Uganda confirms Ebola case in nurse in capital city The case comes at a fragile time for global health, and as U.S.-WHO relations are strained

https://www.statnews.com/2025/01/30/uganda-ebola-sudan-nurse/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-88C6W4WbGRbGioRcBSXXT1gSFouGu-eL2cvdeKmqUeXmTU91_4bd32tHqXWNfa_t0udJXnxRzK83Dg7bTgSn-5FvJAog&_hsmi=345022952&utm_content=345022952&utm_source=hs_email Ebola case confirmed in Uganda Ugandan health officials on Thursday confirmed a case of Ebola in the capital, Kampala, in a 32-year-old nurse. The man died Wednesday at the Mulago National Referral Hospital in Kampala. Officials identified 45 people who were in contact with the man; none have showed any signs of Ebola. Any Ebola outbreak raises fears of transmission, but an outbreak of the disease in an urban setting like Kampala raises particular concerns. The man was also infected with the Sudan strain of Ebola, for which there are no licensed therapeutics or vaccines. The news arrives three years after the country had an outbreak caused by Ebola Sudan that led to 164 cases, including 55 deaths. The confirmation of an Ebola case comes at a fragile time in global health. Under the new Trump administration, the U.S. is moving to withdraw from the World Health Organization and has already paused communications with WHO officials, steps that American and international health officials have widely decried and warned threaten global and U.S. health security. Read more here.

Antidepressants versus placebo for generalised anxiety disorder (GAD)

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012942.pub2/full?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9PXDT7kmlKSNLDsF4mNG1p0o5RgTZ_7CVzO0DraewwonZv_8oVF-MTmrqKL-Tj-6gDjv64cgakZXz9amrYx1lXHkTKaQ&_hsmi=345022952&utm_content=345022952&utm_source=hs_email Anxiety and antidepressants Researchers confirmed that antidepressants lead to a significant reduction in generalized anxiety disorder symptoms in the short term. The long-awaited update, published by the Cochrane Database of Systematic Reviews, considered by some to be the gold-standard of evidence-based health care, considered evidence from 37 unique randomized control trials with 12,226 participants and found that these drugs are effective compared to a placebo. The drugs’ long-term impacts are muddier, said Prof. Peter Tyrer, an emeritus psychiatry professor at Imperial College London who was not involved in the study. Some patients have difficulties stopping antidepressants because of withdrawal problems. “The main reason why antidepressants were preferred to benzodiazepines (drugs that are equally effective in treating generalised anxiety) was the dependence risk, we just seem to have shifted the problem of adverse effects from one class of drugs to another,” Tyrer said.

GLP-1s: Good News, Bad News F. Perry Wilson, MSCE, MD ++++ +++

LATEST GLP-1s: Good News, Bad News GLP-1s: Good News, Bad News F. Perry Wilson, MSCE, MD https://www.medscape.com/viewarticle/glp-1s-good-news-bad-news-2025a10001fm?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 RSV Vaccines Will Carry Neurologic Risk Warning RSV Vaccines Will Carry Warning for Guillain-Barré Syndrome Heidi Splete https://www.medscape.com/viewarticle/rsv-vaccines-will-carry-warning-guillain-barre-syndrome-2025a10001ia?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 22, 2025 Adult ADHD Diagnosis Linked to Earlier Death Adult ADHD Diagnosis Linked to Earlier Death Eve Bender https://www.medscape.com/viewarticle/adult-adhd-diagnosis-linked-earlier-death-2025a10001p8?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 23, 2025 Will Repurposing Meds Aid Dementia Prevention? Repurposing Meds for Dementia Prevention: Will it Work? Megan Brooks https://www.medscape.com/viewarticle/repurposing-meds-dementia-prevention-will-it-work-2025a10001m8?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 23, 2025 From around the world Ketamine-Induced Uropathy: What Urologists Need to Know Ketamine-Induced Uropathy: What Urologists Need to Know Vincent Richeux https://www.medscape.com/viewarticle/ketamine-induced-uropathy-what-urologists-need-know-2025a10001dp?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 21, 2025 PM1 Pollution Drives Respiratory Hospitalizations PM1 Pollution Drives Respiratory Hospitalizations Christina Ferrario https://www.medscape.com/viewarticle/pm1-pollution-drives-respiratory-hospitalizations-2025a10000wk?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 15, 2025 Innovations in HIV Care for Women Worldwide Innovations in HIV Care for Women Worldwide Débora M.G. Cunha https://www.medscape.com/viewarticle/innovations-hiv-care-women-worldwide-2025a10000s0?ecd=mkm_ret_250131_mscpmrk-OUS_ICYMI_etid7192695&uac=148436CN&impID=7192695 January 14, 2025

