Aporte a la rutina de la trinchera asistencial donde los conocimientos se funden con las demandas de los pacientes, sus necesidades y las esperanzas de permanecer en la gracia de la SALUD.
viernes, 31 de diciembre de 2010
Family history not the sole risk for breast cancer: MedlinePlus
Family history not the sole risk for breast cancer
URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_107196.html (*this news item will not be available after 03/30/2011)
Thursday, December 30, 2010 Reuters Health Information Logo
Related MedlinePlus Pages
* Breast Cancer
* Family History
By Lynne Peeples
NEW YORK (Reuters Health) - A new study reconfirms something often forgotten by women and sometimes even by doctors: just because breast cancer has not struck a family before does not mean family members are safe from the disease.
Researchers tracking more than 6,000 women for up to six years found that most cases of breast cancer occurred in those without a family history of the disease, although many of the women had other known risk factors that can help predict an individual woman's likelihood of developing the disease.
Breast cancer accounts for about a quarter of all cancers in women, with nearly 200,000 new cases of invasive breast cancer -- disease that has spread beyond the milk ducts or milk-making glands -- diagnosed in the U.S. every year.
"I have newly-diagnosed breast cancer patients ask me all the time how they could have developed the disease since they did not have a family history," researcher Dr. Lawrence Wickerham of the National Surgical Adjuvant Breast and Bowel Project (NSABP) Allegheny Center, in Pittsburgh, told Reuters Health in an e-mail.
Prior studies have shown that more than 70 percent of primary care doctors ask women about their family histories, while less than half collect information on other known risk factors such as whether a woman's period began before age 12 - which raises risk - or whether she has given birth, which lowers risk.
Wickerham, along with lead researcher Angelina Sontag, of Eli Lilly and Company, and their colleagues analyzed the roles of various risk factors among 6,322 postmenopausal women who had participated in two large trials of osteoporosis medications. (Eli Lilly and Company, a maker of breast cancer treatments, also funded the current study.)
At the time of each trial, all of the women were under 86 years old and none had received a previous diagnosis of breast cancer.
The team used the Breast Cancer Risk Assessment Tool (http://www.cancer.gov/bcrisktool), an online questionnaire developed by NSABP and the National Cancer Institute, to go back in time and predict the odds that the women would develop invasive disease over the next five years.
The risk calculator incorporates age of first menstruation, current age, ethnicity, reproductive history, prior breast biopsies and family history. Its score, on a scale of zero to eight, represents a woman's five-year risk as a percentage.
Some 600 women in the study group -- approximately one in ten -- had a family history of breast cancer and nearly all of these met the predictive tool's definition of high risk: a score of 1.66 percent or above.
More than half of the remaining women without family histories of breast cancer also fit into the high-risk category, however.
A total of 92 women, or 1.5 percent of the study population, went on to develop invasive breast cancer over an average follow-up period of 4 to 6 years. As expected, the actual rate of breast cancers increased with the predicted risks, as well as in the presence of a family history.
Nevertheless, more of the total number of breast cancer cases ended up being reported in women with predictions below the high-risk cut-off or without a family history.
Close to half (40) of the women who developed the disease received a risk score below 1.66 percent, for example, and nearly two of every three (60) diagnosed women had been assigned risks between 1 and 2 percent and had no family history of breast cancer.
"The single largest risk factor for developing a breast cancer is being a woman and the second largest is being a women over 50," said Wickerham. "However, there are some women who are at greater than average risk, particularly those with a family history."
The most common known risk factors found in the study population were being at least 65 years old and beginning menstruation before the age of 12, report the researchers in the journal Menopause.
"Physicians and other health care providers should consider using methods beyond asking about family history to access breast cancer risk," added Wickerham, alluding to the Breast Cancer Risk Assessment Tool. "Such efforts can help better identify women at increased risk and can better focus screening and prevention strategies for them."
SOURCE: http://link.reuters.com/cuf34r Menopause, online December 25, 2010.
Reuters Health
(c) Copyright Thomson Reuters 2010. Check for restrictions at: http://about.reuters.com/fulllegal.asp
Family history not the sole risk for breast cancer: MedlinePlus
Injectable, Oral Birth Control Don't Threaten Glucose, Insulin Levels: Study: MedlinePlus
Injectable, Oral Birth Control Don't Threaten Glucose, Insulin Levels: Study
Women's glucose levels increased with use of injectable DMPA, but not enough to cause concern, research suggests
URL of this page: http://www.nlm.nih.gov/medlineplus/news/fullstory_107056.html (*this news item will not be available after 03/27/2011)
By Robert Preidt
Monday, December 27, 2010 HealthDay Logo
HealthDay news image
Related MedlinePlus Pages
* Birth Control
* Diabetes
MONDAY, Dec. 27 (HealthDay News) -- Injectable and oral birth control do not significantly affect a woman's fasting glucose and insulin levels, according to a new research.
The three-year study is the largest to measure fasting glucose and insulin levels among women using oral (desogestrel), injectable (DMPA), and non-hormonal (bilateral tubal ligation, condom, or abstinence) methods, said the researchers at the University of Texas Medical Branch in Galveston.
They found that women using DMPA experienced slight increases in glucose and insulin levels. Their glucose levels increased steadily during the first 30 months of using DMPA, with the greatest increase occurring during the first six months. These increases, however, were not large enough to cause concern, according to the researchers.
The study appears in the January issue of the journal Obstetrics and Gynecology.
"Previous studies were limited in scope and offered conflicting results, which led physicians to question whether hormonal contraception could lead to diabetes," lead author Dr. Abbey Berenson, professor, Department of Obstetrics and Gynecology and director of the Center for Interdisciplinary Research in Women's Health, said in a UTMB Health news release.
"Further studies are needed to determine how women with diabetes are affected by DMPA and oral contraception, but these results are reassuring for non-diabetic women already receiving the shot or on the pill," she added.
SOURCE: University of Texas Medical Branch at Galveston, news release, Dec. 20, 2010
HealthDay
Copyright (c) 2010 HealthDay. All rights reserved.
Injectable, Oral Birth Control Don't Threaten Glucose, Insulin Levels: Study: MedlinePlus
Cancer Advances in Focus: Brain and Other Central Nervous System - National Cancer Institute
CANCER ADVANCES IN FOCUS: Brain and Other Central Nervous System
Yesterday
* In 1975, the annual incidence of brain and other central nervous system (CNS) cancers, including cancers of the spinal cord, among adults in the United States was 5.9 new cases diagnosed for every 100,000 persons. The incidence of these cancers among children aged 19 years or younger was 2.1 new cases per 100,000 persons.
* In the same year, the annual mortality from brain and other CNS cancers among adults was 4.1 deaths per 100,000 persons; among children aged 19 years or younger, it was 0.9 deaths per 100,000 persons.
* Magnetic resonance imaging (MRI), which facilitates diagnosis as well as treatment of brain and other CNS tumors with surgery and radiation therapy, first became widely available in the 1980s.
* Clinical trials in the 1970s and 1980s showed that adding radiation therapy to surgery prolonged the survival of patients with glioma, a type of brain tumor that accounts for approximately 70% of the malignant primary brain tumors diagnosed in adults in the United States each year.
* Chemotherapy was not a standard treatment for brain tumors because most early chemotherapy drugs could not cross the blood-brain barrier. One class of drugs, the nitrosoureas, was found to cross the blood-brain barrier and was shown in clinical trials to produce a small but clear improvement in the length of patient survival when combined with surgery and radiation therapy.
Today
* In 2007, the latest year for which we have updated statistics, the U.S. incidence rate of brain and other CNS cancers among adults was 6.4 new cases per 100,000 persons; among children aged 19 years or younger, it was 2.9 new cases per 100,000 persons. The higher incidence rates observed today are likely due, in part, to an improved ability to diagnose brain and other CNS tumors with advanced imaging technologies.
* MRI is now an accepted standard technology for imaging brain and other CNS tumors. A newer technology called functional MRI, which measures changes in blood flow that accompany brain activity, can be helpful in determining how well brain regions are working, in assessing potential risk from surgery, and in planning treatment. New intraoperative MRI machines can be used to monitor the extent of tumor removal during surgery.
* The orally administered drug temozolomide, which first became available in the United States in 1999, can prolong the survival of patients with glioma when combined with radiation therapy. High-dose chemotherapy regimens for the treatment of some types of childhood brain tumor can delay the need for radiation therapy, possibly reducing harm to the developing brain.
* Antiangiogenesis agents—drugs that block the growth of new blood vessels to tumors—have shown some promise in the treatment of gliomas. Gliomas are highly vascularized tumors, meaning they have a large number of blood vessels. Drugs that block the development of these blood vessels are being tested in clinical trials of patients with brain tumors. Based on the promising results of two clinical trials, one of which was conducted at the National Institutes of Health (NIH), the Food and Drug Administration gave accelerated approval in May 2009 to the antiangiogenesis agent bevacizumab (Avastin®) for the treatment of recurrent glioblastoma, which is the most common form of glioma. Two phase III clinical trials, including one supported by NIH, are testing the drug in newly diagnosed patients.
* Advanced radiation therapy techniques that target tumor tissue more precisely and reduce radiation damage to surrounding normal tissue (such as 3-dimensional conformal therapy, stereotactic radiation therapy, and intensity-modulated radiation therapy) are being refined.
* Researchers are exploring the use of other novel approaches, such as targeted therapy, gene therapy, immunotherapy, and vaccine therapy, for the treatment of brain and other CNS cancers.
* A new scale developed by NIH, which is based on tumor size, tumor location, and a patient’s ability to perform everyday tasks, can help surgeons identify which patients with glioblastoma will benefit from additional surgery when their tumor recurs.
* Scientists are beginning to understand the genetic complexity of brain tumors, which will facilitate the design of more effective treatments. An understanding of the genetic changes that drive the growth of brain tumors will allow researchers to choose the best candidate targeted drugs for testing in clinical trials.
* In 2008, The Cancer Genome Atlas (TCGA) project reported the first results of its large-scale, comprehensive study of gene changes in glioblastoma (a type of glioma). These results identified three previously unrecognized mutations that occur frequently in glioblastoma and three cell-signaling pathways that may help drive tumor growth. The results also shed new light on molecular mechanisms that may make tumors resistant to some chemotherapy drugs. In 2010, additional results from TCGA showed that glioblastoma comprises four different molecular subtypes that have different responses to chemotherapy and radiation therapy.
* The Glioma Molecular Diagnostic Initiative has already made extensive genetic and related clinical data from more than 800 glioma patients available to researchers worldwide in a public data repository and bioinformatics work space known as REMBRANDT.
* Despite tremendous advances in our understanding of brain cancer biology, substantial progress in brain tumor diagnosis and treatment, and marked improvements in the quality of life of brain tumor patients, the mortality rate for brain and other CNS cancers has remained largely unchanged over the past 30 to 40 years.
Tomorrow
* We will continue to explore the use of new imaging technologies in the diagnosis, treatment, and follow-up care of brain and other CNS cancers. For example, magnetic resonance perfusion imaging is a technology that enables measurement of the volume of blood flowing through the brain. This information will allow better estimates of tumor grade, size, and location before surgery and permit recurrent tumor tissue to be distinguished from damage to brain tissue caused by radiation therapy, thereby reducing the need for follow-up surgical biopsies. In addition, imaging technologies such as positron emission tomography, single photon emission computed tomography, and diffusion-weighted MRI can help measure tumor metabolic activity, tumor cell proliferation, and the amount of oxygen that reaches tumor cells.
