Has PSA Screening Guidance Upped Prostate Cancer Incidence and Mortality? Will Pass February 10, 2025 +++ +++

TRENDING PSA Screening Worsening Outcomes? Has PSA Screening Guidance Upped Prostate Cancer Incidence and Mortality? Will Pass February 10, 2025 https://www.medscape.com/viewarticle/have-anti-psa-screening-guidelines-upped-prostate-cancer-2025a100039w?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 Cancer Risk & Brews: New Data Coffee and Tea Linked to Reduced Cancer Risk, but the Cup Is Murky Jennie Smith February 10, 2025 https://www.medscape.com/viewarticle/coffee-and-tea-linked-reduced-cancer-risk-cup-murky-2025a10003ca?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 Is It Ever Safe to Use the Word ‘Cure’? ‘Cure’ in Cancer: Should Oncologists Use the Word? Kate Johnson February 04, 2025 https://www.medscape.com/viewarticle/cure-cancer-should-oncologists-use-word-2025a10002q4?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 DIAGNOSTIC INSIGHTS Why Identifying Pancreatic Cancer Remains Elusive Identifying Pancreatic Cancer Remains Elusive: Here’s Why Carolyn Crist February 18, 2025 https://www.medscape.com/viewarticle/identifying-pancreatic-cancer-remains-elusive-heres-why-2025a100045t?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 New Test Promising in Bladder Cancer Detection Urine-Based Test Shows Promise in Detecting Bladder Cancer Edited by Gargi Mukherjee February 07, 2025 https://www.medscape.com/viewarticle/urine-based-test-shows-promise-detecting-bladder-cancer-2025a100034k?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 Diagnostic Considerations in Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia (CLL) Differential Diagnoses https://emedicine.medscape.com/article/199313-differential?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665

THERAPEUTIC ADVANCES ++++

THERAPEUTIC ADVANCES OTC Med Cuts CRC Recurrence by Half Low-Dose Aspirin Cuts CRC Recurrence Megan Brooks January 28, 2025 https://www.medscape.com/viewarticle/low-dose-aspirin-cuts-crc-recurrence-2025a100022s?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 The Diet That May Slow Prostate Cancer Diet Changes Show Promise in Early Prostate Cancer Megan Brooks February 20, 2025 https://www.medscape.com/viewarticle/diet-changes-show-promise-early-prostate-cancer-2025a10004gr?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 New Ovarian Cancer Guidelines: Treatment Shift ASCO Updates Treatment Guidance for Newly Diagnosed, Advanced Ovarian Cancer Christos Evangelou, MSc, PhD February 24, 2025 https://www.medscape.com/viewarticle/asco-updates-treatment-guidance-newly-diagnosed-advanced-2025a10004ox?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665 Drug Duo Enhances Myeloma Outcomes Drug Duo Enhances Myeloma Outcomes Edited by Susan Ruel, PhD January 26, 2025 https://www.medscape.com/viewarticle/drug-duo-enhances-myeloma-outcomes-2025a10001w2?ecd=mkm_ret_250228_mscpmrk_onc_top-content_etid7259665&uac=148436CN&impID=7259665

PDQ Updates for Health Professionals +++++++++++ National Cancer Institute

Adult Treatment Acute Lymphoblastic Leukemia Treatment Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq?cid=eb_govdel#top Acute Myeloid Leukemia Treatment Acute Myeloid Leukemia Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq?cid=eb_govdel#top Adult Central Nervous System Tumors Treatment Adult Central Nervous System Tumors Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/brain/hp/adult-brain-treatment-pdq?cid=eb_govdel#top Agnostic Cancer Therapies Agnostic Cancer Therapies (PDQ®)–Health Professional Version https://www.cancer.gov/about-cancer/treatment/types/agnostic-cancer-therapies-hp-pdq?cid=eb_govdel#top Anal Cancer Treatment Anal Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/anal/hp/anal-treatment-pdq?cid=eb_govdel#top Bile Duct Cancer (Cholangiocarcinoma) Treatment Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/liver/hp/bile-duct-treatment-pdq?cid=eb_govdel#top Bladder Cancer Treatment Bladder Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/bladder/hp/bladder-treatment-pdq?cid=eb_govdel#top Breast Cancer Treatment Breast Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/breast/hp/breast-treatment-pdq?cid=eb_govdel#top Cervical Cancer Treatment Cervical Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/cervical/hp/cervical-treatment-pdq?cid=eb_govdel#top Colon Cancer Treatment Colon Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/colorectal/hp/colon-treatment-pdq?cid=eb_govdel#top Endometrial Cancer Treatment Endometrial Cancer Treatment (PDQ®)–Health Professional Version https://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq?cid=eb_govdel#top

