A simple spoonful of peanut butter each day improved lower-body muscle power in older adults, but the study’s primary walking test did not budge, highlighting both the promise and the limits of diet-only strategies for healthy aging.
Gut microbiome may shape response to GLP-1 drugs, new review suggests +++++
Gut microbiome may shape response to GLP-1 drugs, new review suggests
https://www.news-medical.net/news/20260219/Gut-microbiome-may-shape-response-to-GLP-1-drugs-new-review-suggests.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Gut microbiome may shape response to GLP-1 drugs, new review suggestsThis review examines how GLP-1 receptor agonists and the gut microbiome influence one another through bile acid signaling, short-chain fatty acids, and inflammatory pathways. It explores how microbial composition may shape treatment response and highlights the need for controlled human studies to enable microbiome-informed precision therapy.
AI tool can accurately predict colorectal cancer risk in UC-LGD patients
https://www.news-medical.net/news/20260217/AI-tool-can-accurately-predict-colorectal-cancer-risk-in-UC-LGD-patients.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
AI tool can accurately predict colorectal cancer risk in UC-LGD patientsPeople with ulcerative colitis (UC), a chronic inflammatory bowel disease, are up to four times more likely to develop colorectal cancer than the general population.
Developmental ANGPTL4 deficiency protects mice from colitis and tumors
https://www.news-medical.net/news/20260218/Developmental-ANGPTL4-deficiency-protects-mice-from-colitis-and-tumors.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Developmental ANGPTL4 deficiency protects mice from colitis and tumorsA novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development triggers a long-lasting reprogramming of the immune system that protects against intestinal inflammation.
Distinct gut toxicity patterns emerge with targeted cancer treatments
https://www.news-medical.net/news/20260220/Distinct-gut-toxicity-patterns-emerge-with-targeted-cancer-treatments.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
A new paper was published in Volume 13 of Oncoscience on February 6, 2026, titled "Gastrointestinal toxicity of targeted cancer therapies in the United States: Clinicopathologic patterns, FDA safety frameworks, and implications for national patient protection."
Study reveals bacterial duo driving chronic constipation
https://www.news-medical.net/news/20260219/Study-reveals-bacterial-duo-driving-chronic-constipation.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Scientists at Nagoya University in Japan have found two gut bacteria working together that contribute to chronic constipation.
Screening helps detect colorectal cancer at an early stageScreening helps detect colorectal cancer at an early stage +++
Screening helps detect colorectal cancer at an early stageScreening helps detect colorectal cancer at an early stage
https://www.news-medical.net/news/20260220/Screening-helps-detect-colorectal-cancer-at-an-early-stage.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
More cases of colorectal cancer are detected at an early stage with screening. This is according to new research based on data from over 278,000 60-year-olds, who were randomly selected to undergo one of two interventions or no screening at all (usual care).
Gut bacteria patterns help predict insulin resistance in type 2 diabetes, study findsGut bacteria patterns help predict insulin resistance in type 2 diabetes, study finds
https://www.news-medical.net/news/20260219/Gut-bacteria-patterns-help-predict-insulin-resistance-in-type-2-diabetes-study-finds.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Researchers used 16S rRNA sequencing and machine learning to identify gut microbiome patterns associated with insulin resistance severity in people with type 2 diabetes. XGBoost models showed that specific bacterial genera, including Bacteroides and Faecalibacterium, help distinguish individuals with higher insulin resistance from healthy controls.
Study identifies distinctive feature of tissues from young patients with colorectal cancerStudy identifies distinctive feature of tissues from young patients with colorectal cancer
https://www.news-medical.net/news/20260217/Study-identifies-distinctive-feature-of-tissues-from-young-patients-with-colorectal-cancer.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
A study co-led by University of Texas at Dallas bioengineers identified a distinctive feature of tissues from young patients diagnosed with colorectal cancer, a disease that typically affects older patients.
How Different Types of Fiber Improve Blood Sugar Control and Metabolic Health
https://www.news-medical.net/health/How-Different-Types-of-Fiber-Improve-Blood-Sugar-Control-and-Metabolic-Health.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Dietary fiber influences metabolic health through viscosity-driven glycemic control and microbiome-mediated fermentation, with effects that vary by fiber type, metabolic phenotype, and gut microbial composition. evidence from mechanistic studies and large clinical trials shows that fiber’s benefits are real but heterogeneous, supporting a more personalized approach to dietary guidance.
Blood markers can indicate people at risk of developing ulcerative colitis
https://www.news-medical.net/news/20260220/Blood-markers-can-indicate-people-at-risk-of-developing-ulcerative-colitis.aspx?utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=bowel_cancer_newsletter_24_february_2026
Researchers at örebro University have identified blood markers that can indicate who is at risk of developing ulcerative colitis - a chronic inflammatory bowel disease - later in life. These markers can be present for many years before the first symptoms appear.
Rare disease programs are pushing innovation faster than ever When science, manufacturing, and regulatory alignment move together, breakthroughs reach patients faster than ever before.
https://www.drugdiscoverynews.com/rare-disease-programs-are-pushing-innovation-faster-than-ever-17025
Breakthroughs in gene editing and advanced genetic medicines are not happening because development is easy. They are happening because the need is urgent, and because rare disease has pushed innovators to build new toolsets.
Weekly Rundown: First UK baby born from deceased donor womb transplant A first UK birth from a deceased-donor womb transplant, a billion-dollar siRNA deal for GSK, a sobering setback for early cancer blood tests, and more led the news this week.
https://www.drugdiscoverynews.com/weekly-rundown-first-uk-baby-born-from-deceased-donor-womb-transplant-17030
A baby boy has become the first child in the UK to be born following a womb transplant from a deceased donor, marking what doctors called a “ground-breaking moment” for reproductive medicine. Hugo was born just before Christmas 2025 at Queen Charlotte's and Chelsea Hospital to Grace Bell, who was born without a viable womb due to Mayer Rokitansky Küster Hauser (MRKH) syndrome, a condition affecting roughly one in 5,000 women. The birth is the first in the UK to result from a deceased-donor womb transplant under a clinical trial led by teams in Oxford and London, following decades of research by consultant surgeons Richard Smith and Isabel Quiroga, supported by Womb Transplant UK. Their work includes two programs: a living donor initiative aiming for five transplants and the UK INvestigational Study into Transplantation of the Uterus, which involves deceased donors and multiple National Health Services collaborators. Surgeons said the milestone offers new hope to women born without a womb, while Bell and her partner paid tribute to the donor’s family for what they described as the “incredible gift” that made their son’s birth possible. – Bree Foster