* We will refine methods of delivering chemotherapy drugs and other agents to the brain and CNS, including the development of drugs that have the ability to penetrate the blood-brain barrier. Other delivery techniques, such as convection-enhanced delivery, in which drugs or other anticancer agents are delivered under pressure (convection) through a catheter inserted directly into or near a tumor, may prove valuable.
* We will continue to explore the potential of new antiangiogenesis agents in controlling tumor growth.
* Intensive research into the genetic changes that lead to the formation of brain and other CNS cancers, through TCGA and other collaborative projects, will yield new opportunities for developing therapies that target these changes.
* We will expand our understanding of the role that tumor stem cells play in the formation of brain and other CNS tumors and their resistance to treatment and will use that knowledge to develop new therapies that target tumor stem cell-signaling pathways. First discovered in 2003, brain tumor stem cells make up only a small proportion of the cells in human brain tumors, but they may drive tumor growth and metastasis and contribute to resistance to treatment.
Cancer Advances in Focus: Brain and Other Central Nervous System - National Cancer Institute
Yesterday
* In 1975, the annual incidence of brain and other central nervous system (CNS) cancers, including cancers of the spinal cord, among adults in the United States was 5.9 new cases diagnosed for every 100,000 persons. The incidence of these cancers among children aged 19 years or younger was 2.1 new cases per 100,000 persons.
* In the same year, the annual mortality from brain and other CNS cancers among adults was 4.1 deaths per 100,000 persons; among children aged 19 years or younger, it was 0.9 deaths per 100,000 persons.
* Magnetic resonance imaging (MRI), which facilitates diagnosis as well as treatment of brain and other CNS tumors with surgery and radiation therapy, first became widely available in the 1980s.
* Clinical trials in the 1970s and 1980s showed that adding radiation therapy to surgery prolonged the survival of patients with glioma, a type of brain tumor that accounts for approximately 70% of the malignant primary brain tumors diagnosed in adults in the United States each year.
* Chemotherapy was not a standard treatment for brain tumors because most early chemotherapy drugs could not cross the blood-brain barrier. One class of drugs, the nitrosoureas, was found to cross the blood-brain barrier and was shown in clinical trials to produce a small but clear improvement in the length of patient survival when combined with surgery and radiation therapy.
Today
* In 2007, the latest year for which we have updated statistics, the U.S. incidence rate of brain and other CNS cancers among adults was 6.4 new cases per 100,000 persons; among children aged 19 years or younger, it was 2.9 new cases per 100,000 persons. The higher incidence rates observed today are likely due, in part, to an improved ability to diagnose brain and other CNS tumors with advanced imaging technologies.
* MRI is now an accepted standard technology for imaging brain and other CNS tumors. A newer technology called functional MRI, which measures changes in blood flow that accompany brain activity, can be helpful in determining how well brain regions are working, in assessing potential risk from surgery, and in planning treatment. New intraoperative MRI machines can be used to monitor the extent of tumor removal during surgery.
* The orally administered drug temozolomide, which first became available in the United States in 1999, can prolong the survival of patients with glioma when combined with radiation therapy. High-dose chemotherapy regimens for the treatment of some types of childhood brain tumor can delay the need for radiation therapy, possibly reducing harm to the developing brain.
* Antiangiogenesis agents—drugs that block the growth of new blood vessels to tumors—have shown some promise in the treatment of gliomas. Gliomas are highly vascularized tumors, meaning they have a large number of blood vessels. Drugs that block the development of these blood vessels are being tested in clinical trials of patients with brain tumors. Based on the promising results of two clinical trials, one of which was conducted at the National Institutes of Health (NIH), the Food and Drug Administration gave accelerated approval in May 2009 to the antiangiogenesis agent bevacizumab (Avastin®) for the treatment of recurrent glioblastoma, which is the most common form of glioma. Two phase III clinical trials, including one supported by NIH, are testing the drug in newly diagnosed patients.
* Advanced radiation therapy techniques that target tumor tissue more precisely and reduce radiation damage to surrounding normal tissue (such as 3-dimensional conformal therapy, stereotactic radiation therapy, and intensity-modulated radiation therapy) are being refined.
* Researchers are exploring the use of other novel approaches, such as targeted therapy, gene therapy, immunotherapy, and vaccine therapy, for the treatment of brain and other CNS cancers.
* A new scale developed by NIH, which is based on tumor size, tumor location, and a patient’s ability to perform everyday tasks, can help surgeons identify which patients with glioblastoma will benefit from additional surgery when their tumor recurs.
* Scientists are beginning to understand the genetic complexity of brain tumors, which will facilitate the design of more effective treatments. An understanding of the genetic changes that drive the growth of brain tumors will allow researchers to choose the best candidate targeted drugs for testing in clinical trials.
* In 2008, The Cancer Genome Atlas (TCGA) project reported the first results of its large-scale, comprehensive study of gene changes in glioblastoma (a type of glioma). These results identified three previously unrecognized mutations that occur frequently in glioblastoma and three cell-signaling pathways that may help drive tumor growth. The results also shed new light on molecular mechanisms that may make tumors resistant to some chemotherapy drugs. In 2010, additional results from TCGA showed that glioblastoma comprises four different molecular subtypes that have different responses to chemotherapy and radiation therapy.
* The Glioma Molecular Diagnostic Initiative has already made extensive genetic and related clinical data from more than 800 glioma patients available to researchers worldwide in a public data repository and bioinformatics work space known as REMBRANDT.
* Despite tremendous advances in our understanding of brain cancer biology, substantial progress in brain tumor diagnosis and treatment, and marked improvements in the quality of life of brain tumor patients, the mortality rate for brain and other CNS cancers has remained largely unchanged over the past 30 to 40 years.
Tomorrow
* We will continue to explore the use of new imaging technologies in the diagnosis, treatment, and follow-up care of brain and other CNS cancers. For example, magnetic resonance perfusion imaging is a technology that enables measurement of the volume of blood flowing through the brain. This information will allow better estimates of tumor grade, size, and location before surgery and permit recurrent tumor tissue to be distinguished from damage to brain tissue caused by radiation therapy, thereby reducing the need for follow-up surgical biopsies. In addition, imaging technologies such as positron emission tomography, single photon emission computed tomography, and diffusion-weighted MRI can help measure tumor metabolic activity, tumor cell proliferation, and the amount of oxygen that reaches tumor cells.
* We will refine methods of delivering chemotherapy drugs and other agents to the brain and CNS, including the development of drugs that have the ability to penetrate the blood-brain barrier. Other delivery techniques, such as convection-enhanced delivery, in which drugs or other anticancer agents are delivered under pressure (convection) through a catheter inserted directly into or near a tumor, may prove valuable.
* We will continue to explore the potential of new antiangiogenesis agents in controlling tumor growth.
* Intensive research into the genetic changes that lead to the formation of brain and other CNS cancers, through TCGA and other collaborative projects, will yield new opportunities for developing therapies that target these changes.
* We will expand our understanding of the role that tumor stem cells play in the formation of brain and other CNS tumors and their resistance to treatment and will use that knowledge to develop new therapies that target tumor stem cell-signaling pathways. First discovered in 2003, brain tumor stem cells make up only a small proportion of the cells in human brain tumors, but they may drive tumor growth and metastasis and contribute to resistance to treatment.
Cancer Advances in Focus: Brain and Other Central Nervous System - National Cancer Institute
Regular Sunscreen Use May Reduce Invasive Melanoma Risk - National Cancer Institute
Regular Sunscreen Use May Reduce Invasive Melanoma Risk
Adapted from the NCI Cancer Bulletin, vol. 7/no. 24, December 14, 2010 (see the current issue).
Regular sunscreen use may reduce the risk of developing melanoma, according to results of a randomized controlled trial that were reported December 6, 2010, in the Journal of Clinical Oncology. The trial is the first prospective, randomized study to investigate the link between sunscreen use and melanoma, the most deadly type of skin cancer.
Researchers led by Adèle Green, Ph.D., of the Queensland Institute of Medical Research examined the incidence of melanoma among 1,621 white adults in a township in Queensland, Australia. They divided the study participants, age 20 to 69, into two groups. From 1992 to 1996, the participants in one group were given an unlimited supply of a broad-spectrum sunscreen with a sun protection factor (SPF) of 16 and were asked to apply it every morning to their head, neck, arms, and hands, and reapply it after heavy sweating, bathing, or long sun exposure. The control group continued using sunscreen of any SPF at their usual discretionary frequency, which for some included no use.
Dr. Green and her colleagues followed the study participants for 10 additional years and tracked all cases of primary melanoma newly diagnosed between 1993 and 2006. They found 11 new cases of melanoma in the daily sunscreen group compared with 22 cases in the discretionary sunscreen group, a 50 percent reduction. Invasive melanoma was reduced by 73 percent in the daily sunscreen group compared with the control group (3 versus 11 cases).
The authors noted that their results are of borderline statistical significance and suggested that their findings for invasive melanoma in particular “should be interpreted cautiously.” Nevertheless, they concluded, “among adults age 25 to 75 years, regular application of SPF 15+ sunscreen in a 5-year period appeared to reduce the incidence of new primary melanomas for up to 10 years.”
In an accompanying editorial, Phyllis Gimotty, Ph.D., and Karen Glanz, Ph.D., of the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine wrote: “To our knowledge, the trial’s findings are the first to provide strong evidence for a reduction in the incidence of invasive melanoma after regular application of broad-spectrum sunscreen in adults…. It is unlikely that another trial of comparable scope and rigor will be conducted in the foreseeable future.”
Furthermore, they wrote, although “the question of its efficacy with respect to melanoma prevention should no longer deter scientists or clinicians from recommending sunscreen use,” effective skin cancer prevention should also include avoiding exposure to ultraviolet rays, using clothing to shield skin from the sun, and performing regular skin self examinations.
“This study provides important evidence regarding the role of sunscreen use as part of a range of sun-protective behaviors that effectively reduce risk of melanoma,” commented Margaret Tucker, M.D., of NCI’s Division of Cancer Epidemiology and Genetics
Regular Sunscreen Use May Reduce Invasive Melanoma Risk - National Cancer Institute
Adapted from the NCI Cancer Bulletin, vol. 7/no. 24, December 14, 2010 (see the current issue).
Regular sunscreen use may reduce the risk of developing melanoma, according to results of a randomized controlled trial that were reported December 6, 2010, in the Journal of Clinical Oncology. The trial is the first prospective, randomized study to investigate the link between sunscreen use and melanoma, the most deadly type of skin cancer.
Researchers led by Adèle Green, Ph.D., of the Queensland Institute of Medical Research examined the incidence of melanoma among 1,621 white adults in a township in Queensland, Australia. They divided the study participants, age 20 to 69, into two groups. From 1992 to 1996, the participants in one group were given an unlimited supply of a broad-spectrum sunscreen with a sun protection factor (SPF) of 16 and were asked to apply it every morning to their head, neck, arms, and hands, and reapply it after heavy sweating, bathing, or long sun exposure. The control group continued using sunscreen of any SPF at their usual discretionary frequency, which for some included no use.
