Powering up natural killer cells to fight cancer | Drug Discovery News

Powering up natural killer cells to fight cancer | Drug Discovery News: Natural killer cells offer safe and effective cancer treatment, but to succeed in the clinic, they need a bit of an energy boost.

Lighting the way to pain relief | Drug Discovery News

Lighting the way to pain relief | Drug Discovery News: Rodent studies and clinical trials increasingly demonstrate the soothing effects of green light, and now, researchers are revealing the underlying neural mechanisms.

Sensitizing pancreatic cancer to immunotherapy | Drug Discovery News

Sensitizing pancreatic cancer to immunotherapy | Drug Discovery News: A new mouse study suggests that folinic acid treatment could help the immune system penetrate pancreatic cancer’s protective shell.

Breast tumors may mimic neurons to invade the brain | Drug Discovery News

Breast tumors may mimic neurons to invade the brain | Drug Discovery News: Breast cancer cells can pass through the bone marrow to reach the tissues surrounding the brain and spinal cord in mice — a new way for cancer to spread.

8 tips for talking (and listening) to your teens about drugs and alcohol How families can have better, nonjudgmental conversations

https://magazine.medlineplus.gov/article/8-tips-for-talking-and-listening-to-your-teens-about-drugs-and-alcohol?utm_medium=email&utm_source=govdelivery Talking to your children about drugs and alcohol can be…well, awkward. It’s hard to know what to ask them, what to say, and if you’ll get through to them. But talking about substance use is important for promoting healthy behaviors. If you’re not sure how to get the conversation started, these tips from the Substance Abuse and Mental Health Services Administration (SAMHSA) may help. No matter what, be open-minded, well-informed,

A better way to say that: Stigmatizing language affects how we treat addiction

https://magazine.medlineplus.gov/article/a-better-way-to-say-that-stigmatizing-language-affects-how-we-treat-addiction?utm_medium=email&utm_source=govdelivery Substance use disorders (SUDs) are chronic, treatable conditions that people can recover from, but stigma around them makes it hard to seek treatment. SUDs are very common and can affect anyone, but the disorders are often misunderstood. In 2023, an estimated 16% of people with SUDs reported that they did not seek treatment because they worried about what their community would think. Stigma refers to negative attitudes about people based on their

The Eyes Have it: A Functional Role for Prion Protein

https://www.niaid.nih.gov/news-events/prion-role-light?utm_campaign=+62411034&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term= In the early 1980s, scientists identified clumps of abnormal, misfolded prion protein in mammals as the cause of brain-wasting diseases, now called prion diseases. Human prion diseases include Creutzfeldt-Jakob disease, fatal familial insomnia and kuru; animal prion diseases include scrapie in sheep and chronic wasting disease in cervids. Since identifying prion protein, researchers have struggled to answer: What do they do? A new study published in iScience from NIAID scientists at Rocky Mountain Laboratories in Hamilton, Montana, and colleagues provides details of how prion protein functions in the retina of mouse eyes, helping them respond to light. The researchers believe the prion protein must be present for rods and cones to function normally. The team hopes these findings help colleagues who study prion diseases better understand what might occur in humans when natural forms of prion protein are therapeutically removed. New treatment strategies for prion diseases focus on using drugs that remove natural prion protein to eliminate the potential for misfolding and clumping. The findings also could extend to other protein-related neurodegenerative diseases, such as Alzheimer’s (amyloid beta protein) and Parkinson’s diseases (alpha synuclein protein).

jueves, 26 de septiembre de 2024

Putting the power of lab-based diagnostic testing in the palm of your hand

Putting the power of lab-based diagnostic testing in the palm of your hand: Due to its high accuracy, lab-based PCR testing is the gold standard for infectious disease diagnostics. Yet PCR's availability is limited, especially in low-resource settings. New research suggests a new kind of test could be more streamlined without sacrificing performance.

Wearable lung patch uses deep learning to detect asthma and COPD

Wearable lung patch uses deep learning to detect asthma and COPD: Early detection of respiratory diseases is critical for treatment. Researchers at the Georgia Institute of Technology have developed a wearable lung patch which, in a pilot study, detected wheezing, a common indicator of asthma and COPD.

Taking cues from nature, medical soft robots get smart

Taking cues from nature, medical soft robots get smart: Physical human feats require a high level of coordination between sensory and motor functions. What kind of achievements could robots perform with the same cohesion between sensing and action? In the medical space, researchers have begun to explore the possibilities.