Stimulating mice brains with focused ultrasound changes behavioral responses to pain

Stimulating mice brains with focused ultrasound changes behavioral responses to pain: Stimulating mice brains with focused ultrasound changes behavioral responses to pain Science Highlights February 13, 2025 Transcranial focused ultrasound (tFUS) is a promising technique for non-invasive brain stimulation. By transmitting low-intensity ultrasound waves, tFUS can target deep brain regions with potentially greater precision than other forms of non-invasive brain stimulation. As the brain is involved in pain processing and perception, researchers want to learn whether targeting specific brain structures with tFUS stimulation can potentially change how the brain processes pain. In a preclinical study published in Blood, a collaborative research team designed a new multi-element ultrasound device to target specific brain regions in mice that process pain. The researchers used a genetically engineered mouse model of sickle-cell disease, a painful human condition characterized by sickle-cell shaped red blood cells. This condition leads to heightened sensitivity to different types of pain and was chosen to determine if this ultrasound approach could impact sensitivity to pain. Treatment with the new device showed a significant decrease in pain hypersensitivity, particularly in response to heat-induced pain in the mouse model. https://pubmed.ncbi.nlm.nih.gov/38976875/

We bought all these illegal products in the FDA’s backyard

Secret shoppers went to NY’s unlicensed dispensaries Unlicensed dispensaries and smoke shops are significantly less likely than licensed retailers to require age verification before somebody enters a store or makes a purchase, according to a secret shopper study published today in Pediatrics. Shoppers went to 37 dispensaries and smoke shops in New York City, also finding that unlicensed stores more often sold products that appeal to young people like energy drinks, soda, and candy. Part of the point of legalizing weed is to reduce risk through regulation, the authors write. But in New York, unlicensed retailers outnumber the licensed, regulated ones. In a First Opinion essay last year, three researchers and advocates wrote that, “implementing strong and comprehensive protections for children is not the norm in many states that have legalized recreational marijuana use.” And because we’re talking about how easy it can be to get illegal drugs, I must once again remind you of this iconic STAT video. https://www.statnews.com/2024/06/05/as-states-legalize-recreational-marijuana-use-for-adults-they-must-prioritize-protecting-kids/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9OW7sqi944emy25T5XDaZg34UGnCzNby6J-3xqPV3UqaurcpspED5LHktYPNBUKzcFqpwVTMnn-XxdxaeXLcDNNGSnjw&_hsmi=348565801&utm_content=348565801&utm_source=hs_email Cannabis Access by Retailer Type in New York https://publications.aap.org/pediatrics/article-abstract/155/3/e2024068669/201048/Cannabis-Access-by-Retailer-Type-in-New-York?redirectedFrom=fulltext

Social Factors, Age, and Health at Time of Dementia Diagnosis

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2830594?guestAccessKey=02aaa416-168d-4a8f-90d5-dbbb5c13cf3e&utm_term=022125&utm_campaign=ftm_links&utm_medium=referral&_hsenc=p2ANqtz-8yxcuGdktVwqdxP_-viOqUeBdMGB34mtc3oyYryj5cp8VGTKhvzCRAcAcTjxabKhYklQ3vWp5N_e9X3txItquKtchbew&_hsmi=348565801&utm_content=tfl&utm_source=for_the_media The factors influencing when people are diagnosed with dementia People with lower levels of education, who live alone or in a care home, or who don’t have a close relative, are about three years older when they receive an official dementia diagnosis compared to their counterparts, according to a study published Friday in JAMA Network Open that looked at more than 107,000 people in Sweden who were diagnosed with dementia between 2018 and 2022. On top of that, people who had less than a high school education (fewer than nine years) had more comorbidities and took more medications than those with more schooling. The results could indicate that these populations tend to have more advanced disease or a poorer prognosis, the authors write. They couldn’t say what caused the delayed diagnoses, of course, but hypothesized that the risk of losing a driver’s license may play a larger role in when to seek care for people who live alone or have fewer family members.

Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers

https://www.nature.com/articles/s41467-025-56448-y?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8ZmpJMB2sohpOu6PQ61jflMAo2caMUg5stkmd4pYlwP-j8dqVODNi1QGm4q-jFn2Hs0-cmI20_k6WBhUXTwLmsOhN-wg&_hsmi=348565801&utm_content=348565801&utm_source=hs_email Can treatments for lung conditions go deeper? Between common chronic conditions like COPD and asthma, and acute harm inflicted by viruses, lung damage is a big problem. Many treatments focus on the upper airways. But to go deeper, researchers are studying the pair found in some Covid vaccines: mRNA + a lipid nanoparticle. New research in mice, published Friday in Nature Communications, posits that a similar technology could be used to stimulate healing in parts of the lung not easily reached by conventional therapies. The team reports a nanoparticle, called ionizable amphiphilic Janus dendrimer, targets mRNA therapy directly to the lung and promotes tissue repair. “If introduced early in the inflammatory process,” this mechanism could speed up healing, “ultimately reducing the incidence of complex lung injury and disease,” write the authors (several of whom are named on patents and patent applications related to the research). — Isabella Cueto

domingo, 23 de febrero de 2025

Is MMR vaccine safe for kids? Dr. Nicole Saphier addresses concerns as measles cases rise Dr. Nicole Saphier addresses concerns about side effects, autism and more Angelica Stabile By Angelica Stabile Fox News Published February 11, 2025 4:30am EST | Updated February 21, 2025 2:46pm EST

Is MMR vaccine safe for kids? Dr. Nicole Saphier addresses concerns as measles cases rise Dr. Nicole Saphier addresses concerns about side effects, autism and more Angelica Stabile By Angelica Stabile Fox News Published February 11, 2025 4:30am EST | Updated February 21, 2025 2:46pm EST https://www.foxnews.com/health/mmr-vaccine-safe-kids-dr-saphier-adresses-concerns-measles-cases-rise-us

CHILDHOOD CRISIS: HELPING KIDS THROUGH ADVERSITY & TRAUMA

Childhood Adversity: Helping Kids Through Adversity & Trauma By Ivanhoe Broadcast News on February 23, 2025 https://www.ivanhoe.com/?p=35066&preview=1&_ppp=d7508007c2

OVERSHARING ONLINE: THINGS TO NEVER POST ON SOCIAL MEDIA

Over Sharing Online: Things To Never Post On Social Media By Ivanhoe Broadcast News on February 26, 2025 https://www.ivanhoe.com/?p=35075&preview=1&_ppp=24ce430719

MANKEEPING: THE IMPACT OF THE MALE FRIENDSHIP RECESSION

Mankeeping: The Impact Of The Male Friendship Recession By Ivanhoe Broadcast News on February 25, 2025 https://www.ivanhoe.com/?p=35072&preview=1&_ppp=5bd92961a3

THE HIGH 5 CHALLENGE: 5 MINUTE FIX FOR STRESSED OUT KIDS

The High 5 Challenge: 5 Minute Fix For Stressed Out Kids By Ivanhoe Broadcast News on February 24, 2025 https://www.ivanhoe.com/?p=35069&preview=1&_ppp=bb909f3ba9

Portable MRI, enhanced by AI, proves viable in brain imaging for dementia

Portable MRI, enhanced by AI, proves viable in brain imaging for dementia: The low image quality of small, affordable MRI machines have prevented their widespread use. But a boost from AI could close the gap, bringing MRI to more patients. Of all the instruments in the modern medicine toolbox, magnetic resonance imaging, or MRI, is one of the most powerful. But in many regions, the expense, space, and expertise required to use it puts this tool out of reach. A new study suggests that, with a performance boost from artificial intelligence (AI), existing portable, low-cost MRI tech could make high-quality brain imaging available to more patients. The new system employs AI techniques to improve the quality of, and then automatically analyze, images taken from low-field strength MRI devices that, due to being smaller, sacrifice image quality compared to conventional MRI machines. In a recent clinical study, researchers from Massachusetts General Hospital, Harvard Medical School, and Yale School of Medicine used their automated approach to detect Alzheimer’s disease markers in humans, finding that their technique performed at the same level as higher-power MRI. Their results, published in Nature Communications, point to the new method as a potential means of providing broad access to high-quality brain imaging.