Dr. Green and her colleagues followed the study participants for 10 additional years and tracked all cases of primary melanoma newly diagnosed between 1993 and 2006. They found 11 new cases of melanoma in the daily sunscreen group compared with 22 cases in the discretionary sunscreen group, a 50 percent reduction. Invasive melanoma was reduced by 73 percent in the daily sunscreen group compared with the control group (3 versus 11 cases).
The authors noted that their results are of borderline statistical significance and suggested that their findings for invasive melanoma in particular “should be interpreted cautiously.” Nevertheless, they concluded, “among adults age 25 to 75 years, regular application of SPF 15+ sunscreen in a 5-year period appeared to reduce the incidence of new primary melanomas for up to 10 years.”
In an accompanying editorial, Phyllis Gimotty, Ph.D., and Karen Glanz, Ph.D., of the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine wrote: “To our knowledge, the trial’s findings are the first to provide strong evidence for a reduction in the incidence of invasive melanoma after regular application of broad-spectrum sunscreen in adults…. It is unlikely that another trial of comparable scope and rigor will be conducted in the foreseeable future.”
Furthermore, they wrote, although “the question of its efficacy with respect to melanoma prevention should no longer deter scientists or clinicians from recommending sunscreen use,” effective skin cancer prevention should also include avoiding exposure to ultraviolet rays, using clothing to shield skin from the sun, and performing regular skin self examinations.
“This study provides important evidence regarding the role of sunscreen use as part of a range of sun-protective behaviors that effectively reduce risk of melanoma,” commented Margaret Tucker, M.D., of NCI’s Division of Cancer Epidemiology and Genetics
Regular Sunscreen Use May Reduce Invasive Melanoma Risk - National Cancer Institute
Zoledronic Acid Did Not Improve Disease-Free Survival in Breast - National Cancer Institute
Zoledronic Acid Did Not Improve Disease-Free Survival in Breast Cancer
Adapted from the NCI Cancer Bulletin, vol. 7/no. 24, December 14, 2010 (see the current issue).
The addition of zoledronic acid, a bisphosphonate, to standard adjuvant therapy for women with stage II or III breast cancer did not extend disease-free survival (DFS), according to results from the phase III AZURE trial presented December 9, 2010, at the San Antonio Breast Cancer Symposium (SABCS). The findings run counter to those from an earlier trial, ABCSG-12, which showed improved DFS in premenopausal women with early-stage breast cancer who received zoledronic acid in addition to hormone therapy.
It is important to note, said Robert Coleman, M.D., the AZURE trial’s principal investigator, that the patient populations in the two trials were very different. AZURE enrolled both premenopausal and postmenopausal women; ABCSG-12 enrolled only premenopausal women who, as part of the trial, received the drug goserelin to induce early menopause.
The AZURE investigators enrolled 3,360 women at 174 treatment centers in the United Kingdom. The women were randomly assigned to receive either standard adjuvant treatment—chemotherapy, hormone therapy, or both, chosen by their treating physician—or to standard adjuvant treatment plus 5 years of zoledronic acid.
After almost 5 years of follow-up, no difference in DFS or overall survival (OS) was observed between the groups. However, in a preplanned subset analysis, women who had been menopausal for at least 5 years had significantly increased DFS and OS with the addition of zoledronic acid to standard treatment. Premenopausal women experienced no benefit from the addition of the bisphosphonate in the subset analysis. The updated results from ABCSG-12 presented at SABCS continued to show a statistically significant improvement in DFS and a trend toward improved OS in women who received zoledronic acid.
“Our results are strikingly different from those observed in ABCSG-12, and we need to understand why. I don’t believe one is right and one is wrong. I think we need to understand the biology as to why we’re seeing these different outcomes,” said Dr. Coleman. “Our hypothesis would be that adjuvant bisphosphonate efficacy is dependent on a low estrogen or inhibited concentration within the bone microenvironment,” he continued.
“Based on these data, I believe the routine adjuvant use of zoledronic acid to prevent recurrence is not indicated,” said Sharon Giordano, M.D., from the University of Texas M. D. Anderson Cancer Center at the press conference. “The difference in outcome by menopausal status is very intriguing but not definitive.” She continued, “the AZURE trial will not be the final word on this topic.” Ongoing large trials testing bisphosphonates for the adjuvant treatment of breast cancer include NSABP B-34, the Gain trial, the NATAN trial, and SWOG-S0307.
Zoledronic Acid Did Not Improve Disease-Free Survival in Breast - National Cancer Institute
Exceptions and Alternative Procedures Approved Under 21 CFR 640.120
Exceptions and Alternative Procedures Approved Under 21 CFR 640.120
Title 21 Code of Federal Regulations 640.120(a) - The Director, Center for Biologics Evaluation and Research, may approve an exception or alternative procedures to any requirement in subchapter F (Biologics) of Chapter I (Parts 600 - 680) of title 21 of the Code of Federal Regulations regarding blood, blood components or blood products.
Both licensed and unlicensed blood establishments must submit requests for an exception or alternative procedure to the requirements in Parts 600-680. Licensed establishments should submit the request in accordance with 21 CFR 601.12 and may reference our guidance document entitled: Guidance for Industry: Changes to an Approved Application: Biological Products: Human Blood and Blood Components Intended for Transfusion or for Further Manufacture (July 2001).
Requests for such exceptions or alternative procedures should ordinarily be made in writing, however, in limited circumstances, such requests may be made orally and permission may be given orally by the Director. Oral requests and approvals must be promptly followed by written requests and written approvals.
It should be noted that requests for exceptions or alternate procedures includes specific circumstances and may require submission of supporting data unique to the circumstance. Publication of these approvals for a specific exception or alternative procedure does not necessarily mean that they can be generally applied to other manufacturers.
FEDERAL REGISTER: Cumulative List of Exceptions and Alternative Procedures Approved by the Director of the Center for Biologics Evaluation and Research - 9/28/2004 - (PDF - 61 KB)
Exceptions and Alternative Procedures Approved Under 21 CFR 640.120
Approved Products > Gardasil
Gardasil
Proper Name: Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant
Tradename: Gardasil
Manufacturer: Merck & Co., Inc, License #0002
Indications:
* Prevention of vulvar and vaginal cancer
* Vaccination in females 9 to 26 years of age for prevention of the following diseases caused by Human Papillomavirus (HPV) Types 6, 11, 16, and 18:
o Cervical cancer
o Genital warts (condyloma acuminata) and the following precancerous or dysplastic lesions:
+ Cervical adenocarcinoma in situ (AIS)
+ Cervical intraepithelial neoplasia (CIN) grade 2 and grade 3
+ Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3
+ Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3
+ Cervical intraepithelial neoplasia (CIN) grade 1
* Vaccination in boys and men 9 through 26 years of age for the prevention of genital warts caused by HPV types 6 and 11
* Vaccination in people ages 9 through 26 years for the prevention of anal cancer and associated precancerous lesions due to human papillomavirus (HPV) types 6, 11, 16, and 18
Approved Products > Gardasil
Science & Research (Biologics) > Proof-of-concept Dual Vaccine against both Smallpox and Anthrax
Proof-of-concept Dual Vaccine against both Smallpox and Anthrax
Scientists at the Food and Drug Administration’s Center for Biologics Evaluation and Research developed an anthrax challenge model that was used to characterize a novel prototype dual vaccine against smallpox and anthrax developed by investigators at the National Cancer Institute. This vaccine incorporates the genes for two proteins, IL-15 and anthrax protective antigen (PA), into an existing smallpox vaccine virus. One protein (IL-15) enhances the vaccine’s anti-smallpox potency; the other protein (PA) stimulates immune responses to anthrax. This low-cost, reliable challenge model will facilitate proof-of-concept evaluations of other candidate anthrax vaccines and therapeutics.
The currently licensed smallpox vaccine, Acam2000® is highly effective; however, it is associated with serious complications, such as those affecting the heart, brain, and skin, and is not recommended for use in certain groups, such as those with severe immune deficiency. This was also true of the previously licensed smallpox vaccine, Dryvax®.
(ACAM2000, (Smallpox (Vaccinia) Vaccine, Live). The currently licensed anthrax vaccine must be administered multiple times over a long period in order to provide protection (BIOTHRAX (Anthrax Vaccine Adsorbed).
"Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities"
Proc Natl Acad Sci USA Oct. 19, 2010; 107(42):18091-18096
http://www.pnas.org/cgi/doi/10.1073/pnas.1013083107
Authors:
Tod J. Merkel, Vanessa K. Kelly, Anita Verma (Food and Drug Administration, Bethesda, MD)
Pin-Yu Perera (Veterans Affairs Medical Center, Washington, DC)
Zara N. Llewellyn (Southern Research Institute, Birmingham, AL)
Thomas A. Waldman, Liyanage P. Perera (National Cancer Institute, National
Institutes of Health, Bethesda, MD)
Joseph D. Mosca (JDM Technologies, Ellicott City, MD)
Science & Research (Biologics) > Proof-of-concept Dual Vaccine against both Smallpox and Anthrax
Science & Research (Biologics) > Universal Influenza Vaccine against H5N1, H3N2, and H1N1 Shown Effective in Pre-Clinical Trials
Universal Influenza Vaccine against H5N1, H3N2, and H1N1 Shown Effective in Pre-Clinical Trials
Researchers in the Center for Biologics Evaluation and Research and the Centers for Disease Control and Prevention developed a "universal," off-the-shelf vaccine designed to reduce illness and slow the spread of disease caused by new influenza A viruses that emerge suddenly, spread quickly, and for which there is no specific vaccine available. A single dose of the vaccine reduced illness and virus levels in mice later infected with highly virulent (disease-causing) H1N1 and H3N2 (seasonal influenza), and H5N1 (bird flu).
The key to the new vaccine's broad protection is that it is designed to trigger immune responses against proteins called NP and M2--two protein targets in all influenza viruses that change over time much more slowly than the HA and NA proteins targeted by traditional vaccines. The vaccine is designed to express NP and M2 from a replication-defective form of another respiratory virus, and is administered nasally, which enables it to stimulate the immune system in the mucous membranes, where influenza viruses launch their infection.
This type of vaccine, if effective in humans, could be stockpiled and then used to reduce deaths and severe illness in the event of delayed production of traditional vaccine against a newly emergent influenza virus.
"Single-dose Mucosal Immunization with a Candidate Universal influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses"
PLoS 2010; 5(10) October 4
http://dx.plos.org/10.1371/journal.pone.0013162.
Authors:
Graeme E. Price, Mark R. Soboleski, Chia-Yun Lo, Julia A. Misplon, Mary R. Quirion, Suzanne L. Epstein (Food and Drug Administration, Bethesda, MD) Katherine V. Houser, Melissa B. Pearce, Claudia Pappas, Terrence M. Tumpey
(Centers for Disease Control and Prevention, Atlanta, GA)
Science & Research (Biologics) > Universal Influenza Vaccine against H5N1, H3N2, and H1N1 Shown Effective in Pre-Clinical Trials
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INFECCIONES RESPIRATORIAS AGUDAS, MUERTES - GLOBAL...
Emergence of New Delhi metallo-β-lactamase, Austri...
New Delhi metallo-β-lactamase in Klebsiella pnemon...