Growing Evidence Suggests Plant-Based Diets Reduce Cancer Risk Tara Haelle January 16, 2025 +++ ++++ ++

RISKS & PREVENTION How Plant-Based Diets Affect Cancer Risk: New Findings Growing Evidence Suggests Plant-Based Diets Reduce Cancer Risk Tara Haelle https://www.medscape.com/viewarticle/growing-evidence-suggests-plant-based-diets-reduce-cancer-2025a100011d?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 January 16, 2025 Is Red Wine a Cancer Risk? Red Wine May Not Be a Health Tonic, but Is It a Cancer Risk? Amy Norton https://www.medscape.com/viewarticle/red-wine-may-not-be-health-tonic-it-cancer-risk-2025a10000o5?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 January 13, 2025 Dietary Calcium Cuts CRC Risk by 17% Dietary Calcium Cuts Colorectal Cancer Risk by 17% Dr Sheena Meredith | 08 January 2025 https://www.medscape.co.uk/viewarticle/dietary-calcium-cuts-colorectal-cancer-risk-17-2025a10000e0?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490&sso=true DETECTION & TREATMENT Milestone in Cancer Care: Cell Therapy for Solid Tumors Cellular Therapies for Solid Tumors: The Next Big Thing? Whitney McKnight https://www.medscape.com/viewarticle/cellular-therapies-solid-tumors-next-big-thing-2024a1000p01?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 December 23, 2024 Are MRI-Invisible Prostate Lesions Dangerous? MRI-Invisible Prostate Lesions: Are They Dangerous? Howard Wolinsky https://www.medscape.com/viewarticle/mri-invisible-prostate-lesions-are-they-dangerous-2025a10000cw?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 January 08, 2025 Harmful Variants in Cancer Genes Identified Study Identifies Risk Potential for Thousands Of Mutations Of a Cancer Gene Julie Steenhuysen https://www.medscape.com/s/viewarticle/study-identifies-risk-potential-thousands-mutations-cancer-2025a10000dg?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 January 08, 2025 Blood Test May Detect Multiple Cancers Early Blood Test Shows Promise for Early Cancer Detection Peter Russell | 10 January 2025 https://www.medscape.co.uk/viewarticle/blood-test-shows-promise-early-cancer-detection-2025a10000ld?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490&sso=true CANCER TRENDS UPDATE ‘Noteworthy’ Shift in Cancer Burden to Women ‘Alarming Disparities’ in Cancer Trends and Shift to Women, Younger Adults Richard Mark Kirkner https://www.medscape.com/viewarticle/alarming-disparities-cancer-trends-and-shift-women-younger-2025a1000166?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490 January 17, 2025 ‘Profound’ Implications for Cancer Survivors in Future Cancer Survivors: A Rising Population With Big Implications Maurie Markman, MD https://www.medscape.com/viewarticle/cancer-survivors-rising-population-big-implications-2024a1000ou6?ecd=mkm_ret_250131_mscpmrk_onc_top-content_etid7196490&uac=148436CN&impID=7196490

Common mental disorder could shorten your life, study finds Those with ADHD found to have ‘significantly’ shorter life expectancy, but more research is needed Melissa Rudy By Melissa Rudy Fox News Published January 28, 2025 3:08pm EST

Common mental disorder could shorten your life, study finds Those with ADHD found to have ‘significantly’ shorter life expectancy, but more research is needed Melissa Rudy By Melissa Rudy Fox News Published January 28, 2025 3:08pm EST https://www.foxnews.com/health/common-mental-disorder-could-shorten-life-study-finds