From flat to overflowing: adding another dimension to tissue analysis

From flat to overflowing: adding another dimension to tissue analysis: A team of NIBIB-funded researchers recently developed an AI platform that can analyze 3D pathology images to predict disease outcomes. Their method had improved performance in predicting prostate cancer outcomes when compared with traditional pathology approaches, such as analysis by expert pathologists using 2D images.

Drug Trials Snapshots: ZEVTERA (ceftobiprole medocaril sodium for injection)

ZEVTERA is a cephalosporin antibacterial drug used for the treatment of serious infections including Staphylococcus aureus bacteremia (SAB) in adults, acute bacterial skin and skin structure infections (ABSSSI) in adults, and community-acquired bacterial pneumonia (CABP) in adults and children aged 3 months to less than 18 years. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-zevtera

The top 5 worries — and 5 worst sleep habits — that are keeping Americans up at night Stress negatively impacts 74% of adults’ sleep routines, a new survey found Melissa Rudy By Melissa Rudy Fox News Published September 25, 2024 4:30am EDT

The top 5 worries — and 5 worst sleep habits — that are keeping Americans up at night Stress negatively impacts 74% of adults’ sleep routines, a new survey found Melissa Rudy By Melissa Rudy Fox News Published September 25, 2024 4:30am EDT https://www.foxnews.com/health/top-worries-sleep-habits-keeping-americans-up-night

Federal judge orders EPA to further regulate fluoride in drinking water due to concerns over lowered IQ in kid Municipalities have been adding fluoride to water supplies for decades to prevent tooth decay but critics have long questioned its potential side effects By Michael Dorgan Fox News Published September 26, 2024 8:40am EDT

Federal judge orders EPA to further regulate fluoride in drinking water due to concerns over lowered IQ in kid Municipalities have been adding fluoride to water supplies for decades to prevent tooth decay but critics have long questioned its potential side effects By Michael Dorgan Fox News Published September 26, 2024 8:40am EDT https://www.foxnews.com/health/federal-judge-orders-epa-further-regulate-fluoride-drinking-water-due-concerns-over-lowered-iq-kid

Drug Trials Snapshots: XACDURO (sulbactam for injection; durlobactam for injection), co-packaged for intravenous use

XACDURO is an antibacterial drug to treat adults who have hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) caused by specific bacteria called Acinetobacter baumannii-calcoaceticus complex. It should not be used to treat pneumonia, which is caused by other bacteria. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-xacduro

Augmented reality navigation system could improve lumbar puncture accuracy

Augmented reality navigation system could improve lumbar puncture accuracy: A team of researchers funded by a NIBIB Small Business program grant developed a new ultrasound navigation system that could provide accurate, real-time, and intuitive needle insertion planning and guidance for lumbar puncture procedures.

Color coding colorectal cancer | Drug Discovery News

Color coding colorectal cancer | Drug Discovery News: Researchers captured a multicolored image of an aggressive colorectal tumor, revealing a unique biomolecular profile, growth mechanism, and drug target.

The dual role microbiota in cancer immunotherapy | Drug Discovery News

The dual role microbiota in cancer immunotherapy | Drug Discovery News: Gut bacteria influence the already complex relationship between immune cells and cancer. Understanding this three-way communication sheds light on why immunotherapies fail in some patients but succeed in others.

A squishy solution for smoother drug delivery | Drug Discovery News

A squishy solution for smoother drug delivery | Drug Discovery News: Customizable hydrogels could make taking diabetes and cancer medications as well as other biologics easier for patients.

No oxygen? No problem for these cancer-aiding bacteria | Drug Discovery News

No oxygen? No problem for these cancer-aiding bacteria | Drug Discovery News: Bacteria can invade colorectal cancer tumors, leading to worse disease outcomes. Oxygen — or lack thereof — plays a vital role in this interaction.