Alkhurma hemorrhagic fever in travelers returning ...
FDA Approves Egrifta to Treat Lipodystrophy in HIV...
Lynx1, a Cholinergic Brake, Limits Plasticity in A...
Revista Española de Cardiología: Resumen
Gene Identified For Spread Of Deadly Melanoma
Genetic Prostate Cancer Risk Assessment: Common Va...
Pancreatic Cancer: Cell Signaling Protein May Hold...
Researchers Discover Expanded Role For Cancer-Caus...
Smokers' Lung Cancer Could Be Different Disease To...
Single Gene Target Could Boost Bowel Cancer Surviv...
New Findings On Chromosome Changes In Tumour Cells...
PHG Foundation | Gene variants linked to control o...
Genetic Secret to AIDS Immunity Found - Technology...
Fracture Risk Seen With Hormone Therapy for Prosta...
Few Young Women Getting Cervical Cancer Vaccine: M...
Cancer patients pick antidepressant for hot flashe...
Higher Statin Doses Linked to Fewer Heart Attacks,...
Racial/Ethnic Disparities and Geographic Differenc...
Increasing Prevalence of Parent-Reported Attention...
TESAMORELIN - FDA Approves Egrifta to Treat Lipody...
IntraMed - Artículos - Tumor filodes de la vulva
Aumentan las alergias a alimentos y digestivas - D...
Scientists Say They've Made Blood From Skin: Medli...
Early Chemotherapy to Prevent Ovarian Cancer Recur...
Romidepsin Reduces Disease Burden and Skin Symptom...
Less-Invasive Lymph Node Surgery Safe for Women wi...
cabazitaxel improved the survival of some patients...
Medical Countermeasures Initiative - Science Boar...
NCTR Publications NCTR Research Highlights
Fire Fighter Fatality Investigation Report F2010-1...
FDA: Majority of drug and biological product maker...
Lot Release (Biologics) Influenza Virus Vaccine f...
Study provides link between tumor suppression and ...
Mammography Benefits? MedlinePlus.gov
JAMA -- Therapeutic Interventions for Systemic Vas...
CDC - Blogs - Safe Healthcare – Automating Infecti...
Anorexia Linked With Unplanned Pregnancies: Medlin...
Products - Health E Stats - Prevalence of Underwei...
Products - Health E Stats - Prevalence of Underwei...
Anti-Delirium Drug May Harm Critically Ill Patient...
NIH to host sickle cell disease symposium, Novembe...
FDA working to prevent radiation overdoses during ...
New Malaria Drug Proves Effective in Study of Afri...
Rheumatoid Arthritis May Raise Risk of Blood Vesse...
Silicone Implants Preferred by Mastectomy Patients...
Smoking May Raise Risk of Death in Women With Brea...
Cancer patients pick antidepressant for hot flashe...
Cheaper, Older Treatment for Vasculitis Beats Out ...
Statins Don't Reduce Colon Cancer Risk, Study Find...
Study links painkillers to reproductive disorders ...
Solar Blood-Pressure Device Shows Promise for Use ...
Study Warns of Risks for Early Dialysis - MedlineP...
New Drug, Pradaxa, May Prevent Second Stroke in Ce...
Common Foot Disorders Can Be Inherited, Research S...
Obesity Not Tied to Breast Cancer Risk in Mexican ...
Lung Cancer in Smokers, Nonsmokers May Be a Differ...
The treatment of glenohumeral joint osteoarthritis...
The treatment of distal radius fractures. American...
The diagnosis and treatment of acute Achilles tend...
ACS: Chest Pain and Acute Coronary Syndrome, Diagn...
Clinical guidelines for the use of chronic opioid ...
Clinical practice guideline for prostate cancer tr...
Venous thromboembolism diagnosis and treatment. In...
Diagnosis and management of attention deficit hype...
Treatment of childhood overweight and obesity. Mic...
Routine prenatal and postnatal care. Michigan Qual...
Prevention and identification of childhood overwei...
Ustekinumab for the treatment of adults with moder...
Cetuximab for the first-line treatment of metastat...
World Gastroenterology Organisation Global Guideli...
Cellular 'alchemy' transforms skin into blood
Research Suggests Link Between 'Handedness' and Dy...
Gene Associated With Autism May Alter How Brain Fu...
Genetic Deletion Linked to Raised Risk of Autism, ...
Vitamin D No Magic Bullet for Osteoarthritis
Controlling Computers with Your Mind
Lead Poisoning Treatment Less Effective for Mercur...
Malaria Mosquitoes Evolving
Evidence-based classification of recommendations o...
Use of genomic profiling to assess risk for cardio...
Recommendations from the EGAPP Working Group: Geno...
El Hospital: Ecri Institute - Monitores transcut...
Abstract | The genetic basis of multiple sclerosis...
Individualizing treatment duration in hepatitis C ...
Genome-Wide Association Study of Suicide Attempts ...
Genetic findings in anorexia and bulimia nervosa. ...
Australian Schizophrenia Research Bank: a database...
BMB reports Online: Overview of personalized medic...
Cutting the fat the genetic dissection of body wei...
GAPPKB|Home (beta version)
HuGENavigator|HuGE Literature Finder|Search (versi...
Genetic variations in toll-like receptor pathway g...
The pharmacogenetics of antidepressant-induced man...
Reduced-function CYP2C19 genotype and risk of adve...
Gene Variants Affect Hepatitis C Treatment, But Li...
How genetic variation affects patient response and...
Fcγ receptor polymorphisms and clinical efficacy o...
Effects of CYP2C19 genotype on outcomes of clopido...
JAMA -- Clopidogrel and the Reduced-Function CYP2C...
SARAMPIÓN, BROTE ESCOLAR - ESPAÑA (GRANADA)
FDA clears Cymbalta to treat chronic musculoskelet...
TRIQUINOSIS, EMBUTIDOS, BROTE - ARGENTINA (CÓRDOBA...
MALARIA, ALTA LETALIDAD, COMUNIDADES YANOMAMI - VE...
Nicaragua reporta 527 casos leptospirosis y dos ni...
Vaccines: Pubs/SurvManual/main page
Modifier genes in Mendelian disorders: the example...
GSTM1 Null and NAT2 Slow Acetylation Genotypes, Sm...
BRCA1 and BRCA2 genetic test in high risk patients...
Association of KRAS p.G13D mutation with outcome i...
LOC387715/HTRA1 gene polymorphisms and susceptibil...
Primary immunodeficiency diseases: Practice among ...
Europe’s Plagues Came From China, Study Finds - NY...
Science - UMass Medical School study points to gen...
Sigma nonopioid intracellular receptor 1 mutations...
Autism study reveals how genetic changes rewire th...
Boy with rare genetic disorder touches many :: The...
Genomics: DNA's master craftsmen
New global map shows distribution of sickle cell g...
Researchers Find 'Goldilocks' Of DNA Self-Assembly...
Scientists Describe New Approach For Identifying G...
New Methods Detect Subtleties In Human Genomes' Re...
Uncovering The Cause Of A Common Form Of Muscular ...
New approach for identifying genetic markers for c...
Sistema de Información de Medicamentos (SIM) // e-...
NIDA Drugs of Abuse and Related Topics - Medical C...
Severe morning sickness runs in families: MedlineP...
Multivitamins don't reduce diabetes risk: MedlineP...
First ladies join The Heart Truth to raise women's...
Lung cancer trial results show mortality benefit w...
The third International Meeting on Emerging Diseas...
The Major Genetic Determinants of HIV-1 Control Af...
Blood -- AICAR induces apoptosis independently of ...
Scientists find gene variant associated with reduc...
Researcher Uses Gene Defect Discovery To Help Card...
Test May Diagnose Deadly Niemann-Pick Type C Disea...
Genetic Variants May Affect The Risk Of Breast Can...
PHG Foundation | Genetic loci associated with Hodg...
Successful aging in the Amish: Researchers discove...
New mutation linked to non-Hodgkin's lymphoma
Asthma Linked to Lung Cancer Risk in Study: Medlin...
Retinal implant trial helps blind people see shape...
Gene Associated With Autism May Alter How Brain Fu...
Cuatro casos de malaria en Rosario por un barco pr...
Hereditary thrombophilia and recurrent pregnancy l...
PLoS ONE: Breast Cancer Stem-Like Cells Are Inhibi...
Cellular & Gene Therapy Guidances > Guidance for I...
NIH videos help health providers answer questions ...
Chemicals in Meat Cooked at High Temperatures and ...
DNA Region on Chromosome 1 Is Linked to Neuroblast...
Reducing Treatment Intensity in Early-Stage Hodgki...
Hemophilia drug can damage heart, study finds: Med...
Announcement: World Pneumonia Day --- November 12,...
Notes from the Field: Malaria Imported from West A...
Cholera Outbreak --- Haiti, October 2010
Evaluation of Acute Hepatitis C Infection Surveill...
Outbreaks Following Wild Poliovirus Importations -...
FDA reclassifies certain digital mammography devic...
CDC - Rotarix and RotaTeq Rotavirus Vaccines and I...
NIAID Web Bulletin: NIH Network Identifies Better ...
CDC - Blogs - Safe Healthcare – Investigating Rare...
V. CHOLERAE, IDENTIDAD GENÉTICA CON CEPAS ASIÁTIC...
DENGUE, BROTE: NO OFICIAL - CUBA (LA HABANA)
CÓLERA, BROTE, MUERTES - HAITÍ (05)
MALARIA, ALTA LETALIDAD, COMUNIDADES YANOMAMI - VE...
Heart Attack Symptoms and Calling 9-1-1 Campaign f...
Incidence of End-Stage Renal Disease Attributed to...
Cost-effectiveness of interventions to reduce diet...
Urine bisphenol-A (BPA) level in relation to semen...
NCCN 16th Annual Conference - Event Summary | Onli...
NCCN 2010 Congress Series: Respiratory Tract Cance...
Centros Control Enfermedades EEUU estudian cólera ...
CDC - Hepatitis B and Multiple Sclerosis ( MS) - V...
HepB_WAPIANTK_T.pdf (What Asian and Pacific Island...
NCTR Publications > NCTR Research Highlights
Statement from NIDDK Director Griffin P. Rodgers f...
NIH alerts caregivers to increase in SIDS risk dur...
NIH researchers identify genetic elements influenc...
National Guideline Clearinghouse | Work-related ra...
National Guideline Clearinghouse | Asthma.
National Guideline Clearinghouse | Adult immunizat...
National Guideline Clearinghouse | Incorporating a...
National Guideline Clearinghouse | SAGES guideline...
National Guideline Clearinghouse | Guidelines for ...
CDC - Hepatitis B and Multiple Sclerosis ( MS) - V...
NIH-supported mouse studies suggest treatment targ...
NIAID Media Availability: New Study Re-examines Ba...
Thermal Enhancement with Optically Activated Gold ...
Everolimus - About the Center for Drug Evaluation ...
Trastuzumab - (Labeling Change) - About the Center...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Practice parame...
National Guideline Clearinghouse | Assessment: eff...
National Guideline Clearinghouse | Human milk stor...
DNA Region on Chromosome 1 Is Linked to Neuroblast...
Plastics Chemical BPA Tied to Poor Sperm Quality: ...
The Origins of Autoimmunity-Causing T Cells
Gene Variants Tied to Poor Outcomes with Heart Dru...