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(25)00005-0?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_sb7bubYg26slaJuOqlBDdC7TUs0xUg-ZawsZ1UXwb0ntR7cgy5frimgwuId7-pIvVGshrbLRnvoslkEDaGRwBjYO3gw&_hsmi=344625380&utm_content=344625380&utm_source=hs_email The first mice with two dads have reached adulthood There’s been so much news on the “chaos” beat this week that I just had to share this: Scientists in China have successfully engineered “bi-paternal” mice (those with two male parents) that have lived until adulthood, according to a study published yesterday in Cell Stem Cell. Previous attempts have been complicated due to genetic imprinting abnormalities that lead to defects, which the authors say is a major barrier to these types of experiments. But in this study, researchers individually modified 20 key imprinting genes using multiple different methods to combat that issue. It’s cool science (that MIT Technology Review explains in more detail) but don’t forget the caveats: These are mice, not humans, or even primates. Also: Most of these embryos didn’t even make it to birth — only seven mice made it that far out of 164 embryos. Not all of those seven made it to adulthood either, and those that did often had altered growth, a shortened lifespan, and were sterile. https://www.technologyreview.com/2025/01/28/1110613/mice-with-two-dads-crispr/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_Vbfz3cakm6LrKBZZ9sBJPW1nnLwoLloxm2d0UnsvUapPlbBk5CSa9Q3KjxnvlIcbf6f3w9L5h4skIae26pT8TrWUp5g&_hsmi=344625380&utm_content=344625380&utm_source=hs_email

Key Statistics for Cervical Cancer

https://www.cancer.org/cancer/types/cervical-cancer/about/key-statistics.html?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--FoYig1qQHneJmE5mFR-vJgtonzUbErYUpQAtIOFytMBonzTqxcQRFJUZQKhX6Mpp_Uv4mTc1O7uCLfOzbzH2al-KvuA&_hsmi=344625380&utm_content=344625380&utm_source=hs_email Why are cervical cancer death rates so bad in the Mississippi Delta? While politics over DEI are roiling Washington, work to end racial health disparities continues. This morning, the Southern Rural Black Women’s Initiative for Economic and Social Justice and Human Rights Watch released a report on the findings of 10 community health researchers who spent 18 months interviewing more than 150 women in the Mississippi Delta to understand the factors driving the area's inflated rates of cervical cancer, which are among the nation’s highest. The mortality rate for cervical cancer is 65% higher for Black women than white women. The report found that access to gynecological care was a major reason for the disparities. A cascade of factors are to blame, including Mississippi’s refusal to expand Medicaid through the ACA, which has contributed to rural hospital closures and helped fuel a shortage of OB-GYNs in the state. A lack of access to public transportation and racial discrimination from health providers also limited access, which led to less cancer screening and surgical treatment. Poor access to information on sexual and reproductive health, the report said, is another reason the state is ranked last in the nation in rates of uptake of the HPV vaccine which prevents cervical cancer. — Usha Lee McFarling https://www.statnews.com/2025/01/27/trump-dei-executive-order-quick-nih-funding-cuts/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-9jcH9FqKZ1DUvcCQUqL4GgppGkZPJ_ZowpXG1YAT62eGbRAXlI8m5s-iro-blfjoFImmQhi5cEK7Uk9dH3hqNzOmzcKA&_hsmi=344625380&utm_content=344625380&utm_source=hs_email

January 28, 2025 Brain Function Outcomes of Recent and Lifetime Cannabis Use

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829657?guestAccessKey=f8f351db-7527-4a41-a8f8-7726890cbbc9&utm_term=012825&utm_campaign=ftm_links&utm_medium=referral&_hsenc=p2ANqtz-9WalvwIQ5fjRvk-YZSGQ-2hTXePZGkwhoMUe735rFDjgnMte_931ZmJukzLcc3JyDij7zoqM6V4BHOAImGH4nayjnI8Q&_hsmi=344625380&utm_content=tfl&utm_source=for_the_media How weed may affect brain function People who use a lot of cannabis over time may experience reduced brain activity in certain situations, according to a study published yesterday in JAMA Network Open. Between 2012 and 2015, researchers tested more than 1,000 people ages 22-36. About 63% of “heavy users” — meaning those who have used cannabis 1,000 times or more — in the study had lower amounts of brain activity during a task, such as solving a math problem, that tests one’s ability to remember other information. There were similar associations between recent cannabis use and poor performance on working memory tasks, but other functions like motor skills, reward processing, emotion, and language did not see the same effects. It’s the largest study yet focusing on cannabis and brain function, the study authors write. Still, even larger and long-term studies are needed to fully understand the effects that cannabis has on the brain.

