Recovery LIVE!SAMHSA’s Bringing Recovery Supports to Scale Technical Assistance Center Strategy (BRSS TACS) invites you to learn about the Health Resources & Services Administration’s National Health Service Corps (NHSC) program. NHSC began in 1972 with the aim of building healthy communities by placing qualified healthcare practitioners in underserved areas of the United States. Today, the program continues to address healthcare worker shortages in rural, urban, and tribal communities, in an effort to ensure access to care for everyone, prevent disease and illness, and care for vulnerable and underserved people. Currently, more than 4,000 of the 13,000 members of the corps are mental and substance use disorder (SUD) clinicians. Recent awards from the U.S. Department of Health and Human Services will enable the NHSC to support an additional 1,250 clinicians who will provide SUD treatment in an effort to combat the opioid epidemic in underserved communities. Searchable on the Health Workforce Connector, there are more than 20,000 health care facilities approved by the NHSC. Eligible clinicians may apply for loan repayment during one cycle each year if they are employed at an NHSC-approved facility. Awards will be prioritized to those practicing in areas of greatest need. Eligible professions include:
Presenters will discuss the increasing need for providers who can treat mental and substance use disorders in underserved communities, describe their own experience in the NHSC, and provide information on the application process. Join us for this free, interactive virtual event, moderated by CAPT Wanda Finch, Health Services Officer in the U.S. Public Health Service. Register For The Virtual Event Presenters: Malissa Lewis, Chief, Loan Repayment Branch, Division of National Health Service Corps, Bureau of Health Workforce, Health Resources and Services Administration Dr. Mbeja Lomotey, DrPH, Substance Use Disorder Public Health Analyst, Division of Regional Operations, Bureau of Health Workforce, Health Resources and Services Administration Heather Rogers, LPC, National Health Service Corps Recipient at Change Point Integrated Health in Snowflake, AZ |
Aporte a la rutina de la trinchera asistencial donde los conocimientos se funden con las demandas de los pacientes, sus necesidades y las esperanzas de permanecer en la gracia de la SALUD.
martes, 31 de diciembre de 2019
Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite
Recovery LIVE! From Sea to Shining Sea: Workforce Efforts to Build Healthy Communities through the National Health Service Corps Tickets, Wed, Jan 8, 2020 at 2:00 PM | Eventbrite
Molecular Brain | Home page
Molecular Brain | Home page
Articles
The acute transcriptome response of the midbrain/diencephalon to injury in the adult mummichog (Fundulus heteroclitus)
Authors:Eleanor C. Bisese, Chandler M. Ciuba, Amelia L. Davidson, Akanksha Kaushik, Sabrina M. Mullen, Jeremy L. Barth, E. Starr Hazard, Robert C. Wilson, Gary Hardiman and David M. HollisContent type:Micro report30 December 2019Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation
Authors:Qin Gong, Xiao-Jin Yan, Fan Lei, Mu-Lan Wang, Lu-Ling He, Ying-Ying Luo, Hong-Wei Gao, Yu-Lin Feng, Shi-Lin Yang, Jun Li and Li-Jun DuContent type:Research30 December 2019TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
Authors:Flávio Henrique Pequeno de Macedo, Rosária Dias Aires, Esdras Guedes Fonseca, Renata Cristina Mendes Ferreira, Daniel Portela Dias Machado, Lina Chen, Fang-Xiong Zhang, Ivana A. Souza, Virgínia Soares Lemos, Thiago Roberto Lima Romero, Aubin Moutal, Rajesh Khanna, Gerald W. Zamponi and Jader S. CruzContent type:Short report30 December 2019Plasma membrane localization of MLC1 regulates cellular morphology and motility
Authors:Junmo Hwang, Hung M. Vu, Min-Sik Kim and Hyun-Ho LimContent type:Research30 December 2019
Molecular Medicine | Articles
Molecular Medicine | Articles
Molecular Medicine
Molecular Medicine
Post-sepsis syndrome – an evolving entity that afflicts survivors of sepsis
The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patt...Authors:Zachary Mostel, Abraham Perl, Matthew Marck, Syed F. Mehdi, Barbara Lowell, Sagar Bathija, Ramchandani Santosh, Valentin A. Pavlov, Sangeeta S. Chavan and Jesse RothCitation:Molecular Medicine 2019 26:6Content type:ReviewPublished on: 31 December 2019HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material
HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, d...Authors:William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken and Peter LundbäckCitation:Molecular Medicine 2019 26:5Content type:Research articlePublished on: 31 December 2019Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape
The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique disulfide bridge pattern which attains a correct fold in t...Authors:Reham M. Milhem and Bassam R. AliCitation:Molecular Medicine 2019 26:4Content type:ReviewPublished on: 31 December 2019Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1
The main features of bronchopulmonary dysplasia (BPD) are alveolar simplification, pulmonary growth arrest, and abnormal lung function. Multiple studies have highlighted microRNA-29 (miR-29) as a potential bio...Authors:Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou and Hanmin LiuCitation:Molecular Medicine 2019 26:3Content type:Research articlePublished on: 31 December 2019Role of 5-HT7 receptors in the immune system in health and disease
In mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intes...Authors:Alejandro Quintero-Villegas and Sergio Iván Valdés-FerrerCitation:Molecular Medicine 2019 26:2Content type:Mini-reviewPublished on: 31 December 2019Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...Authors:Lourdes Valdés-Sánchez, Sofia M. Calado, Berta de la Cerda, Ana Aramburu, Ana Belén García-Delgado, Simone Massalini, Adoración Montero-Sánchez, Vaibhav Bhatia, Eduardo Rodríguez-Bocanegra, Andrea Diez-Lloret, Daniel Rodríguez-Martínez, Christina Chakarova, Shom S. Bhattacharya and Francisco J. Díaz-CorralesCitation:Molecular Medicine 2019 26:1Content type:Research articlePublished on: 31 December 2019The neuroprotective mechanisms of ginkgolides and bilobalide in cerebral ischemic injury: a literature review
The incidence and mortality of strokes have increased over the past three decades in China. Ischemic strokes can cause a sequence of detrimental events in patients, including increased permeability and dysfunc...Authors:Zili Feng, Qian Sun, Wang Chen, Yu Bai, Daihua Hu and Xin XieCitation:Molecular Medicine 2019 25:57Content type:ReviewPublished on: 21 December 2019Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation
There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...Authors:Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi and Toshiro OkazakiCitation:Molecular Medicine 2019 25:56Content type:Research articlePublished on: 17 December 2019Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer
Pancreatic cancer (PC) is a type of malignant gastrointestinal tumor. Long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to stimulate proliferation, migration and invasion in several typ...Authors:Ming Yang, Shijuan Sun, Yao Guo, Junjie Qin and Guangming LiuCitation:Molecular Medicine 2019 25:55Content type:Research articlePublished on: 12 December 2019Edaravone reduces oxidative stress and intestinal cell apoptosis after burn through up-regulating miR-320 expression
Intestinal mucosa barrier dysfunction after burn injury is an important factor for causing mortality of burn patients. The current study established a burn model in rats and used a free radical scavenger edara...Authors:Jiaxiang Ke, Xi Bian, Hu Liu, Bei Li and Ran HuoCitation:Molecular Medicine 2019 25:54Content type:Research articlePublished on: 11 December 2019Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment
Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adv...Authors:Shimin An, Nimra Gilani, Yuan Huang, Adam Muncan, Youhua Zhang, Yi-Da Tang, A. Martin Gerdes and Kaie OjamaaCitation:Molecular Medicine 2019 25:53Content type:Research articlePublished on: 6 December 2019Recombinant human milk fat globule-EGF factor VIII (rhMFG-E8) as a therapy for sepsis after acute exposure to alcohol
Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytos...Authors:Wayne W. Chaung, Max Brenner, Hao-Ting Yen, Mahendar L. Ochani, Asha Jacob and Ping WangCitation:Molecular Medicine 2019 25:52Content type:Research articlePublished on: 20 November 2019Comparison of blood lipid profile/thyroid function markers between unipolar and bipolar depressed patients and in depressed patients with anhedonia or suicidal thoughts
This study aimed to investigate the differences in the serum levels of glucose, lipid, and thyroid function markers between unipolar and bipolar depressed patients, as well as the effect of anhedonia and suici...Authors:Meilei Su, Enze Li, Chong Tang, Yongzhi Zhao, Ruqing Liu and Keming GaoCitation:Molecular Medicine 2019 25:51Content type:Research articlePublished on: 20 November 2019Circulating tumor cells: a valuable marker of poor prognosis for advanced nasopharyngeal carcinoma
To evaluate the prognostic value of circulating tumor cells (CTCs) in nasopharyngeal carcinoma (NPC).Authors:Guoping Ou, Shan Xing, Jianpei Li, Lin Zhang and Shulin ChenCitation:Molecular Medicine 2019 25:50Content type:Research articlePublished on: 15 November 2019Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells
Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulat...Authors:Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria and Nhan L. TranCitation:Molecular Medicine 2019 25:49Content type:Research articlePublished on: 14 November 2019Association of radiation risk in the second and third generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid
To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.Authors:Meruyert Massabayeva, Nailya Chaizhunusova, Nurlan Aukenov, Tolkyn Bulegenov, Bakytbek Apsalikov, Aigerim Shapihanova and Yersin ZhunussovCitation:Molecular Medicine 2019 25:48Content type:Research articlePublished on: 14 November 2019Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer
The hunt for the molecular markers with specificity and sensitivity has been a hot area for the tumor treatment. Due to the poor diagnosis and prognosis of pancreatic cancer (PC), the excision rate is often lo...Authors:Yang-Yang Zhou, Li-Ping Chen, Yi Zhang, Sun-Kuan Hu, Zhao-Jun Dong, Ming Wu, Qiu-Xiang Chen, Zhi-Zhi Zhuang and Xiao-Jing DuCitation:Molecular Medicine 2019 25:47Content type:Research articlePublished on: 9 November 2019An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components
Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes rel...Authors:Wai Hoong Chang and Alvina G. LaiCitation:Molecular Medicine 2019 25:46Content type:Research articlePublished on: 4 November 2019Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2
Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-in...Authors:Baolin Xu, Andrea Janicova, Jan Tilmann Vollrath, Philipp Störmann, Lukas Martin, Ingo Marzi, Sebastian Wutzler, Frank Hildebrand, Sabrina Ehnert and Borna ReljaCitation:Molecular Medicine 2019 25:45Content type:Research articlePublished on: 30 October 2019PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer
Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/...Authors:Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin and Feng GaoCitation:Molecular Medicine 2019 25:44Content type:Research articlePublished on: 14 September 2019Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis
The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this study was to explore the role of melatonin in b...Authors:Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng HuangCitation:Molecular Medicine 2019 25:43Content type:Research articlePublished on: 28 August 2019Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue
HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 s...Authors:Diana B. Peckys, Daniela Hirsch, Timo Gaiser and Niels de JongeCitation:Molecular Medicine 2019 25:42Content type:Research articlePublished on: 28 August 2019Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats
Peritoneal fibrosis (PF) represents a long-term complication of peritoneal dialysis (PD), affecting peritoneal membrane (PM) integrity and function. Understanding the mechanisms underlying PF development in an...Authors:Filipe M. O. Silva, Elerson C. Costalonga, Cleonice Silva, Ana C. O. Carreira, Samirah A. Gomes, Mari C. Sogayar, Camilla Fanelli and Irene L. NoronhaCitation:Molecular Medicine 2019 25:41Content type:Research articlePublished on: 28 August 2019Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a rat model of renal ischemia-reperfusion injury
Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. ...Authors:Takashi Tani, Ken Okamoto, Megumi Fujiwara, Akira Katayama and Shuichi TsuruokaCitation:Molecular Medicine 2019 25:40Content type:Research articlePublished on: 22 August 2019The cholinergic anti-inflammatory pathway in resistant hypertension treated with renal denervation
Renal denervation (RDN) reduces sympathetic tone and may alter the sympathetic-parasympathetic balance. The autonomic nervous system is partly a regulator of innate immunity via the cholinergic anti-inflammato...Authors:Marie Hilderman, Abdul Rashid Qureshi, Farhad Abtahi, Nils Witt, Christina Jägren, Joakim Olbers, Martin Delle, Kaj Lindecrantz and Annette BruchfeldCitation:Molecular Medicine 2019 25:39Content type:Research articlePublished on: 15 August 2019High co-expression of TNF-α and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia
Early distinction between refractory M. pneumoniae pneumonia (RMPP) and non-RMPP (NRMPP) is still difficult. The community-acquired respiratory distress syndrome (CARDS) toxin can induce inflammatory and histopat...Authors:Gang Li, Liping Fan, Yuqing Wang, Li Huang, Meijuan Wang, Canhong Zhu, Chuangli Hao, Wei Ji, Hansi Liang, Yongdong Yan and Zhengrong ChenCitation:Molecular Medicine 2019 25:38Content type:Research articlePublished on: 9 August 2019FOXD1 mutations are related to repeated implantation failure, intra-uterine growth restriction and preeclampsia