A New Phase for Human Genomics
Independent panel discourages routine use of treat...
Children with ADHD Symptoms at Higher Risk of Obes...
Heavy Smoking Linked to Alzheimer's in Study: Medl...
Treatment of Patients With Major Depressive Disord...
Updated Recommendations for Prevention of Invasive...
National Guideline Clearinghouse | Antiretroviral ...
National Guideline Clearinghouse | World Gastroent...
National Guideline Clearinghouse | World Gastroent...
Study finds gene links to common lymphoma cancer: ...
Race Affects Hepatitis C Recurrence After Liver Tr...
Concerns Grow Over Dangers of Caffeinated Alcohol ...
FDA approves new indication for Afinitor
Women's Health Topics > Women and Diabetes
FDA Approves Teflaro for Bacterial Infections
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EL BIRUNI: DIRECTORIO DE DOCUMENTOS EDITADOS EN DICIEMBRE 2010 [*]
DIRECTORIO DE DOCUMENTOS EDITADOS EN DICIEMBRE 2010 [*]
CIENCIAS MÉDICAS NEWS
CIENCIAS MÉDICAS APLICADAS
RESEARCH & CLINICAL DEVELOPMENT
▲ VISIÓN: proporcionar fuentes de información científica calificadas en ciencias médicas, farmacéuticas y bioquímicas, genéticas y epigenéticas
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Consultas acumuladas desde enero 2009 a la fecha: 283.810
Consultas totales conjuntas (todos los blogs): 1.213.631
Páginas consultadas desde el inicio de los blogs [3]: > 3 millones 500 mil
Discriminadas como sigue:
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4. U.S.A.: 36.079 [12,7%]
5. COLOMBIA: 16.397 [ 5.8%]
6. PERÚ: 15.468[ 5,5%]
7. VENEZUELA: 14.259 [ 5,0%]
8. CHILE: 9.923 [ 3,5%]
9. ECUADOR: 6.621 [ 2,3%]
10. BOLIVIA: 4.781 [ 1,7%]
11. LOS DEMÁS: 59.635 [21.0%]
Total de consultas: 283.810
Documentos del mes de DICIEMBRE: 630
Documentos acumulados en 2010: 6.299
Documentos editados desde el inicio del blog: 10.805
Archivo del blog
▼ 2010 (6299)
▼ diciembre (630)
Novel HIV-1 Recombinant Forms in Antenatal Cohort,...
Alert System to Detect Possible School-based Outbr...
Characteristics of Patients with Oseltamivir-Resis...
Inappropriate drugs still given for sinus woes: Me...
Trace amounts of germ-killing molecules predict di...
Biologics Guidances > Guidance for Industry: “Look...
Trial Suggests New Treatment Option for Hodgkin Ly...
Arch Intern Med -- Abstract: Risk of Renal Cell Ca...
National Guideline Clearinghouse | Management of d...
National Guideline Clearinghouse | The continued u...
National Guideline Clearinghouse | First-line syst...
National Guideline Clearinghouse | Sunitinib malat...
National Guideline Clearinghouse | The use of beva...
More girls developing a form of hearing loss: Medl...
Inappropriate drugs still given for sinus woes: Me...
e- Boletín DROGAS Y MEDICAMENTOS - Año I - Nº 12 –...
Drug Safety Podcasts > FDA Drug Safety Podcast for...
Drug Safety Podcasts > FDA Drug Safety Podcast for...
Drug Safety Podcasts > FDA Drug Safety Podcast for...
Development of Genetic Testing for Breast, Ovarian...
Data mining methods for classification of Medium-C...
Common human genetic variants and HIV-1 susceptibi...
Alzheimer's disease gene signature says: beware of...
Genetic screening for metabolic and age-related co...
The influence of family history on prostate cancer...
Cancer risks for monoallelic MUTYH mutation carrie...
Genetic polymorphisms in diabetes: Influence on th...
Genetic factors in contact allergy-review and futu...
Perspectives for tailored chemoprevention and trea...
KRAS, BRAF, PIK3CA, and PTEN mutations: implicatio...
How new advances in genetic analysis are influenci...
Genetic Correction of PSA Values Using Sequence Va...
New Test Shows Promise For Accurate Early Diagnosi...
Genetic Sequencing Used To Identify And Treat Unkn...
Echinostoma revolutum Infection, Cambodia | CDC EI...
S. pneumoniae in Children with Chronic Kidney Dise...
Ciprofloxacin Susceptibility in Salmonella enteric...
Foodborne Illness: MedlinePlus
Blastocystis hominis infection - MayoClinic.com
Approved Products > FDA Actions
Kidney (Renal Cell) Cancer Tumor Prevention, Scree...
GRIPE A en EMBARAZO - JANOes y agencias - La neumo...
With Cataracts, Misinformation Seems to Abound: Me...
Scientists Spot DNA Linked With Dangerous Heart Rh...
Epilepsy Found to Be More Common in U.S. Than Thou...
Cord-Blood 25-Hydroxyvitamin D Levels and Risk of ...
Apoptosis signal-regulating kinase 1 and cyclin D1...
Cancer Cell - Leukemic IDH1 and IDH2 Mutations Res...
Cancer Cell - Antiangiogenic Therapy Elicits Malig...
New Technology Could Slash Gene Sequencing Time
Genetic Switch Discovered That Turns On Pain
Study Identifies Genetic Mutations Associated With...
MRI Scans Reveal Brain Changes In People At Geneti...
Genome-Wide Hunt Reveals Links To Abnormal Rhythms...
Genetic Markers Discovered That Improve The Power ...
Experts Collaborate In Gene Survey Of Childhood Br...
'Junk' DNA Reveals Key Information About Breast Ca...
Pandemic (H1N1) 2009 Outbreak at Camp for Children...
S. pneumoniae, Palestinian Territories | CDC EID
Roundworm Larvae in Raccoon Latrines | CDC EID
Identification of Rickettsial Infections | CDC EID...
CTX-M–producing Non-Typhi Salmonella spp., USA | C...
Rickettsia africae, Oceania | CDC EID
NDM-1 Metallo-β-Lactamase, Canada | CDC EID
Influenza in Early Pregnancy and Fetal Demise | CD...
Measles Virus Transmission, Uganda | CDC EID
Babesiosis in Immunocompetent Patients | CDC EID
Primary Infections with PARV4, Finland | CDC EID
Pandemic (H1N1) 2009 Virus, Taiwan | CDC EID
New Links Found between Familial and Sporadic ALS:...
Lupus Treatment May Soon Take Leap Forward: Medlin...
NCTR Publications > NCTR Research Highlights
Development of an ovarian cancer screening decisio...
Body Fat Distribution and Risk of Premenopausal Br...
SpringerLink - Familial Cancer, Volume 9, Number 3...
TMEM106B regulates progranulin levels and the pene...
Laboratory Investigation - Role of serum response ...
Laboratory Investigation - p66Shc has a pivotal fu...
Laboratory Investigation - A mouse model of autoim...
Laboratory Investigation - Viral factors induce He...
Laboratory Investigation - Abstract of article: PP...
Ectopic Expression of Germline Genes Drives Malign...
Recurrence of Oral Cancer Found to Signal Poor Out...
Single Embryo Beat Double Embryo Transfer in IVF S...
New Drug Strategy Shows Promise Against HIV: Medli...
Death Rates Higher for Those With Lasting Epilepsy...
The genetic basis of brain diseases
23andMe receives NIH funding to evaluate web-based...
Parents favor genetic testing for melanoma in thei...
Gene alteration identified that predisposes to syn...
Electromyography (EMG) and Nerve Conduction Veloci...
Safety Alerts for Human Medical Products > Dexamet...
HIV/AIDS Update - New Intelence (etravirine) dosag...
Human Listeriosis, England, 1999–2009 | CDC EID
Rotavirus Genotypes from Rapid Test Strips | CDC E...
African Swine Fever, Senegal | CDC EID
TSEs of Small Ruminants, France | CDC EID
Dengue Virus Type 2, Puerto Rico | CDC EID
HEV in Solid-Organ Transplant Recipients, CME Acti...
Communicable Disease Reporting, NC, USA | CDC EID
Foodborne Illness, USA—Unspecified Agents | CDC EI...
Foodborne Illness, USA—Major Pathogens | CDC EID
Cysticercosis Acquired in the United States | CDC ...
Clostridium sphenoides Bloodstream Infection in Ma...
Vibrio cholerae O1 in 2 Coastal Villages, Papua Ne...
Buruli Ulcer Prevalence and Altitude, Benin | CDC ...
Zoonotic Cryptosporidiosis from Petting Farms, Eng...
Role of National Travel Health Network and Centre ...
Ceftriaxone-Resistant Neisseria gonorrhoeae, Japan...
Sparganosis, Henan Province, Central China | CDC E...
Identification of Legionella feeleii Cellulitis | ...
Class D OXA-48 Carbapenemase in Multidrug-Resistan...
Cancer Cells May Be Able to Urge Their Own Death: ...
Crimean-Congo Hemorrhagic Fever Virus, Northeaster...
Intensive Care Unit Admission for Pandemic (H1N1) ...
Empyema caused by MRSA ST398 with Atypical Resista...
Apophysomyces variabilis Infections in Humans | CD...
Change in Age Pattern of Persons with Dengue, Nort...
Carbapenemases in Enterobacteria, Hong Kong, China...
Emergence of New Delhi Metallo-β-Lactamase, Austri...
Vol. 17, No. 1 Cover: Manna to Gall | CDC EID
How Safe Is Our Food? | CDC EID
Foodborne Illness, USA—Major Pathogens | CDC EID
WHO | Vaccine innovation done differently [english...
Gene Mutation Suggests New Treatment Target for Sp...
Study Adds to Evidence That Rituximab Slows Lympho...
CDC Data & Statistics | Feature: Incidence of Food...
CDC Data & Statistics | Feature: Adults Having Fiv...
NIH-led study identifies genetic variant that can ...
Benefits of a Placebo in Adults With IBS Do Not De...
Most Medicare stroke patients rehospitalized or de...
Strict heart rate control provides no advantage ov...
Liver Cancer Survival Rates May Be Worse for Black...
Whole-Fat Dairy Products May Lower Type 2 Diabetes...
For Most, Chronic Heartburn Not a Big Risk for Eso...
Tanning Beds Still Popular Despite Skin Cancer Ris...
Factores de riesgo para los complicaciones quirúrg...
Convulsiones febriles y su relación con las vacuna...
Guía de recomendaciones para la prevención y detec...
BioMed Central | Abstract | Characteristic odour i...
El Grupo Solti convoca la primera beca para jóvene...
Massive parallel DNA pyrosequencing analysis of th...
Announcements: Maternal & Child Health Epidemiolog...
Update: Influenza Activity --- United States, Octo...
Salmonella Montevideo Infections Associated with S...
Transmission of Multidrug-Resistant Escherichia co...
Update on Cholera --- Haiti, Dominican Republic, a...
FELIZ NAVIDAD - MERRY CHRISTMAS - Froehliche Weihn...
PLoS ONE: Placebos without Deception: A Randomized...
Short-Term Monotherapy in HIV-Infected Patients wi...
FDA: Gardasil approved to prevent anal cancer
American adults hear better than they did 40 years...