Prescription Stimulant Dispensing to US Children: 2017–2023

https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2024-068558/200682/Prescription-Stimulant-Dispensing-to-US-Children?&utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8nJL6tYLG-4WPjC2ZfZRv4zT2ehqGmaWTzFJ5GX7-8hLGGKprchbkL1zJKeKUPtnPhdCo3zVqijWS6osBHobl_2OE-QQ&_hsmi=344409238&utm_content=344409238&utm_source=hs_email?autologincheck=redirected Kids with ADHD and the Adderall shortage In Oct. 2022, the FDA announced a shortage of Adderall, the go-to treatment for ADHD. Since then, an increasing number of kids have gotten prescriptions for other stimulants, according to a study published yesterday in Pediatrics. The dip in Adderall prescriptions has been offset by an increase for a drug called Focalin. Researchers analyzed trends in the dispensation of stimulants to kids ages 5 to 17 between 2017 and 2023. Prescriptions declined in the beginning of the pandemic, but they’ve slowly climbed back up to normal, with a few exceptions. Most notably, in December 2023, girls aged 11 and younger had a monthly stimulant-dispensing rate that was 9% higher than pre-pandemic trends predicted. This likely doesn’t mean that more girls have ADHD than before, but perhaps signals that the condition isn’t going undiagnosed in girls as often as it used to. (In the last days of the Biden administration, the DEA proposed a long-awaited special registration process for prescribers who want to provide controlled substances like Adderall via telehealth. It’s unclear how the Trump administration will move forward on the rule.) https://www.statnews.com/2025/01/15/telehealth-adderall-buprenorphine-dea-rules/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-828Q8ChlapSEVkD79TAiKPxjP8xUllfzED_-5UtujRqt-dIe4caZ8G-EGByJZh26r7mnMqgUmvfJ6d81CCuHQsrGp3bw&_hsmi=344409238&utm_content=344409238&utm_source=hs_email

Bariatric surgery halted progression of liver disease in patients with obesity and cirrhosis, study finds ‘We can change the trajectory of the disease’

https://www.statnews.com/2025/01/27/bariatric-surgery-cirrhosis-liver-disease/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8fRLFzt1Hi-kOuxb2zCBWnaF2bbtOT5iyL09p_xuebmtE4EsQ8r2ePN0SumKD0folVrbFuSFfVgOtgo-epk2y98XjXqA&_hsmi=344205424&utm_content=344205424&utm_source=hs_email Could bariatric surgery help treat liver disease? For people with obesity and cirrhosis, a late stage of liver disease, one new, small study says that bariatric surgery might be an option. The study, published today in Nature Medicine, followed 168 patients, about a third of whom underwent bariatric surgery. After 15 years, fewer people in the surgical group developed one of the major complications of liver disease, which include cancer and death, than in the non-surgical group. “We can change the trajectory of the disease,” Ali Aminian, a co-author on the study, told STAT’s Liz Cooney. Read more on the specifics.

State of the Heart (and Brain) in 2025

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.073826?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_FUgukJCJosv4sJCs0bCYivchKaojOuqFQNGruYMr7qEzMbhnEYYXib-WAwr3-7vs6guypuvaUhpbDagOolJOuDjkLLA&_hsmi=344205424&utm_content=344205424&utm_source=hs_email Heart disease is still the biggest killer In 2022, about 40% of deaths in the U.S. were caused by cardiovascular heart disease, including heart disease and stroke, which kill more people in the U.S. than the next two biggest killers — all forms of cancer and accidental deaths — combined. That’s according to an annual update from the American Heart Association on heart disease and stroke statistics, published today in Circulation. Cardiovascular disease is “common, catastrophic, and costly,” an accompanying editorial notes. Despite its dominance, the overall number of deaths is leveling out after the pandemic shot numbers upwards. Yet contributing risk factors like high blood pressure and obesity continue to rise. Here are some more interesting findings: The percentage of high schoolers who are physically active for over an hour every day decreased from almost 29% to just under 24% between 2011 to 2021. Nearly 47% of all Americans have high blood pressure. In 2022, the prevalence was worst in Mississippi at about 40% and best in Colorado, at just under 25%. The rate of gestational diabetes in the U.S. increased 38% from 2016 to 2021, to 8.3% of pregnancies. https://www.ahajournals.org/journal/circ?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--ygkV5trH0Cbfrt3-hi7r76or309VrIG3Tz_Gv-6ikM6wPFA-WJnn6Hr7QxevLFYb-3PrlCRzNG_vq_xoESrWwJl6yNg&_hsmi=344205424&utm_content=344205424&utm_source=hs_email