Human reproductive disorders consist of frequently occurring dysfunctions including a broad range of phenotypes affecting fertility and women’s health during pregnancy. Several female-related diseases have bee...Authors:Paula Quintero-Ronderos, Karen Marcela Jiménez, Clara Esteban-Pérez, Diego A. Ojeda, Sandra Bello, Dora Janeth Fonseca, María Alejandra Coronel, Harold Moreno-Ortiz, Diana Carolina Sierra-Díaz, Elkin Lucena, Sandrine Barbaux, Daniel Vaiman and Paul LaissueCitation:Molecular Medicine 2019 25:37Content type:Short reportPublished on: 8 August 2019Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children and Glucocorticoids (GCs) form an essential component of the standard chemotherapy in most treatment regimens. The cat...Authors:Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah and Ali Masoudi-NejadCitation:Molecular Medicine 2019 25:36Content type:Research articlePublished on: 1 August 2019Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose onset and progression are affected by genetic and environmental factors. The purpose of this study is to identify the influence of gut m...Authors:Yiyangzi Ma, Xiaoxue Xu, Mengtao Li, Jun Cai, Qiang Wei and Haitao NiuCitation:Molecular Medicine 2019 25:35Content type:Research articlePublished on: 1 August 2019Correction to: Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity
Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows:Authors:Vijay K. Sonkar, Paresh P. Kulkarni, Susheel N. Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata DashCitation:Molecular Medicine 2019 25:34Content type:CorrectionPublished on: 30 July 2019The original article was published in Molecular Medicine 2016 22:2201224Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice
The beneficial effects of angiotensin II type 1 receptor blockers (ARBs) on atherosclerosis have been demonstrated in numerous studies. We investigated the effects of fimasartan on reducing neointimal formatio...Authors:Jong-Ho Kim, I-Rang Lim, Hyung Joon Joo, Chi-Yeon Park, Seung-Cheol Choi, Han Saem Jeong and Soon Jun HongCitation:Molecular Medicine 2019 25:33Content type:Research articlePublished on: 15 July 2019YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11
Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While the roles of Yes-associated protein (YAP), the key transducer of Hippo signals, in the development of en...Authors:Jing Wang, Tiefang Song, Suiyang Zhou and Xianchao KongCitation:Molecular Medicine 2019 25:32Content type:Research articlePublished on: 12 July 2019Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function
Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the...Authors:Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan and Yi LaiCitation:Molecular Medicine 2019 25:31Content type:Research articlePublished on: 2 July 2019Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume ...Authors:Ali Khosravi, B. Jayaram, Bahram Goliaei and Ali Masoudi-NejadCitation:Molecular Medicine 2019 25:30Content type:Research articlePublished on: 20 June 2019A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease
Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of L...Authors:Yuya Asanomi, Daichi Shigemizu, Akinori Miyashita, Risa Mitsumori, Taiki Mori, Norikazu Hara, Kaoru Ito, Shumpei Niida, Takeshi Ikeuchi and Kouichi OzakiCitation:Molecular Medicine 2019 25:20Content type:Research articlePublished on: 20 June 2019FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease
Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immu...Authors:Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng, Yong-Jian Wang, Jun Lu, Shao-Hua Fan, Chun-Hui Sun, Dong-Mei Wu, Meng-Qiu Li, Bin Hu, Qing-Qing Wang, Zi-Feng Zhang and Yuan-Lin ZhengCitation:Molecular Medicine 2019 25:29Content type:Research articlePublished on: 18 June 2019CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways
Circular RNAs (circRNAs) contribute to the epigenetic modulation of pathological and physiological conditions. The understanding of the impact of circRNAs on generation of testicular inflammatory reactions is ...Authors:Le Qin, Jie Lin and Xiaoxiao XieCitation:Molecular Medicine 2019 25:28Content type:Research articlePublished on: 13 June 2019Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology with only two federally approved drug options. Given the complex molecular pathogenesis of IPF involving multiple cell types and ...Authors:L. R. Rodriguez, S. N. Bui, R. T. Beuschel, E. Ellis, E. M. Liberti, M. K. Chhina, B. Cannon, M. Lemma, S. D. Nathan and G. M. GrantCitation:Molecular Medicine 2019 25:27Content type:Research articlePublished on: 13 June 2019miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-12...Authors:Jun-Ke Long, Wen Dai, Ya-Wen Zheng and Shui-Ping ZhaoCitation:Molecular Medicine 2019 25:26Content type:Research articlePublished on: 13 June 2019IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis
Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build a...Authors:Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Li Jin, Hejian Zou, Shifang Ren and Jiucun WangCitation:Molecular Medicine 2019 25:25Content type:Short reportPublished on: 13 June 2019Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice
Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been com...Authors:Asha Jacob, Yilong Ma, Elham Nasiri, Mahendar Ochani, Joseph Carrion, Shichun Peng, Max Brenner, Patricio T. Huerta and Ping WangCitation:Molecular Medicine 2019 25:24Content type:Research articlePublished on: 30 May 2019CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer
Cervical cancer is the third most common gynecological malignancy. Conventional treatment options are known to be ineffective for the majority of patients with advanced or recurrent cervical cancer. Therefore,...Authors:Sungha Lee, Jung Yoon Ho, Jing Jing Liu, Hyewon Lee, Jae Young Park, Minwha Baik, Minji Ko, Seon Ui Lee, Youn Jin Choi and Soo Young HurCitation:Molecular Medicine 2019 25:23Content type:Research articlePublished on: 28 May 2019Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats
Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition ...Authors:Tao Jiang, Meiyan Wu, Zhanqin Zhang, Chaoying Yan, Zhi Ma, Shan He, Wei Yuan, Kairui Pu and Qiang WangCitation:Molecular Medicine 2019 25:22Content type:Research articlePublished on: 22 May 2019Astragalus polysaccharides suppresses high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195
Metabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we...Authors:Ping Liu, Qing-Hua Peng, Ping Tong and Wen-Jie LiCitation:Molecular Medicine 2019 25:21Content type:Research articlePublished on: 22 May 2019Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma
The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their per...Authors:Amol Kolte and Rainer KönigCitation:Molecular Medicine 2019 25:19Content type:Research articlePublished on: 16 May 2019Circulating miR-26a-1, miR-146a and miR-199a-1 are potential candidate biomarkers for acute myocardial infarction
Acute myocardial infarction (AMI) was considered to be one of the major causes of morbidity and mortality worldwide. In order to manage the acute myocardial infarction outbreaks, accurate biomarkers for risk p...Authors:Sheng Xue, Wenjie Zhu, Dacheng Liu, Zhe Su, Liwei Zhang, Qing Chang and Peifeng LiCitation:Molecular Medicine 2019 25:18Content type:Research articlePublished on: 15 May 2019Silencing of SAA1 inhibits palmitate- or high-fat diet induced insulin resistance through suppression of the NF-κB pathway
Obesity is one of the leading causes of insulin resistance. Accumulating reports have highlighted that serum amyloid A-1 (SAA1) is a potential candidate that is capable of attenuating insulin resistance. Hence...Authors:Yong Wang, Feng Cao, Yang Wang, Gang Yu and Ben-Li JiaCitation:Molecular Medicine 2019 25:17Content type:Research articlePublished on: 6 May 2019Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutr...Authors:Andreea-Manuela Mirea, Erik J. M. Toonen, Inge van den Munckhof, Isabelle D. Munsterman, Eric T. T. L. Tjwa, Martin Jaeger, Marije Oosting, Kiki Schraa, Joost H. W. Rutten, Marinette van der Graaf, Niels P. Riksen, Jacqueline de Graaf, Mihai G. Netea, Cees J. Tack, Triantafyllos Chavakis and Leo A. B. JoostenCitation:Molecular Medicine 2019 25:16Content type:Research articlePublished on: 2 May 2019Tag-based next generation sequencing: a feasible and reliable assay for EGFR T790M mutation detection in circulating tumor DNA of non small cell lung cancer patients
The demonstration of EGFR T790M gene mutation in plasma is crucial to assess the eligibility of Non Small Cell Lung Cancer (NSCLC) patients, who have acquired resistance to first or second generation Tyrosine Kin...Authors:Mariella Dono, Giuseppa De Luca, Sonia Lastraioli, Giorgia Anselmi, Maria Giovanna Dal Bello, Simona Coco, Irene Vanni, Francesco Grossi, Antonella Vigani, Carlo Genova, Manlio Ferrarini, Jean Louis Ravetti and Simona ZupoCitation:Molecular Medicine 2019 25:15Content type:Research articlePublished on: 27 April 2019Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients
Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations. Although the aetiology of CFS/ME remains elusive, immunolo...Authors:H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines and S. Marshall-GradisnikCitation:Molecular Medicine 2019 25:14Content type:Research articlePublished on: 23 April 2019