Scientists reveal how biological activity is regul...
NCI announces plans to reinvigorate clinical trial...
Psoriasis Linked to Raised Heart Risks: MedlinePlu...
Docs Claim Transplant Cured Man of HIV, But Expert...
Interactions cause seniors to drop antidepressants...
Characterization of the proteome, diseases and evo...
Germline Epigenetic Regulation of KILLIN in Cowden...
Call for Public Review: Update on Horizon Scans of...
Severe Pain Can Trigger Suicide in Hospital ERs: M...
TRIAL´s: Open Studies | "Suicidal Ideation" - List...
National Guideline Clearinghouse | Guideline Synth...
National Guideline Clearinghouse | Expert Commenta...
NIH researchers link rare cancer to cell oxygen de...
National Guideline Clearinghouse | Surgical approa...
National Guideline Clearinghouse | Prevention of v...
National Guideline Clearinghouse | Nonpharmacologi...
National Guideline Clearinghouse | Myocarditis: cu...
National Guideline Clearinghouse | Managing patien...
National Guideline Clearinghouse | Management of h...
National Guideline Clearinghouse | Management of a...
National Guideline Clearinghouse | Heart failure i...
National Guideline Clearinghouse | Genetic evaluat...
National Guideline Clearinghouse | Evaluation of p...
National Guideline Clearinghouse | Evaluation and ...
National Guideline Clearinghouse | Evaluation and ...
National Guideline Clearinghouse | Evaluation and ...
National Guideline Clearinghouse | Electrophysiolo...
National Guideline Clearinghouse | Disease managem...
Study finds contamination in virus link to fatigue...
Heartburn Drugs May Raise Pneumonia Risk: MedlineP...
Change in B Cell Protein Production Drives Bone Lo...
TRIAL´s: Open Studies | "Osteoporotic Fractures" -...
Structural Genomics Centers for Infectious Disease...
Cancer - NPCR - USCS - View Data Online
Antioxidant, Antiproliferative, and Pro-apoptotic ...
The Proteome of Human Brain After Ischemic Stroke ...
Study ties blood protein to Alzheimer's brain abno...
Brain activity pattern signals ability to compensa...
Treatment for Addicted Moms Has Better Outcomes fo...
Alzheimer's Disease May Stem from Protein Clearanc...
Preventing Bacterial Infections from Medical Devic...
Research Activities, December 2010: Child/Adolesce...
Research Activities, December 2010: Chronic Diseas...
Management of Acute Otitis Media: Update: Structur...
A Primary Care-Focused, Computer-based Clinical De...
Conference Scene: Pediatric pharmacogenomics and p...
Genetic and epigenetic influences associated with ...
HuGENavigator|HuGE Literature Finder|Search (versi...
Gene-Lifestyle and Gene-Pharmacotherpy Interaction...
Recommendations from the EGAPP Working Group: Rout...
Familial Tendency and Risk of Nasopharyngeal Carci...
Components of family history associated with women...
Genes and Abdominal Aortic Aneurysm. [Ann Vasc Sur...
Association between familial atrial fibrillation a...
Predicting and preventing cardiotoxicity in the er...
Multicenter Surveillance of Women at High Genetic ...
Environmental Health Perspectives: Moving Forward ...
Ability to predict breast cancer in Asian women us...
Molecular determinants of anti-EGFR sensitivity an...
European Medicines Agency - News and press release...
European Medicines Agency - News and press release...
European Medicines Agency - News and press release...
European Medicines Agency - News and press release...
ANTIBIOTICOS, RESISTENCIA CRECIENTE, DESAFIOS - EU...
DNA Sequence Variation Associated With Earlier Ons...
Marfan Syndrome -- A Frequently Undiagnosed Geneti...
Gene That Causes Some Cases Of Familial ALS Discov...
Expert Analysis Of HER2 Tests Reveals Issues With ...
Alzheimer's And Heart Attacks Share The Same Genes...
Personalized Molecular Therapy Shows Promising Res...
Gene Information Predicts Survival Time, Possible ...
CDC - Women's Health - Leading Causes of Death in ...
Surveillance of Screening-Detected Cancers (Colon ...
2009 Sexually Transmitted Diseases Surveillance - ...
Trends in Intake of Energy and Macronutrients in A...
CDC - 2010 Guidelines for Prevention of Perinatal ...
CISTICERCOSIS, CASOS, INMIGRANTES: COMENTARIO - A...
VIH-2, HTLV-1 Y 2, PREVALENCIA, EPIDEMIOLOGÍA - E...
New Cardiovascular Risk Assessment Guidelines Ques...
UMB News: Dr. Fraser-Liggett Reports on Impact of ...
Genetic variants linked to increased risk of commo...
Ovarian cancer advances when genes are silenced
Alcoholics beware -- genetic variation linked to l...
Identifying lung cancer gene markers shows promise...
Safety Alerts for Human Medical Products > Anzemet...
Renal sympathetic denervation in patients with tre...
Frontotemporal Disorders
U.S. Latinos Have High Rates of Developing Vision ...
Parkinson’s Disease: More Signs of Mitochondrial D...
Inhalers Linked to Higher Odds of Diabetes in Asth...
ACCORD Eye Study Finds Two Therapies Slow Diabetic...
Cell Host and Microbe - An ATM/Chk2-Mediated DNA D...
Naturally High Hemoglobin Levels May Not Threaten ...
Gene scan shows childhood brain cancer is differen...
FDA begins process to remove breast cancer indicat...
Establishing Precompetitive Collaborations to Stim...
A Primary Care-Focused, Computer-based Clinical De...
Awareness and Utilization of BRCA1/2 Testing Among...
EGAPP|Evaluation of Genomic Applications in Practi...
IntraMed - Artículos - Haciendo posible el debate ...
CISTICERCOSIS, CASOS, INMIGRANTES - ARGENTINA (CHU...
Products - Data Briefs - Number 52 - December 2010...
Humanidades médicas - Juan Pablo Beca Mila Razmili...
HIV/AIDS Update - New Guidance for Industry: Codev...
FDA Hepatitis Update - New Guidance for Industry: ...
Scientists Spot Genetic Areas Key to Embryonic Dev...
Second Brain Death Exam Unnecessary, Study Finds: ...
Consumer Updates > Tainted Products Marketed as Di...
New superbug genes sure to spread, U.S. expert say...
Belly Fat May Make Some Breast Cancers More Likely...
FDA begins process to remove breast cancer indicat...
Announcement: 14th Annual Conference on Vaccine Re...
Notes from the Field: Emergence of Shigella flexne...
Adverse Childhood Experiences Reported by Adults -...
Sexually Transmitted Diseases Treatment Guidelines...
Immune Epitope Database and Analysis Resource Prog...
PRECLINICAL SERVICES FOR THE DEVELOPMENT OF BIOPHA...
Prevention of Pneumococcal Disease Among Infants a...
Frequent and Focal FGFR1 Amplification Associates ...
Differences in Knowledge of Breast Cancer Screenin...
National Guideline Clearinghouse | Physical and sh...
National Guideline Clearinghouse | Upper limb diso...
National Guideline Clearinghouse | Occupational as...
National Guideline Clearinghouse | Latex allergy: ...
National Guideline Clearinghouse | Infected food h...
National Guideline Clearinghouse | Dermatitis: occ...
National Guideline Clearinghouse | Use of tumor ma...
National Guideline Clearinghouse | Emerging biomar...
TRIAL´s: Open Studies | "Peritoneal Dialysis" - Li...
FDA: Tainted products marketed as dietary suppleme...
PT/INR: The Test - PT and INR (Prothrombin Time, I...
CDC - Blogs - Safe Healthcare – State Tackles Winn...
New Method Might Raise Number of Donor Lungs: Medl...
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NCI Cancer Bulletin - National Cancer Institute - ...
Call for Public Review: Lifestyle Interventions fo...
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Oxycontin, Other Opioid Painkillers Tied to Higher...
Black, Low-Income Patients More Disabled by Parkin...
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Fire Fighter Fatality Investigation Report F2010-2...
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Call for Public Review
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Practice Guidelines - American Association of Diab...
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Collaboration offers Clinical Center resources to ...
2009 H1N1 Vaccine Safe and Induces Robust Immune R...
HIV/AIDS Update - New labeling approved for Prezis...
Update of Upcoming Advisory Committee Meetings and...
Bacteria Can Grow Using Arsenic
Insight into Memory Loss in Alzheimer's Disease
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Molecular Cancer | Full text | Cannabinoids reduce...
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Certain Drug Combinations May Beat Back Aggressive...
Even One Cigarette Can Prove Lethal, U.S. Surgeon ...
Weight Gain Seems to Change the Brain's Response t...
Targeted Paths to HIV Prevention - CDC - Grand Rou...
European Medicines Agency - News and press release...
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FDA warns consumers to avoid Man Up Now capsules
CÓLERA, CASOS: ACTUALIZACIÓN - REPÚBLICA DOMINICAN...
INFLUENZA, H1N1, MUERTES - REINO UNIDO
Por primera vez miden científicamente las consecue...
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Fatal 1918 Pneumonia Case Complicated by Erythrocy...
AHRQ: Don't Let Medicines Cause Harm
Show #105, December 2010
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Do the recent American Thyroid Association (ATA) G...
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Radiotherapy in the treatment of hereditary breast...
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30 New Genes Responsible For Early-Onset Puberty U...
Changes In Genetic Networks Caused By DNA Damage M...
The Causes Of Common Diseases Are Not Genetic Conc...
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Decoding Fetal DNA From Mother's Blood Opens Door ...
Genetic Link Found Between Spinal Arthritis And In...
Discovery Of A Mechanistic Link Between Genetic Va...
New International Cancer Effort Akin To Human Geno...
The significance of the complement system for the ...
Family Health History Beats Personal Genomic Scree...
'Clueless' housekeeping genes are activated random...
Earliest brain changes linked to Alzheimer's genet...
Spontaneous mutations important cause of mental re...
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Atypical antidepressants - MayoClinic.com
Understanding Radiotherapy for Head and Neck Cance...
FDA Announces New Prescription Drug Information Fo...
AHRQ Announces Areas of Interest for Research on H...
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Low-Dose Aspirin Boosts Accuracy of Colon Cancer T...
Wait-and-see OK for some mid-risk prostate cancers...
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Both High, Low Levels of Vitamin D in Older Women ...
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Full sequence confirms Haiti cholera came from Asi...
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Update: Outbreak of Cholera --- Haiti, 2010
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Preclinical Services for the Development of Interv...
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Children with heart disease risk factors have high...
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NIAID Media Availability: Landmark Discoveries Cha...
Statement from the National Institutes of Health o...
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Young women with menopause-like condition at risk ...
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Scientists identify molecular link between BRCA1 p...
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In Bangladesh, Developing Models for Cancer Care
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Enhancing Cancer Information Materials with Multim...
PROFILES IN CANCER RESEARCH
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A Conversation with… NCI’s Office of International...
Considering Culture When Providing Cancer Care
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Conference on Methodological Challenges in Compara...
Conference_Support_Projects2011.pdf (Objeto applic...
Safety Alerts for Human Medical Products > Vigor-2...
Drug Information Update: FDA warns consumers not t...
Safety Alerts for Human Medical Products > Propoxy...
Mental Illness Hit 1 in 5 U.S. Adults in Past Year...