To block dengue, humans and mosquitoes could share antivirals A compound that inhibits replication of the dengue virus in mammals was similarly effective in mosquitoes consuming it via blood, reducing transmissibility. ++++

https://www.drugdiscoverynews.com/to-block-dengue-humans-and-mosquitoes-could-share-antivirals-16207 Boosting ovarian cancer immunotherapy with fatty acid uptake Ovarian tumors are extremely difficult to get rid of. Scientists are figuring out how to leverage the immune system to help. https://www.drugdiscoverynews.com/boosting-ovarian-cancer-immunotherapy-with-fatty-acid-uptake-16205 Immunotherapy boosts chemotherapy in rare urological cancers An immune checkpoint inhibitor and chemotherapy extended progression-free survival in late-stage small cell bladder and prostate cancers. https://www.drugdiscoverynews.com/immunotherapy-boosts-chemotherapy-in-rare-urological-cancers-16203 WHAT IS MESENCHYMAL STEM CELL THERAPY? https://www.drugdiscoverynews.com/what-is-mesenchymal-stem-cell-therapy-16153

‘Alarming Disparities’ in Cancer Trends and Shift to Women, Younger Adults Richard Mark Kirkner January 17, 2025 +++ ++++ +++

RISK MITIGATION ‘Noteworthy’ Shift in Cancer Burden to Women ‘Alarming Disparities’ in Cancer Trends and Shift to Women, Younger Adults Richard Mark Kirkner https://www.medscape.com/viewarticle/alarming-disparities-cancer-trends-and-shift-women-younger-2025a1000166?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 January 17, 2025 Reduce Breast Cancer Risk With Plant-Based Diet? Growing Evidence Suggests Plant-Based Diets Reduce Cancer Risk Tara Haelle https://www.medscape.com/viewarticle/growing-evidence-suggests-plant-based-diets-reduce-cancer-2025a100011d?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 January 16, 2025 Airborne Dioxins May Up Breast Cancer Risk Airborne Dioxin Pollution May Increase Breast Cancer Risk Miriam Davis, PhD | https://www.medscape.co.uk/viewarticle/airborne-dioxin-pollution-may-increase-breast-cancer-risk-2024a1000m56?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572&sso=true TREATMENT ADVANCES PARP Inhibitor Extends Survival in High-Risk Breast Cancer Olaparib Continues to Protect Patients From High-Risk Cancer Recurrences Neil Osterweil https://www.medscape.com/viewarticle/olaparib-continues-protect-patients-high-risk-cancer-2024a1000mzd?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 CDK 4/6 Blocker Prolongs Survival in HER2+ Mets Breast Cancer CDK 4/6 Blocker Prolongs Survival in HER2+ Metastatic Breast Cancer M. Alexander Otto, PA, MMS https://www.medscape.com/viewarticle/cdk-4-6-blocker-prolongs-survival-her2-metastatic-breast-2025a10000fe?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 January 09, 2025 New ADC for HR+, HER2- Breast Cancer FDA Approves New ADC for HR+, HER2- Breast Cancer Sharon Worcester, MA https://www.medscape.com/viewarticle/fda-approves-new-adc-hr-her2-breast-cancer-2025a100017n?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 January 17, 2025 T-DXd Shows Strong Efficacy for HER2-Low Breast Cancer T-DXd Shows Consistent Benefit Across Endocrine-Resistant HR+/HER2-Low Breast Cancer Subgroups Christos Evangelou, MSc, PhD https://www.medscape.com/viewarticle/t-dxd-shows-consistent-benefit-across-endocrine-resistant-hr-2024a1000ojy?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 December 19, 2024 LONG-TERM MANAGEMENT Oncs or PCPs to Lead Breast Cancer Survivorship Care? Oncologists More Often Provide Long-Term Care of Breast Cancer Survivors Than PCPs Edited by Katie Lennon https://www.medscape.com/viewarticle/oncologists-more-often-provide-long-term-care-breast-cancer-2024a1000n1x?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 December 13, 2024 Immediate Surgery Improves Long-Term Survival in Older Patients Immediate Surgery Significantly Improves Long-Term Survival in Older Breast Cancer Patients, Meta-Analysis Shows Christos Evangelou, MSc, PhD https://www.medscape.com/viewarticle/immediate-surgery-significantly-improves-long-term-survival-2024a1000mz3?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 December 12, 2024 Can Some Patients Safely Skip Postmastectomy Radiation? Can Some Patients Safely Skip Postmastectomy Radiation? M. Alexander Otto, PA, MMS https://www.medscape.com/viewarticle/can-some-patients-safely-skip-postmastectomy-radiation-2025a10000fw?ecd=mkm_ret_250126_mscpmrk_onc_breast_etid7184572&uac=148436CN&impID=7184572 January 09, 2025