3 diet and health tips for someone struggling with IBS Irritable bowel syndrome can negatively impact quality of life for individuals who live with the digestive condition By Ashlyn Messier Fox News Published September 20, 2024 3:58pm EDT

3 diet and health tips for someone struggling with IBS Irritable bowel syndrome can negatively impact quality of life for individuals who live with the digestive condition By Ashlyn Messier Fox News Published September 20, 2024 3:58pm EDT https://www.foxnews.com/health/diet-health-tips-someone-struggling-ibs

Children once held hostage still working through trauma: 'Are they coming for us again?' Those released from captivity fight for normalcy as therapists, family members reveal challenges By Eve Glover Fox News Published September 21, 2024 4:30am EDT

Children once held hostage still working through trauma: 'Are they coming for us again?' Those released from captivity fight for normalcy as therapists, family members reveal challenges By Eve Glover Fox News Published September 21, 2024 4:30am EDT https://www.foxnews.com/health/children-held-hostage-working-trauma-coming-us-again

Prostate cancer signs, symptoms and lifestyle changes that could reduce your risk Symptoms of prostate cancer are often slim to none By Ashlyn Messier Fox News Published September 19, 2023 6:45am EDT | Updated September 22, 2024 8:15am EDT

Prostate cancer signs, symptoms and lifestyle changes that could reduce your risk Symptoms of prostate cancer are often slim to none By Ashlyn Messier Fox News Published September 19, 2023 6:45am EDT | Updated September 22, 2024 8:15am EDT https://www.foxnews.com/health/prostate-cancer-symptoms-and-warning-signs

Latest COVID variant, XEC, has spread to half of US states, reports say The mutated strain poses ‘no unique concern,’ according to infectious diseases expert Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News Published September 20, 2024 8:17pm EDT

Latest COVID variant, XEC, has spread to half of US states, reports say The mutated strain poses ‘no unique concern,’ according to infectious diseases expert Melissa Rudy By Melissa Rudy , Angelica Stabile Fox News Published September 20, 2024 8:17pm EDT https://www.foxnews.com/health/latest-covid-variant-xec-has-spread-half-us-states-reports-say

NIGHTY NIGHT: DON’T SABATOGE YOUR CHILDS SLEEP

Nighty Night: Don’t Sabotage Your Childs Sleep By Ivanhoe Broadcast News on September 29, 2024 https://www.ivanhoe.com/?p=34161&preview=1&_ppp=05ffa87126

SEAL THE DEAL: NEGOTIATING FOR THE BEST JOB OFFER

Seal the Deal: Negotiating for the Best Job Offer By Ivanhoe Broadcast News on September 28, 2024 https://www.ivanhoe.com/?p=34156&preview=1&_ppp=8be1d0a17a

PARKINSON’S SYMPTOM RARELY MENTIONED: HALLUCINATIONS

Parkinson’s Symptom Rarely Mentioned: Hallucinations By Ivanhoe Broadcast News on September 27, 2024 https://www.ivanhoe.com/?p=34179&preview=1&_ppp=852fe86594

HOPE ON THE HORIZON: TREATING LEWY BODY DEMENTIA

Hope On the Horizon: Treating Lewy Body Dementia By Ivanhoe Broadcast News on September 23, 2024 https://www.ivanhoe.com/?p=34167&preview=1&_ppp=ee40b4885c

viernes, 20 de septiembre de 2024

TeamSTEPPS 3.0

TeamSTEPPS 3.0: TeamSTEPPS is an evidence-based set of teamwork tools, aimed at optimizing patient outcomes by improving communication and teamwork skills among health care professionals. The training provides guides, videos, and exercises to practice the skills.

TeamSTEPPS Training Opportunities

TeamSTEPPS Training Opportunities: AHRQ is providing virtual TeamSTEPPS trainings led by experienced facilitators at no charge to participants through November 2024.

AHRQ's Healthcare Extension Service: State-Based Solutions to Healthcare Improvement

AHRQ's Healthcare Extension Service: State-Based Solutions to Healthcare Improvement: The Agency for Healthcare Research and Quality (AHRQ) intends to publish a funding opportunity announcement to create State-based Healthcare Extension Cooperatives that can accelerate the implementation of actionable evidence into practice.

Quality and Safety Review System (QSRS)

Quality and Safety Review System (QSRS): AHRQ developed and tested the Quality and Safety Review System (QSRS), an improved patient safety surveillance system to replace MPSMS. The QSRS relies on clinical information recorded in medical records and is designed to make use of structured data where it is or may become available.