Key Brain Area for Vision May Be Organized by Colo...
British Study Supports Mammograms for Some Women U...
HIV Patients Do Well After Kidney Transplants: Stu...
Body's 'Clock' Gene May Play Role in Depression: M...
Organ fat linked to liver surgery problems: Medlin...
Arthritis drug less effective for obese patients: ...
CÓLERA, PRIMER CASO CONFIRMADO - EEUU EX: HAITI
ENTEROBACTERIAS, GEN NDM-1, DISEMINACIÓN RÁPIDA - ...
Sociedad Argentina de Lipidos - 1ra. Jornada Trans...
Extending The Cure
RESISTANCE MAP >> | The Center for Disease Dynamic...
CDC - Seasonal Influenza (Flu) | Interim Guidance ...
New Study Finds Increased Tumor Growth Associated ...
Organ fat linked to liver surgery problems: Medlin...
DENOSUMAB - FDA approves Xgeva to help prevent can...
Healthy lifestyle has bigger impact on cardiovascu...
Atrial Fibrillation Risk Higher Among This With Cl...
Gene Screening May Refine Prediction Of Heart Atta...
Researchers discover key mutation in acute myeloid...
AACR Feature: Genetic test may help target lung ca...
Our Normal Genetics May Influence Cancer Growth To...
New Risk Factor For Developing Breast Cancer
Scientists discover new genetic variants linked to...
In Resistant Cancer, Targeted Therapy Reactivates ...
Novel genetic mutation that causes the most common...
CHOP Expert Collaborates In Successful Gene Therap...
Viral counts necessary for gauging health of child...
CDC Data & Statistics | Feature: Reported Tubercul...
Reunión Monotemática de Falla Hepática Aguda en el...
Syringe Exchange Programs --- United States, 2008
Occupational Transmission of Neisseria meningitidi...
Update: Cholera Outbreak --- Haiti, 2010
Prevention of Perinatal Group B Streptococcal Dise...
Laboratory Study Suggests Potential Anti-Cancer Be...
CDC - News (November 17, 2010): Anti-rabies Virus ...
NCTR Centers of Excellence > Bioinformatics
NIAID Media Availability: NIH Experts Describe Inf...
AHRQ's Career Development and Postdoctoral Trainin...
Management of Acute Otitis Media: Update: Structur...
Adding therapy to coordinate heart contraction red...
New pump to treat heart failure in waiting transpl...
Eplerenone significantly improves survival in syst...
Large study of patients with severe heart failure ...
Antibiotics a Mixed Bag for Kids' Ear Infections: ...
Severe Bacterial Strain Found in Cystic Fibrosis P...
U.S. Scientists Commit Most Research Fraud: Study:...
Women with high job strain have 40 percent increas...
Catheter procedure to close hole in heart no more ...
Prescription omega-3 no better than placebo in tre...
Standard pacing therapy regulates heart pumping as...
Rivaroxaban comparable to warfarin in preventing s...
Minimally invasive procedure safe alternative for ...
Drug thought to protect kidneys from imaging dye d...
Treating heart attack with fat-derived stem cells ...
DOLOR AJENO - IntraMed - Arte y Cultura - "Pastill...
Experimental gene therapy did not prevent amputati...
Energy Drinks May Fuel College Kids' Alcohol Use: ...
CDC - Blogs - Safe Healthcare – How much antibioti...
Adding Surgery to Meds May Help Diabetics With Hea...
Treatment that includes surgery results in better ...
Drug-eluting stents are as safe as non-coated sten...
Higher dose of anti-clotting drug no better than s...
miR-200 family and targets, ZEB1 and ZEB2, modulat...
Call for Public Review: Outcomes of Sipuleucel-T T...
NCCN Guidelines Update Webinar Series™: Chronic My...
NCCN Webinar: Treatment Strategies for Mesotheliom...
NCCN Guidelines Update Webinar Series
Blog.AIDS.gov: Lessons for the mHealth HIV Communi...
National Guideline Clearinghouse | Osteoporosis: p...
National Guideline Clearinghouse | Chronic obstruc...
National Guideline Clearinghouse | Acute low back ...
National Guideline Clearinghouse | Guideline for t...
National Guideline Clearinghouse | Management of s...
National Guideline Clearinghouse | Management of p...
National Guideline Clearinghouse | Management of p...
Multidisciplinary Cancer Care With a Patient and P...
Systemic Therapy for Metastatic Colorectal Cancer:...
Management of Unexplained Symptoms in Survivors of...
Employment of Nurse Practitioners and Physician As...
Implementing Clinical Trials: A Review of the Attr...
CDC: Vaccines: You Call the Shots
CDC - Blogs - Safe Healthcare – Let’s Take an Anti...
NCI Cancer Bulletin for November 16, 2010 - Nation...
A Cancer Genome Is Sequenced, Revealing Rare Mutat...
Mutated Gene Linked to Poor Survival in Acute Myel...
Malaria Eradication: Back to the Future - CDC - Gr...
NIAID Media Availability: NIH Scientists Explore 1...
AHRQ Health Care Innovations Exchange
National Guideline Clearinghouse | Bevacizumab (fi...
National Guideline Clearinghouse | Alitretinoin fo...
National Guideline Clearinghouse | VA/DoD clinical...
National Guideline Clearinghouse | VA/DoD clinical...
National Guideline Clearinghouse | VA/DoD clinical...
National Guideline Clearinghouse | PBM-MAP clinica...
CÓLERA, BROTE, MUERTES - HAITÍ (07)
MALARIA AUTÓCTONA, INTRODUCIDA, MOSQUITOS INFECTAD...
Multidisciplinary Cancer Care With a Patient and P...
Establishing a Community-Based Lung Cancer Multidi...
Team Dynamics, Decision Making, and Attitudes Towa...
Multidisciplinary Reference Centers: The Care of N...
Enhancing Prostate Cancer Care Through the Multidi...
Pharmacist-Led, Interdisciplinary Model for Delive...
Does Multidisciplinary Care Enhance the Management...
Effect of Initiating a Multidisciplinary Care Clin...
Models of Multidisciplinary Cancer Care: Physician...
Do Multidisciplinary Meetings Follow Guideline-Bas...
Fundación INECO - CONFERENCIAS INTERNACIONALES
Findings of NIH Clinical Center nursing initiative...
Mouse study shows effect of blood pressure drug on...
Understanding West Nile Virus
eribulin mesylate - FDA approves new treatment opt...
No link found between iron and breast cancer: Medl...
No Benefit of Early Chemotherapy for Ovarian Cance...
Age Could Affect How Well Cancer Patients Cope: Me...
Low Vitamin D Linked to Deterioration in Certain L...
Romiplostim or Standard of Care in Patients with I...
Some Foot Troubles Hit Blacks, Whites More Often: ...
Vitamin D Shortage Not Tied to Stroke Deaths in Bl...
Fast heart rate, rhythm problems found in bereaved...
Brain Organizes Itself for Introspection as Childr...
For Some, Care May Be Withdrawn Too Soon After Car...
Antibody Linked to Allergies on the Rise: MedlineP...
Among Cell-Phone Junkies, Rash on the Rise: Medlin...
Development Resources Pediatric Exclusivity Stati...
Development Resources > Written Requests Issued
About the Center for Biologics Evaluation and Rese...
HANTAVIRUS, CASOS: ACTUALIZACIÓN - CHILE
DENGUE, CASO AUTÓCTONO, RE-EMERGENCIA - EEUU (MIAM...
Entry and retention in medical care among HIV-diag...
Anal Cancer Is Increasing Among People with HIV In...
Epidemiology of HIV in Major Urban Areas Shows Epi...
Postmarket Requirements and Commitments > Final Re...
Safety Information > October 2010
Alcohol Consumption and Cancer Risk: Structured Ab...
The Possible Role of Epigenetics in Gestational Di...
Parental preferences for CDKN2A/p16 testing of min...
Children with genetic disorders undergoing open-he...
Looking on the Bright Side of Serotonin Transporte...
GAPPKB|Home (beta version)
HuGENavigator|HuGE Literature Finder|Search (vers...
Lessons learned from the introduction of personali...
Clinical applications of pharmacogenomics guided w...
Compilation of a comprehensive gene panel for syst...
From evidence based medicine to mechanism based me...
Future Medicine - Pharmacogenomics - 11(10):1439 -...
Genome-wide association study of theta band event-...
Nurses' and midwives' knowledge and perceptions of...
Mitochondrial genetic diseases. [Curr Opin Pediatr...
DENGUE, AUMENTO MARCADO DE MUERTES - BRASIL
innovation.org - Alzheimer's Disease
innovation.org - Infectious Diseases
Basic Information about ARG - STD information from...
Female veterans aged 20-39 less likely to use most...
Search of: Open Studies | "Adolescent" - List Resu...
A Study to Evaluate the Safety and Tolerability of...
Special Infant Formula Might Help Shield Babies fr...
Romidepsin Appears Effective for Previously Treate...
Radiation-Emitting Products
ENFERMEDAD DE CHAGAS AGUDA, MUERTE - VENEZUELA (TÁ...
CÓLERA, BROTE, MUERTES - HAITÍ (06)
TRAUMATISMO DE CRÁNEO - INECO: lunes 15 de noviemb...
NIAID Media Availability: NIH Scientists Unveil Me...
Permanent neonatal diabetes mellitus – the importa...
Discovery and replication of novel blood pressure ...
Abstract | Inflammation gene variants and suscepti...
Cell - A Genome-wide Drosophila Screen for Heat No...
NIAID Media Availability: NIH Scientists Explore 1...
Researchers discover key mutation in acute myeloid...
WHO | Antimicrobial resistance: revisiting the “tr...
The use of current genetic testing oversight to se...
PHG Foundation | Major new biobank to launch in Qa...
Huge International Group To Map Genomes Of 2,500 P...
Gene Discovery Supports Link Between Handedness An...
Extreme Form Of Pregnancy-Related Morning Sickness...
Study Identifies Possible Genetic Origin for ADHD ...
Genetic deletion discovered as risk factor for aut...
Studies validate use of family health history as g...
CDC - Blogs - Safe Healthcare – Antibiotic Prescri...
INFECCIONES RESPIRATORIAS AGUDAS, MUERTES - GLOBAL...
Emergence of New Delhi metallo-β-lactamase, Austri...
New Delhi metallo-β-lactamase in Klebsiella pnemon...
Alkhurma hemorrhagic fever in travelers returning ...
FDA Approves Egrifta to Treat Lipodystrophy in HIV...
Lynx1, a Cholinergic Brake, Limits Plasticity in A...
Revista Española de Cardiología: Resumen
Gene Identified For Spread Of Deadly Melanoma
Genetic Prostate Cancer Risk Assessment: Common Va...
Pancreatic Cancer: Cell Signaling Protein May Hold...
Researchers Discover Expanded Role For Cancer-Caus...
Smokers' Lung Cancer Could Be Different Disease To...
Single Gene Target Could Boost Bowel Cancer Surviv...
New Findings On Chromosome Changes In Tumour Cells...
PHG Foundation | Gene variants linked to control o...
Genetic Secret to AIDS Immunity Found - Technology...
Fracture Risk Seen With Hormone Therapy for Prosta...
Few Young Women Getting Cervical Cancer Vaccine: M...