What do we mean by evidence? How choosing the right methods can improve the real-world relevance of mental health research

IAMHRF Online Symposium: What do we mean by evidence?, inspired by The Lancet Psychiatry’s Commission on Transforming Mental Health Implementation Research. Feb 6, 2024, 1:30 PM GMT / 8:30 AM ET. https://events.teams.microsoft.com/event/d1fd5400-eaad-4123-9cbe-addf8b108d2d@91a138ee-d6db-40d9-9ca7-44fcd132fa5e

Urinary Metals Linked to Increased Dementia Risk Edited by Anushree Chaphalkar +++ +++ ++

RISK FACTORS Urinary Metals Linked to Increased Dementia Risk Urinary Metals Linked to Increased Dementia Risk Edited by Anushree Chaphalkar https://www.medscape.com/viewarticle/urinary-metals-linked-increased-dementia-risk-2024a1000pgu?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 Common Gut Infection May Elevate AD Risk Common Gut Infection Tied to Alzheimer’s Disease Pauline Anderson https://www.medscape.com/viewarticle/common-gut-infection-tied-alzheimers-disease-2024a1000p1x?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 Processed Red Meat Tied to Dementia Processed Red Meat Tied to Increased Dementia Risk Eve Bender https://www.medscape.com/viewarticle/processed-red-meat-tied-increased-dementia-risk-2025a100013j?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 January 16, 2025 DIAGNOSTIC ADVANCES New Alzheimer’s Guidelines: First Update in 24 Yrs Updated Alzheimer’s Guidelines Chart the Full Diagnostic Journey Megan Brooks https://www.medscape.com/viewarticle/updated-alzheimers-guidelines-chart-full-diagnostic-journey-2025a10000y1?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 January 15, 2025 Recognizing Unusual Neurological Conditions Fast Five Quiz: Recognizing Unusual Neurologic Conditions Heidi Moawad, MD https://reference.medscape.com/viewarticle/1001995?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 Dementia Cases Could Double in 40 Yrs US Dementia Cases Projected to Double Within 40 Years Pauline Anderson https://www.medscape.com/viewarticle/us-dementia-cases-projected-double-within-40-years-2025a10000qn?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 PROTECTIVE STRATEGIES The Curious Reason Taxi Drivers Are Protected From Alzheimer’s The Curious Reason Taxi Drivers Are Protected From Alzheimer’s F. Perry Wilson, MSCE, MD https://www.medscape.com/viewarticle/curious-reason-taxi-drivers-are-protected-alzheimers-2024a1000n9h?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671 Can GLP-1s Reduce Alzheimer’s Disease Risk? Can GLP-1s Reduce Alzheimer’s Disease Risk? Caroline Messer, MD https://www.medscape.com/viewarticle/can-glp-1s-reduce-alzheimers-disease-risk-2025a100007w?ecd=mkm_ret_250126_mscpmrk_neuro_dementia_etid7184671&uac=148436CN&impID=7184671

SMALL STEPS, BIG IMPACT: GROWING A LOVE FOR NATURE

Small Steps, Big Impact: Growing A Love for Nature By Ivanhoe Broadcast News on January 29, 2025 https://www.ivanhoe.com/?p=34938&preview=1&_ppp=9014ee81c4

DON’T BE AN ALICE! TIPS FOR FINANCIAL FREEDOM AT EVERY AGE

Don’t Be An ALICE! Tips For Financial Freedom At Every Age By Ivanhoe Broadcast News on January 28, 2025 https://www.ivanhoe.com/?p=34935&preview=1&_ppp=13d21d92d1

THE SOCIAL DILEMMA: REWIRING THE TEENAGE BRAIN

The Social Dilemma: Rewiring The Teenage Brain By Ivanhoe Broadcast News on January 27, 2025 https://www.ivanhoe.com/?p=34932&preview=1&_ppp=4c8518dec6