Palliative Care in Emergency Departments: Addressing the Needs of Seriously Ill Older Adults

https://www.nccih.nih.gov/research/research-results/palliative-care-in-emergency-departments-addressing-the-needs-of-seriously-ill-older-adults?nav=govd Among people aged 65 and older, half visited the emergency department (ED) in the last month of their lives, and three in four visited the ED during the 6 months before their deaths. However, emergency care has not adapted to meet these patients’ needs, with palliative care teams, present in two-thirds of hospitals, not typically available in EDs for crisis response. A new study, published in the Journal of the American Medical Association and conducted by researchers from Memorial Sloan Kettering Cancer Center, New York University Grossman School of Medicine, and Tibor Rubin Long Beach Veterans Affairs, evaluates the effect of a multicomponent intervention to initiate palliative care in the ED on hospital admission rates for older adults with serious, life-limiting illnesses. This research was supported by the National Center for Complementary and Integrative Health and other components of the National Institutes of Health (NIH) within the NIH Pragmatic Trials Collaboratory.

lunes, 17 de febrero de 2025

Finerenone and new-onset diabetes in heart failure: a prespecified analysis of the FINEARTS-HF trial ++++++

https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00309-7/fulltext?dgcid=hubspot_update_feature_updatealerts_landia&utm_campaign=update-landia&utm_medium=email&_hsenc=p2ANqtz-96DygjA-lykZjE4mGbkQtdGTGYfsBTRqxG5yKLzczDe9NSOO4Rmjh4mbD9GVQohPhaRbe0CWUjVyYMaK78ZvhVDMV5BQ&_hsmi=346816850&utm_content=346774970&utm_source=hs_email Feb 2025 Volume 13Number 2p75-164, e2 Redefining obesity: advancing care for better lives The Lancet Diabetes & Endocrinology https://www.thelancet.com/journals/landia/issue/vol13no2/PIIS2213-8587(25)X0002-4 Definition and diagnostic criteria of clinical obesity https://www.thelancet.com/commissions/clinical-obesity?dgcid=hubspot_update_feature_landiaobesity25&utm_campaign=update-landia&utm_medium=email&_hsenc=p2ANqtz-9KtW9qd3RJCSWJNjgd-KWiEkaNATcOHiOkUptd9-A8I2XvMh71ZLcQIDVLpNU9Zo_WqZPrKXjlrG22fSb551MwW3_XHw&_hsmi=346816850&utm_content=346774970&utm_source=hs_email Diagnosing clinical obesity https://www.thelancet.com/infographics-do/clinical-obesity-25?dgcid=hubspot_update_feature_landiaobesity25&utm_campaign=update-landia&utm_medium=email&_hsenc=p2ANqtz-8nzmEOOSMXFCnOiUuvEbBQqRKwXZvvlrrUO7Sek-JBCTwZwL_iFu1EBKvydKhNzV5hw5obpPvJnYgYlJz8FKIgETTjQA&_hsmi=346816850&utm_content=346774970&utm_source=hs_email Hybrid closed-loop insulin therapy and risk of severe hypoglycaemia and diabetic ketoacidosis in young people (aged 2–20 years) with type 1 diabetes: a population-based study https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00284-5/fulltext?dgcid=hubspot_update_feature_updatealerts_landia&utm_campaign=update-landia&utm_medium=email&_hsenc=p2ANqtz-8C-78AZFeMzhNQa8va4x1mV_t2vqEnzboN9EBbfH_zr7a8-7fWdiMC6gXynOLLwCfR4f6vcJ_m61BXXJvnOdp3HByohQ&_hsmi=346816850&utm_content=346774970&utm_source=hs_email Overweight and obesity among Israeli adolescents and the risk for serious morbidity in early young adulthood: a nationwide retrospective cohort study https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00287-0/abstract?utm_campaign=update-landia&utm_medium=email&dgcid=hubspot_update_feature_updatealerts_landia&_hsenc=p2ANqtz--Fk_w_EaOe5xm7f9B-0JUTajoS7BZjGBJp6KjSmjaK2SRtItrITyQ2WXg4ceIPL8xwT-aKCwFbCCYHwSUnIhRJWZZtmA&_hsmi=346816850&utm_content=346774970&utm_source=hs_email