Cancer patients pick antidepressant for hot flashe...
Higher Statin Doses Linked to Fewer Heart Attacks,...
Racial/Ethnic Disparities and Geographic Differenc...
Increasing Prevalence of Parent-Reported Attention...
TESAMORELIN - FDA Approves Egrifta to Treat Lipody...
IntraMed - Artículos - Tumor filodes de la vulva
Aumentan las alergias a alimentos y digestivas - D...
Scientists Say They've Made Blood From Skin: Medli...
Early Chemotherapy to Prevent Ovarian Cancer Recur...
Romidepsin Reduces Disease Burden and Skin Symptom...
Less-Invasive Lymph Node Surgery Safe for Women wi...
cabazitaxel improved the survival of some patients...
Medical Countermeasures Initiative - Science Boar...
NCTR Publications NCTR Research Highlights
Fire Fighter Fatality Investigation Report F2010-1...
FDA: Majority of drug and biological product maker...
Lot Release (Biologics) Influenza Virus Vaccine f...
Study provides link between tumor suppression and ...
Mammography Benefits? MedlinePlus.gov
JAMA -- Therapeutic Interventions for Systemic Vas...
CDC - Blogs - Safe Healthcare – Automating Infecti...
Anorexia Linked With Unplanned Pregnancies: Medlin...
Products - Health E Stats - Prevalence of Underwei...
Products - Health E Stats - Prevalence of Underwei...
Anti-Delirium Drug May Harm Critically Ill Patient...
NIH to host sickle cell disease symposium, Novembe...
FDA working to prevent radiation overdoses during ...
New Malaria Drug Proves Effective in Study of Afri...
Rheumatoid Arthritis May Raise Risk of Blood Vesse...
Silicone Implants Preferred by Mastectomy Patients...
Smoking May Raise Risk of Death in Women With Brea...
Cancer patients pick antidepressant for hot flashe...
Cheaper, Older Treatment for Vasculitis Beats Out ...
Statins Don't Reduce Colon Cancer Risk, Study Find...
Study links painkillers to reproductive disorders ...
Solar Blood-Pressure Device Shows Promise for Use ...
Study Warns of Risks for Early Dialysis - MedlineP...
New Drug, Pradaxa, May Prevent Second Stroke in Ce...
Common Foot Disorders Can Be Inherited, Research S...
Obesity Not Tied to Breast Cancer Risk in Mexican ...
Lung Cancer in Smokers, Nonsmokers May Be a Differ...
The treatment of glenohumeral joint osteoarthritis...
The treatment of distal radius fractures. American...
The diagnosis and treatment of acute Achilles tend...
ACS: Chest Pain and Acute Coronary Syndrome, Diagn...
Clinical guidelines for the use of chronic opioid ...
Clinical practice guideline for prostate cancer tr...
Venous thromboembolism diagnosis and treatment. In...
Diagnosis and management of attention deficit hype...
Treatment of childhood overweight and obesity. Mic...
Routine prenatal and postnatal care. Michigan Qual...
Prevention and identification of childhood overwei...
Ustekinumab for the treatment of adults with moder...
Cetuximab for the first-line treatment of metastat...
World Gastroenterology Organisation Global Guideli...
Cellular 'alchemy' transforms skin into blood
Research Suggests Link Between 'Handedness' and Dy...
Gene Associated With Autism May Alter How Brain Fu...
Genetic Deletion Linked to Raised Risk of Autism, ...
Vitamin D No Magic Bullet for Osteoarthritis
Controlling Computers with Your Mind
Lead Poisoning Treatment Less Effective for Mercur...
Malaria Mosquitoes Evolving
Evidence-based classification of recommendations o...
Use of genomic profiling to assess risk for cardio...
Recommendations from the EGAPP Working Group: Geno...
El Hospital: Ecri Institute - Monitores transcut...
Abstract | The genetic basis of multiple sclerosis...
Individualizing treatment duration in hepatitis C ...
Genome-Wide Association Study of Suicide Attempts ...
Genetic findings in anorexia and bulimia nervosa. ...
Australian Schizophrenia Research Bank: a database...
BMB reports Online: Overview of personalized medic...
Cutting the fat the genetic dissection of body wei...
GAPPKB|Home (beta version)
HuGENavigator|HuGE Literature Finder|Search (versi...
Genetic variations in toll-like receptor pathway g...
The pharmacogenetics of antidepressant-induced man...
Reduced-function CYP2C19 genotype and risk of adve...
Gene Variants Affect Hepatitis C Treatment, But Li...
How genetic variation affects patient response and...
Fcγ receptor polymorphisms and clinical efficacy o...
Effects of CYP2C19 genotype on outcomes of clopido...
JAMA -- Clopidogrel and the Reduced-Function CYP2C...
SARAMPIÓN, BROTE ESCOLAR - ESPAÑA (GRANADA)
FDA clears Cymbalta to treat chronic musculoskelet...
TRIQUINOSIS, EMBUTIDOS, BROTE - ARGENTINA (CÓRDOBA...
MALARIA, ALTA LETALIDAD, COMUNIDADES YANOMAMI - VE...
Nicaragua reporta 527 casos leptospirosis y dos ni...
Vaccines: Pubs/SurvManual/main page
Modifier genes in Mendelian disorders: the example...
GSTM1 Null and NAT2 Slow Acetylation Genotypes, Sm...
BRCA1 and BRCA2 genetic test in high risk patients...
Association of KRAS p.G13D mutation with outcome i...
LOC387715/HTRA1 gene polymorphisms and susceptibil...
Primary immunodeficiency diseases: Practice among ...
Europe’s Plagues Came From China, Study Finds - NY...
Science - UMass Medical School study points to gen...
Sigma nonopioid intracellular receptor 1 mutations...
Autism study reveals how genetic changes rewire th...
Boy with rare genetic disorder touches many :: The...
Genomics: DNA's master craftsmen
New global map shows distribution of sickle cell g...
Researchers Find 'Goldilocks' Of DNA Self-Assembly...
Scientists Describe New Approach For Identifying G...
New Methods Detect Subtleties In Human Genomes' Re...
Uncovering The Cause Of A Common Form Of Muscular ...
New approach for identifying genetic markers for c...
Sistema de Información de Medicamentos (SIM) // e-...
NIDA Drugs of Abuse and Related Topics - Medical C...
Severe morning sickness runs in families: MedlineP...
Multivitamins don't reduce diabetes risk: MedlineP...
First ladies join The Heart Truth to raise women's...
Lung cancer trial results show mortality benefit w...
The third International Meeting on Emerging Diseas...
The Major Genetic Determinants of HIV-1 Control Af...
Blood -- AICAR induces apoptosis independently of ...
Scientists find gene variant associated with reduc...
Researcher Uses Gene Defect Discovery To Help Card...
Test May Diagnose Deadly Niemann-Pick Type C Disea...
Genetic Variants May Affect The Risk Of Breast Can...
PHG Foundation | Genetic loci associated with Hodg...
Successful aging in the Amish: Researchers discove...
New mutation linked to non-Hodgkin's lymphoma
Asthma Linked to Lung Cancer Risk in Study: Medlin...
Retinal implant trial helps blind people see shape...
Gene Associated With Autism May Alter How Brain Fu...
Cuatro casos de malaria en Rosario por un barco pr...
Hereditary thrombophilia and recurrent pregnancy l...
PLoS ONE: Breast Cancer Stem-Like Cells Are Inhibi...
Cellular & Gene Therapy Guidances > Guidance for I...
NIH videos help health providers answer questions ...
Chemicals in Meat Cooked at High Temperatures and ...
DNA Region on Chromosome 1 Is Linked to Neuroblast...
Reducing Treatment Intensity in Early-Stage Hodgki...
Hemophilia drug can damage heart, study finds: Med...
Announcement: World Pneumonia Day --- November 12,...
Notes from the Field: Malaria Imported from West A...
Cholera Outbreak --- Haiti, October 2010
Evaluation of Acute Hepatitis C Infection Surveill...
Outbreaks Following Wild Poliovirus Importations -...
FDA reclassifies certain digital mammography devic...
CDC - Rotarix and RotaTeq Rotavirus Vaccines and I...
NIAID Web Bulletin: NIH Network Identifies Better ...
CDC - Blogs - Safe Healthcare – Investigating Rare...
V. CHOLERAE, IDENTIDAD GENÉTICA CON CEPAS ASIÁTIC...
DENGUE, BROTE: NO OFICIAL - CUBA (LA HABANA)
CÓLERA, BROTE, MUERTES - HAITÍ (05)
MALARIA, ALTA LETALIDAD, COMUNIDADES YANOMAMI - VE...
Heart Attack Symptoms and Calling 9-1-1 Campaign f...
Incidence of End-Stage Renal Disease Attributed to...
Cost-effectiveness of interventions to reduce diet...
Urine bisphenol-A (BPA) level in relation to semen...
NCCN 16th Annual Conference - Event Summary | Onli...
NCCN 2010 Congress Series: Respiratory Tract Cance...
Centros Control Enfermedades EEUU estudian cólera ...
CDC - Hepatitis B and Multiple Sclerosis ( MS) - V...
HepB_WAPIANTK_T.pdf (What Asian and Pacific Island...
NCTR Publications > NCTR Research Highlights
Statement from NIDDK Director Griffin P. Rodgers f...
NIH alerts caregivers to increase in SIDS risk dur...
NIH researchers identify genetic elements influenc...
National Guideline Clearinghouse | Work-related ra...
National Guideline Clearinghouse | Asthma.
National Guideline Clearinghouse | Adult immunizat...
National Guideline Clearinghouse | Incorporating a...
National Guideline Clearinghouse | SAGES guideline...
National Guideline Clearinghouse | Guidelines for ...
CDC - Hepatitis B and Multiple Sclerosis ( MS) - V...
NIH-supported mouse studies suggest treatment targ...
NIAID Media Availability: New Study Re-examines Ba...
Thermal Enhancement with Optically Activated Gold ...
Everolimus - About the Center for Drug Evaluation ...
Trastuzumab - (Labeling Change) - About the Center...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Guideline imple...
National Guideline Clearinghouse | Practice parame...
National Guideline Clearinghouse | Assessment: eff...
National Guideline Clearinghouse | Human milk stor...
DNA Region on Chromosome 1 Is Linked to Neuroblast...
Plastics Chemical BPA Tied to Poor Sperm Quality: ...
The Origins of Autoimmunity-Causing T Cells
Gene Variants Tied to Poor Outcomes with Heart Dru...
A New Phase for Human Genomics
Independent panel discourages routine use of treat...
Children with ADHD Symptoms at Higher Risk of Obes...
Heavy Smoking Linked to Alzheimer's in Study: Medl...
Treatment of Patients With Major Depressive Disord...
Updated Recommendations for Prevention of Invasive...
National Guideline Clearinghouse | Antiretroviral ...
National Guideline Clearinghouse | World Gastroent...
National Guideline Clearinghouse | World Gastroent...
Study finds gene links to common lymphoma cancer: ...
Race Affects Hepatitis C Recurrence After Liver Tr...
Concerns Grow Over Dangers of Caffeinated Alcohol ...
FDA approves new indication for Afinitor
Women's Health Topics > Women and Diabetes
FDA Approves Teflaro for Bacterial Infections
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