Alzheimer’s disease could be slowed by boosting a certain protein in the brain, researchers say A new study challenges longstanding assumptions about what causes the common dementia Melissa Rudy By Melissa Rudy Fox News Published September 16, 2024 4:30am EDT | Updated September 16, 2024 5:03am EDT

Alzheimer’s disease could be slowed by boosting a certain protein in the brain, researchers say A new study challenges longstanding assumptions about what causes the common dementia Melissa Rudy By Melissa Rudy Fox News Published September 16, 2024 4:30am EDT | Updated September 16, 2024 5:03am EDT https://www.foxnews.com/health/alzheimers-disease-slow-boosting-certain-protein-brain-researchers-say

Leukemia patient receives first-ever bone marrow transplant from deceased organ donor Ossium Health is building a 'life-saving' bank of frozen bone marrow to cut wait for matched donors Melissa Rudy By Melissa Rudy Fox News Published September 17, 2024 5:15am EDT | Updated September 17, 2024 5:24am EDT

Leukemia patient receives first-ever bone marrow transplant from deceased organ donor Ossium Health is building a 'life-saving' bank of frozen bone marrow to cut wait for matched donors Melissa Rudy By Melissa Rudy Fox News Published September 17, 2024 5:15am EDT | Updated September 17, 2024 5:24am EDT https://www.foxnews.com/health/leukemia-patient-receives-first-bone-marrow-transplant-deceased-organ-donor

Flu shot scheduling: When is the best time to get the vaccine? The CDC recommends that the flu shot is given to everyone 6 months and older, with rare exceptions Angelica Stabile By Angelica Stabile Fox News Published September 18, 2024 3:20pm EDT

Flu shot scheduling: When is the best time to get the vaccine? The CDC recommends that the flu shot is given to everyone 6 months and older, with rare exceptions Angelica Stabile By Angelica Stabile Fox News Published September 18, 2024 3:20pm EDT https://www.foxnews.com/health/flu-shot-scheduling-when-best-time-get-vaccine

Ovarian cancer signs, symptoms, diagnosis and treatment options OB-GYN can help answer your questions about ovarian cancer and how to potentially reduce your risk By Ashlyn Messier Fox News Published September 19, 2023 3:00am EDT | Updated September 19, 2024 7:59pm EDT

Ovarian cancer signs, symptoms, diagnosis and treatment options OB-GYN can help answer your questions about ovarian cancer and how to potentially reduce your risk By Ashlyn Messier Fox News Published September 19, 2023 3:00am EDT | Updated September 19, 2024 7:59pm EDT https://www.foxnews.com/health/ovarian-cancer-symptoms-and-warning-signs

Soy milk could reduce risk factors for heart disease, research shows While soy milk is classified as 'ultra-processed,' experts claim it's a nutritious alternative to cow's milk Angelica Stabile By Angelica Stabile Fox News Published September 18, 2024 7:49pm EDT

Soy milk could reduce risk factors for heart disease, research shows While soy milk is classified as 'ultra-processed,' experts claim it's a nutritious alternative to cow's milk Angelica Stabile By Angelica Stabile Fox News Published September 18, 2024 7:49pm EDT https://www.foxnews.com/health/soymilk-could-reduce-risk-factors-heart-disease-research-shows

During pregnancy, a woman's brain experiences 'profound changes,' new study finds Researchers scanned a first-time mother's brain before, during and after pregnancy, finding significant changes Angelica Stabile By Angelica Stabile Fox News Published September 20, 2024 4:30am EDT

During pregnancy, a woman's brain experiences 'profound changes,' new study finds Researchers scanned a first-time mother's brain before, during and after pregnancy, finding significant changes Angelica Stabile By Angelica Stabile Fox News Published September 20, 2024 4:30am EDT https://www.foxnews.com/health/pregnancy-woman-brain-experiences-profound-changes-new-study-finds

European Health Data Space (EHDS) Training Sessions September 2024

https://www.eurordis.org/european-health-data-space-ehds-training-sessions/ Training Session 1: How does the EHDS work? ➡️ Register now! 🗓️ 30 September 2024 ⏰ 2:00 pm CET Training Session 2: EHDS and Primary Data ➡️ Register now! 🗓️ 28 October 2024 ⏰ 2:00 pm CET Training Session 3: EHDS and Secondary Data ➡️ Register now! 🗓️ 25 November 2024 ⏰ 2:00 pm CET

EURORDIS Mental Health & Wellbeing Open Webinar: 🗓️ 23 October 2024 ⏰ 2:00 pm to 3:30 pm CET

https://www.eurordis.org/mental-health-open-webinar-how-to-deliver-a-diagnosis/ Join us for the EURORDIS 6th Mental Health & Wellbeing Webinar, “How to Deliver a Diagnosis,” on October 23, 2024, from 2:00 pm to 3:30 pm CET (Paris time). This webinar will explore the critical milestone of delivering a rare disease diagnosis for families and individuals affected by rare conditions. A timely and empathetic diagnosis can empower families, while poor communication can lead to significant emotional distress and mistrust in the healthcare system. Experts from European Reference Networks, including ERN CRANIO, ERN-EYE, and VASCERN, will share real cases and best practices, followed by a panel discussion. Don’t miss this opportunity to learn from leading specialists about best practices in delivering a rare disease diagnosis.

miércoles, 18 de septiembre de 2024

Neurostimulation shines a light on dopamine brain circuits | Drug Discovery News

Neurostimulation shines a light on dopamine brain circuits | Drug Discovery News: Stimulating dopamine neurons in adolescent mice rescued cognitive deficits associated with future development of neuropsychiatric disorders.