Final sale: my eight-year struggle to return recalled breast implants After a voluntary double mastectomy, I learned that my implants put me at risk of lymphoma — and no one would remove them

https://www.statnews.com/2025/01/21/allergan-natrelle-breast-implants-recall-fda-lymphoma/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--wVG1oYJdhvaynMc13ng8GHKritRCkoZ-xqBy2JXWwpWDDnzzDR00Kdz4CfdfGf55_3Ge8EF38qCMQc0kPOAvP04oVBA&_hsmi=343359550&utm_content=343359550&utm_source=hs_email How she finally got a ticking time bomb out of her body We have a ton of news to digest today, but make room for this First Opinion. Oceana Callum tells a haunting and horrifying story of living with breast implants after cancer treatment that were later voluntarily recalled because they were linked to another form of cancer. No surgeon would agree to remove them unless she actually developed lymphoma, a decision supported by the FDA. Insurers have to cover breast reconstruction, for its mental health and other benefits, but not implant removal. “For many cancer survivors, potentially carcinogenic implant removal is, obviously, integral to our peace of mind,” Callum writes. “Having a ticking time bomb in one’s body is, ironically, to be imprisoned in the same situation from which many of us struggled brutally to be freed.” Read how she got out.

Alcohol labels should carry ‘Alcohol Facts’ box listing nutrition and allergens, regulator says The Alcohol and Tobacco Tax and Trade Bureau’s proposal follows years of consumer petitioning

https://www.statnews.com/2025/01/17/nutrition-fact-labels-on-alcoholic-beverages-treasury-department-proposed-new-rule/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8UGMlQd9qoo1YGHscgI0Rd__rsHY0zLQnBgjXxi3DvecwDvI1Wz6Qmv47f7diVCbgvQms4JYqzbGxtCwlJmPlhllmM7A&_hsmi=343359550&utm_content=343359550&utm_source=hs_email Do numbers on a label work to help people make healthier choices? Two approaches: You’re familiar with the nutrition box for food labels. Now it’s alcohol’s turn. The Alcohol and Tobacco Tax and Trade Bureau has proposed requiring companies to disclose alcohol content and any major food allergens. Information boxes would list the alcohol content of a drink, in fluid ounces of pure alcohol per serving, as well as the familiar calories, carbohydrates, protein, and fats. What took so long? The FDA rules over food, while the Alcohol and Tobacco Tax and Trade Bureau (an agency within the U.S. Treasury) rules over, well, alcohol. STAT’s Isabella Cueto tells us more. Calorie counts on menus for foods you order have been around since 2018, when the FDA ordered chain restaurants to display them, and in the U.K. since 2022, when regulators there introduced the same rule. The Cochrane Collaborative concludes after its hallmark systematic review that the benefits are pretty slim, possibly leading diners to choose foods with an average 1.8% fewer calories than they would without calorie labels. But it’s not nothing, STAT’s Sarah Todd learned. Do calorie counts on menus really change how people eat? Calorie labels on menus have a small but meaningful impact on people’s choices, review finds https://www.statnews.com/2025/01/16/calorie-counts-on-menus-effects-on-choices-cochrane-review/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_19lHCGT6j68WmJuoWVkHy9H0rwsB1SyqEgcaJqPzP6O5w7ecmhDs4FSRghoPGpE9eAwnbkK9Hc28dXr37INTTn5C9Ew&_hsmi=343359550&utm_content=343359550&utm_source=hs_email

Mapping the effectiveness and risks of GLP-1 receptor agonists

https://www.nature.com/articles/s41591-024-03412-w What can’t GLP-1 drugs do? Ziyad Al-Aly led a team trying to compile what he calls an atlas of risks and benefits from the obesity drugs. You’ve heard of health benefits linked to weight loss, like better heart health or diabetes control (the original intent). You may also know people feel the pull of addiction to alcohol or other drugs isn’t so strong. In a large study of VA patients, a new paper out in Nature Medicine Monday found 42 benefits but 19 harms, some of them not familiar. “We tend to think of drugs sort of like they are surgically designed to do only one thing. But the reality is it's almost never like this,” Al-Aly explained. I have more here. What can’t GLP-1s do? Study maps benefits while warning of uncommon risks Atlas of good and bad effects aims to close knowledge gap for blockbuster obesity drugs https://www.statnews.com/2025/01/20/glp-1-drugs-more-than-weight-loss-new-study-42-possible-benefits/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--XahccMtgXVU3JMSaGAG82VCV4jsJT3Bn5YhOww-op5ZhK8mcopboNLfO6x2MBhkPcbcDNIjaCzrrzmngML6dickt04g&_hsmi=343359550&utm_content=343359550&utm_source=hs_email