A genetic link to the development of epilepsy and autism | Drug Discovery News

A genetic link to the development of epilepsy and autism | Drug Discovery News: Epilepsy onset and seizure severity are linked to variants in the SCN2A gene, potentially leading to improved diagnostics and treatments.

Drug Trials Snapshots: YORVIPATH (palopegteriparatide) injection

YORVIPATH is a parathyroid hormone analog that is approved for the treatment of hypoparathyroidism in adults. Hypoparathyroidism is a disease in which there is insufficient parathyroid hormone (PTH) production, which leads to hypocalcemia (blood calcium levels that are low). https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-yorvipath

Multiple sclerosis 2024: Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and remaining challenges Chataway et al. The Lancet Neurology

Executive Summary Multiple sclerosis is an immune-mediated disease of the central nervous system and a leading cause of neurological disability. Considerable progress in imaging techniques and fluid biomarkers have enhanced our understanding of MS, improving diagnostic, prognostic, and treatment monitoring tools. However, understanding the different clinical manifestations, timely diagnosis and treatment success remains a critical unmet need. https://www.thelancet.com/series/multiple-sclerosis-2024?dgcid=hubspot_update_feature_infocusbrainhealth_lanepemultiplesclerosis24&utm_campaign=update-lanepe&utm_medium=email&_hsenc=p2ANqtz--lf7Lfvy6QVrDoMswBrxjtxJvxRj8Hlfggxm8jOX9uYMQpwOrYDASmy05XGFaqr8m-DSmUqfX8hGMywHbHuIf5GQMpKQ&_hsmi=325079447&utm_content=325001241&utm_source=hs_email

Respiratory Syncytial Virus Published: September 9, 2024

Executive Summary Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infection (LRTI) and is responsible for a high burden of hospital admission and mortality in children. RSV–LRTI is also associated with long-term respiratory sequelae. Recent advances show great promise such as RSV vaccines and monoclonal antibodies. In the first of a Series of four papers, disease burden, clinical management, risk factors, and emerging therapies are discussed for severe RSV infection in children. The second paper reviews possible long-term sequelae, addressing inequities. The third paper focuses on RSV infections in adults, highlighting the neglect of this patient group. The fourth paper discusses RSV vaccination and immunoprophylaxis in young children, as well as exploring potential regulatory, policy, and implementation pathways. It also addresses the health economic evidence to inform product introduction decisions. Evidence reviewed in this Series should help implement preventive strategies to reduce the burden of RSV-related disease in vulnerable populations worldwide. https://www.thelancet.com/series/respiratory-syncytial-virus?dgcid=hubspot_email_conferencealerts_ers24_rsv24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-8ohvq5juZEaL8jE5bLb1RoMmISdi9gGjmWMsWOp_gA8j3A5Sf2UEyod2s_X313tJo_pybhF0G-YLJx1oQNJNNlUcQFyQ&_hsmi=325072833&utm_content=323935440&utm_source=hs_email

Head and neck cancer consensus recommendations

Heterogeneity in diagnostic criteria for extranodal extensions results in inconsistencies in clinical decision making. Moreover, there is an urgent need for standardisation of endpoints in clinical trials for head and neck cancer. In this four-part Series by The Lancet Oncology, the Head and Neck Cancer International Group—a consortium of 21 national head and neck oncology research groups—provides consensus recommendations for clear definitions of extranodal extensions and clinical-trial endpoints to inform and standardise clinical practice globally. https://www.thelancet.com/series/head-and-neck-cancer-consensus-recommendations?dgcid=hubspot_email_infocusalerts-oncology_feature_lanoncheadneckcancer24&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz--39y8Juo1h7k3zHCNmCAjen0kdGJsVP3PK8KcxJl2XmxKcVsbAnYUScL7VYQtoeRpzCEp1MijvzPTZY0SH1tfQEoDaCA&_hsmi=324659725&utm_content=322872993&utm_source=hs_email